GlaxoSmithkline
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Transcript of GlaxoSmithkline
Improving Health and Quality of Life Do More, Feel Better, Live Longer
Zuhal Tompkins Raman GoyalRamola ChendvankarRuchi Shah Elias Sobrino
Improving Health and Quality of Life Do More, Feel Better, Live Longer
AGENDA:
Introduction / Company Overview
Zuhal Tompkins, CEO
Research and Development
Ramola Chendvankar, CSO
Raman Goyal, CSO
Marketing and Commercialization
Ruchi Shah, CCO
Financial Outlook
Elias Sobrino, CFO
GSK Overview
• The world's second largest pharmaceutical company • Headquartered in the UK and with operations based in the US• ZANTAC• 40 plants throughout the world• Presence in almost 100 countries• Listed on London and New York stock exchanges.• Revenue of £22.7 billion• Net Income of £7.8 billion in 2007
Improving Health and Quality of Life Do More, Feel Better, Live Longer
History / Mile Stones of GSK
1830 - John K Smith opens his first drugstore in Philadelphia.
1842 - Thomas Beecham launches the Beecham’ Pills business in England.
1873 - Joseph Nathan establishes Joseph Nathan and Company, the foundation for the
Glaxo Company to be formed later.
1881 - Burroughs Wellcome & Company is established in London
1989 - SmithKline and Beecham merge to form SmithKline Beecham.
1995 - Glaxo and Wellcome merge to form Glaxo Wellcome.
2001 - GlaxoSmithKline is formed by the merger of Glaxo Wellcome and SmithKline
Beecham.
Improving Health and Quality of Life Do More, Feel Better, Live Longer
Improving Health and Quality of Life Do More, Feel Better, Live Longer
Our MissionOur global quest is to improve the quality of human life by enabling people to do more, feel better, and live longer.
Our Strategy Our strategy is to strive for excellence in the following five key areas of our business:
1. Optimising the performance of key products– achieving worldwide sales force excellence – achieving Pharmaceutical and Consumer Healthcare marketing
excellence – maintaining the highest ethical standards (intellectual property )– improving the cost-effectiveness of operations
2. Delivering the product pipeline for patients3. Being the best place for the best people to do their best work 4. Improving access to medicines 5. Maximising total shareholder return (TSR)
Andrew Philip Witty - CEO
Base Salary:
$1.7 million
Chief Executive Officer on 21 May 2008
Joined Glaxo in 1985
Held a variety of roles in the UK business from sales representative to Director of Pharmacy and Distribution.
43-year-old
WITTY’s GOALS
Plans to radically alter GSK’s R&D work
Shifting more to a biotech approach
Set up a venture arm to invest in promising new therapies
Improving Health and Quality of Life Do More, Feel Better, Live Longer
Extensive Pipeline
Improving Health and Quality of Life Do More, Feel Better, Live Longer
Improving Health and Quality of Life Do More, Feel Better, Live Longer
Improving Health and Quality of Life Do More, Feel Better, Live Longer
Research and Development
Raman Goyal
Ramola Chendvankar
Improving Health and Quality of Life Do More, Feel Better, Live Longer
What is Asthma???
Chronic inflammatory disorder of the airways.
Can be controlled and treated.Not the same as allergies.Not contagious.Increased bronchial hyper
responsiveness to a variety of stimuli.
Improving Health and Quality of Life Do More, Feel Better, Live Longer
Symptoms and Severity of Asthma
Symptoms of asthma
Coughing
Shortness of breath
Wheezing
Tight chest/chest pain
In severe cases asthma can be deadly
Severity of asthma
Mild intermittent
Mild persistent
Moderate persistent
Severe persistent
Improving Health and Quality of Life Do More, Feel Better, Live Longer
Causes of Asthma
Causes of Asthma:
UNKNOWN
Asthma triggers:
Inhaled allergens(specific).
Irritants(non specific).
Contaminants.
Genetic factors.
Improving Health and Quality of Life Do More, Feel Better, Live Longer
Improving Health and Quality of Life Do More, Feel Better, Live Longer
Diagnosis of Asthma
Pulmonary Function Tests.(VC,PEFR,FEV1)
Allergy Test.
Other Tests(Blood count, chest and sinus xrays, CT scans etc).
Improving Health and Quality of Life Do More, Feel Better, Live Longer
Asthma Medications
RELIEVERS:(Relaxes airways)examples:
VentolinBricanylAiromirSalbutamol
COMBINATION MEDICATION:ADVAIRSymbicort
CONTROLLERS:(Decreases swelling and mucus)examples:
PulmicortPrednisoneSEREVENTAccolate
Improving Health and Quality of Life Do More, Feel Better, Live Longer
Advair Diskus
• ADVAIR DISKUS first dual acting asthma medication Approved for use in the US.
• ADVAIR DISKUS is a combination product containing a corticosteroid and a long-acting beta2-adrenergic agonist
• ADVAIR DISKUS acts on the 2 main components of asthma
• Inflammation • Constriction of the artery.• Advair reduces exacerbation in COPD
by 30%
Improving Health and Quality of Life Do More, Feel Better, Live Longer
Chronic Obstructive Pulmonary Disease (COPD)
Improving Health and Quality of Life Do More, Feel Better, Live Longer
Components of ADVAIR DISKUS
Fluctisone propionate
• Corticosteroid • Anti inflammatory activity.• Inhibits the release of mucus • Reduce swelling• Breathing Easier
Salmetrol
• B2 adrenogonist• Activates adenyl cyclase• ATP to cyclic AMP• Relaxation of bronchial
muscles• Breathing easier
Improving Health and Quality of Life Do More, Feel Better, Live Longer
Advair Diskus Vs Its individual components
Improving Health and Quality of Life Do More, Feel Better, Live Longer
Composition of Advair diskus
• Disposible purple device 60 blisters
Composition• Advair Diskus 100/50 • Advair Diskus 250/50 • Advair Diskus 500/50
Improving Health and Quality of Life Do More, Feel Better, Live Longer
How to use Advair Diskus
Improving Health and Quality of Life Do More, Feel Better, Live Longer
Improving Health and Quality of Life Do More, Feel Better, Live Longer
Marketing and Commercialization
Ruchi Shah, CCO
Strategy
• Well-positioned to peers.
• Broad-based, geographically-diverse and well-balanced business.
• Improved pipeline productivity.
• Reduce expenditure, work closely with customers. • Use opportunities in the growing healthcare economies.
Improving Health and Quality of Life Do More, Feel Better, Live Longer
Our Products
• Prescription medicines: Treatments for asthma, HIV/AIDS, malaria, depression, migraine, diabetes, heart failure, digestive conditions and cancer.
• Vaccines: Over 25 vaccines to protect against illnesses such as hepatitis A and B, diphtheria, tetanus, whooping cough, typhoid and influenza.
• Consumer healthcare: Dental health products, over-the-counter medicines and nutritional drinks. Ex. Panadol, Aquafresh, and Lucozade.
Improving Health and Quality of Life Do More, Feel Better, Live Longer
Our top selling products in 2007
Improving Health and Quality of Life Do More, Feel Better, Live Longer
Product Turnover
Seretide/Advair 3.5 £b Vaccines 2.0 £b Valtrex 934 £m Lucozade 347 £m Requip 346 £m Aquafresh 308 £m Sensodyne 293 £m Panadol 262 £m Horlicks 174 £m
Products of Companies in Phases of Development
Improving Health and Quality of Life Do More, Feel Better, Live Longer
Intellectual Property
Improving Health and Quality of Life Do More, Feel Better, Live Longer
Trademark & In-licensing
Improving Health and Quality of Life Do More, Feel Better, Live Longer
Competitors
Improving Health and Quality of Life Do More, Feel Better, Live Longer
Diagnose GSK’s Product Competitor and Its Product
CNS Disorders Paxil Prozac (Eli Lilly)Zoloft (Pfizer)Celexa(Forest Laboratories)
Imigran Maxalt (Merck)
Respiratory Advair SereventFlixotide
Singular (Merck)Symbicort (AstraZeneca)Spriva(Pfizer)
Anti-bacterials
Anti-malarials
AugmentinAmoxil
Malarone
Zithromax (Pfizer)Cipro (Bayer)Levaquin (J&J)
Anti-viral RetrovirEpivirCombivirZiagenAgeneraseTrizivirValtrexZovirax
Famvir (Novartis)Aciclovir
Vaccines Angerix-B Havrix
Comvax(Merck)Recombivax HB
GSK AZN MRK
Advair Symbicort Singulair
$ 6.9 billion $1.6 Billion (2007 launched)
$4.3 billion
long-acting beta antagonist
long-acting beta antagonist
leukotriene receptor antagonist
4 years old and up 4 years old and up use in children
Relatively slow slightly faster action then Advair
cannot be used to treat acute asthma attacks
Effective Effective less effective than ICSs
SWOT Analysis
Improving Health and Quality of Life Do More, Feel Better, Live Longer
Strengths
Strong sales growth forecast from launch portfolio in the 2006-2012 period
Extensive early to mid stage R&D pipeline driven by CEDD
Vast sales and marketing force through mergersStrong capability, leadership and experience in
pharmaceutical management strategiesPositive Cash Reserves
Weaknesses
An aging portfolio of products heavily exposed to generic competition
High dependence on respiratory and CNS therapy markets (low growth)
Failure to diversify and strengthen product portfolio and lack of novel product launches since 2002
Impact of safety issues relating to AvandiaRecently expired patents
Opportunities
CEDD’s potential to deliver strong sales growth in the future as demonstrated by launch portfolio forecastProduct launches such as Tykerb and Cervarix (high
growth oncology market)Recent Cost cutting initiatives
Strong forecast sales growth from vaccine products in the 2006-2012 period could support performance of
non-vaccine pharma products
Threats
Anticipated high exposure to generic competition over the 2006-2012 period
Forecast negative sales growth performance over the 2006-2012 could drive leadership to
change business modelStrong competition over the next four years
Large scale M&A activity
Improving Health and Quality of Life Do More, Feel Better, Live Longer
Financials
Elilas Sobrino, CFO
Income Statement
Improving Health and Quality of Life Do More, Feel Better, Live Longer
Balance Sheet
Cash Flow
Improving Health and Quality of Life Do More, Feel Better, Live Longer
Key facts• Every second...
we distribute more than 35 doses of vaccine• Every minute...
more than 1,100 prescriptions are written for GSK products• Every hour...
we spend more than £300,000 (US$562,000) to find new medicines
• Every day...more than 200 million people around the world use a GSK brand toothbrush or toothpaste
• Every year...our factories produce 9 billion Tums tablets, 6 billion Panadol tablets and 600 million tubes of toothpaste
Improving Health and Quality of Life Do More, Feel Better, Live Longer