Androgenetic Alopecia and Cardiovascular Risk

FactorsGretel S. Montañez

RISE Program- Fall 2011

What is alopecia?

(Nordqvist, 2009) ( Mosby, 2009) Illustration copyright 2000 by Nucleus Communications, Inc. All rights reserved. http://www.nucleusinc.com

Types of alopecia Areata Totalis Universalis Barbae Mucinosa Androgenetic

(Nordqvist, 2007) Illustration (Breeling, 2008)

What is Androgenetic Alopecia?

(Nordqvist, 2007) (Berman, Zieve, 2011)

Diagnosis Eliminating other

causes of baldness

Trichonoscopy Biopsy

Treatments Finasteride Minoxidil Laser

phototherapy Dermabrasion gel

(Nordqvist, 2007)

Baldness could be a signal of other diseases prostatic cancer heart problems emotional problems

Relations between baldness and cardiovascular risk factors

(Arias, 2009)

Androgenetic alopecia and cardiovascular risk factors in men and

women: A comparative study

Present the relations between the androgenic alopecia and cardiovascular risk factors

Objectives: analyze the presence of cardiovascular risk factors and find the cardiovascular risk in Adult Panel III for metabolic factors, hormonal factors Comparison between genres

Use 154 Caucasian participants, 77 early-onset AGA and 77 healthy controls

Results: diagnosed metabolic syndrome in 60% males and 48.6% woman with AGA

(Arias, Gutiérrez, Castellote, Buendía, Naranjo, 2009)

Results: Diagnosed metabolic syndrome in 60% males

and 48.6% woman with AGA Carotic atheroma plaques in 29.9% in patients

with AGA and 7.8% in the control group High levels of aldosterone and insulin in males

and woman with AGA

Conclusion: Using ultrasound would be useful to find

methods to detect cardiovascular risks with early-onset AGA and find an early preventive treatment

(Arias, Gutiérrez, Castellote, Buendía, Naranjo, 2009)

Baldness and coronary heart disease risk factors

Study the relation between the prevalence of baldness and coronary risks factors in male workers

3 periods of examination (1987-1980)

Participants: 872 males 280 fronto-occipital baldness 273 frontal baldness 231 no baldness

MAHADEVIA, 2011

(Trevisan, Farinaro, Krogh, Joss, Giumfxti, Fusco, Panico, Mellone, Frascatore, Scottoni, Mancini , 1993)

Method Make a personal profile that include

Resting electrocardiogram Blood pressure measurement Height and weight measurements Blood sample for cholesterol and triglycerides

Results: 38% participants not present signs of hair loss 31.3% had slow frontal baldness 31.9% had fronto-occipital baldness Baldness was associated with high levels of cholesterol and blood

pressure

(Trevisan, Farinaro, Krogh, Joss, Giumfxti, Fusco, Panico, Mellone, Frascatore, Scottoni, Mancini , 1993)

Baldness and Myocardial Infarction in Men

The Atherosclerosis Risk in Communities Study

Examined the associations between baldness and myocardial infarction and the risk of atherosclerosis

Method: Blood sample took from National Heart Lung Two groups: Experimental= risk of atherosclerosis and Control=

free baldness Classified the baldness by the Hamilton/Norwood scale Technician observed the patient head from side and top and

compared with normal hair Organized in 5 groups

No baldness moderate vertex baldness Frontal baldness alone severe vertex baldness Mild vertex baldness skip

(Shahar, Heiss, Rosamond, Szklo et al , 2007)

back

2008 DermaGenoma Inc, all rights reserved.

Method (cont.) Distribution of baldness pattern by myocardial infarction status and the

relations of baldness in several risk factors for coronary heart disease. The relations of baldness patterns in a carotid thickness The subject were 5,056 men (52-75 years)

767 had history of myocardial infarctions Results:

.28 (frontal baldness), 1.02 (mild vertex baldness) 1.40 (moderate vertex baldness) 1.18 (severe vertex baldness) Baldness patterns were not an important risk factor for myocardial

infarction or atherosclerosis

(Shahar, Heiss, Rosamond, Szklo et al , 2007)

Discussion First study

Confirms the association between early-onset Androgenetic alopecia and a higher cardiovascular risk

Prevalence of carotid atheromatosis in patients with AGA

Second study Pattern of male baldness were associated with increased levels of

serum total cholesterol and high blood pressure

Third study No evidence of an association between baldness and carotid

thickness

Conclusion 2/3 studies reviewed sustain my statement

Contributions to science Lead to future studies about the relations of alopecia with other

diseases Informs society