Clinical Genetics Cytogenetics Molecular Genetics National Centre for Medical Genetics.
Genetics
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Transcript of Genetics
A M E N D E L A P P R OAC H
GENETICS
GREGOR MENDEL
• The laws of inheritance were derived by Gregor Mendel, a nineteenth-century Austrian monk conducting hybridization experiments in garden peas• Between 1856 and 1863, he cultivated and tested
some 5,000 pea plant
• He only measured absolute characteristics, such as color, shape, and position of the offspring, rather than quantitative characteristics.
• Mendel picked common garden pea plants for the focus of his research because they can be grown easily in large numbers and their reproduction can be manipulated.
• Pea plants have both male and female reproductive organs. As a result, they can either self-pollinate themselves or cross-pollinate with another plant.
• In his experiments, Mendel was able to selectively cross-pollinate purebred plants with particular traits and observe the outcome over many generations. This was the basis for his conclusions about the nature of genetic inheritance.
• Phenotype: The expression of the genes in a living organism.
• Genotype: The gene composition of a living organism
TRAITS- WHAT ARE SEEN
• Dominant allele- the one allele that is expressed
• AA
• Recessive allele- the one allele that is not expressed but present.
• aa
Homozygous- when two identical alleles are present.
Heterozygous- when two diverse alleles are present. Qq or qQ
• “Law of Segregation”, states that every individual possesses a pair of alleles for any particular trait and that each parent passes a randomly selected copy (allele) of only one of these to its offspring.
• "Inheritance Law", states that separate genes for separate traits are passed independently of one another from parents to offspring.
LAW OF SEGREGATION
INHERITAGE LAW
MENDEL’SLAWS
31
PUNNETT SQUARE
9331
EXAMPLES
• Earwax• Brachydactyly (shortness of fingers and toes)• Eye Color• Hair Color
Recessive
Dominant Recessive/ Dominant
REVIEW
• Crashcourse• SAMPLES