Globular Proteins Proteins with a compact folded structure (with an interior and exterior),...

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Globular Proteins Proteins with a compact folded structure (with an interior and exterior), generally containing different types of secondary structure elements as well as irregular regions. Note: the vast majority of proteins are globular.

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Transcript of Globular Proteins Proteins with a compact folded structure (with an interior and exterior),...

Page 1: Globular Proteins Proteins with a compact folded structure (with an interior and exterior), generally containing different types of secondary structure.

Globular Proteins

Proteins with a compact folded structure (with an interior and exterior), generally containing different types of secondary structure elements as well as irregular

regions.

Note: the vast majority of proteins are globular.

Page 2: Globular Proteins Proteins with a compact folded structure (with an interior and exterior), generally containing different types of secondary structure.

Ribbon Diagram Showing Secondary Structures in a Globular Protein

Page 3: Globular Proteins Proteins with a compact folded structure (with an interior and exterior), generally containing different types of secondary structure.

Some Globular Protein Structures

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Myoglobin

Hemoglobin(complex of 4 polypeptide chains or subunits)

Triose phosphate isomerase (complex of 2 subunits) 20S Proteasome (complex of 28 subunits)

Page 4: Globular Proteins Proteins with a compact folded structure (with an interior and exterior), generally containing different types of secondary structure.
Page 5: Globular Proteins Proteins with a compact folded structure (with an interior and exterior), generally containing different types of secondary structure.

QuickTime™ and aTIFF (Uncompressed) decompressor

are needed to see this picture.

Page 6: Globular Proteins Proteins with a compact folded structure (with an interior and exterior), generally containing different types of secondary structure.

Additional Elements of Structure: Turns

turns turn

R2 often Pro

R2 often Pro

Most common type of turn

R3 never Pro

R3 never Pro

trans-Pro (above) or cis-Pro (in Type VI turns) often found in turns, but rarely in helices and sheets.

Page 7: Globular Proteins Proteins with a compact folded structure (with an interior and exterior), generally containing different types of secondary structure.
Page 8: Globular Proteins Proteins with a compact folded structure (with an interior and exterior), generally containing different types of secondary structure.

Turns with cis-Proline: Type VI

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Type VIa

Type VIb

Page 9: Globular Proteins Proteins with a compact folded structure (with an interior and exterior), generally containing different types of secondary structure.

cis-trans Isomerization of Proline Residues

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Peptidyl-prolyl cis-trans isomerases accelerate the isomerization.

Page 10: Globular Proteins Proteins with a compact folded structure (with an interior and exterior), generally containing different types of secondary structure.

Additional Elements of Structure: Loops

•Irregularly structured elements•More disordered and flexible than turns•Connects secondary structure elements•Variable in length and shape•Frequently form binding sites and enzyme active sites

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The N- and C-terminal arms of proteins are also generally more disordered and irregularly structured.

Page 11: Globular Proteins Proteins with a compact folded structure (with an interior and exterior), generally containing different types of secondary structure.

Domain and Motifs in Globular Proteins: Supersecondary Structure

Page 12: Globular Proteins Proteins with a compact folded structure (with an interior and exterior), generally containing different types of secondary structure.

Some Common Motifs Found in Proteins

motif

hairpin

motif

barrelsbarrel

Page 13: Globular Proteins Proteins with a compact folded structure (with an interior and exterior), generally containing different types of secondary structure.

Role of solvent for globular proteins in solution of solvent for globular proteins in solution A. Shiryayev, D. L. Pagan, J. D. Gunton Department of Physics, Lehigh University, Bethlehem,

Role of solvent for globular proteins in solution of solvent for globular proteins in solution A. Shiryayev, D. L. Pagan, J. D. Gunton Department of Physics, Lehigh University, Bethlehem,

Structure proteins

Structure proteins

Universal Stability Model for Globular Proteins

Universal Stability Model for Globular Proteins

Fact 1 Globular proteins are folded into their functional tertiary structure in the Golgi body.

Fact 1 Globular proteins are folded into their functional tertiary structure in the Golgi body.

Cold Gelation of Globular Proteins-dizertacija

Cold Gelation of Globular Proteins-dizertacija

Coalescence stability of emulsions containing globular ... · stability of oil-in-water emulsions, stabilized by globular proteins, whereas for the other modes of emulsion destabiliza-tion

Coalescence stability of emulsions containing globular ... · stability of oil-in-water emulsions, stabilized by globular proteins, whereas for the other modes of emulsion destabiliza-tion

Chapter 5 Membranes. 2 Membrane Structure Phospholipids arranged in a bilayer Globular proteins inserted in the lipid bilayer Fluid mosiac model – mosaic.

Chapter 5 Membranes. 2 Membrane Structure Phospholipids arranged in a bilayer Globular proteins inserted in the lipid bilayer Fluid mosiac model – mosaic.

Protein Structure and Function Review: Fibrous vs. Globular Proteins.

Protein Structure and Function Review: Fibrous vs. Globular Proteins.

QUATERNARY STRUCTURE OF PROTEINS Arrangement of chains in a multichain protein Noncovalent association for globular proteins Covalent association likely.

QUATERNARY STRUCTURE OF PROTEINS Arrangement of chains in a multichain protein Noncovalent association for globular proteins Covalent association likely.

Chapter 3 Proteins and Enzymes (Chapter 7). Protein Structure – determined by folding Can be globular (spherical) or fibrous (long fibers) Proteins fold.

Chapter 3 Proteins and Enzymes (Chapter 7). Protein Structure – determined by folding Can be globular (spherical) or fibrous (long fibers) Proteins fold.

State that enzymes are globular proteins with a specific tertiary structure. State that enzymes catalyse metabolic reactions in living organisms. © Pearson.

State that enzymes are globular proteins with a specific tertiary structure. State that enzymes catalyse metabolic reactions in living organisms. © Pearson.

Membranes Chapter 5. 2 Membrane Structure Phospholipids arranged in a bilayer Globular proteins inserted in the lipid bilayer Fluid mosiac model – mosaic.

Membranes Chapter 5. 2 Membrane Structure Phospholipids arranged in a bilayer Globular proteins inserted in the lipid bilayer Fluid mosiac model – mosaic.

Predicting the Secondary Structure of Globular Proteins Using Neural Network Modelspapers.cnl.salk.edu/PDFs/Predicting the Secondary... · 2011-01-28 · Predicting the Secondary

Predicting the Secondary Structure of Globular Proteins Using Neural Network Modelspapers.cnl.salk.edu/PDFs/Predicting the Secondary... · 2011-01-28 · Predicting the Secondary

Edexcel IAL Biology A Level Topic 2 : Membranes, Proteins ... · The tertiary structure of proteins is the 3D shape of the protein, it can be globular or fibrous . Globular proteins,

Edexcel IAL Biology A Level Topic 2 : Membranes, Proteins ... · The tertiary structure of proteins is the 3D shape of the protein, it can be globular or fibrous . Globular proteins,

Structure of Proteins

Structure of Proteins

Globular Proteins UNIT I: Protein Structure and Function.

Globular Proteins UNIT I: Protein Structure and Function.

Globular Proteins Respiratory Block | 1 Lecture Dr. Usman Ghani.

Globular Proteins Respiratory Block | 1 Lecture Dr. Usman Ghani.

Salt-bridge Networks within Globular and Disordered ... · Salt-bridge Networks within Globular and Disordered Proteins – Characterizing Trends for Designable Interactions Sankar

Salt-bridge Networks within Globular and Disordered ... · Salt-bridge Networks within Globular and Disordered Proteins – Characterizing Trends for Designable Interactions Sankar

Chapter - 2 Structure of Proteins. Lecture 4 ContentsOverview Primary structure of proteins: – Peptide bond Secondary structure of proteins: – - Helix.

Chapter - 2 Structure of Proteins. Lecture 4 ContentsOverview Primary structure of proteins: – Peptide bond Secondary structure of proteins: – - Helix.

Lecture 17: Denaturation of Globular Proteins ...12/01/2009 PHYS 461 & 561, Fall 2009-2010 1 Lecture 17: Denaturation of Globular Proteins & Cooperative Transitions Lecturer: Prof.

Lecture 17: Denaturation of Globular Proteins ...12/01/2009 PHYS 461 & 561, Fall 2009-2010 1 Lecture 17: Denaturation of Globular Proteins & Cooperative Transitions Lecturer: Prof.