Gq Cardiomyopathy Recovery from Cardiomyopathy.
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Transcript of Gq Cardiomyopathy Recovery from Cardiomyopathy.
Gq Cardiomyopathy
Recovery fromCardiomyopathy
Conclusions 1
Looking at functional groups of genes is often MUCH more informative than single genes
Free, software tools help make sense of DNA-microarray data and share information
GenMAPP for displaying any type of genomic data
RNAi, plasmids, antibodies…
Example: Gene trapping atBayGenomics
• >7100 Cell Lines Frozen Down• >2200 Different Genes Inactivated
BayGenomicshttp://baygenomics.ucsf.edu
Distribution of BayGenomics ES Cells
>550 ES cell lines to investigators throughout the world.
Is gene trapping a random event?
No sign of saturation, but initial analysis suggests patterns
Is gene trapping a random event?
No sign of saturation, but initial analysis suggests patterns
No clear relationship with expression levels
Is gene trapping a random event?
No Sign of saturation, but initial analysis suggests patterns
No clear relationship with expression levels
Potential relationship with specific functional groups of genes
Is there a functional relationship between the genes
that are being trapped?
Merge gene trap data with functionalbiological groups of genes from
www.GeneOntology.org
Advantages of GenMAPP
1. Allows users to construct custom pathways2. Allows users to analyze private data
Advantages of GenMAPP
1. Allows users to construct custom pathways2. Allows users to analyze private data3. GenMAPP is robust and easy to install
Advantages of GenMAPP
1. Allows users to construct custom pathways2. Allows users to analyze private data3. GenMAPP is robust and easy to install 4. Free to all users5. Open source code
Advantages of GenMAPP
1. Allows users to construct custom pathways2. Allows users to analyze private data3. GenMAPP is robust and easy to install 4. Free to all users5. Open source code
Caveats,1. GenMAPP is limited to data display (no modeling,
not a pathway database, we need data exchange)2. Windows-specific for now2. Client-server version several months away
Nathan Salomonis
Kam Dahlquist
KarenVranizan
ScottDoniger
Pathway-orientedanalysis of DNA microarraydata with GenMAPP
SteveLawlor
