General features of insulin signal transduction pathways Jeong-a Kim, et al. Circulation...
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![Page 1: General features of insulin signal transduction pathways Jeong-a Kim, et al. Circulation 2006;113:1888-1904.](https://reader035.fdocuments.us/reader035/viewer/2022070415/5697c02b1a28abf838cd8631/html5/thumbnails/1.jpg)
General features of insulin signal transduction pathways
Jeong-a Kim, et al. Circulation 2006;113:1888-1904
![Page 2: General features of insulin signal transduction pathways Jeong-a Kim, et al. Circulation 2006;113:1888-1904.](https://reader035.fdocuments.us/reader035/viewer/2022070415/5697c02b1a28abf838cd8631/html5/thumbnails/2.jpg)
Insulin-stimulated secretion of ET-1 from vascular endothelial cells is mediated by MAP-kinase (MAPK)-dependent pathways but not PI
3-kinase–dependent pathways
Jeong-a Kim, et al. Circulation 2006;113:1888-1904
![Page 3: General features of insulin signal transduction pathways Jeong-a Kim, et al. Circulation 2006;113:1888-1904.](https://reader035.fdocuments.us/reader035/viewer/2022070415/5697c02b1a28abf838cd8631/html5/thumbnails/3.jpg)
Parallel impairment in insulin-signaling pathways under pathological conditions
contributes to synergistic coupling of insulin resistance and endothelial
dysfunction
Jeong-a Kim, et al. Circulation 2006;113:1888-1904
![Page 4: General features of insulin signal transduction pathways Jeong-a Kim, et al. Circulation 2006;113:1888-1904.](https://reader035.fdocuments.us/reader035/viewer/2022070415/5697c02b1a28abf838cd8631/html5/thumbnails/4.jpg)
Shared and interacting mechanisms of glucotoxicity, lipotoxicity, and
inflammation
Jeong-a Kim, et al. Circulation 2006;113:1888-1904
![Page 5: General features of insulin signal transduction pathways Jeong-a Kim, et al. Circulation 2006;113:1888-1904.](https://reader035.fdocuments.us/reader035/viewer/2022070415/5697c02b1a28abf838cd8631/html5/thumbnails/5.jpg)
Pathway-specific insulin resistance creates imbalance between
prohypertensive and antihypertensive vascular actions
Jeong-a Kim, et al. Circulation 2006;113:1888-1904
![Page 6: General features of insulin signal transduction pathways Jeong-a Kim, et al. Circulation 2006;113:1888-1904.](https://reader035.fdocuments.us/reader035/viewer/2022070415/5697c02b1a28abf838cd8631/html5/thumbnails/6.jpg)
Vasodilator actions of insulin and DHEA
mediated by NO are regulated by PI 3-kinase (PI3K)-dependent signaling
pathways
Jeong-a Kim, et al. Circulation 2006;113:1888-1904
![Page 7: General features of insulin signal transduction pathways Jeong-a Kim, et al. Circulation 2006;113:1888-1904.](https://reader035.fdocuments.us/reader035/viewer/2022070415/5697c02b1a28abf838cd8631/html5/thumbnails/7.jpg)
In vitro model of metabolic insulin resistance with
compensatory hyperinsulinemia in vascular endothelium
Jeong-a Kim, et al. Circulation 2006;113:1888-1904
![Page 8: General features of insulin signal transduction pathways Jeong-a Kim, et al. Circulation 2006;113:1888-1904.](https://reader035.fdocuments.us/reader035/viewer/2022070415/5697c02b1a28abf838cd8631/html5/thumbnails/8.jpg)
Mechanisms for the contribution of insulin resistance to atherosclerosis
Jeong-a Kim, et al. Circulation 2006;113:1888-1904
![Page 9: General features of insulin signal transduction pathways Jeong-a Kim, et al. Circulation 2006;113:1888-1904.](https://reader035.fdocuments.us/reader035/viewer/2022070415/5697c02b1a28abf838cd8631/html5/thumbnails/9.jpg)
SHRs serve as a model of the metabolic syndrome
Jeong-a Kim, et al. Circulation 2006;113:1888-1904
![Page 10: General features of insulin signal transduction pathways Jeong-a Kim, et al. Circulation 2006;113:1888-1904.](https://reader035.fdocuments.us/reader035/viewer/2022070415/5697c02b1a28abf838cd8631/html5/thumbnails/10.jpg)
Losartan therapy simultaneously improves adiponectin levels (A),
insulin resistance (B), endothelial dysfunction (C), and inflammatory markers (D) in subjects with hypercholesterolemia and hypertension
Jeong-a Kim, et al. Circulation 2006;113:1888-1904QUICKI indicates Quantitative Insulin-Sensitivity Check Index