GREEN CHEMISTRY IN PHARMACEUTICAL

INDUSTRIESPresented by

Shamna c3rd Bsc CHEMISTRY

what is green chemistry? It is the utilization of a set of principles

that reduces or eliminates the use or generation of hazardous substances in design, manufacture and application of chemical products.

It is also called sustainable chemistry which is a chemical philosophy encouraging design of products and processes that reduce or eliminate use of hazardous substances.

Principles of green chemistry1.Prevent waste.2.Design safer chemicals and products.3.Design less hazardous chemical syntheses.4.Use renewable feed stocks.5.Use catalysts non stoichiometric reagent.6.Avoid chemical derivatives.7.Minimize atom economy.8.Use safer solvents and reaction conditions.9.Increase energy efficiency.10.Design chemicals and products to degrade after

use.11.Analyse in real time to prevent pollution.12.Minimize potentials for accidents.

Need for green drug Incidents of mass death of animals. eg:Diclofenac used in cattles killed

vultures.

Side effects of certain drugs-decrease the ability to provide milk, renal failure.

Effect food chain.

Advantages of green pharma practices

Reduces ecological impact of drugs. It is less toxic.Reduced dosing frequency. It is environment friendly.Benefit millions of patients.Maximum usage of raw materials to

produce active drugs.

Green chemistry in pharmaceutical industries

our quality of life depend upon on products of pharmaceutical industries.

‘YIELD’-main concern of industries. Amount of waste produced in synthesizing and

purifying drugs produced-secondary concern. In past decade pharma companies started

designing green chemical drugs to reduce E-factor (measure of waste produced).

For bulk chemicals - < 1.5 kg,For pharmaceutic-25-100kg

Green chemist perspective on pharmaceutical life cycle

Petroleum based chemicals.

Bulk chemicals . Fine chemicals.

Regulatory starting materials to API.

Dosage form to patient .

Patient tothe environment.

API to dosage form. Dosage form to

packaged product.

Achievements of green chemistry in pharmaceutical

industries A drug slidenafil citrate (viagra) manufactured

has very low E-factor about 6. In reveloutionary drug delivery methods-to

deliver cutting edge drugs. In coating drugs-plastic design-patient need less

no:of injections. In making polymers-biodegradable plastics from

lactic acid-dissolvable stiches. Discovery of regio and enantiospecific microbial

hydroxylation of progesterone to 11alpha –hydroxy progesterone.

ResearchesDevelopment in making greener

cymene which is currently sourced from petrochemicals.

Development of pencillin antibiotics.

Perceived green chemistry of phRMA member companies

Over 10,000 different drugs are sold in world wide today.

1% ARE MADE BY PROCESS THAT COULD BE CONSIDERED ‘GREEN’.

The graph shows the activity of phRMA companies.

CONCLUSION Green chemistry in pharmaceutical

industries seems developing day by day. As our population is increasing year after year, amount of wastes produced will also increase, which will adversely effect our environment. With different life styles, there is a great chance of people subjected to diseases. So our principles must be the principle of green chemistry which in turn promises as to make chemical industry cleaner and safer ,while producing better , purer product in process.