WELCOME

WELCOME

GREEN CHEMISTRY IN PHARMACEUTICALS

PRESENTED BY,NIKHIL MOHAN.P.MAYISHAMUBEENA.ASREELAKSHMI.KSAREENANASRIN.K.PAKHILAATHIRA HARIDAS

What is green chemistry?

Green chemistry is a pro-active approach to pollution preventionIt targets pollution at the design stage, before it even begins.It is designing chemical produts and processes that reduce or eliminate the use and the generation of hazardous substances.

PRINCIPLES OF GREEN CHEMISTRY Waste reduction in chemical synthesisUsing rawmaterials and feedstocks from renewable sourcesEmploying catalysts.Avoiding chemical derivatives.Maximising atom economy

Replacing or reducing solvents.Increasing energy efficiency of chemical reactionsUsing in-process or real time monitoring.Other process safety and environmental consideration.

GREEN CHEMISTRY IN PHARMACEUTICALCurrently,the pharma industry is trying to curb spending in the industry.Green chemistry offers significant cost advantages.Compared with other sectors in its green practices,the pharma ranks lowThe E-factor

American chemical society green chemistry institute [acsgci]In 2005,several firms along with ACSGCI established the GCI Phrmaceutical Round table [ACSGCIPR].The major companies included in this are Pfizer,Johnson&Johnson, Astrazeneca,GalaxoSmithKline etc.They reviewed work in 14 areas.

The areas reviewed by acsgciprSolvent reduction or replacement.OxidationAmide formationAssymetric hydrogenationsFlourinationCarbon-hydrogen activationBio catalysisChemistry in waterAlcohol activation for nucleophilic displacemtFriedel-crafts chemistryContinous processing intensification Supercritical fluid chromatography separation

GSKS Eco-design tool kitA Green chemistry &technological guideA material guide to solvents & bases with related environmental health &safety dataA fast lifecycle assesment for synthetic chemistry that streamlines evaluations of environmental lifecycle & measures green metricsA green packaging guideA guide that identifies legislation phasing out hazardous substances

Some high profile successes in pharmaceutical industryRoche betters route for Pyridinylimadazole based drug.Mercks green process for RaltegravirPfizers green synthesis of PregabalinEli Lilly optimizes production of neurokinin-1 antagonist

ON GOING GREEN IS COST BENEFICIAL &ECO FRIENDLY

THANK YOU