Generation of Oncogenes The major ways of generating oncogenes: Proliferation stimulating gene...
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Generation of Oncogenes
The major ways of generating oncogenes:
Proliferation stimulating gene acquired by a virus.
Proviral insertional mutagenesis places growth promoting gene under the transcriptional control of viral elements.
Mutation of a proto-oncogene to an oncogene.
Gene Amplification.
Chromosomal Translocation.
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Figure 4.2 The Biology of Cancer (© Garland Science 2007)
Assaying for an Oncogenic Mutation
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Figure 4.10 The Biology of Cancer (© Garland Science 2007)
Point mutation can change a proto-oncogene into an oncogene
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Figure 5.12a The Biology of Cancer
Mutation can change a proto-oncogene into an oncogene
Epidermal growth factor provides an example
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Figure 3.23b The Biology of Cancer (© Garland Science 2007)
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Figure 4.11b The Biology of Cancer (© Garland Science 2007)
HSR revealed by myc specific probe
N-myc is amplified in childhood neuroblastomas
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Figure 4.6b The Biology of Cancer (© Garland Science 2007)
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Figure 4.6c The Biology of Cancer (© Garland Science 2007)
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Figure 5.12b The Biology of Cancer (© Garland Science 2007)
(eg. the effect of the SIS oncoprotein)
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Figure 4.15a The Biology of Cancer (© Garland Science 2007)
The ‘Classic’ Oncogenic Translocation: The Philadelphia Chromosome & CML
Cytogenetic Findings
Molecular genetic findings
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Figure 4.13a The Biology of Cancer (© Garland Science 2007)
Chromosomal Translocation in Burkitts Lymphoma