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![Page 1: Gender Differences in Longevity Predictors: Effects of Early-Life and Midlife Conditions on Exceptional Longevity Leonid A. Gavrilov Natalia S. Gavrilova.](https://reader035.fdocuments.us/reader035/viewer/2022062717/56649e495503460f94b3c415/html5/thumbnails/1.jpg)
Gender Differences in Longevity Predictors: Effects of Early-Life and Midlife Conditions on Exceptional
Longevity
Leonid A. GavrilovNatalia S. Gavrilova
Center on Aging
NORC and The University of Chicago Chicago, USA
![Page 2: Gender Differences in Longevity Predictors: Effects of Early-Life and Midlife Conditions on Exceptional Longevity Leonid A. Gavrilov Natalia S. Gavrilova.](https://reader035.fdocuments.us/reader035/viewer/2022062717/56649e495503460f94b3c415/html5/thumbnails/2.jpg)
Approach
To study “success stories” in long-term avoidance of fatal diseases (survival to 100 years) and factors correlated with this remarkable survival success
![Page 3: Gender Differences in Longevity Predictors: Effects of Early-Life and Midlife Conditions on Exceptional Longevity Leonid A. Gavrilov Natalia S. Gavrilova.](https://reader035.fdocuments.us/reader035/viewer/2022062717/56649e495503460f94b3c415/html5/thumbnails/3.jpg)
Winnie ain’t quitting now.
Smith G D Int. J. Epidemiol. 2011;40:537-562
Published by Oxford University Press on behalf of the International Epidemiological Association © The Author 2011; all rights reserved.
An example of incredible resilience
![Page 4: Gender Differences in Longevity Predictors: Effects of Early-Life and Midlife Conditions on Exceptional Longevity Leonid A. Gavrilov Natalia S. Gavrilova.](https://reader035.fdocuments.us/reader035/viewer/2022062717/56649e495503460f94b3c415/html5/thumbnails/4.jpg)
Studies of centenarians require careful design and
serious work on age validation
The main problem is to find an appropriate control group
![Page 5: Gender Differences in Longevity Predictors: Effects of Early-Life and Midlife Conditions on Exceptional Longevity Leonid A. Gavrilov Natalia S. Gavrilova.](https://reader035.fdocuments.us/reader035/viewer/2022062717/56649e495503460f94b3c415/html5/thumbnails/5.jpg)
Approach
Compare centenarians and shorter-lived controls, which are randomly sampled from the same data universe: computerized genealogies
![Page 6: Gender Differences in Longevity Predictors: Effects of Early-Life and Midlife Conditions on Exceptional Longevity Leonid A. Gavrilov Natalia S. Gavrilova.](https://reader035.fdocuments.us/reader035/viewer/2022062717/56649e495503460f94b3c415/html5/thumbnails/6.jpg)
Design of the study Compare centenarians with
their peers born in the same year but died at age 65 years
It is assumed that the majority of deaths at age 65 occur due to chronic diseases related to aging rather than injuries or infectious diseases (confirmed by analysis of available death certificates)
![Page 7: Gender Differences in Longevity Predictors: Effects of Early-Life and Midlife Conditions on Exceptional Longevity Leonid A. Gavrilov Natalia S. Gavrilova.](https://reader035.fdocuments.us/reader035/viewer/2022062717/56649e495503460f94b3c415/html5/thumbnails/7.jpg)
Case-control study of longevity
Cases - 765 centenarians survived to age 100 and born in USA in 1890-91
Controls – 783 their shorter-lived peers born in USA in 1890-91 and died at age 65 years
Method: Multivariate logistic regression
Genealogical records were linked to 1900 and 1930 US censuses providing a rich set of variables
![Page 8: Gender Differences in Longevity Predictors: Effects of Early-Life and Midlife Conditions on Exceptional Longevity Leonid A. Gavrilov Natalia S. Gavrilova.](https://reader035.fdocuments.us/reader035/viewer/2022062717/56649e495503460f94b3c415/html5/thumbnails/8.jpg)
Age validation is a key moment in human longevity studies
Death dates of centenarians were validated using the U.S. Social Security Death Index
Birth dates were validated through linkage of centenarian records to early U.S. censuses (when centenarians were children)
![Page 9: Gender Differences in Longevity Predictors: Effects of Early-Life and Midlife Conditions on Exceptional Longevity Leonid A. Gavrilov Natalia S. Gavrilova.](https://reader035.fdocuments.us/reader035/viewer/2022062717/56649e495503460f94b3c415/html5/thumbnails/9.jpg)
A typical image of ‘centenarian’ family in 1900
census
![Page 10: Gender Differences in Longevity Predictors: Effects of Early-Life and Midlife Conditions on Exceptional Longevity Leonid A. Gavrilov Natalia S. Gavrilova.](https://reader035.fdocuments.us/reader035/viewer/2022062717/56649e495503460f94b3c415/html5/thumbnails/10.jpg)
Genealogies and 1900 and 1930 censuses provide three
types of variables
Characteristics of early-life conditions
Characteristics of midlife conditions
Family characteristics
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Early-life characteristics
• Type of parental household (farm or non-farm, own or rented),
• Parental literacy,
• Parental immigration status
• Paternal (or head of household) occupation
• Number of children born/survived by mother
• Size of parental household in 1900
• Region of birth
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Midlife Characteristics from 1930 census
• Type of person’s household
• Availability of radio in household
• Person’s age at first marriage
• Person’s occupation (husband’s occupation in the case of women)
• Industry of occupation
• Number of children in household
• Veteran status, Marital status
![Page 13: Gender Differences in Longevity Predictors: Effects of Early-Life and Midlife Conditions on Exceptional Longevity Leonid A. Gavrilov Natalia S. Gavrilova.](https://reader035.fdocuments.us/reader035/viewer/2022062717/56649e495503460f94b3c415/html5/thumbnails/13.jpg)
Family Characteristicsfrom genealogy
• Information on paternal and maternal lifespan
• Paternal and maternal age at person’s birth,
• Number of spouses and siblings
• Birth order
• Season of birth
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Example of images from 1930 census (controls)
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Parental longevity, early-life and midlife conditions and survival to age 100.
Men
Multivariate logistic regression, N=723
VariableOdds ratio
95% CI P-value
Father lived 80+ 1.841.35-2.51
<0.001
Mother lived 80+ 1.701.25-2.32
0.001
Farmer in 1930 1.671.21-2.31
0.002
Born in North-East 2.081.27-3.40
0.004
Born in the second half of year
1.361.00-1.84
0.050
Radio in household, 1930
0.87 0.63-1.19 0.374
![Page 16: Gender Differences in Longevity Predictors: Effects of Early-Life and Midlife Conditions on Exceptional Longevity Leonid A. Gavrilov Natalia S. Gavrilova.](https://reader035.fdocuments.us/reader035/viewer/2022062717/56649e495503460f94b3c415/html5/thumbnails/16.jpg)
Parental longevity, early-life and midlife conditions and survival to age 100
WomenMultivariate logistic regression, N=815
Variable
Odds
ratio
95% CIP-
value
Father lived 80+ 2.19 1.61-2.98<0.00
1
Mother lived 80+ 2.23 1.66-2.99<0.00
1
Husband farmer in 1930 1.15 0.84-1.56 0.383
Radio in household, 1930
1.61 1.18-2.20 0.003
Born in the second half of year
1.18 0.89-1.58 0.256
Born in the North-East region
1.04 0.62-1.67 0.857
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Variables found to be non-significant in multivariate
analyses Parental literacy and immigration
status, farm childhood, size of household in 1900, percentage of survived children (for mother) – a proxy for child mortality, sibship size, father-farmer in 1900
Marital status, veteran status, childlessness, age at first marriage
Paternal and maternal age at birth, loss of parent before 1910
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Conclusions
Both midlife and early-life conditions affect survival to age 100
Parental longevity turned out to be the strongest predictor of survival to age 100
Men are likely to be more sensitive to the effects of early-life conditions.
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Mortality patterns of men and women suggest that women may have more reserves (redundancy) compared to men in terms of reliability theory of
aging
U.S. population, 1999
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Failure Rate as a Function of Age in Systems with Different Redundancy
Levels
Failure of elements is random
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Possible explanation from the reliability theory of aging point of
view
Men are likely to have less reserves (lower redundancy) compared to women
Organisms with lower redundancy may be more vulnerable to external shocks early in life, which deplete further their low reserves
Hence men are more sensitive to the effects of early-life conditions.
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References
Gavrilov L.A., Gavrilova N.S. Predictors of Exceptional Longevity: Effects of Early-Life Childhood Conditions, Mid-Life Environment and Parental Characteristics. In: 2014 Living to 100 Monograph [published online – August, 2014, http://livingto100.soa.org/]. The Society of Actuaries, 2014, 18 pages
Gavrilov L.A., Gavrilova N.S. Determinants of exceptional human longevity: new ideas and findings. Vienna Yearbook of Population Research, 2013, 11: 291-323
Gavrilov L.A., Gavrilova N.S. Biodemography of exceptional longevity: Early-life and mid-life predictors of human longevity. Biodemography and Social Biology, 2012, 58(1):14-39, DOI: 10.1080/19485565.2012.666121
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Acknowledgment
This study was made possible thanks to:
generous support from the National Institute on Aging
grant #R01AG028620
stimulating working environment at the Center on
Aging, NORC/University of Chicago
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For More Information and Updates Please Visit Our Scientific and Educational
Website on Human Longevity:
http://longevity-science.org
And Please Post Your Comments at our Scientific Discussion Blog:
http://longevity-science.blogspot.com/
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Final Conclusion
The shortest conclusion was suggested in the title of the New York Times article about this study
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