Goethar
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Transcript of Goethar
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MOBI-KIDSStudy on communication technology, environment and brain tumours in young people
MOBIMOBI--KIDSKIDSStudy on communication technology, environment and brain tumours in young people
Geertje GoedhartNational field work coordinator MOBI-KIDS The Netherlands
MOBI-KIDS study coordinator: Elisabeth Cardis, CREAL, Spain
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Outline presentation Background Study objective Study design Data collection Validation studies Planning Questions?
MOBI-KIDS study
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Background: Brain tumours Brain tumours second most common
cancer type in young people (after leukemia)
Risk factors of brain tumours largely unknown◦ Known risk factors: Family history of brain tumours Ionizing radiation◦ Speculated risk factors: Chemicals Allergies Electromagnetic fields (EMF)
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Background:Communication technologies Dramatic increase in wireless
communication technology usage, e.g. mobile phone, WiFi, particularly among young people
Public and public health concern/interest◦ International recommendations: WHO International EMF Project EU supported EMF-Net◦ National recommendations
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RF & (Children’s) Health Health effects of radiofrequency fields (RF)
hardly demonstrated at this point, e.g. INTERPHONE
… but if there is a risk, it is likely to be greater for exposures in childhood and adolescence …
Children will have more exposure:◦ Greater quantity of use as much cheaper than
before ◦ Many more years of use
Children may be more vulnerable due to developing brain and skullMOBI-KIDS study
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Children’s exposure is greater…
MOBI-KIDS study
The relative mean MSAR1g tends to be higher in children than in adult brain tissues
(results normalized to children)
Wiart et al, 2008
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Study objective
To assess the risk of brain tumours in young people in relation to:◦ childhood and adolescent
exposure to EMF from wireless communication technologies
◦ other potential environmental and host factors
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8MOBI-KIDS study
Participating countries (15) Australia Austria Canada France Germany Greece India Israel Italy Japan
New Zealand Spain Taiwan The Netherlands UK
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9MOBI-KIDS study
Project management Funding:◦ European Union – FP7 -
Grant agreement nº226873◦ National and local
grants
International coordinator: Elisabeth Cardis, CREAL, Barcelona, Spain
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10MOBI-KIDS study
Study design Case-control study◦ Cases
Benign and malignant brain tumours Aged 10-24y Diagnosed during study period Residing in study region
◦ Controls Hospital-based (to minimize non-participation and
selection bias): patients operated for suspected appendicitis
Aged 10-24y 2 per case Individually matched on age, sex and region
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11MOBI-KIDS study
Country Expected number of cases Per year Study periodAustralia 71 178Austria 35 86Canada 94 234France 94 235Germany 125 313Greece 25 63India ? ?Israel 40 120Italy 68 169Japan ? ?New Zealand 25 63Spain 125 313Taiwan ? ?The Netherlands 84 210 Total 786 1,984
Expected number of brain tumour cases in the age range 10-24y
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12MOBI-KIDS study
Data collection Face-to-face interview with subject &
parent(s):
◦ Detailed communication technology usage, e.g. mobile phone, cordless phone, WiFi◦ History of home and school addresses◦ Subject and family history of diseases◦ Exposure to medical and dental radiation◦ Occupational history◦ Exposures in utero and preconception
Optional: Saliva collection for genetic analyses
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13MOBI-KIDS study
Validation self-reported mobile phone use Historical traffic/billing records
from providers ◦ Frequency and duration of voice and data
use
Software-modified-phones (SMP) study among volunteers◦ Frequency and duration of voice and data
use◦ Laterality◦ Estimated output power
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Validation brain tumour diagnosis
Tumour localisation: review of MRI/CT scans to mark precise location of tumour on specially developed grids
Tumour diagnosis: central review of sample of histological slides by international panel of neuropathologists to verify diagnosis
MOBI-KIDS study
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15MOBI-KIDS study
Planning Ethics approvals:◦ Obtained or ongoing in most countries
First interviews started in first countries in October 2010
Data collection duration: 2.5 years
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Questions?Questions?Questions?Thanks to: S Sadetzki, R Bruchim, E Cardis, H Kromhout, M
Kundi, M Maslanyj, F Merletti, K Radon, M Sim, R Vermeulen, J Wiart on behalf of the MOBI-KIDS Study Group*
*MOBI-KIDS Study Group: Spain, coordinating centre: E Cardis (Scientific Coordinator), J Alguacil, N Aragones, L Kincl, M Morales, G Carretero; Australia: M Sim, B Armstrong, G Benke, L Milne, R Schattner; Austria: M Kundi; Canada: D Krewski, D Bédard; France: B Lacour, M Hours, D Delmas, J Wiart; Germany: K Radon, S Brilmayer, S Heinrich,T Weinmann; Greece: E Petridou, V Panagopoulou; India: R Dikshit, R Nagrani; Israel: S Sadetzki, R Bruchim; Italy: F Merletti, M Maule, E Migliore; New Zealand: A Woodward, A ´t Mannetje; Taiwan: CC Lin, MOBI-KIDS study
www.mbkds.com