GOALS OF THIS PRESENTATION - Daniela White MD · GOALS OF THIS PRESENTATION ... Exposure to...
Transcript of GOALS OF THIS PRESENTATION - Daniela White MD · GOALS OF THIS PRESENTATION ... Exposure to...
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GOALS OF THIS PRESENTATION
Create familiarity with the use of psychometric scales to help in the differential diagnosis of mood disorders
Formulate an integrative treatment, tailored to the individual needs of the patient
Provide understanding of the principles of newer treatments of depression (i.e.TMS)
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STYLE OF THIS PRESENTATION
Created with the clinical approach in mind as a collection of clinical “pearls”
Suggests an open approach to a variety of treatment modalities
Open to discussion and questions, best at the end of it
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MOOD DISORDERS
Pharmacology and Beyond…
© Daniela M. White, MD 2011
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MOOD DISORDERS by DSM-IV TR
MAJOR DEPRESSIVE DISORDER DYSTHYMIA BIPOLAR DISORDERS CYCLOTHYMIA MOOD DISORDERS DUE TO A GENERAL
MEDICAL CONDITION
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AND LAST BUT NOT LEAST…
MOOD DISORDER NOS. When nothing else fits, a diagnosis of mood
disorder nos. is appropriate Very helpful for the child and adolescent
patients with ‘severe disturbance of temperament’ (a possible future diagnosis in DSM –V)
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MAJOR DEPRESSIVE DISORDER
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ESSENTIALS OF DIAGNOSIS
Sleep changes Interest (loss of) Guilt (worthlessness, regret) Energy loss or fatigue Concentration difficulties Appetite changes Psychomotor retardation or agitation Suicidality
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DIFFERENTIAL DIAGNOSIS
CLINICAL INTERVIEW
PSYCHOMETRIC SCALES (PHQ-9 or QIDS-SR; MDQ;)
BASELINE BLOOD TESTS: METABOLIC PANEL, CBC WITH DIFF, TFT’S, TESTOSTERONE LEVEL,VITAMINS LEVELS, LIPID PROFILE
RULE OUT BIPOLAR DISORDER
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PHQ-9 AND QIDS-SR
Psychometric scales for depression Help the patient to have an objective sense
of their depression Help us to evaluate the response to the
treatment Very useful for legal depositions
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PHQ-9 AND QIDS-SR
PHQ-9 is a patient health questionnaire, comprising 9 questions.
Scoring helps differentiating between different degrees of severity of the depression
QIDS-SR – quick inventory of depressive symptoms, also allowing scoring and differentiating the degrees of depression
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REMEMBER….IT’S NOT A BIPOLAR DISORDER IF ….
THERE IS NO HISTORY OF A MANIC OR HYPOMANIC EPISODE…
MDQ is a very handy tool for reviewing the manic/hypomanic symptoms
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MDQ
Mood Disorder Questionnaire Screening for bipolarity, especially sensitive
for Bipolar I 13 items, reviewing symptoms of mania 7 items answered with yes , happening within
the same period of time Level of severity – moderate Developed by Hirschfeld, MD
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ONE MANIC OR HYPOMANIC EPISODE
Changes the diagnosis to a Bipolar Disorder
Changes the treatment
Changes the outcome
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WHEN IN DOUBT:
ITS BETTER TO BE SAFE THEN SORRY Is safer to err on the side of bipolar disorder (esp. in
children and adolescents when the criteria are less well defined)
In doing so, explain your rationale to the caregivers Finding the right medication can be a balancing act
(unipolar vs. bipolar depression, side effects vs. therapeutic effects)
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BIO-PSYCHO-SOCIAL
ASSESSMENT
FORMULATION
TREATMENT
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BIO-PSYCHO-SOCIAL MODEL
Represents factors that we need to be aware of in order to make an accurate diagnosis and treatment BIO-
PSYCHO- SOCIAL
BIOLOGY Genetics; Biological response
ENVIRONMENT Life events
SOCIO- CULTURAL
Social support Customs values
COGNITIVE Appraisal Meaning
perception
BEHAVIOR Coping illness
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BIOLOGY OF DEPRESSION
• Genetic predisposition (suggested by the familial nature of the depression or mood disorder)
• Medical conditions: low vitamin D, low B12, hypothyroidism, autoimmune disorders; low testosterone, blood dyscresias ( anemia)
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BIOLOGY OF DEPRESSION
Depletion of monoamine levels; Abnormalities of intracellular signal
transmission and/or gene expression; Other neurotransmitters (GABA, glycine etc); Hormones (thyroid and adrenal hormones); Neuropeptides (CRH,endorphines,substance
P)
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NEUROENDOCRINE FACTORS
Abnormalities of the HPA axis (hypothalamic-pituitary-adrenal axis) : increased cortisol, increased ACTH
Most depressed patients are euthyroid; some have subclinical hypothyroidism ( more association with cognitive impairment)
BDNF( brain derived neurotropic factor) levels are decreased with stress
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BRAIN IMAGING
Decreased left prefrontal cortex (PFC) blood flow and metabolism
Basal ganglia abnormalities Increased amygdala activity Abnormalities in hippocampus
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NEURAL MODEL
Dysfunction of the DLPFC, limbic and striatal systems impair the modulation of the amygdala/hippocampal structures
Neuroimaging is not cost effective for the clinical practice, at this point (not used for diagnosis purposes)
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PSYCHOLOGY OF DEPRESSION
Psychoanalytic and psychodynamic theories (depression as a result of loss, anger turned against self …)
Behavioral and cognitive theories ( cognitive distortions and misrepresentation of life events)
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SOCIAL-ENVIRONMENTAL FACTORS ASSOCIATED WITH DEPRESSION
Life events ( death, divorce, loss of loved one, loss of career, change in career, job conflicts...)
Evaluate social network ( let’s not forget the social media…FB, twitter)
Evaluate spiritual or religious life, belief system Family life, living situation, family diagram, family
conflicts… Military service Hobbies, extracurricular activities Exercise, nutrition, sleep habits
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WHAT FOLLOWS NEXT?
How do we formulate treatment? Following the same guidelines of the bio-
psycho-social model…towards an integrative approach in psychiatry
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INTEGRATIVE TREATMENT
Pharmacological (SSRI, SNRI, NRI, SSRI+ 5HT1 partial agonist, SSRI+ 5HT2 antagonism)
Biological treatments (TMS, light therapy) Psychological treatment (various forms of therapy) CAM (complementary and alternative medicine)
including: -Meditation for stress management (yoga) -Dietary guidelines, exercise, nutritional
supplements -Botanical remedies -Bibliotherapy ( effective treatment for
mild moderate)
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PHARMACOLOGICAL TREATMENT
Antidepressants (SSRI, SNRI, NRI, SSRI+5HT1 partial agonists)
Check for a family history of a good response to a particular antidepressant
What worked before will work again Some patients are sensitive to the difference
between brands and different generics
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PHARMACOLOGICAL TREATMENT
Always optimize one medication before switching the class or augmenting
Discuss side effects ( patient education is very helpful to increase compliance)
Take into account patient’s financial concerns (increases compliance)
Discontinue medications that do not work to avoid unnecessary polypharmacy
More doses, less compliance
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SSRIs
All of them in generic forms, including Lexapro;
Mostly helpful in depression with anxiety, obsessive features;
Less desirable for lethargic forms of depression;
Increased crave for carbohydrates, possible weight gain and sexual side effects;
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SSRI’s continue..
Risk of SSRI induced apathy ( patients are not depressed anymore, just blah..)
Risk of SIADH – rare, but possible especially with polypharmacy
Possible drug-drug interactions with fluoxetine, paroxetine, less with escitalopram
Prozac FDA approved for child/adolescent depression
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SSRI’S continues
Sertraline FDA approved for OCD in children and adolescent patients
Lexapro approved for GAD and depression in 10-13 years old
Discuss with patients and the families the black box warning ( suicide risk under age 24)
MDD could end with suicide, as an outcome to the lack of medical intervention
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SNRI-Cymbalta, Effexor, Pristiq
Think about them like the broad range antibiotic…work on serotonin and norepinephrine
Cymbalta has equal action on both S and NE from a lower dose
Effexor and Pristiq tend to act more on NE as the dose escalates, at lower doses acts like SSRI (more or less)
Less apathy because of the NE component Less sexual side effects because of NE component
(especially with women)
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SNRI continue
Risk of HTN with Pristiq, Effexor, less with Cymbalta
Less discontinuation syndrome with Cymbalta, because of the longer half-life time
Warnings for the Serotonin syndrome from the pharmacies and manufacturers
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NRI –wellbutrin, aplenzin and generics
Great antidepressants, but not antianxiety medications
Rarely useful in anxious depressed patients, could increase the anxiety levels
No sexual side effects, no weight gain Help with the SSRI induced apathy, because
of the NE component.
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TRAZODONE AND VIIBRYD
Practically weight neutral and not causing sexual side effects
Viibryd works as SSRI and partial 5HT1 agonist Trazodone works as a SSRI and 5HT2 antagonism(
SARI=serotonin antagonist-reuptake inhibition) Oleptro (Trazodone –ER) helps with sleep, the
formulation allows qhs dosing, less next day drowsiness then Trazodone-IR
Viibryd: absorption is increased with food ( also nausea, a main side effect is mitigated when given with food)
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MIRTAZEPINE
Antagonism of pre-synaptic alpha2-receptors Helps the depression associated with anxiety Main side effects are weight gain and
sedation; no sexual side effects Has antiemetic properties Could cause granulocitopenia (pay attention
to increase frequency of sore throat complaints)
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MOST COMMOM STRATEGIES
Augmentation with atypical antipsychotics (Abilify, Seroquel, Zyprexa)
Weight gain a possible side effect, as well as next day sedation; akathisia possible with Abilify
Fairly rapid response, within two weeks separation on MADRAS scales from placebo
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Continue…
Thyroid, lithium augmentation ( needs TFT’s monitoring, and li levels)
Lithium shown as having antisuicidal properties, even at lower doses 300-600 mg/day
Lamictal augmentation, not as popular Folate (Deplin) supplementation enhances the
response to antidepressants Buspar augmentation suggested by STAR -D Pindolol augmentation also noted to increase the
rate of response to antidepressants
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QUESTIONS?
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Best Practices Treatment Guideline for Depression Based on 2010 APA practice guidelines and NeuroStar TMS Therapy® indication for use.
Adapted from: Practice Guideline for the Treatment of Patients with Major Depressive Disorder, 3rd Edition, APA (2010)
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Unmet Medical Needs
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BIOLOGICAL TREATMENTS
TMS – the new kid on the block Light therapy
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Transcranial Magnetic Stimulation (TMS)
The treatment coil produces MRI-strength magnetic field pulses.
Magnetic field pulses pass unimpeded through the cranium for 2-3 cm. and induce a small electric current.
Induced electric currents stimulate the firing of nearby neurons, causing the release of neurotransmitters and clinical effects.
Faraday (1839) Experimental Research in Electricity. Vol 1; Barker (1991) J Clin Neurophysiol; Barker (1985) Lancet
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A Proven
Approach
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TMS
Requires a Neurostar
Device Chair Computer system
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TMS
Refer back to the APA 2010 guidelines FDA clearance since 2008 for depressed
patients who failed between 1-4 trials of antidepressants
Indicated before the atypical augmentation Delivers treatment locally, therefore it has no
systemic side effects
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Treating the Brain as an Electrochemical Target
Major brain regions known to be involved in mood regulation
Amygdala
Ventromedial Prefrontal Cortex
Prefrontal Cortex
Anterior Cingulate Gyrus
Brain activity can be altered: • Chemically (eg, via
drugs) or, • Electrically (eg, via
TMS)
– Drug action is anatomically diffuse and systemic
– TMS is focused, non-invasive and non-systemic
Pizzigalli (2011) Neuropsychopharmacology
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A Proven
Approach
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TMS
One of the four types of neuromodulation Other neuromodulation treatments: DBS,
VNS, ECT The only one that is not invasive The patient is awake while receiving
treatment
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Activation of fronto-cingulate brain circuit following a course of TMS applied to the left dorsolateral prefrontal cortex in patients with Major Depression
Targeted Effects on Mood Circuits in Brain
Kito (2008) J Neuropsychiatry Clin Neurosci
TMS Coil L
L
R
R
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A Proven
Approach
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LIGHT THERAPY
Usually used to treat Seasonal Affective Disorder with specially build lamps
Parameters for use are 7000 lx intensity at 20 inches exposure, about 60 minutes, in the morning after arousal
Has been used in the treatment for unipolar depression in special population (pregnant and elderly patients)
Shows improvement compared to the placebo studies using blue or red light exposure
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COMORBID MEDICAL PROBLEMS
Need to be addressed accordingly Refer to a PCP and establish a good
connection to help coordinate treatment (adequate treatment of HTN, obesity, diabetes, anemia, low testosterone levels)
Refer to a specialist for endocrine problems (hypothyroidism, adrenal insufficiency, hypogonadism)
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CAM
Complementary and Alternative Medicine Used in addition to conventional medicine Represents a diverse set of therapies Most commonly represented by the dietary
supplements Also includes: acupuncture, hypnosis,
homeopathy, ayurveda yoga, meditation etc
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NUTRITION
• SPECIAL DIETS? • FOOD PREFERANCES
(CARBOHYDRATES CRAVINGS)? • EMOTIONAL EATING? • NUMBER OF MEALS PER DAY? • SNACKS?
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NUTRITION- the minimum we could do
Ask about the number of meals and snacks per day Ask about food preferences Ask about illnesses that could require special diets
or expose patients to certain nutritional deficits (malabsorption of B12, Folic acid)
Ask patients to keep a journal of their daily intake, of food and beverages (include water, soda and alcohol intake) for 3-5 days
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NUTRITION-the minimum we could do
DIABETES patients could have hypoglycemic episodes that could cause palpitation and diaphoresis, irritability
ALCOHOL dependent patient could have B12, folic acid malabsorption – contributing to the depressive symptoms, lack of energy
Folic acid deficiency reduces the response to antidepressant ( less substrate for their action)
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NUTRITION - supplements
If deficient in folic acid or B12, supplement with folic acid (OTC) or Deplin ( metfolate)
B12 injections and the nasal spray have a better absorption rate that the oral tablets
Sometimes blood levels are irrelevant, and a lot of physicians supplement based on the history of poor/inadequate nutrition
Encourage a balance diet, sometimes calculating the baseline metabolic rate help the patient to establish goals ( there are apps for that)
Vit D. deficiency-supplement with vit D
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EXERCISE
Ask patient if exercise is part of their daily or weekly routine
Ask details about what the exercise involves Playing drums, picking up the mail, or walking the
dog doesn’t count as physical exercise The minimum they could do is walking with a speed
of 2 per 30 minutes, 4-5 times per week
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EXERCISE-common chores examples
Washing and waxing a car for 45-60 min Washing windows or floors for 45-60 min Gardening for 30-45 min Wheeling self in wheelchair for 30-40 min Raking leaves for 30 min Stair walking for 15 minutes etc
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EXERCISE-AT WORK
Stand instead of sitting when talking on the phone
Take the stairs instead of the elevators Walk down the hall to talk to somebody then
calling on the phone Schedule exercise time and treat it like a
business appointment
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EXERCISE – overcoming barriers
Ask about physical exercise at every appointment
Discuss benefits of exercise for depression (augmentation value to antidepressants)
Recommend exercise as a prescription Encourage patient to increase physical
activity daily
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EXERCISE – possible mechanisms
Elevations of endorphins in CNS Changes in Serotonin and Norepinephrine Increased levels of BDNF (Brain Derived
Neurotrophic Factor) Reduction of serum cortisol Elevation of body temperature Improved self-esteem Distraction from daily stress Induction of a relaxed state via biofeedback
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YOGA
Can reduce depressive symptoms and induce remission
Questionable application in older or less fitted patients ( since the patients in the studies were young and relatively fit)
No safety issues or adverse events
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MEDITATION
Is a complex mental process that involves changes in cognition, sensory perception, emotions, hormones and autonomic activity.
Likely affects different neurotransmitters systems, including dopamine, serotonin, glutamate.
The overall understanding of the biological mechanism in terms of the effects on body and brain is still limited.
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MEDITATION
attempts to reach a subjective state characterized by a sense of no space, no time, no thought (i.e. thevada)
attempts to focus attention on a particular image, object, phrase, or word (tibetan buddhism)
focuses on whatever thought and feelings enter the mind (mindfulness meditation)
etc
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GOALS of MEDITATION
• Used in psychiatric and medical practices for stress management
• Depression relapse prevention programs • Pain treatment • Eating disorders • etc
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St. John’s wort
Hypericum perforatum) Induces significantly higher remission rates
than placebo in mild to moderate depression 900-1500 mg/day Can affect blood levels of medications
metabolized by Cyt P450 Mostly recommended for depressed patients
who can’t tolerate SSRIs
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SAMe
Metabolite involved in biosynthesis of norepinephrine, serotonin, dopamine
Shows greater efficacy then placebo 800-1600 mg/d Can be used as an adjunctive treatment for
incomplete response to standard treatment Can be used as a complementary treatment
to speed the onset of antidepressants
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PUFA-polyunsaturated fatty acids Most commonly known Omega 3 (EPA and DHA)
come from fish oil Most sources of Omega 6 come from cooking oil The ratio between Omega 6 and Omega 3 is
currently greater then 10:1 when “ man has evolved on a diet ratio of 1:1”
The change in ratio has been linked with a lot of health problems, including emotional problems
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OMEGA 3-Dietary Recommendations
Two servings of fatty fish each week One caps of most supplements has 180 mg of EPA
and 120 mg of DHA 3 capsules per day are needed to reduce cardiac
risk (900 mg ) Patients with cardiovascular disease have a higher
incidence of depression Depression studies used higher doses ( 1800-9000
mg of n-3)
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HYPNOSIS
Is a social interaction in which one person, designated the subject , responds to suggestions offered by another person, designated the hypnotist, for experiences involving alterations in perceptions, memory and voluntary action.
Depends upon the dissociation from normal thought process and awareness, and a relative shift towards the unconscious process.
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HYPNOSIS
Is rarely a therapy in itself but rather a vehicle for therapy when the unconscious mind would otherwise get in the way.
The hypnotist is guiding the patient to self-hypnosis.
Patient’s ability to do so depends on the relationship he has with the hypnotist.
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HYPNOSIS APPLICATIONS
Ego strengthening Anxiety Depression Stress reduction Public speaking fear etc
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PSYCHOTHERAPY
Interpersonal psychotherapy- addresses interpersonal loses, social isolation, role transitions and disputes, deficits in social skills
Cognitive therapy- helps patients recognize and correct erroneous beliefs and maladaptive behaviors
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PSYCHOTHERAPY
Marital and family therapy- reduces the risk of relapse in depressed patients who also have marital problems
Selection of the specific therapy is based on the patients needs and strengths
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QUESTIONS?
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MOOD DISORDERS by DSM-IV TR
MAJOR DEPRESSIVE DISORDER DYSTHYMIA BIPOLAR DISORDERS CYCLOTHYMIA MOOD DISORDERS DUE TO A GENERAL
MEDICAL CONDITION
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BIPOLAR DISORDERS
I – episodes of mania cycling with depressive episodes
II- episodes of hypomania cycling with depressive episodes
Cyclothymia- hypomania cycling with less severe episodes of depression
MANIA WITHOUT DEPRESSION IS VERY RARE
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MANIC EPISODE
Inflated self esteem/grandiosity Decreased need for sleep Talkativeness Flight of ideas Distractibility Increased goal directed activity/agitation Engaging in high risk activities
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MDQ
Mood Disorder Questionnaire Screening for bipolarity, especially sensitive
for Bipolar I 13 items, reviewing symptoms of mania 7 items answered with yes , happening within
the same period of time Level of severity – moderate Developed by Hirschfeld, MD
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BIO-PSYCHO-SOCIAL MODEL
Represents factors that we need to be aware of in order to make an accurate diagnosis and treatment BIO-
PSYCHO- SOCIAL
BIOLOGY Genetics; Biological response
ENVIRONMENT Life events
SOCIO- CULTURAL
Social support Customs values
COGNITIVE Appraisal Meaning
perception
BEHAVIOR Coping illness
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BIOLOGICAL FACTORS
BP has a strong genetic association, more then 2/3 of patients show family history of affective disorder
Neurotransmitters theories conceptualized depression and mania as two opposing poles
i.e.: less NE/S available in depression, more NE/S present in mania ( antidepressants increasing the levels of NE/S induce mania)
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BIOLOGICAL FACTORS
Abnormalities in electrolyte distribution in affective disorders ( retention of sodium during intracellularly during depression)
The activity of sodium/potassium-activated ATP-ase is lower in the depressive phases
Lithium responders are reported to have lower erythrocyte Na/K ATPase
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PSYCHOSOCIAL THEORIES
Same as in depression More stressful life events precede earlier
episodes Early episodes increase the vulnerability for
future episodes Kindling- repeated episodes increase the
severity and duration of the illness
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PHARMACOTHERAPY of BIPOLAR DISORDER
Treatment of acute mania
Treatment of acute bipolar depression
Maintenance treatment of bipolar disorder
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ACUTE MANIA
MOOD STABILIZERS
Typical (lithium carbonate, valproate, carbamazepine)
Atypical antipsychotics (all of them approved by FDA for antimanic properties except LATUDA (lurasidone)
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MOOD STABILIZERS
First line-atypicals Easier to use (no need for frequent monitoring of blood
levels) and faster response Less likelihood of toxicity (vs. lithium or carbamazepine) Safer in overdose Adverse effects include weight gain and possibility of
metabolic syndrome (need monitoring of weight, lipid panel, VS)
All, but one FDA approved, for mania treatment One approved for both mania and depression (Seroquel)
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MOOD STABILIZERS
Traditional mood stabilizers tend to be added on to atypicals if failure to respond exist
LITHIUM levels need to be 0.6-1.2 mEq/L ( varies slightly with the laboratory used)
High potential of toxicity (with NSAIDS, dehydration and low salt–diet)
Monitor for side effects and the appearance of new ones during the treatment (signs of toxicity)
Still very reliable and the cheapest on the market
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MOOD STABILIZERS
VALPROATE-750-2500 MG/DAY Rapid oral loading at 15-20 mg /kg Faster response then lithium Risk of liver toxicity, need to check LFT For women in child age bearing age,
supplement with high doses of folic acid ( preventive of neural tubal defects)
Blood levels btw 50-120ug/ml Increases levels of other medication by enzyme
inhibition
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MOOD STABILIZERS
CARBAMAZEPINE Approved for mania in 2004 600-1800 mg /day Blood levels of 4-12 ug/mL Add high doses of folic acid for women with
child bearing potential Potential of blood dyscrasias ( check CBC) Weight neutral is a great benefit Decreases levels of other medications by
enzymes induction
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BIPOLAR DEPRESSION
Most antidepressants do not work, work for a short period of time or induce mania
Best treatment is a mood stabilizer (i.e.lithium, or atypicals with that indication-Seroquel, or Symbiax)
A combination of two mood stabilizers if one fails to induce response/remission
An antidepressant could be added as a third line Lamictal or Ziprazidone low doses could also work (
not FDA approved)
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OTHER TREATMENTS
TMS, Light therapy, ECT All the other treatments discussed in the MDD
treatment Therapy including the education about the
disorder
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MAINTENANCE TREATMENT OF BIPOLAR DISORDER
Prevention of recurrent episodes is the greatest challenge
Kindling will make future episodes more severe and more difficult to treat ( rapid cycling occurs later in the disorder
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FDA Approved Agents for BD AGENT MANIA MAINTENANCE Aripiprazol Yes (2004) No Carbamazepine XR Yes (2004) No Divalproex Yes (1996) No Lamotrigine No Yes (2003) Lithium Yes (1970) Yes (1974) Olanzepine Yes (2000) Yes (2004) Risperidone Yes (2003) No Asenapine Yes (2009) No Quetiapine Yes (2004) No Ziprazidone Yes (2004) No
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PRINCIPLES OF BD TREATMENT
Maintain dual focus: short term and prophylaxis Mania as medical emergency: treat first, chemistries
later Load lithium and valproate; titrate lamotrigine Retain lithium in treatment for antisuicidal and
neuroprotective properties Educate patient about the illness Use regular visits Contract with patient as needed for suicide and
substance use avoidance
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DYSTHYMIA
Depressed mood most of the day and present almost continuously
“ill humored” – term introduced in 1980 Used to be called-”depressive neurosis” Pts. complain that they have always been
depressed (early onset) Low-grade chronicity for about 2 years 5-6 % in general population
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BIO-PSYCHOSOCIAL MODEL
Biological Factors: similar to depression Psychosocial Factors:
– Personality and ego development culminating with difficulties adapting in adolescence
– Early interpersonal disappointment leads to ambivalent love relationship as an adult
– Disparity between actual and fantasized situations lead to diminished self-esteem
– etc.
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TREATMENT
Psychotherapy is considered the treatment of choice Medications such as an NRI (bupropion) and SNRI
(venlafaxine, duloxetine) are effective treatments Exercise, healthy diet Meditation Supplements such as PUFA and Vit B12, folic acid
(for documented deficiencies)
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CYCLOTHYMIC DISORDER
A mild form of Bipolar Disorder II Has episodes of hypomania and mild
depression Mostly agreed over a biological origin of the
disorder Some psychiatrists believe it’s just the result
of a chaotic life
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TREATMENT
Biological therapies – Mood stabilizers as the first line – Caution with antidepressant since the high risk of
inducing a manic episode (40-50 % conversion) – Same guidelines for the dosing of mood
stabilizers
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TREATMENT
Psychosocial therapies Increasing the awareness about the disorder Family and group therapy to repair the damage caused
by the disorder
CAM Exercise Dietary supplementation (PUFA) Bibliotherapy (i.e. An Unquiet Mind) Meditation etc
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MOOD DISORDER NOS
A very common diagnosis for children and adolescent psychiatry
Anytime there are difficulties in distinguishing between depression and mania and doesn't meet criteria for other diagnosis (different then the mixed episode when depressive and hypomanic symptoms coexist)
Use mood stabilizers as the first line treatment
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QUESTIONS?