GENOMICS MEETS GRID

INTRODUCTION

CHRIS THOMPSON

BACKGROUND

• SR 2000 - £120M NATIONAL PROGRAMME ON e-SCIENCE

• £8M BBSRC PROGRAMME ON BIOINFORMATICS AND e-SCIENCE IN 2001:

– 5 PILOT PROJECTS (ca £5M)

– ENABLING TECHNOLOGIES

– SUMMER SCHOOL TRAINING

– GRID SUPPORT CENTRE POST

GRID PILOT PROJECTS

• STERNBERG et al: A distributed pipeline for structure-based proteome annotation using GRID technology

• SANSOM et al: A GRID database for biomolecular simulations

• NAVE et al: An e-Science resources for high through-put structural biology

• BISBY: A problem-solving environment for global biodiversity: prototype and demonstrator

• KIRKWOOD et al: Biology of Ageing: e-Science integration and simulation system

• GODDARD et al: Grid-enabled modelling tools and databases for neuroinformatics

GAPS

• Areas not supported through the e-Science programme:– Genomics– Investigating Gene Function Initiative groups– BBSRC-supported Institutes

• Grid Support Centre post - £200K over 3 years

SR2002 e-SCIENCE

• Up to £10M for a new BBSRC initiative• Focus on integrating data from different sources to

inform about systems, organisms and their interaction

• Build on existing e-Science activities• Develop Grid technology for use in key areas not

covered by SR2000:

Genomics, IGF and the Institutes

AIMS OF THIS MEETING

• To educate the e-Science community about informatics problems in genomics

• To inform the genomics community about what Grid technology can offer

• To explore opportunities for collaboration

• To identify possible pilot projects

• To define how the Grid Support Centre can help

MEETING STRUCTURE 1

• Short presentations from genomics groups highlighting key issues; Grid people to respond with first thoughts on how their technology might help

• Plenary brainstorming; write on Post-its:

– Genomics informatics problems

– Possible Grid solutions

– Synergy with ongoing projects

Group them and identify breakout groups

MEETING STRUCTURE 2

• Breakout groups to explore opportunities and identify some possible pilot projects – identify a rapporter

• Re-convene breakout groups the next day to prepare for report-back

• Report-back on ideas generated

NEXT STEPS

• Develop collaborative groupings

• Seek input from Grid Support Centre

• Establish pilot projects; funding can be sought from BBSRC responsive mode committees – Bioinformatics and e-Science Cross Committee priority

• Develop bids for Sr2002 e-Science Initiative