G 9( I rJ Io~KfV tA I. \j93\ ~ Y vl'(\\LW'

C)rlù~~0 S0 -'

~ ...-.i: ..9th 'European Meeting

on Injectab(e 'Bane

and Joint Substitution Materiafs

March 1 - 21 1999'EP!JL1 Lausanne

Final Program

Abstracts

List of Participants

Auditorium C02

Ecole Polytechnique Fédérale de Lausa.hne

EPFL Ifpr~ 1999

The structures of GRIBOI, Groupe de Recherche Interdisciplinaire sur

les Biomatériaux Ostéo-articulaires Injectables:

President

Vice-president

Secretar

Treasurer

Vice-treasurer

J. Lemaître, Lausane, Switzerland

B. Duquesnoy, Lile, France

P. Hardouin, Berck-sur-Mer, France

P. Van Landuyt, Lausane, Switzerland

B. Cortet, LilIe, France

Scientific committee

D. Bemache-Assolant (Limoges, F), J.P. Delagoutte (Nancy, F), J. De1ecrin (Nantes, F),

H. Deramond (Amiens, F), P. Hardouin (Berck-sur-Mer, F), H.P. Hildebrand (Lile, F), P.

Kaemmerlen (Lyon, F), J.L. Lacout (Toulouse, F), A. Laurent (Paris, F), H. Leclet (Berck-

sur-Mer, F), J. Lemaître (Lausanne, CH), G. Leroy (Lile, F), D. Mainard (Nancy, F), P.

Sharock (Toulouse, F), C. ValIée (Garches, F).

Local organizing committee

Swiss Federal Institute ofTechnology, Lausanne (EPFL)

J. Lemaître, P. Van Landuyt (EPFL)

We are extremely grateful to the following companies and institutions

who have generously contributed to GRIBOI99:

Sponsors

Dr. h.c. Robert Mathys Stiftg, Bettlach, Switzerland

Stratec Medical, Ol?erdorf, Switzerland

Osteotech, Eatontown NJ, USA

Reto LerfWERKSTOFFBERATUNG, Wildegg, Switzerland

Exhibitor

Teknmed SA, Vic en Bigorre, France

Scientific Endorsement

Groupe d'Etudes et de Travail en Radiologie Ostéo-Ariculaire (GETROA)

Association pour 1 , Etude des Greffes et Substituts Tissulaires de l' Appareil

Locomoteur (GESTO)

Groupe de recherche et d'expérientation en chirugie orthopédique (GRECO)

Société Française de Radiologie

Société Française de Rhumatologie

Fédération Nord-Pas de Calais

Swiss Society ofBiomaterials (SSB)

Groupe Français de la Céramique

. Conference Programme

Monday March 1, 1999

08h15 Welcome and paricipants registration

08h45 Opening address

Session 1. Acrylic vertebroplasty.

09hOO Vertebroplasty - clinical experience and follow-up results.D. Rüfenacht et al (Neuroradiology, Genève, Switzerland)

09h30 Temperatue generation ofbone cement polymerization during vertebroplasty.H Deramond et al (Université Hospital, Amiens, France)

10hOO Evaluation of bone cements for use in percutaneous vertebroplasty.S.M Belkoff et al (University of Maryland, USA)

10h30 The effect ofmonomer-to-powder ratio on the material properties ofCranioplastic.L.E. Jasper et al (University of Maryland, USA)

1 1 hOO Coffee break

Invited lecture

1lh30 "Futue potentials for using osteogenic stern cells and biomaterials in orthopaedics."J T Triftt (University of Oxford, GB).

12hl5 Lunch and poster session

Session 2. Calcium phosphate cements.

14h30 Calcium phosphate hydraulic cements : state ofthe art and clinical perspectives.J Lemaître (Swiss Federal Institute ofTechnology, Lausanne)

15hOO Effects of varous additives: lactic acid, glycerol, chitosan on the injectabilty of acalcium phosphate cement.

L. Leroux et al (Laboratoire des Matériaux, Toulouse, France)

15h30 Coffee Break

16hOO Volume effect on biological properties of an hydraulic calcium phosphate cement.Experimental study in sheep.B. Flautre et al (IRMS, Berck-sur-Mer, France)

16h30 Histological and biomechancal studies oftwo bone colonizable cements in rabbits.Lu JX et al (Faculté d'Odontologie, Marseile, France)

l7hOO Physico-chemical properties, composition and in vivo resorption behaviour of a highstrengt calcium-phosphate cement.

R. Wenz (Merck Biomaterial GmbH, Darmstadt, Germany)

19h30 Conference diner

Tuesday March 2,1999

Session 3. Hybrid biomaterials.

08h30 The use of autologous platelet-derive rowth-factor~~

G:J.Eawez::::!/0. searc . ute Inter 'ol1a1,-Gainesvile, USA) ..

09hOO Association of porous hydroxyapatite and bone marow cells for bone regeneration.K. Anselme et al (IRMS, Berck-sur-Mer, France)

09h30 Evaluation of rhBMP-2 loaded tricalcium phosphate implants in rabbits bone defeets.P. LajJargue et al (Faculté de Médecine, CHRU Lile, France)

10hOO Carilage repair : curent possibilities.D. Mainard (Hôpital Central, CHU Nancy, France)

10h30 Coffee break.

Session 4. Injectable calcium phosphate ceramics.

IlhOO BCPIHPMC composites : a new concepts for bone and dental substitutionbiomaterials.G. Daculsi (Faculté de Chirurgie Dentaire, Nantes, France)

Ilh30 Sterelization effects on injectable biomaterials.P. Sharrock et al (Université Paul Sabatier, Toulouse, France)

12hOO Injectable bone substitute (IBS) : how choosing a convenient polymerie carer?P. Weiss et al (Faculté de Chirurgie Dentaire, Nantes, France)

12h30 Granulometr ofthe mieral phase infuences the biological behavior of an injectablecalcium phosphate bone substitute.0. Gauthier et al (Fapulté de Chirurgie Dentaire, Nantes, France)

13hOO Lunch and poster session.

Regulatory aspects.

14h30 A regulatory perspective on injectable bone andjoint substitution materials.JH Shaw (Medical Devices Agency, London, United Kingdom)

Session 5. Physico-chemical characterization of biomaterials.

15hOO Morphological and mechancal properties of trabecular bone : state of the ar andimplications for substitution materials.P. Zysset (Swiss Federal Institute ofTechnology, Lausanne)

15h30 Mechancal aspects of cement/prosthesis interface: adhesion or interlocking.NEon et al (Ecole Centrale et CHU de Nantes, France)

16hOO Coffee break

16h 15 Test procedure for bone substitute materials.A. Gisep et al (AD Research Institute, Davos, Switzerland)

16h35 Potentialites of ultrasounds for the non-destructive evaluation of cell adhesion.A. Myrdycz et al (Université de Valenciennes, France)

17h05 Quantitative investigation of brushite cements and apatite implants by Ramanmicrospectrometry .G. Penel et al (Faculté d'Odontologie, Lile, France)

17h35 Closing remarks.

Poster Session.

POl Biomechanical comparison oftwo bone cements for use in vertebroplasty.SM Belkoff et al (University of Maryland, USA)

P02 Vertebroplasty - the interest of pretreatment contrast material injection.JE. Martin et al (Neuroradiology, Genève, Switzerland)

P03 Vertebroplasty - possibilities of opacification to control the polymer implantationprocedure.F. Mottu et al (Neuroradiology, Genève, Switzerland)

P04 Pathology findings in a case of vertebroplasty with PMMA.D. San Milan et al (Neuroradiology, Genève, Switzerland)

P05 Effect ofbone cement augmentation on the mechancal properties ofhuman cadavericvertebrae.P.F. Heini et al (Orthopaedic Surgery, Bern, Switzerland)

P06 Nacre induced bone marow cells stimulation and new bone formation, an in vivo and invitro study.

M Lamghari et al (URA CNRS, Muséum National d'Histoire Naturelle, Paris)

P07 Bone cement is not equal to bone cement : the morphological appearance of somePMMA-products in clinical use.F. Li et al (Labor für orthopädische Biomechanik, Felix Platter Spital, Basel,Switzerland)

P08 A novel bioactive ortopaedic composite.E. Erbe et al (Orthovita, Malvern, USA)

P09 CementekQì : chemIcal and mechancal characterization. First histological results.S Viala et al (Teknimed, Toulouse, France)

P10 Injectable bioactive cement for hyperthermiaJR. Cavalheiro et al (INEB, Porto, Portugal)

Pli Percutaneous treatment ofhighly vascular bone lesions.

E. Jean et al (Neuroradiology, Genève, Switzerland)

P 12 Mechancal characterization of biocements.E. Charrière et al (Swiss Federal Institute ofTechnology, Lausanne)

P 13 Mechanical characterization of brushite cements.C. Pittet et al (Swiss Federal Institute ofTechnology, Lausanne)

P 14 Reinforcement of osteQsynthesis screws with brushite cement.P. Van Landuyt et al (Swiss Federal Institute ofTechnology, Lausanne)

P 15 Infuence of polymeric additives on the mechancal properties of a-trcalciumphosphate cement.

L.A. dos Santos et al (State University 01 Campinas, Brésil)

P 16 Histological aspects of an association of porous HA and bone marow cells in bone

regeneration.B. Flautre et al (IRMS, Berck-sur-Mer, France)

P17 Macroporous biphasic calcium phosphate ceramic MBCPQY, a carier for human growthhormone umatropeQY.

G. Daculsi et al (Faculté de Chirurgie Dentaire, Nantes, France)

P 18 NMR spectroscopy of bone substitutes.A.P. Legrand et al (ESPC!, Paris, France)

P 19 Characterization of various fluorohydroxyapatites by solid state multinuclear magneticresonance.H Sfihi et al (ESPC!, Paris, France)

P20 Biomimetic calcium-phosphate coatings on Ti6AI4V. A crystal growth study of OCPand inhibition by Mg2+ and HC03-.F Barrere et al (IsoTis BV, Bilthoven, The Netherlands)

P21 Vertebroplasty of spine metastases.J Chiras et al (La Salpêtrière Hospital, Paris, France)

Prof M. AlIgõwer Prof M. Anseau

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er E. Erbe

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EPFLLab. Technologie des Poudres

MX-EcublensCH-l015 LausanneSUISSEPhone (021) 693 4907Fax (021) 693 3089e_Mail Stephane. T errazzoni t9 epfl.ch

MA E. PennisiResearch Institute International, Inc

6400 W Newberry Road, Suite 206-A

FL - 32 605 GainesvilleUSA

PhoneFaxe_Mail

1 352-331-81091 352-332-2119epennisi fl ad-hoc.gainesville.fl.us

Mr B. PeterEPFL

DMX

LMCH

CH-1015 LausanneSUISSEPhone (021) 69341 20Fax (021) 693 39 46e_Mail bastian.peter(g epfl.ch

Mr C. PittetEPFL

Dr M. PLAIS

SOFAMOR DANEKDépartement des MatériauxLaboratoire de Technologie des PoudresCH-1015 LausanneSuissePhoneFaxe_Mail

(021) 693 58 96(021) 693 30 89christian.pittet (g epfl.ch

13, rue de la Perdrix BP 50302

F-95940 ROISSY CDG CEDEXFRANCE

Phone 33149388015Fax 33149388013e_Mail phplais fl sofamordanek.com

Prof J. PROUST

UFR Odontologie

Lab. IMEB-EA n° 2198

27, Bd Jean-MoulinF-13385 MARSEILLE Cedex 5

FRANCE

Phone (33) 4 91 78 46 70Fax (33) 4 91 80 43 43e_Mail imebfl voltaire.timone.univ-mrs. fr

Dr P. ROTHE

Centre Hospitalier La BeauchéeServo Chirurgie OrthopédiqueBP 2367

F-22023 SAINT BRIEUC CEDEX 1

FRANCE

Phone 33 2 96 01 71 23Fax 33 2 96 01 73 62e_Mail

Dr J. Royer

Ecole Centrale de NantesLaboratoire de Mécanique des Structures1,rueNoÎF-4 300 NantesFRANCE

PhoneFaxe_Mail

Dr MD D. RufenachtHCUG

Neuroradiologie24 rue Micheli-du-Crest

CH-1211 Genève 14SUISSEPhone (022) 372 7030Fax (022) 372 7072e_Mail Daniel.Ruefenachtfl dirn. hcuge.ch**.*.

Dr M. RuhliSchulthess Klinik

Dr i. Salani

Lengghalde 2CH-8008 ZürichSwitzerlandPhone 01 38571 71Fax 01 385 75 38e_Mail

Via Massagno 36

CH-900 LuganoSUISSEPhone (091) 910 31 72Fax (091) 91031 73e_Mail

*****

Dr J. Triffitl \ ù-University of Oxford 'ìlv\ \i~ _MRC Bone Research Laboratory I¿ V'Nuffield Orthopaedic Centre CfvY "t) íOX3 7LD Headington-Oxford "J ( YGRANDE BRETAGNE rr 'CPhone 00 44 1865 227 660 \; J'0 -\ \~ ~r'Fax 00441865227 673 ~ 0-' ,e_Mail james.triffttC1ndos.ox.ac.uk G- "J \-.

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Dr S. Viala

TEKNIMED

8 Rue Corps Franc PommiesF-65502 Vic-en-Bogorre CEDEX

FRANCE

Phone 0033 562 96 88 38Fax 0033 562 96 28 72

e_Mail

Mr N. Vuilème

Métaux Précieux SA Métalor

Avenue du Vignoble

CH-2009 NeuchâtelSUISSEPhone (032) 720 6574Fax (032) 720 6609e_Mail

Dr R. Wenz

Merck Biomaterial GmbH

Frankfurterstr. 1290-4271 DarmstadtALLEMAGNE

Phone 06151-72-6248Fax 06151-72-3151

e_Mail robert. wenz C1 merck.de

Prof P. Zysset

EPFLLab. Mécanique AppliquéeME-EcublensCH-1015 LausanneSUISSEPhone (021) 693 5973Fax (021) 693 2999e_Mail Philppe.ZyssetC1epfl.ch

Dr P. Van Landuyt

EPFL

Lab. Technologie des Poudres

MX-EcublensCH-1015 LausanneSUISSEPhone (021) 693 5106Fax (021) 693 3089e_Mail PascaL. VanlanduytC1 epfl.ch*****

Dr MD G. VIastosHôpitaux Universitaires de Genève

Hôpital Cantonal

rue Micheli-du-Crest 24

CH-1211 Genève 14SUISSEPhone (022)Fax (022)e_Mail

Prof P. Weiss

4 im passe du Coteau BodinF-4 800 Saint HerblainFRANCE

Phone 0240851541

Faxe_Mail pweiss C1 sante. univ .nantes. fr

Prof G. Ziegler

University of Bayreuth

0-95 440 Bayreuth

DeutschlandPhone 921-555501

Fax 921-555502e_Mail Guenter.zieglercg uni-bayreuth.de