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Overcoming Attenuation Artifacts: How to useattenuation correction
Is SPECT/CT Superior to SPECT?
Raffaele GiubbiniChair and Nuclear Medicine UnitUniversity and Spedali Civili
Brescia - Italy
Overcoming Attenuation Artifacts: How to useattenuation correction
Is SPECT/CT Superior to SPECT?
Raffaele GiubbiniChair and Nuclear Medicine UnitUniversity and Spedali Civili
Brescia - Italy
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Artifacts in SPECT MPI•Mechanical & electronical
–Energy window–Detector center-of-rotation and alignment –Flood field non-uniformity–Degradation in resolution with distance from the collimator
•Biological–Myocardial hypertrophy –Left bundle branch block –Cardiac position with thorax•Patient-related artifacts
–Soft-tissue attenuation •breast lateral chest-wall fat diaphragm
–Superimposed abdominal visceral activity–Motion artifactsTechnical artifacts
– Selection or cardiac axes – Selection of apex and base for polar map
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As a gamma camera head rotates around the body the attenuation of the projected radiation varies with the amount of tissue and the type of tissue that it had to travel through
ATTENUATION
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The attenuation equation is:Ax = A0e-ux
The most frequently noted effects of attenuation in myocardial SPECT are artifacts associated with breast attenuation in women and diaphragmatic attenuation in men
Attenuation artifacts are more severe using Tl201 than with Tc99m due to Thallium’s lower energies
ATTENUATION
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Attenuation causes quantitative errors as well as distortions inthe projection profiles that are propagated into the reconstructed images. Knowledge of the attenuatingdistribution is required for attenuation correction. Solid linesdepict true profile; dotted lines depict attenuated profile.
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Soft-tissue attenuation• Soft-tissue attenuator overlie the left ventricle • => decrease in count density • Location: depend on the position of soft-tissue
attenuator • Severity: depend on size, density, energy of
radioisotope, 360 or 180 degree acquisition • artifact: fix, reversible defect or reverse
redistribution
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Breast attenuation• Most commonly encountered attenuation
artifact in cardiac SPECT • Extremely variable in appearance • Consider the position and configuration
of the breasts with patients in supine position
• Breast prosthesis
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Breast attenuation• Women of average body habitus: anterior,
anteroseptal, anterolateral walls • Women with large, pendulous breasts: lateral
attenuation artifacts • Elderly women with very large, pendulous
breasts: lateral abdominal wall • Not necessarily directly proportional to breast
size, but may vary considerably according to the position, configuration, and density of the breast.
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Diaphragmatic attenuation• Left hemidiaphragm, right ventricle
(lesser degree) => decrease count density in inferior wall of left ventricle
• Diaphragmatic elevation: obesity, pleural or pulmonary parenchymal disease, atelectasia, loss of lung volume, diaphragmatic paralysis, gastric dilation.
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Diaphragmatic attenuation• Attenuation artifacts usually constant
(fixed) • Ascites, peritoneal dialysis: Upright
exercise => ascites fluid may shift to the pelvis => less marked attenuation than in resting images
• Barium contrast
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• One method of handling attenuation artifacts is simply to reduce their clinical impact through scanning techniques and knowledge of their location and severity when they occur
ATTENUATION CORRECTION
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Conventional Correction MethodsThe most common correction methods have been a pre-reconstruction method based on work by Sorensen and a post reconstruction method developed by ChangNot used in myocardial perfusion because the thorax is too varied for a constant attenuation coefficient to be effective
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Sealed source transmission scan-based correction methods
• Most common sealed source is gadolinium-135• Used as a sealed line source with a collimator
on top and passed along the patient either after or at the same as the gamma camera is reading
• Important to realize that defects in transmission scan can have a detrimental effect to the attenuation corrected images
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A collimated planar beam of photons traverses the patient forming a complete projection profile as the source moves across the full field of view parallel to the system axis. Within the detector, an electronic mask defines a narrow spatial window” opposite the source and moving in unison. external radionuclide source approach whereby a series of 14
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external radionuclide source approach whereby a series of 14 collimated and shuttered line sources are positioned in an “array”opposite each detector such that the full detector field of view is irradiated simultaneously.
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2 point sources collimated to be incident at oblique angles on the opposing detectors. 133Ba point sources (t1/2 10.5 years, 356 keV gamma emissions) translate along the system axis simultaneously or sequentially with the emission acquisition. The transmission source is positioned such that the beam is incident on the detectors at an angle to the hole axes. Transmission photons penetrate thecollimator septa for detection.
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Sealed SourceMany of the SPECT QC procedures transfer over to the transmission imaging systemsYou must check the transmission tomogram for artifacts (motion, gating, missing frames)Other problems arise from old line sources decayed beyond being usable and body truncation
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G.A.
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Attenuation MapA CT image is a mesure of attenuation profiles in different angular projections
The reconstructed image is a two dimensional map of linear attenuation correction µ(x,y) of the X radiation
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µ(x,y) is depending on the energy of the X ray and it is expressed asHounsfield Units
Attenuation Map
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Conversione #CT in funzione delle diverse energie del fascio
COEFFICIENTE LINEARE DI ATTENUAZIONE
0,00
0,05
0,10
0,15
0,20
0,25
0,30
0,35
0,40
-1500 -1000 -500 0 500 1000 1500#CT
µ (c
m-1
)
kV 140kV 100keV 140
Mix aria-acqua Mix osso-acqua
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0
5
10
15
20
0,0 0,1 0,2 0,3 0,4 0,5 0,6Energia (MeV)
Cortical Bone vs Soft TissueCortical Bone vs Inflated LungSoft Tissue vs Inflated Lung
99mTc 511 keV
TC
Rapporto tra i coefficienti di attenuazione lineare in funzione dell’energia del fotone per diversi tessuti
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Beam hardening
L’aumento della energia media del fascio di raggi X è funzione:della densità dell’assorbitoredello spessore dell’assorbitore
Correzione mediantecalibrazione
Correzione mediantecalibrazione e correzione
iterativa
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Normalization for matrix size
CT scan512×512
SPECT Image 64×64
Attenuation Image 64×64
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0 90 180
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Motion artifacts: Upward creep• A patient’s rate and depth of respiration increase
markedly during dynamic exercise, resulting in more marked, increased lung volume, and a lower position of the diaphragm. During the acquisition, as the depth of respiration decreases, the height of the diaphragm will progressively rise, with a gradual upward shift of the heart
• Due to abdominal relaxation and modification of diaphragmatic excursion a upward-shift of the heart is commonly observed during acquisition even after rest injection
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uncorr. Stasis MDC MOCO
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A new source of errors:
• Misregistration of Emission and Transmission Scans
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Stress RestStress
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Stress Rest
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Single Photon Emission Computerized Tomography (SPECT/CT)
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A multicenter evaluation of commercial attenuation compensation techniques
in cardiac SPECT using phantom models
O'Connor MK et al. J Nucl Cardiol 2002;9:361-76
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A multicenter evaluation of commercial attenuation compensation techniques
in cardiac SPECT using phantom models O'Connor MK et al. J Nucl Cardiol 2002;9:361-76
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Clinical validation of SPECT attenuation correction using x-ray CT
Masood Y et al. J Nucl Cardiol 2005;12:676-86
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AC
AC
NC
NC
AC
AC
NC
NCPrevious Inferior MI
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S.A.
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uncorrected corrected
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109 Consecutive pts with inferior MIATN ATN
uncorrecteuncorrectedd
ATN ATN correctedcorrected
SSSSSS 14.0214.02±±7.97.9 9.49.4±±7.17.1
SRSSRS 9.59.5±±77 5.65.6±±6.16.1
SDSSDS 4.54.5±±3.23.2 3.83.8±±2.82.8
✔
✔
✔
✔
✔✔
✔
P<0.001
P<0.001
P<n.s.
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Kaplan-Meier survival curves (end point cardiac death) based on the locationof reversible perfusion abnormalities.
Kaplan-Meier survival curves (end point reinfarction) based on the locationof reversible perfusion abnormalities.
Elhendy A. et al. Am J Cardiol 2004;94:289–293)
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• Attenuation correction in cardiac SPECT: The boy who cried wolf?– G Germano, et al (J Nucl Cardiol 2007;14:25-35)
CONTROVERSIES IN NUCLEAR CARDIOLOGY
Although no one would deny that accurate AC could improve SPECT MPI, the question as to whether current implementations are sufficiently robust remains unanswered, especially with regard to the average user.
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Clinical value of attenuation correction instress-only Tc-99m sestamibi SPECT imaging
Gary V.
Heller G et al. J Nucl Cardiol 2004;11:273-81.
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CONTROVERSIES IN NUCLEAR CARDIOLOGY
• SPECT attenuation correction: An essential tool to realize nuclear cardiology’s manifest destiny– E.V. Garcia (J Nucl Cardiol 2007;14:16-24.)
Sensitivity % Specificity % Normalcy %Years Pazienti NC AC NC AC NC AC
totale -media
1996 -2006 1327 86 86 57 77 75 92
AC markedly improves diagnostic accuracy over no AC regardless of :� clinical site,� radionuclide used, � camera manufacturer, � whether quantitative versus qualitative techniques are used, � whether an obese versus a non obese population is studied� whether exercise or pharmacologic stress is used
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What is needed?• Adequate technology• Application specialists aware of technical and physiopatological issues
• A quick automatic quality control on MPI SPECT and CT realignement
• A possibility of manual realignement for SPECT and CT
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Shielding (1/16-inch lead) is usually required at the walls along the sides and back of the gantry
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EXPERIMENTAL EVALUATION
LV wall Volume 110 ccExternal souceVolume 150 ccSource-myocardial wall distance 30 - 50 mmUptake ratio LV wall ext.souce
1 01 11 21 4
Pixel size 4.5 mmrange 180°°°°step 3°°°°collimator cast HRBPF Butt. 0.35 - 5Max count density(wall) 95 counts
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1 : 1 1 : 21 : 0 Ratio 1 : 2 Ratio 1 : 4
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Results:
Ratio 1 : 1
Ratio 1 : 2
Ratio 1 : 4
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Minimize superimposed abdominal visceral activity
• Exercise Tl-201 studies: maximal exercise • Dipyridamle Tl-201 and Tc-99m sestamibistudies: add dynamic, submaximal exercise (walking, biking) – Exercise is performed immediately after the infusion
of dipyridamole, and radiotracer is injected during exercise, at least 1 minute before its cessation.
• Tc-99m sestamibi: wait 60 min, fat meal after injection, 2 glasses of water before imaging
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Conclusion:• SPECT myocardial perfusion imaging
• Poor specificity caused by image artifacts.
• Recognize the sources of artifacts to avoid misinterpretations
• => Improve the specificity
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11th statement