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Toxicology Letters 158 (2005) 167175
Mini Review
Adverse effects of anabolic steroids in athletesreat
C. Maravelias, A. Dona, M. Stefanidou , C. SpiliopoulouDepartment of Forensic Medicine and Toxicology, University of Athens, Medical School,
75 Mikras Asias Street, Goudi, Athens 115 27, Greece
Received 7 April 2005; received in revised form 8 June 2005; accepted 8 June 2005Available online 6 July 2005
Abstract
Anabolic-augmentinggenerally dodamage. Ammasculinizahepatic neopthe reproducpsychologicemphasizing 2005 Else
Keywords: A
Contents
1. Introdu2. Mecha3. Advers
3.1.3.2.3.3.3.4.
CorresponE-mail ad
0378-4274/$doi:10.1016/jandrogenic steroids (AAS) are used as ergogenic aids by athletes and non-athletes to enhance performance bymuscular development and strength. AAS administration is often associated with various adverse effects that arese related. High and multi-doses of AAS used for athletic enhancement can lead to serious and irreversible organong the most common adverse effects of AAS are some degree of reduced fertility and gynecomastia in males and
tion in women and children. Other adverse effects include hypertension and atherosclerosis, blood clotting, jaundice,lasms and carcinoma, tendon damage, psychiatric and behavioral disorders. More specifically, this article reviewstive, hepatic, cardiovascular, hematological, cerebrovascular, musculoskeletal, endocrine, renal, immunologic andeffects. Drug-prevention counseling to athletes is highlighted and the use of anabolic steroids is must be avoided,that sports goals may be met within the framework of honest competition, free of doping substances.
vier Ireland Ltd. All rights reserved.
nabolic-androgenic steroids (AAS); Testosterone; Adverse effects; Athletes; Doping
ction . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 168nism of action . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 169e effects of AAS. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 169Reproductive effects . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 170Hepatic effects . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 170Cardiovascular, cerebrovascular and hematological effects . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 171Musculoskeletal effects . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 171
ding author. Tel.: +30 210 7716098; fax: +30 210 7716098.dress: [email protected] (M. Stefanidou).
see front matter 2005 Elsevier Ireland Ltd. All rights reserved..toxlet.2005.06.005A constant th
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168 C. Maravelias et al. / Toxicology Letters 158 (2005) 167175
3.5. Endocrine effects . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1713.6. Renal effects . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1723.7. Immunologic and infectious effects . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1723.8. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 172
4. Conclu . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 172Refere . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 173
1. Introdu
Since thous derivatand studielife of theterone hasas androgenon-reprodresponsibleand develowhereas anand increas
The potanabolic aled to syntately calledthe goals oparent molegens, and dand moreof testosternot been aanabolic acity (Shahid
The anatives is primwhich resuin conjuncton the braeuphoria anwidespreadwell as bylimited to pfocusing onand significletes and nand Dumitrate of useical risks,
medical and athletic organizations as well as byidual scientists (American Academy of Pediatrics,). These statements condemn the use of anabolicids but confirm that they enhance strength veryitively (Bhasin et al., 1996a,b). It has become evi-that prohibitions against anabolic steroid use ands that steroids lack efficacy or produce harm haveinsufficient to curtail their use (Marshall, 1988;berg et al., 1990). In addition, anabolic steroidslong ago been available on the black market andare easy to obtain in many gyms or health clubshaine, 1989).is an uone stred to
inclut. Theased g
on or
etholzolol.rolone
1lic ster
nabolicic nameetholonroloneandrostestrenololola
ymesterandrolnolonePsychologic effects . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .sions . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .nces . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
ction
e discovery of testosterone in 1935, numer-ives of testosterone have been synthesizedd in order to prolong the metabolic half-parent molecule and its efficacy. Testos-been found to exert its effects; designatednic and anabolic, on both reproductive anductive target tissues. Androgenic effects arefor growth of the male reproductive system
pment of secondary sexual characteristics,abolic effects stimulate nitrogen fixationed protein synthesis (Kuhn, 2002).ential therapeutic value of testosteronesctivity in various catabolic situations hashesis of many derivatives, more appropri-, anabolic-androgenic steroids (AAS) withf prolonging the biological activity of thecule in vivo, producing orally active andro-eveloping products that are less androgenicanabolic. Although complete dissociationones androgenic and anabolic effects havechieved, the AAS have shown significanttivity with somewhat reduced androgenic-i, 2001).bolic activity of testosterone and its deriva-
arily manifested in its myotrophic action,lts in greater muscle mass and strength. This,ion to the stimulatory effects of androgensin, which frequently result in a feeling ofd increased aggressiveness, has led to theuse of AAS by athletes at all levels, as
recreational drug users. Such use is notrofessional and Olympic athletes. Studies
manyindiv1997sterodefindentclaimbeenGoldhavethey(Duc
Itthanreferoftenagenincrecomm
oxymstanonand
TableAnabo
Oral a(generOxymOxandMethaEthyleStanozFluoxNorethMetheanabolic steroids have shown a continuingant increase of use among adolescent ath-on-athletes alike (Wagner, 1989; Windsorru, 1989). In response to the alarming highof anabolic steroids and the attendant med-policy statements have been published by
MesteroloneTestosterone u
a 17-Alphab 19-Nortesc Testosterod Veterinarynfortunate fact that most athletes use moreeroid at one single time. This state is oftenas stacking. The stack or array of drugsdes at least one oral and one injectabledrugs may be taken at low doses initially,radually, and then tapered. Some of theally administered anabolic steroids include
one, oxandrolone, methandrostenolone andSome of the injectable steroids includedecanoate, nandrolone phenpropionate,
oids generally used by athletes
steroids)
Injectable anabolic steroids(generic name)
ea Nandrolone decanoatebNandrolone phenpropionateb
nolonea Testosterone cypionateca Testosterone enanthatec
Testosterone propionateconea Methenolone enanthateone Boldenone undecyclenateacetate Trenbolone acetated
dTrenbolonendecanoate Stanozolol
alkylated steroids.tosterone esters.ne esters.steroids.
-
C. Maravelias et al. / Toxicology Letters 158 (2005) 167175 169
testosterone cypionate, and boldenone undecylenate(Table 1).
The fact remains that the abuse of androgenicanabolic sproblem inThe goal ovant issuesmechanismThis informpharmacistteenagers,from any d
2. Mechan
Studiesanabolic stecontroversian increaseno increasetocols, as wdrugs takencould explaRovere, 19be effective
1. They coitive onand incthe abilmuscle ctheir effcellularchromaing proding protThe vartype andenzymeorgan. Tto be idand Gri
2. Steroidscausingcocorticthesis d1984).
Table 2Desired effects of anabolic steroids as perceived by sportscompetitorsa
Increased mused streased recsed aggte heal
ain saming a w
apted f
thletescreasetigue80). T
om wod inte
overe,sted (summ
ids in
dvers
is a wof th
ree ofand t
s of litis andeffect). In adcteriae reactlthougts of alinican on adverse reactions is anecdotal, or is assumedknown problems associated with therapeutic usese agents (Lamb, 1984; Yesalis and Bahrke, 1995;
son et al., 1989; Sullivan et al., 1999; Mottrameorge, 2000; Kuhn, 2002; Kutscher et al., 2002;
inen and Seppala, 2002; Juhn, 2003; Bahrke andlis, 2004). Nevertheless, one has to pay attentionconfound these health consequences of AAS withprovoked by other performance enhancing andteroids (AAS) is a remarkably prevalentcompetitive and non-competitive athletes.f this is to summarize the clinically rele-regarding AAS abuse, including prevalence,
of action, efficacy and adverse effects.ation will therefore enable physicians and
s to adequately educate and guide athletes,parents, teachers and coaches to stay awayoping process.
ism of action
performed to determine the effects ofroids on muscle strength and size have beenal, with approximately half of them findingwith steroid use and the other half finding(Johnson, 1990). Differences in study pro-ell as uncontrolled dosages and number ofby athletes, who participate in the studies,in discrepancies in the results (Haupt and
84). Nevertheless, anabolic steroids seem toin three ways:
nvert a negative nitrogen balance to a pos-e by improving the use of ingested proteinreasing nitrogen retention. They also haveity to induce protein synthesis in skeletalells). Anabolic steroids are believed to exert
ects by binding to androgen receptors at thelevel, which translocate to binding sites on
tin, promoting gene transcription, stimulat-uction of mRNA, and ultimately increas-ein synthesis (Bahrke and Yesalis, 2004).ious clinical effects are determined by the
concentrations of androgen receptors ands controlling steroid metabolism in a givenhe structure of androgen receptors appears
entical in muscle and other organs (Wilsonffin, 1980; Snyder, 2001).compete for glucocorticosteroid receptors,
an anti-catabolic effect by blocking the glu-osteroid effects of depressed protein syn-uring stressful training (Haupt and Rovere,
IncreaDecreIncreaPromoMaintObtain
a Ad
3. Ainfa19fran
Rge
Astero
3. A
Ittrialsnot fdose-levelhepathese1990to batissu
Aeffecthat cmatiofromof theHickand GParssYesanot tothosescle massngthovery timeressioning of injuriese advantage as ones opponentinning edge
rom Hough (1990).
often experience a state of euphoria,d aggressive behavior, and diminishedduring steroid use (Wilson and Griffin,hey report that they recover more rapidlyrkouts and they can train more frequentlynsively while using the drugs (Haupt and1984). A placebo effect has also been sug-Ariel and Saville, 1972).
ary of the desired effects of anabolicsports competitors appears in Table 2.
e effects of AAS
ell known fact that the clinical-therapeutice main AAS often used by physicians areadverse effects. These adverse effects areype of steroid-related and include elevatedver enzymes, cholestatic jaundice, peliosisvarious neoplastic lesions. An overview ofs is outlined in Table 3 (Landry and Primos,dition, deep IM injections of AAS may lead
l and fungal abscesses and exuberant localions (Shahidi, 2001).h many excellent reviews on the adversenabolic steroids are available, due to the factl trials are not feasible, much of the infor-
-
170 C. Maravelias et al. / Toxicology Letters 158 (2005) 167175
Table 3Possible adverse effects of anabolic steroidsa
ReproductiveMale
Decreased reproductive hormonesTesticular atrophyOligospermia/azoospermiaImpotenceProstatic hypertrophyProstatic carcinomaGynecomastiaPriapism
FemaleMenstrual irregularitiesClitoral hypertrophyUterine atrophyBreast atrophyTeratogenicity
LiverHepatocellular damageCholestasisPeliosis hepatisHepatoadenomaHepatocarcinoma
Cardiovascular and hematologic effectsIncreased cholesterolDecreased HDL cholesterolHypertensionThrombosis
MusculoskeletalEarly epiphyseal closure in childrenIncreased rate of muscle strains/rupturesIncreased risk of musckulotendinous
Endocrine (other than reproductive)Decreased glucose tolerance
LarynxDeepening of the voice
IntegumentAcneAlopeciaHirsutismMale pattern baldnessEdema
UrinaryElevated BUN, creatinineWilms tumor
Immunologic and Infectious effectsDecreased IgA levelsHepatitis B or C; HIV infection
PsychologicMood swingsAggressive behaviorDepressionPsychosisAddictionWithdrawal and Dependency Disorders
a Adapted from Landry and Primos (1990).
illicit drugs co-administered with AAS (Bahrke andYesalis, 2004).
3.1. Repro
Use of sing hormonleads to detion, decrephy. The tazoospermthe drugs, bmay be abn2000; Dohhypertrophprostate caHolden etthe peripheestrone. Thsons with lhepatic clemetabolitesprominentsteroids instrual abnowell. Thessutism, acnphy, and mgenic effecof Pediatric
3.2. Hepat
Elevatioaminotranstate dehydruse steroidbe elevated(Hough, 19associated2000; Snydsionally wi3 monthsboth benigadministrat1993; SoeAlter, 2004steroid useductive effects
teroids in men decreases levels of luteiniz-e and follicle-stimulating hormones, whichcreased endogenous testosterone produc-
ased spermatogenesis, and testicular atro-esticular atrophy and the oligospermia oria usually resolve after discontinuation ofut the count and morphology of the spermormal for up to 6 months (Boyadjiev et al.,
le et al., 2003; Eklof et al., 2003). Prostaticy, priapism, and, rarely, carcinoma of then be associated with steroid use (Wemyss-al., 1994). Gynecomastia may result fromral conversion of androgens to estradiol andis side effect can be pronounced in per-
iver disease, probably because of decreasedarance of the parent steroid or estrogenic. The breast tissue becomes softer and lessafter steroid use stops. Use of anabolicwomen, is not only associated with men-rmalities but with masculinizing effects ase effects of AAS in women include hir-e, deepening of the voice, clitoral hypertro-ale-pattern baldness. Some of these andro-ts may be irreversible (American Academys, 1997; Elliot and Goldberg, 2000).
ic effects
ns in levels of liver enzymes (aspartateferase, alanine aminotransferase, and lac-ogenase) are also common in athletes whos. Nevertheless, these enzymes can oftenin weightlifters who are not using steroids
90). Hepatic dysfunction is most commonlywith the 17-alpha alkylated steroids (Friedl,er, 2001). Cholestatic jaundice occurs occa-th steroid use and typically resolves withinof discontinuing the drugs. Liver tumors,n and malignant, have been linked to theion of steroids (Watanabe and Kobayashi,et al., 1994; Friedl, 2000; Velazquez and). Several athletes with extensive histories ofhave died of hepatocellular carcinoma or of
-
C. Maravelias et al. / Toxicology Letters 158 (2005) 167175 171
hepatic tumor rupture. Hepatocellular carcinomas weremore often associated with oxymetholone and methyltestosterone (Velazquez and Alter, 2004). There is anincreased ris a rare foof multiplecan be fataPavlatos et
3.3. Cardihematologi
Anabolilipid profilopment ofdeterminedanabolic stetions and liAdelman, 1
A signitein (HDLlow-densitysteroid useatherosclerreturn or nuse and norabuse (CohHartgens e
Hyperteand myocaathletes whtime (Ferenthe actual fden death areported inrelationshipeffect is pRockhold,al., 2004).to irreversicentric left2004).
Anabolimass, hemIncreased fiting factorssteroids. Cein two ster
1988; Kledal et al., 2000; Shahidi, 2001). A case oflethal cerebral oedema has been associated with mas-sive abuse of AAS in a previously healthy 21-year-old
(Kled
Muscu
f partire inase ingens
ve thaous inase inased inr riskshed rugh ethat sndon,n collupture
Endoc
theid usequentdary
lteredance,also
ale poidi, 20cne isult of ts. Le, do nly et amporand whs of twom
d of titism, dies theversiesalisisk of peliosis hepatis with steroid use. Thisrm of hepatitis characterized by formationblood-filled cysts within the liver, which
l (Lamb, 1984; Dourakis and Tolis, 1998;al., 2001).
ovascular, cerebrovascular andcal effects
c steroids may adversely affect the serume, but their long-term effects on the devel-
coronary artery disease have not been. Thrombotic phenomena associated withroid use include strokes, myocardial infarc-
mb loss (Ferenchick, 1990; Ferenchick and992).ficant decrease in high-density lipopro-) cholesterol and, often, an increase in
lipoprotein (LDL) cholesterol occur with, placing the user at increased risk forotic heart disease. Cholesterol levels mayot to normal following cessation of steroidmalization depends on the duration of AASen et al., 1988; Glazer, 1991; Shahidi, 2001;t al., 2004).nsion is associated with anabolic steroid userdial infarction has been reported in severalo used steroids for a prolonged period ofchick, 1990). These case reports reveal thatrequency of myocardial infarction and sud-mong users of AAS is presumably under-medical literature and although a causalhas not yet been established, a pathogenic
lausible (Ferenchick and Adelman, 1992;1993; Ansell et al., 1993; Halvorsen etMoreover, anabolic use has been relatedble changes to myocardium, such as con-ventricular hypertrophy (Urhausen et al.,
c steroids increase red blood cell (RBC)atocrit and RBC count (Snyder, 2001).brinolytic activity and an increase in clot-have been associated with the use of specificrebrovascular accidents have been reported
oid-using athletes (Mochizuki and Richter,
man
3.4.
OclosudecreandrobelietendiincreincrehighepubliAlthogestof teshowdon r
3.5.
Insterosubsesecon
Aresisthavein mShah
Aa res
glandchest(Kira
Temen
lengtIn
periohirsuularitbe irrand Yal et al., 2000).
loskeletal effects
cular concern is the premature epiphysealany child/adolescent, which results in aadult height after prolonged exposure to
(Al-Ismail et al., 2002). Some scientistst there is an increased risk of musculo-juries with steroid use. Tendons may notstrength as muscles do and, when subject totensity and frequency of training, may be atfor rupture according to a small number ofeports (Shahidi, 2001; Battista et al., 2003).xperimental data from animal models sug-teroids alter the biomechanical propertiesultrastructural analysis of tendons has notagen changes that might predispose to ten-
in humans (Evans et al., 1998).
rine effects
prepubertal or pubertal male, prolongedwill result in accelerated maturation withchanges in physique and development of
sexual characteristics.glucose tolerance with increased insulinas well as, decreases of thyroid hormonesbeen reported with anabolic steroid usewer lifters (Cohen and Hickman, 1987;01; Snyder, 2001).a common side effect of steroid use and it ishe androgenic stimulation of the sebaceoussions, most often located on the back andot always respond to routine acne therapyl., 1987).
al hair recession and alopecia can be seen inomen using anabolic steroids for extendedime.en using anabolic steroids for a prolongedme, masculinization may be manifested aseepening of the voice, and menstrual irreg-
at are caused by steroid use, but which mayble once the drugs are discontinued (Bahrke, 2004).
-
172 C. Maravelias et al. / Toxicology Letters 158 (2005) 167175
3.6. Renal effects
Weightlifters not using anabolic steroids may expe-rience a risskeletal muelevation i(BUN), andmal once tRichter, 19
Acute reolysis in a(Hagelochcreatinineby body budiffuse membeen report
Wilmsreported in(Joyce, 19steroids aregrowth or pcarcinogen1993).
3.7. Immu
There hinfections rneedles forrisks of infand needlealso been reShahidi, 20
3.8. Psych
Some iand behavincluding irsion, mood(Kashkin adleman an2003).
A recen90% of useand violentby steroidsies do not
aggressive behavior (Bhasin et al., 1996a,b; Yates etal., 1999).
Anabolic steroid withdrawal and dependency dis-s havr, 199rawalergicnia,
nausea
rtensioalso osychoem ofve psyprior
eroidsing the dep
chanlant dkle e, similrred uids. Mren mal efferity toges. Inl skillangesly thaere h
onshipdal stemotionscentsere re
quenc2003)studi
olled)genic
onclu
tentianue toe in serum creatinine as a result of increasedscle mass. Steroid use may also cause an
n serum creatinine, blood urine nitrogenuric acid. These values often return to nor-
he drugs are discontinued (Mochizuki and88; Juhn, 2003).nal failure as a complication of rhabdomy-body builder using AAS has been reportedet al., 1988). The combination of AAS andsupplement that has been currently abusedilders may cause renal damage. A case ofbranoproliferative glomerulonephritis has
ed (Revai et al., 2003).tumor, uncommon in adults, has beenseveral athletes using anabolic steroids
91). There is evidence suggesting thatweak carcinogens that can initiate tumor
romote such growth in the presence of others (Lamb, 1984; Watanabe and Kobayashi,
nologic and infectious effects
ave been cases of hepatitis B or C and HIVeported in bodybuilders who were sharingsteroid injections in some cases. Increased
ections from improper handling of syringess and from use of impure substances haveported (Rogol and Yesalis, 1992; Wu, 1997;01).
ologic effects
ndividuals may experience mental statusioral changes with anabolic steroid use,ritability, aggressiveness, euphoria, depres-swings, altered libido, and even psychosis
nd Kleber, 1989; Bahrke et al., 1990; Mid-d DuRant, 1996; Clark and Henderson,
t study of health club athletes revealed thatrs reported episodes of over aggressivenessbehavior which were believed to be induced(Tamir et al., 2004), whereas other stud-
support any association between AAS and
orderlowewithdadreninsomgia,hypemayrisk pproblrelatiusers
Stmeetstancgramstimu(Frantomsoccu
sterochildlogicmatuchansociatal chrapid
Threlatigonathe eadoleels wconse
son,
dinalcontrandro
4. C
Pocontie also been reported (Foley and Schyd-3; Bahrke, 2000). Acute anabolic steroid
may produce symptoms of central non-hyperactivity including anxiety, irritability,hot flashes, sweats, chills, anorexia, myal-, vomiting, piloerection, tachycardia, andn. Depression and anabolic steroid cravingccur with withdrawal. Nevertheless, highlogical behaviors may also be the primarythose who take anabolic steroids althoughchiatric disorders may be observed on theseto use (Middleman and DuRant, 1996).may be psychologically addicting, even
e DSM-IV criteria for psychoactive sub-endence in some cases. Electroencephalo-ges similar to those seen with psycho-rugs have been reported with steroid uset al., 1988). Physical withdrawal symp-ar to those seen in opiate withdrawal, havepon cessation of extremely high doses oforeover, the developing nervous system ofay be especially vulnerable to the psycho-cts of steroids. Adolescents may lack the
cope with possible drug-induced moodaddition, the development of appropriate
s and controls necessary to deal with puber-may be made difficult if changes occur moren expected (Snyder, 2001).ave also been reports stating that there is a
between hormone levels (gonadotropins,roid hormones, and adrenal androgens) andal dispositions and aggressive behaviors of. The results indicate that high hormone lev-lated to potentially adverse psychologicales for boys and girls (Clark and Hender-
. Nevertheless, more sophisticated longitu-es (probably placebo and training regimenare required to dissect the role of anabolic-steroids in behavioral disturbances.
sions
l anabolic steroid users have been and willbe involved in sports where strength and
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C. Maravelias et al. / Toxicology Letters 158 (2005) 167175 173
muscle mass are at a premium. Endurance athletes andnon-athletes at any age, seeking to add strength, bulk,muscle definition, or to improve their self-image mustalso be con
Anabolibe aware thsteroids msigns. Nevethe risks aning that thiscence aboucated approin internatiticipants, aeffects of astrength trameet theirYesalis, 19niques candrug use (G
Drug-prpreferablya healthy ala way to msteroids. Ahealth, fitntion can beenhancingthat steroidto point outsuccess did
With thand side epharmacistletes, teenaaway fromof the socfree athletiPhysiciansing controlhave alsoand treatinstances. Moanti-dopinga problemauthorities.must fighting the nee
or any other methods known in the long run of sportshistory.
rence
ail, K.uteal mcation ocan Aceroids:l, J., Tiasociated7371.G., Savects ofe, M.S.roids anarmacoe, M.S.one andabolicnetics,e, M.Sd behavabolic-aed. 10,ta, V., Chilles t
ed. 31,, S., Sillips, J96a. Thscle siz
7., S., Stillips, J96b. Thscle siz
7.jiev, N
I., 2000anabolity disor1274.A.S., Hponsesv. 27, 4, J.C., Hcose to
in. End, J.C.,olemiaroids. P, G.R.,ity. Worsidered to be at risk.c steroid users and potential users shouldat many of the adverse effects of anabolic
ight be present without obvious warningrtheless, one should present youth with bothd the benefits of anabolic steroids use, hop-will be more effective in convincing adoles-t steroids negative effects. A more sophisti-ach might be methods that have been used
onal programs, such as ATLAS, where par-part from being informed on the potentialnabolic steroids, they are also informed howining and proper nutrition can help them togoals (Landry and Prinos, 1990, Rogol and92). In addition, proper weightlifting tech-be offered by trainers as an alternative tooldberg et al., 1996, 2000).
evention counseling should be providedat early adolescence which hopefully lead toternative to drug use. Most athletes will findeet their sports goals without using anabolicthletes may need to be reminded that theess and social benefits of sports participa-
readily met without use of performance-substances. For the athlete who is convinceds are essential for success, it may be helpfulrole models in the sports community whosenot depend on the use of drugs.
e appropriate knowledge about the effectsffects of anabolic steroids, physicians ands can adequately educate and guide ath-gers, parents, teachers and coaches to staydoping and help towards the ultimate goal
iety to accomplish not only totally drug-c competitions, but also a drug-free youth.and pharmacists play a key role in dop-programs in a number of ways and they
the obligation when counseling, advisingg athletes to help them avoid banned sub-reover, the challenge of developing a globalprogram requires acceptance of doping as
by sport organizations, athletes and publicAll parties involved in this type of programs
for drug free sports, particularly emphasiz-d to keep away from any doping substance
Refe
Al-IsmGlpli
AmeriSt
Anselas
36Ariel,
effBahrk
stePh
BahrkterAnKi
Bahrkan
an
MBattis
AcM
BhasinPh19mu
1Bhasin
Ph19mu
1Boyad
S.ofali27
Clark,res
ReCohen
gluCl
Cohenterste
Dohletils
, Torreggiani, W.C., Munk, P.L., Nicolaou, S., 2002.ass in a bodybuilder: radiological depiction of a com-f anabolic steroid use. Eur. Radiol. 12, 13661369.
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Adverse effects of anabolic steroids in athletesIntroductionMechanism of actionAdverse effects of AASReproductive effectsHepatic effectsCardiovascular, cerebrovascular and hematological effectsMusculoskeletal effectsEndocrine effectsRenal effectsImmunologic and infectious effectsPsychologic effects
ConclusionsReferences