Good Morning! Welcome Applicants!
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Transcript of Good Morning! Welcome Applicants!
GOOD MORNING! WELCOME
APPLICANTS!December 1st, 2011
Ingestion Many medications
are brightly colored and taste like candy
Toddlers don’t know that pills can be toxic
Ingestion in older children and adolescents is usually intentional
Ingestion Availability of prescription or nonprescription
drugs should be entertained There may be no specific history of ingestion
In the absence of a clear cause of alteration of concsiousness (afebrile toddler or adolescent), a toxic ingestion should be suspected
If possible, the bottle of meds should be checked for remaining pills
Consult poison control. They are very helpful!!
1-800-222-1222
Risperdal Ingestion
Atypical antipsychotic Dopamine receptor blockade Causes side effects such as acute dystonia,
parkinsonism, akathisia, tardive dyskinesia Children are at increased risk of toxicity
Metabolize these drugs more rapidly Increased bioavailability
Toxicity usually begins within 1 to 2 hours, peaks by 4 to 6, and usually resolves by 12 to 48 hours
Risperdal Ingestion Clinical presentation
Nausea/vomiting Lethargy Drowsiness Somnolence Tachycardia CNS depression
Extrapyramidal side effects (EPS) are more common in children Acute dystonia - involuntary, sustained muscle
contractions that result in twisting and repetitive movements or abnormal postures
Risperdal Ingestion Management
Supportive care Continuous cardiac monitoring, IV access,
reevaluation of mental status Single dose of activated charcoal
Withold in patients who are sedated or unable to protect airway
EPS treated with anticholinergics Diphenhydramine Benztropine
Poisoning Potpourri !
15-year-old with nausea and vomiting. No other signs or symptoms. Mom found empty medicine bottle in trash can. On CMP elevated liver transaminases.
A. Salicylates
B. Tricyclic antidepressants
C. Methanol
D. Acetaminophen
E. Acids, alkali, and alkaloids
F. Ethanol
G. Anticholinergic
H. Hydrocarbons
I. Opiates
J. Organophosphates
16-year-old with suspected ingestion. HR 44, RR 10, BP 85/40. Pinpoint pupils on exam. Difficult to arouse.
A. Salicylates
B. Tricyclic antidepressants
C. Methanol
D. Acetaminophen
E. Acids, alkali, and alkaloids
F. Ethanol
G. Anticholinergic
H. Hydrocarbons
I. Opiates
J. Organophosphates
4-year-old "seems delirious" per mom. On PE, has a temperature of 104.2°F (40.1°C), heart rate of 160 beats/min, respiratory rate of 36 beats/min, and blood pressure of 135/87 mm Hg. Her pupils are dilated and sluggishly reactive.
Skin is flush. 5-year-old brother fed her pink “candy” today.
A. Salicylates
B. Tricyclic antidepressants
C. Methanol
D. Acetaminophen
E. Acids, alkali, and alkaloids
F. Ethanol
G. Anticholinergic
H. Hydrocarbons
I. Opiates
J. Organophosphates
6-year-old vomiting since last night and “not acting like himself.” Had low-grade fever this morning. Complaining of ringing in his ears. His BMP revealed an anion gap of 19. Dad has coronary artery disease and takes a few different medications.
A. Salicylates
B. Tricyclic antidepressants
C. Methanol
D. Acetaminophen
E. Acids, alkali, and alkaloids
F. Ethanol
G. Anticholinergic
H. Hydrocarbons
I. Opiates
J. Organophosphates
4-year-old acting “loopy.” On PE, tachycardic and hypertensive. Skin is dry, red, and warm. Pupils are dilated. ECG shows QRS widening. Older brother is being treated for bedwetting.
A. Salicylates
B. Tricyclic antidepressants
C. Methanol
D. Acetaminophen
E. Acids, alkali, and alkaloids
F. Ethanol
G. Anticholinergic
H. Hydrocarbons
I. Opiates
J. Organophosphates
16-year-old male brought into ER by friends with vomiting and ataxia. Has trouble following commands, and slurred speech. Glucose is 45. The friends report they have just left a party.
A. Salicylates
B. Tricyclic antidepressants
C. Methanol
D. Acetaminophen
E. Acids, alkali, and alkaloids
F. Ethanol
G. Anticholinergic
H. Hydrocarbons
I. Opiates
J. Organophosphates
4-year-old with vomiting, abdominal pain, and “acting funny.” BMP reveals anion gap of 18. Dad mentions that she was playing in the garage earlier today while he was working on the car.
A. Salicylates
B. Tricyclic antidepressants
C. Methanol
D. Acetaminophen
E. Acids, alkali, and alkaloids
F. Ethanol
G. Anticholinergic
H. Hydrocarbons
I. Opiates
J. Organophosphates
15-year-old male with coughing, tachypnea, retractions, and wheezing. Was involved in a dare earlier today with some friends. You suspect a chemical pneumonitis and order a CXR.
A. Salicylates
B. Tricyclic antidepressants
C. Methanol
D. Acetaminophen
E. Acids, alkali, and alkaloids
F. Ethanol
G. Anticholinergic
H. Hydrocarbons
I. Opiates
J. Organophosphates
5-year-old brought to ER for altered mental status. Had abdominal pain and vomiting earlier today. Also with excessing drooling, incontinence, and diarrhea. He had been playing outside while dad cut the grass.
A. Salicylates
B. Tricyclic antidepressants
C. Methanol
D. Acetaminophen
E. Acids, alkali, and alkaloids
F. Ethanol
G. Anticholinergic
H. Hydrocarbons
I. Opiates
J. Organophosphates
4-year-old found playing near the kitchen sink with a bottle of oven cleaner. She is drooling and is burns are starting to form on her lips and in her mouth.
A. Salicylates
B. Tricyclic antidepressants
C. Methanol
D. Acetaminophen
E. Acids, alkali, and alkaloids
F. Ethanol
G. Anticholinergic
H. Hydrocarbons
I. Opiates
J. Organophosphates
Acetaminophen Signs and symptoms
Nausea and vomiting 18 to 24 hours later hepatic damage
(elevated transaminases) 2 to 3 days progresses to severe hepatic damage (including fulminant failure)
Management (suspected or confirmed) Measure serum level between 4 and 10 hours Transaminases and coags Treat with N-acetylcysteine (initiate within 10
hours)
Opiates Signs and symptoms
Miosis Sedation, coma Respiratory depression Hypotension, bradycardia Constipation
Management Assessment and establishment of effective
ventilation and oxygenation Hemodynamic support Opioid antagonist
Naloxone
Anticholinergics Signs and symptoms
Hot as a hare Dry as a bone Blind as a bat Red as a beet Mad as a hatter Hypertension, tachycardia
Management ABCs Decontamination
ExamplesAntihistaminesTCAsPhenothiazinesAtropineBelladonna alkaloids (Jimson weed)
Salicylates Signs and symptoms
Nausea Vomiting Altered hearing (tinnitus) Fever Altered mental status Increased anion gap metabolic acidosis
Management Check electrolytes, blood gas, LFTs, serum level Consider activated charcoal Correct acidosis
Tricyclic Antidepressants Risk for accidental ingestion by siblings Signs and symptoms
Dry mouth Ileus Dilated pupils Urinary retention Delirium Agitation Convulsions Cardiac dysrhythmias
Cardiac dysrhythmias• Most occur in first 24 hours• *Reports of late dysrhythmias
( 2 to 5 days later)• Maximal QRS duration is useful
for predicting which patients will have dysrhythmias
Management• ABCs• Decontamination with activated
charcoal• Benzos for convulsions• Sodium bicarb bolus for
dysrhythmias
Ethanol
Ethanol Signs and symptoms
*Hypoglycemia Inebriation Vomiting Ataxia Respiratory depression Hypotension
Management Measure serum electrolytes, glucose, ethanol level Symptomatic and supportive *Can mask toxicities from other drugs
Methanol Found in windshield
washer fluid Nausea, abdominal
pain, vomiting Metabolized to formic
acid metabolic acidosis and ocular findings
Blurred vision, “snow field,” edema of optic disks
Correct acidosis Ethanol to block
metabolism Leucovorin or folate Dialysis
Hydrocarbons Cause chemical
pneumonitis if aspirated Tachypnea, retractions,
bronchospasm Peaks at 3 days
Oropharyngeal and gastric irritation
Coughing, choking Vomiting Supportive care
Blood gas Chest X-ray
Organophosphates Cholinergic poisoning Insecticides, lawn and garden care products Signs and symptoms
“SLUDGE” Salivation, lacrimation, urination, defecation, gastric
emesis Twitching, weakness, or paralysis
Management Stabilization Decontamination Antidote
Atropine
Acids, Alkali, and alkaloids Laundry detergent, toilet bowel cleaner,
stain and mildew removers, floor cleaner, ammonia, oven cleaner, window cleaner, batteries, pine oil cleaners
Acid ingestions are more likely to cause injury to the stomach and less likely to cause esophageal and pharyngeal injury
Alkaline ingestions tend to injure the esophagus and pharynx
Gastric lavage contraindicated Endoscopy within 12 to 48 hours
Have a Great Day! Noon ConferenceADHD, Dr. Khouri