Gsk influenza virus vaccine
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Transcript of Gsk influenza virus vaccine
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Influenza Virus Vaccine
Presented by: Mahak Ajmera
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Contents
Company Introduction
Health Care Portfolio
Influenza Virus
Products
Vaccine Development Process
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GlaxoSmithKline
World largest research based pharmaceutical corporation that discover, develops, manufactures and markets branded health care products.
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2012
Source:http://www.gsk.com/content/dam/gsk/globals/documents/pdf/GSK-Annual-Report-2012.pdf
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Key Facts
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GlaxoSmithKline - Mission
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GlaxoSmithKline - Where they are?
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GSK - Turnover
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Source:http://www.gsk.com/content/dam/gsk/globals/documents/pdf/GSK-Annual-Report-2012.pdf
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Healthcare Portfolio
Pharmaceuticals
Infectious diseases
Cancer
Epilepsy
Heart Disease
Asthma and chronic pulmonary disease
AIDS
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Vaccines
Hepatitis A and B
Diphtheria, Tetanus, Whooping cough
Polio
Measles, Mumps, Rubella
Typhoid
Influenza
Bacterial meningitis
Consumer
Healthcare
Oral Care
Nutritional
Total wellness
Skin Health
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Healthcare Portfolio
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Source:http://www.gsk.com/content/dam/gsk/globals/documents/pdf/GSK-Annual-Report-2012.pdf
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GlaxoSmithKline Vaccines – Market Share
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Source: http://who.int/influenza_vaccines_plan/resources/session_10_kaddar.pdf
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Influenza
Influenza (the flu) contagious respiratory disease caused by influenza viruses.
Affect the respiratory track (nose, throat and lungs).
Symptoms : fever, headache, malaise, cough, sore throat, nasal congestion and body aches.
10% to 20% of the population is infected with influenza virus each year
It can cause to severe illness and at times lead to death.GSK - Influenza Virus Vaccine 12/3/2014 11
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Types of Influenza Virus
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Sr. No
Basis Type A Type B Type C
1 Symptoms Moderate to Severe Mild Mild
2 Age Group All Primarily children All
3 Affect Humans and animal Affects human only
Affects human only
4 Divided Subdivided based on antigenic differences
Not divided intosub types
Not divided into sub types
5 Epidemics Widespread Regional Don’t cause
6 Experienced Mostly Less Common than type A
RarelyReported
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Influenza A Virus
Is subdivide into two distinct large surface glycoprotein's antigens.
H- Haemagglutinin which initiates infection and attachment of virus to the susceptible cell
N- Neuraminidase which is responsible for release of virus from the infected cell
Mutations in the antigenic structure of the influenza virus have resulted in a number of different influenza subtypes and strains (antigenic drift)
H Type (1-15) and N Type (1-9)
Only H1, H2 and H3 and N1, N2 are found in humans.
Example: H1N1,H2N2,H3N2 etc.
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Source: Karl G Nicholson, John M Wood, Maria Zambon, THE LANCET • Vol 362 • November 22, 2003 • www.thelancet.com
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Influenza Virus
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Source: http://en.wikipedia.org/wiki/File:InfluenzaNomenclatureDiagram.svg
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Influenza Outbreak
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Types of Influenza Vaccines
Inactivated Vaccine (Killed)
• These type of vaccine are produced by killing the virus with chemicals, heat or radiation.
• There are three types of inactivated vaccine whole virus, split virus and subunit vaccine.
• They are generally injected (intramuscular).
Live Attenuated Vaccine
• The vaccine contain a version of weakened strain of virus.
• They are given intranasal.
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Fluarix
Suspension for injection supplied in 0.5-mL single-dose prefilled syringes
Composition:
• A/Christchurch/16/2010 (H1N1)
• A/Texas/50/2012 (H3N2)
• B/Massachusetts/2/2012
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Source: https://www.gsksource.com/gskprm/en/US/adirect/gskprm?cmd=ProductDetailPage&product_id=1244169218783&featureKey=600572
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Fluarix Quadrivalent
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Suspension for injection supplied in 0.5-mL single-dose prefilled syringes
Composition:
• A/Christchurch/16/2010 (H1N1)
• A/Texas/50/2012 (H3N2)
• B/Brisbane/3/2007
• B/Brisbane/60/2008
Source: https://www.gsksource.com/gskprm/en/US/adirect/gskprm?cmd=ProductDetailPage&product_id=1358783243411&featureKey=603902
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FluLaval
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Supplied in a 5-mL multi-dose vial containing 10 doses (0.5-mL each)
Composition:
• A/California/7/2009 (H1N1)
• A/Texas/50/2012 (H3N2)
• B/Massachusetts/2/2012
Source: https://www.gsksource.com/gskprm/en/US/adirect/gskprm?cmd=ProductDetailPage&product_id=1244169337831&featureKey=600581
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FluLaval Quadrivalent
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Supplied in a 5-mL multi-dose vial containing 10 doses (0.5 mL each)
Composition:
• A/California/7/2009 (H1N1)
• A/Texas/50/2012 (H3N2)
• B/Massachusetts/2/2012
• B/Brisbane/60/2008
Source:https://www.gsksource.com/gskprm/en/US/adirect/gskprm?cmd=ProductDetailPage&product_id=1378227924542&featureKey=604242
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Pandemrix
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For influenza pandemic (H1N1) also know as swine flu
Supplied as suspension to be mixed with emulsion adjuvant (AS03) before injection
Composition:
• A/California/7/2009 (H1N1)
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GSK Flu Vaccine Development Process
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Source: http://www.gsk.com/content/dam/gsk/globals/documents/pdf/GSK-Flu-Vaccine-Production-Process.pdf
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GSK Flu Vaccine Development Process
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GSK Flu Vaccine Development Process
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GSK Flu Vaccine Development Process
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References
http://www.gsk.com/about-us/what-we-do.html
http://www.gsk.com/products/our-vaccines.html
https://www.gsksource.com/gskprm/en/US/adirect/gskprm?cmd=ProductsByName#F
http://www.gsk.com/content/dam/gsk/globals/documents/pdf/GSK-Annual-Report-2012.pdf
http://www.gsk.com/content/dam/gsk/globals/documents/pdf/GSK-Flu-Vaccine-Production-Process.pdf
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