Glasgow Caledonian University: The University for …€¦ · Web viewOn behalf of all the members...
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7 th UK Gap Junction Meeting 2014 Friday December 5 th 9am-6pm Gap Junctions, Connexins & Pannexins Glasgow Caledonian University Centre for Executive Education Room CEE6 We are delighted to present an exciting and varied programme of invited presentations and keynote lectures, which together highlight the enormous scope of gap junction, connexin and pannexin research that is currently ongoing in the UK and Europe. These meetings are an excellent opportunity for young researchers to present their findings The UK gap junction meetings have a strong focus of early career investigators. They aim to encourage young members of the UK Gap Junction community to present and discuss their data with highly prestigious national and international peers and to provide a forum for informal discussion in between the International Gap Junction meetings that are held every two years. On behalf of all the members of the UK and EU gap junction community, we thank the generous support from the Biochemical Society, Zealand Pharma, GCU and Glasgow University for
Transcript of Glasgow Caledonian University: The University for …€¦ · Web viewOn behalf of all the members...
7th UK Gap Junction Meeting 2014Friday December 5th
9am-6pm
Gap Junctions, Connexins & Pannexins Glasgow Caledonian UniversityCentre for Executive Education
Room CEE6
We are delighted to present an exciting and varied programme of invited presentations and keynote lectures, which together highlight the enormous scope of gap junction, connexin and pannexin research that is currently ongoing in the UK and Europe. These meetings are an excellent opportunity for young researchers to present their findings
The UK gap junction meetings have a strong focus of early career investigators. They aim to encourage young members of the UK Gap Junction community to present and discuss their data with highly prestigious national and international peers and to provide a forum for informal discussion in between the International Gap Junction meetings that are held every two years.
On behalf of all the members of the UK and EU gap junction community, we thank the generous support from the Biochemical Society, Zealand Pharma, GCU and Glasgow University for supporting our meeting.
The programme is attached and further details about late registration can be obtained from the organizing committee
Organising committee and contact details: Scott Johnstone: email: [email protected] Tel: 0141 330 2669 Patricia Martin: email: [email protected] Tel: 0141 331 3726 Catherine Wright: email: [email protected] Tel: 0141 331 8017
Programme
Friday 5th December 2014
09.00 - 09.45 Arrival and Registration
10.15 - 10.30 Welcome and IntroductionDr Scott Johnstone University of Glasgow
10.30- 12.15 Session 1: Connexin History structure and FunctionChair: Dr Patricia Martin, Glasgow Caledonian University
Keynote Address: 10:30. Connexin catalysed cell communication. Yesterday and todayProfessor Howard Evans, Cardiff University School of Medicine, UK
Talks:11:15. The function and regulation of internal connexin 43 translationClàudia Salat Canela, Vall d'Hebron Institut de Recerca, Barcelona, Spain
11:30. Amsh-mediated deubiquitination of Cx43 regulates internalization and degradation of gap junctionsTeresa Ribeiro-Rodrigues, University of Coimbra, Portugal
11:45. To beat or not to beat - Detrimental autophagy contributes to gap junction degradation in the ischemic heartTânia Martins-Marques, University of Coimbra, Portugal
12:00. Inhibition of Cx43 modifies metalloproteinase-9 expression and influences cell migration eventsClaire Lorraine, Glasgow Caledonian University, UK
12.15-12.30 Launch of International Gap Junction Conference 2017Patricia Martin and Margaret Sherry (In conference)
12.30 – 1.35 Lunch and Small Group Sessions and networkingPosters
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Continued…1.35-3.10 Session 2: Vascular Connexins and Pannexins
Chair: Professor Sheila Graham, University of Glasgow, UK
Keynote Address: 1:35. Pannexins in the endothelium can regulate the acute inflammatory responseDr Brant Isakson, University of Virginia, USA
Talks:2:20. Gap junctions and connexin hemichannels in the regulation of haemostasis and thrombosisSakthivel Vaiyapuri, University of Reading, UK
2:35. The role of pannexin-1 in human plateletsKirk A. Taylor, University of Leicester, UK
2:50. Investigating connexin gap junction between adult rat cardiomyocytes and cardiac fibroblastsLisa McArthur, University of Glasgow, UK
3:00. A role doe pannexin and connexin signalling in vascular functionMyo Htet, Glasgow Caledonian University, UK
3.10 Coffee & Refreshments
3.45-5.00 Session 3: Connexins and channel gatingChair: Henrique Girao, University of Coimbra, Portugal
3:45. The modulation of Cx26 by CO2
Louise Meigh, University of Warwick, UK
4:00. Cx43 lacking the c-terminus end reduces Nav1.5 current of HL1 cells via a sequence between amino acids 301 and 361Line W. Waring, University of Copenhagen, Denmark
4:15. A role for connexin signalling in the innate immune response in skinAfnan Jan, Glasgow Caledonian University, UK
4:30. Connexin hemichannels – Half the Story?Nanna MacAulay, University of Copenhagen, Denmark
4:45. Closing remarks and prizes: Patricia Martin
5.00 Wine Reception - Posters6.30 Dinner
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Acknowledgements
The organisers of the UK Gap Junction Meeting 2014 gratefully acknowledge the generous support of the following societies and industrial partners:
Biochemical Society Independent Meeting Award
The Biochemical Society webpage: www.biochemistry.org/Biochemical Society Transactions: www.biochemsoctrans.org/
Zealand Pharma meeting support
Zealand Pharma Webpage: www.zealandpharma.com/
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Acknowledgements
School of Health and Life Sciences, Glasgow Caledonian University Speaker sponsorship
http://www.gcu.ac.uk/hls/
College of Medical Veterinary and Life Sciences (MVLS), University of GlasgowSpeaker Sponsorship
http://www.gla.ac.uk/colleges/mvls/
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Keynote Speaker Biographies
Professor W. Howard Evans, School of Medicine, Institute of Infection and Immunity,Cardiff University, UK
Prof. Evans is a professor of Medical Biochemistry in the Institute of Infection and Immunity at Cardiff University Medical School, United Kingdom. His interest in intercellular communication via gap junctions spans from 1972 and his group has studied many facets of the structure and function of these Cx-based channels in a variety of normal and pathological situations. He has investigated the roles of connexin hemichannels, the
precursors of gap junctions, and shown their important roles in the reaction of cells to a range off external stresses e.g. hypoxia, osmotic, oxidative. His recent studies focus on addressing the roles of Cx channels in translational medicine. This has involved the design and development of small Cx mimetic peptides that block the operation of these channels. He also studies their use in addressing cardiac pathology. Other recent collaborative studies include the roles of connexin channels in cardiac repair and limbal epithelial stem cells of the eye, and in damage inflicted by nanoparticles released from implanted metal orthopaedic joints, where intercellular signalling via connexin hemichannels is impaired.
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Dr Brant Isakson, Robert M. Berne Cardiovascular Research Centre, University of Virginia, USA
Brant’s lab focuses on intercellular communication in the microvasculature and how this regulates the critical process of vessel dilation and constriction--elucidating this fundamental process is key to understanding such diseases as hypertension.
To that end, his lab is keenly interested in the membrane bound proteins connexins (which link cellular cytoplasm together physically) and pannexins (which signal other cells by releasing ATP into the extracellular environment), as well as how nitric oxide may regulate these channels directly, or act independently based on it's cellular localization in the vessel wall.
His lab utilizes everything from transgenic animals and isolated intact blood vessels, to unique cell culture techniques and molecular biology, to biophysical techniques such as analytical size exclusion. This provides an integrated way to tackle the most pressing and interesting biological questions.
https://www.cvrc.virginia.edu/Isakson/
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Upcoming Meetings
2015: International Gap Junction Meeting 2015, Valparaiso, Chile. March 28 th - April 2nd 2015 Registration for the meeting: http://cinv.uv.cl/igjc2015/?page_id=481 Or email Juan Carlos Saez: [email protected]
2016: UK Gap Junction Meeting Suggestions are requested for volunteers to host the 2016 UKGJ meeting.Please contact: [email protected]
2017: International Gap Junction Meeting 2017, Glasgow, UK
IGJC 2017 Meeting Organisers: Patricia Martin, Scott Johnstone, Catherine WrightContact: [email protected]
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