DiscoveringCollagen

Think collagen, think Genacol®!Collagen can help:

Joint pain,Fibromyalgia,

Wrinklesand more

NEW!Genacol®

InstantMore details insidePAGES 10 - 11

The most complete reference booklet about collagen!

Collagen, the glue of life!................................................................................ 2

How the body rebuilds itself .......................................................................... 3

Why is collagen necessary for youth and health? ........................................... 4

CartilageCollagen and sleep............................................................................................ 5

Diseases due to collagen deficiency............................................................. 6, 7

Collagen and skin.............................................................................................. 8

Genacol®! A new discovery........................................................................... 9

NNEEWW!! Genacol® Instant - Instant relief! .....................................................10

Genacol® - Clinical Trials ................................................................. 12, 13, 14

Dr. Price’s StudyDr. Sal Martingano’s comments ...................................................................... 13

History of Genacol®..................................................................................... 15

Testimonials .................................................................. 11, 16, 17, 18, 19, 20, 21

Frequently asked questions about Genacol®.................................. 22, 23, 24

Bibliography ................................................................................................... 25

INDEX

1

Dear Readers,

This reference booklet was produced in order to answer your

questions about collagen. You will find a lot of information

on collagen and its properties. Included as well, are clear

and simple explanations about problems related to collagen

deficiency. You’ll understand why Genacol® can bring you

the help that you are looking for.

Genacol® is the result of more than 20 years of research.

Thanks to a unique and exclusive process called AminoLock®

Sequence Technology discovered by the DirectLab Inc.

Research and Development Division, Genacol® is the only

100% pure collagen product that has this concentration of

amino acids.

This booklet contains important information about collagen

and will clearly explain both the difference and superiority

of Genacol® as compared to other collagen products.

Enjoy your reading!

A. Prud’Homme, n.d.

Vice-President

International Sales

Collagen is present in all multi-cellularorganisms. It is the fibrous structural proteinthat makes up the white fibers (collagenfibers) of skin, tendons, bones, cartilage,and all other connective tissues. It alsoprovides structure throughout the gelatinoussubstances of the body, such as in the vitreoushumor of the eye. In other words, collagen isa natural protein that makes up most of thebody’s structural support and is the primarysubstance of connective tissue. It is thisfibrous connective tissue that holds ourbody together.

Collagen gives to different organs and tissuestheir strength and elasticity. Collagen makesup 25% of the dry protein weight in thehuman body. About 75% of our skin is madeof it, and overall, some 30% of our entirebody is collagen. Collagen is part of the naturalmakeup of our tendons, ligaments, joints,muscles, hair, skin, and vital organs. Whenthe body’s essential supply of collagen isreduced, the body is affected. Weakness,fatigue, aches, pain, and an overall lackof energy are frequent symptoms of theproblem – symptoms that only increase aswe get older.

In addition to its many structural properties,collagen serves as a major catalyst for thegrowth and repair of nearly all of the body’stissues. Many different aging and collagendisorders are related to a deficiency of thisvital protein.

Collagen, the glue of life!

2

Collagen molecule

Normal collagen fibers

Arthritic collagen fibers

How the body rebuilds itself

Whether the body can efficientlyrebuild and repair itself is dependentupon its ability to convert one bodyresource into another. This processof protein synthesis is a metabolicprocess requiring collagen as acatalyst. As collagen diminishes inthe body, both the resource and thecatalyst are reduced.

Many factors can harm and reduceour body’s collagen production.Smoking, drinking alcohol on a regularbasis, coffee, intensive stress andexcessive physical training are someof the factors responsible. Also,infections, pollution and bad climaticconditions as well as medication anddrugs weaken our organism.

Those of us who wish to look andfeel younger should be interested incollagen synthesis. Therefore, anyfood supplement that can enhancethe rebuilding or healing process ofour body is something that we shouldstrongly consider.

Producers of health food supplementshave consistently recognized theneed for collagen supplements. Thebody manufactures its own collagenevery single day, but since productiondiminishes with age, the availablesupply of collagen quickly becomesless than enough. Deterioration ofvarious body parts gradually follows.The first signs are wrinkles and thebeginning of unexplained joint pain.This is only part of the effects. Ashealth begins within the body, thesecret to a young and healthyappearance is to act on the cause ofthe deterioration before it takes hold.

The tendons of our bodyact like rubber bands.These fibers are made

up in large part ofcollagen. To maintain

elasticity and flexibility,our tendons require a

large amount ofcollagen, especiallyafter an injury or

because of the naturalaging process.

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Collagen, lookingfor the fountain

of youth

Collagen is naturally produced by thebody. It is vital to the body’s functioningbecause it is the tie that binds! Thebody’s use of collagen cannot beoverstated. It makes up the body’sjoints, muscles, hair, skin, tendons,and ligaments. It provides structureto our body and forms the molecularcables that strengthen the tendons.Collagen makes up the vast resilientsheets that support our skin andinternal organs. Bones and teeth areformed when the body adds mineralsto collagen.

Collagen fibers are woven togetherlike pieces of fabric to form a networkin which new cells grow and reproduce.Any time the body needs to buildnew cells, such as in the healing orgrowing process, collagen plays acentral role. Collagen is the substancethat protects and supports the softertissue of the body, and it is whatconnects them to our skeleton. Inother words, collagen is both thematerial and the glue that holds ourbody together.

COLLAGEN AND AGINGThe body’s production of collagenslows with aging. Things we havealways done, like running or jumping,suddenly seem more painful. Injuriesthat have never proven seriousbefore begin to hurt us. Joint painbecomes more problematic. Withcontinued aging, our connective andmuscle tissues break down due to anincrease in collagen deficiency anddamage. As a result, we experiencea weakening of our skeletal structure.We start to feel the pain of aging. So,what should we do to nourish our joints?

Outside the body, the slowing of theskin’s production of collagen becomesincreasingly more pronounced. Theskin starts to wrinkle. It loses itsyouthful glow. The appearance ofhealthful radiance vanishes. Soonwe develop ridges and furrows, redmarks and brown spots. Our skinloses elasticity and moisture.

Why is collagen necessary for youth and health?

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5

Cartilage

Cartilage is a rather firm rubbermaterial that covers the extremitiesof bones in normal joints. The primaryfunction of cartilage is to reduce jointfriction and, since cartilage can changeshape when compressed, serve as ashock absorber for the bones.

Collagen is a key component ofcartilage (67%), providing it with itsstrength. When the body’s collagenproduction is reduced, cartilageproduction is affected and so are allthe body’s systems that containcartilage. Cartilage can changeshape because it is composed ofover 70% of water, which can beredistributed with compression ormovement. Since cartilage does notcontain nerves, in the beginning, younever feel pain when these changesoccur. As we age, this shock absorbingquality is reduced due to collagendeficiency which is why activities likerunning and jumping feel less com-fortable as we get older.

Collagen and sleep

The vast majority of collagen’s catalyticwork is best conducted by the bodyat night during sleep. Sleep is not aninterruption of activity but simplyanother form of activity. It is indispen-sable for healing.

Research has proved that a largepart of the essential metabolic workin the repair of the body takes placewhen we sleep. Sleep is divided intoseveral phases. Our body regeneratesduring phase 2 and 3; however, itregenerates the most during the firstphase called the Alpha phase. Inother words, during the Alpha phaseour body uses its full regenerativecapacity. During the Alpha phase,our system looks for available aminoacids and nutrients in order to trans-form them into essential elements forour body. The sleep cycle repeatsitself several times over many hours.

The ability to convert collagen intobio-digestible elements takes placewhile we sleep. So, in order to developmuscles, tendons, ligaments and torebuild and repair organs and skin,the body must go through a processof protein synthesis that happensspecifically during the Alpha phase.One thing is for sure, sleep is reallyimportant and essential for good health!

Diseases dueto collagen deficiencyDiseases due to collagen deficiency, long associatedwith aging, are not only found in the elderly. Theyform an entire group of diseases that involveabnormalities of the immune system. The bloodplasma of patients with disease due to collagendeficiency show significant levels of auto-antibodies.This antigen-antibody reaction leads to inflammationof many of the body’s vital tissues. Here is a briefdescription of some of these diseases and a list ofsome auto-immune diseases:

Arthritis

Arthritis is a general term describing inflammationof the joints. The most known form of arthritis isosteoarthritis, which is also called degenerativejoint disease. Osteoarthritis is associated with abreakdown of cartilage in joints and most commonlyoccurs in the hips, knees, shoulders and spine. Itcan dramatically affect the fingers and toes.

All arthritis sufferers share common symptoms ofsevere pain and loss of movement in both rangeand motion, all of which cause premature agingand lead to a diminished quality of life. Researchhas demonstrated that when people suffer fromarthritis, a selective destruction of collagen in thejoint cartilage has occurred. White blood cellsattack the joint cartilage, which in turn activates theimmune system to develop antibodies. Theseantibodies turn around and attack what theyperceive to now be the enemy, i.e. ‘’collagen’’.Consequently, the immune system’s response is toattack all the cartilage that is degenerating in thebody. So, even if there may only be a problem inone wrist or knee, both wrists hurt, both knees hurt,our back, our hips, and both shoulders feel thepain. In the end, the result is the same: age-relatedpain increases along with a pronounced loss inquality of life.

Rheumatic disease is a frequently-used term,since rheumatoid arthritis, the most common of alldiseases, displays many characteristics of thisgroup. The cost of traditional arthritis treatment

has skyrocketed from $65 billion in 1992 to nearly$480 billion in 2002. Most of the cost went todisability payments and lost time at work. Theeffects of arthritis result in 20,000 deaths as well as2 million hospitalizations each and every year.

Furthermore, there is an additional horrific cost oftreating the side effects of arthritis medications,including corticosteroid drugs and immune sup-pressive drugs. Without a doubt, collagen-relateddiseases represent a terrible burden on society.

With 60 million Americans suffering from arthritis,we can say that there is an arthritis epidemic. JohnKlippel, Medical Director of the Arthritis Foundation,flatly stated: this should be a wake up call. We’vealways thought the problem was greater thanexpected. Studies and testimonies have demonstrat-ed that a hydrolysate of collagen such as Genacol®

is one of the most effective solutions.

Fibromyalgia and collagen

The acceptance of fibromyalgia as a disease andits definitive diagnosis has been hampered by alack of knowledge concerning the underlyingphysiopathology of this disease and the lackof specific biochemical markers applicable toits diagnosis.

Research has shown that fibromyalgia patients(diagnosis made by the American College ofRheumatology) had a lower amount of intramuscularcollagen and lower levels of collagen metabolites(urine and serum). This may lower the threshold formuscle micro-injury and contribute to the remodelingof the extra-cellular matrix and collagen depositaround the nerve fibers, as well as contribute to thelower pain threshold at the tender points.

The average complaint level of pain in people whohave had medically diagnosed fibromyalgia for2-15 years and are taking a "collagen hydrolysate"decreased significantly in an overall group average,and, in some individuals, quite dramatically. In ouropinion, patients with fibromyalgia may improvesymptomatically their chronic pain by taking "collagenhydrolysate" such as Genacol®.

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7

Bursitis, tendonitis and tendinosisBursitis is caused by arthritis inflammation or byinfection. The joint areas most commonly affectedare the shoulders, elbows, wrists, hips, back,and ankles, etc.

Individuals with bursitis have pain, tendernessand stiffness near the affected area. Local muscleweakness frequently develops as a result ofavoiding painful joint movements, such as thosecaused by climbing stairs.

Tendinotis, an inflammation of the tendons, hasfrequently been considered the cause of tendonpain and the associated loss of strength andmovement. More recently, researchers havediscovered that most people diagnosed with thisdisease have no sign of tendon inflammation.Consequently, medical science has come to seetendonitis more properly classified as tendinosis.Nowadays, the terms are interchangeable.

Tendinosis/Tendonitis is caused by a breakdownof the collagen-composed tendon. Collagencontributes to the rope-like structure of a tendonand to its strength. When collagen breaks down,small tears appear in the tendon, weakening itand causing pain. It is especially wearing onthose who perform repetitious tasks in theirjobs, sports or daily activities.

Bursitis, tendonitis/tendinosis can be successfullytreated by letting the painful areas rest, applyingice or taking a collagen supplement like Genacol®.This gives the body time to repair and repro-duce the damaged cartilage, provided that thebody is still producing the necessary amountof collagen.

A few more exam-ples of diseasesrelating to collagendeficiencyHere is a list of diseaseswhich DirectLab Inc has fre-quently received eloquenttestimonies where a sig-nificant decline of the symptoms and pain werenoticed after taking Genacol®: All arthritic types,osteoarthritis, fibromyalgia, bursitis, tendonitisor tendinosis, acute rheumatic fever, lupuserythematosus, dermatomyositis, infectiousscleroderma, arthritis, polymyositis, ankylosingspondylitis, etc. Here are more details about twoof these diseases:

-Systemic lupus erythematosus (SLE) is themost common and serious type of lupus. WithSLE, the immune system that normally protectsthe body from germs, viruses, and bacteriabegins to malfunction. It generates antibodiesthat attack healthy tissue in different parts of thebody. These tissues become inflamed as aresult. Inflammation can occur in the skin, muscles,joints, heart, lungs, kidneys, blood vessels andthe nervous system.

-The word scleroderma means 'hard skin.'Scleroderma is a condition where the skin getsthick and hard. Hydrolysate of collagen hasbeen given to people suffering from this diseasewith good results. More research is needed toprove that collagen can really help.

Some collagen diseases have no satisfactorytreatment, but most can be treated medically.For example, rheumatoid arthritis is commonlytreated with aspirin-like compounds, corticosteroidsand immunosuppressive agents, used separatelyor in combination. Some collagen diseases, likerheumatic fever, are treated with antibiotics, butunfortunately, in traditional medicine no treatmentgives complete satisfaction at the moment.

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Collagen and skin

At about twenty-five years of age, the body’scollagen production decreases in the skin. Thisprocess accelerates between the ages of fortyand fifty. Many studies have shown that ournormal collagen production can diminish at a rateof 1% per year after the age of forty which meansthat, by the age of fifty-five, the body has lostapproximately 15% of its capacity to producecollagen. By the age of seventy, the loss of collagenproduction can diminish by 30%.

When the production of collagen slows down, theskin retains less water, gets thinner and beginsto wrinkle.

The lack of collagen in the skin becomes apparentwith thinner skin. Little by little, capillary tissuesof the skin become thicker, which reduces thecapacity of the skin to retain nutrients and water.The skin then presents a bigger risk of developingwrinkles, stretch marks and infections. Its colorand pigmentation change, and brown spotsappear. Since the skin is less healthy, its capacityto serve as barrier to bacteria and viruses isreduced. A supplement of collagen can largelyhelp to regenerate skin tissues and so helps toslow down the aging process, particularly if it isingested, since the effect will occur throughout thewhole body.

A few facts:

- Collagen makes up the majority of the derma.

- Collagen is not found in food. It is made by thefibroblasts of the body.

- Collagen is the structure, the molecule thatholds our body together.

- Collagen is the most abundant protein inthe body.

- Our body is composed primarily of connectivetissues and collagen makes up 85 % of allconnective tissues.

- Collagen is the protein that supports our skin.

Due to its composition, collagen is the mostcomplex protein of the connective tissues of thehuman body.

Genacol®! A new discovery

Genacol® is a hydrolysate of collagen,generated by an enzymatic processand re-modulation of amino/peptides.This exclusive process is calledAminoLock® Sequence Technology.

DirectLab Inc. produces a very highquality collagen product, in 400 mgcapsules, without any preservativeor fillers. No other collagen producton the market possesses the sameconcentration of amino acids asfound in Genacol®.

The unique manufacturing processcalled AminoLock® Sequence Tech-nology is an exclusive approachdeveloped by the Research andDevelopment Division of DirectLabInc. and consists of enhancing collagen

amino/peptides. Genacol® is manu-factured under the highest biotech-nological standards and conforms togovernment requirements.

A collagen matrix is a safe, formulatedsubstance that stimulates the pro-duction of many different kinds ofcollagen in the body. The collagenmatrix, formulated from pure collagen,produces incredible results in thehuman body when used on a regularbasis. Genacol® is a protein complexthat uses specific AminoLock®

Sequence Technology. No otherproduct on the market contains thisconcentration. In order to obtain thisconcentration of amino acids, itwould be necessary to have up to10 times more collagen.

PRINCIPAL TYPES OF COLLAGENGenacol® is a collagen matrix that can help stimulate the production of the principal types of

collagen which make up 99% of all collagen found in the body.They are present in the body in the following way:

Type I - Bones, tendons, ligaments and skin;Type II - Cartilage and structure of the eyes;Type III - Liver, lungs and arteries;Type IV - Kidneys and many other internal organs;Type V - Cells surfaces, hair and placenta.

Genacol® is the only product that has this special amino acid combination.

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AminoLock® Sequence Technologyexclusive to Genacol®

Example of a typical collagen sequence

After more than two years of development,DirectLab inc. is proud to present their newproduct, Genacol® Instant.

This high quality product is a topical gelwith added Genacol® microbeads designedto relieve local muscular, rheumatic andarthritic pains. These microbeads areessential and in large part, responsible forthe excellent results of the product. Here iswhy:

Due to the bio activity of collagen, ourlaboratory concentrated on developing anew technology able to adequately isolateGenacol® in order to maximize its bio activitywhen applied. We reached our goal byinserting Genacol® into the microbeads.

By gently rubbing the painful area withGenacol® Instant, the microbeadsrelease the collagen, immediately activatingand rapidly relieving muscular, rheumaticand arthritic pains.

Furthermore, when the mild wintergreen smellquickly fades away, Genacol® Instantrelieves not only your pain but leaves yourskin feeling soft and smooth.

The soothing effect of Genacol® Instantwill allow you to pursue your daily activities,enjoyably and pain free.

Genacol® and Genacol® Instant areboth available in all pharmacies and healthfood stores.

Genacol® Instant - Instant relief!

INSTANT RELIEF!10

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Testimony

Genacol® Instant microbeadsrelieve muscular, rheumaticand arthritic pain.

About a month ago, I injured myself when I fell off my leg exerciser,which is located near my washing machine.

Being a heavy person, I tired to avoid falling off by shifting all myweight to my left wrist. This had a devastating effect on my entire sideand neck. I then felt intense burning and a numbing sensation forseveral minutes all the way down to my feet. After the numbnessstopped, the pain and inflammation remained intense. Furthermore, Ihurt my leg because when I fell, my thigh hit the exerciser whichcaused a huge bump on my leg. I then went to my doctor who examinedme and prescribed anti-inflammatory drugs and painkillers. After usingthese products for several days without any conclusive results, a friendof mine talked to me about this new product called Genacol® Instant.On top of being a natural product, it is supposedly very effective. So Idecided to try the product. After using the product for a few days andby applying it 4 times a day, the inflammation disappeared and the painalso diminished by 85% which allowed me to go on normally with mydaily activities. As for the bump on my leg, it quickly disappeared andinstead of becoming all shades of colour, the bump went from blue tothe normal skin colour. With each application I felt a light freshnessand afterwards the pain would disappear instantly.

I had to go a few days without the product and that quickly made merealized how much it was helping me! Thanks to Genacol® Instant I cansleep comfortably and without any pain. Otherwise, my neck would hurtall night and would prevent me from getting a good night’s sleep.

Genacol® Instant is truly responsible for my rapid healing and I recommendit to everyone.

Thanks a million!!

Mrs. Éliane Bossé,Montréal, QC

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COLLAGEN PRODUCTS ARE NOTALL THE SAME.

Not all collagen products are thesame. Of the very few collagenproducts, most have a very lowabsorption rate, something in theneighbourhood of 20%.

Genacol® is the best of these products,because it is, first of all, a collagenmatrix. It stimulates production of thevarious types of collagen rather thanjust one of the fourteen kinds.Genacol® is produced from purecollagen through a complex formulationprocess carried out in Canada as aresult of a partnership betweenDirectLab Inc. and a biotechnologicallaboratory. The end product is Genacol®,which has been demonstrated tohave a very high bio-availability.

In a very significant three-monthstudy aimed at comparing Genacol®

with a liquid collagen as well as anover-the-counter collagen supplement,Dr. Stephen Ho, a well known traumaphysician, evaluated the results usingfive groups of test subjects. Eachgroup consisted of 30 subjects, allsimilar in size, weight, health condition,age, and gender. The first group wasgiven Genacol® over a 90-day period;the second group took liquid collagen;the third group received a commoncollagen supplement; the fourth groupwas given a placebo composed ofneutral ingredients; and the fifthgroup (the control group) was givennothing at all.

A physical history was taken beforeand after the 90-day study to compare

the groups. The Genacol® groupobtained the best results, followedby the liquid collagen, the collagensupplement, the placebo, and thenthe control group. The study wasindependent, and Dr. Ho was notpaid by any commercial entity forconducting it. Table 1 summarizesthe results. (See reference on page 13)

The Genacol® group recorded aconsiderable reduction of achesand pains. This group also recordedfeeling much younger and stronger.The liquid collagen group, using aType II collagen in liquid form,demonstrated favourable improve-ments, but nearly 30% less thanthe Genacol® group. Genacol® is thebest of all products because it is acollagen matrix.

Group III, which was administered anover-the-counter collagen supplement,showed only nominal improvement.It obtained the same results as theplacebo group. The placebo group,Group IV received only a non-bioactivecapsule. There were minor improve-ments recorded, most of which canbe attributed to psychological factors,given that they expected results.This group was unaware that it wasnot being given any collagen. TheControl group, Group V was givenneither Type II collagen nor a placebo.In composition, age, gender, andstate of health, the members weresimilar to Groups I through IV.Histories were taken at the beginningof the study and at the end. Nochanges were observed.

Genacol®- Clinical Trials

Genacol®

is the best ofall productsbecause it isa collagen

matrix.

Dr. Stephen Ho,M.D.

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Table 1Comparison Study of collagen matrix and Type II collagen

Summary

Dr. Ho’s conclusion was that the Genacol® brandcollagen matrix in its pure, dry-state form wasfar superior to that of the liquid or theover-the-counter collagen supplement. He alsoconcluded that Genacol®, taken on a regular

basis, resulted in a more youthful appearanceand feeling. Pain was significantly reduced. Healso stated that the group taking Genacol®

reported a more restful and longer sleep period,as well as more energy during waking hours.

Dr. Price’s Study

Dr. Patrick Price, a Houston health professional, conducted another major independent study onGenacol®, which used three groups of patients that were essentially identical in makeup. Dr. Pricefound that Genacol® produced highly-observable improvement in energy, arthritic and injury painrelief, as well as skin texture. A placebo group had only minor improvements, and the control group,like the one in Dr. Ho’s study, remained the same.

Dr. Sal Martingano’s comments

There are many types of collagen that make up most of the body’s skin, tendons, bones, cartilage,and other connective tissue. Although naturally produced by the body, collagen production declinesafter the age of 25. Degenerative collagen diseases associated with aging affect the entire body.Collagen diseases include arthritis, fibromyalgia, bursitis, tendonitis, and other related conditions.Wrinkling, liver spots and joint pain are symptoms of degenerating collagen. Recently, new collagenproducts that help with collagen diseases have appeared on the market. These tend to be Type IIcollagen, collagen matrix, and collagen-derived products such as glucosamine-chondroitin. Of thethree, the collagen matrix has been found to be the most effective. The recommended form ofcollagen matrix is Genacol®. This product is far more bioactive than other products that have beenclinically tested.

Reduction inaches andpainsNoticeablechange in skinNoticeablefeelings ofrenewedenergy

Group IGenacol®

Considerable

Considerable

Considerable

Group II LiquidCollagen

Favourable

Favourable

Favourable

Group IIICollagenSupplement

Some

Very little

Very little

Groupe IVPlacebo

Some

None

Small

Group V Control Group

None

None

None

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AminoLock®

Sequence Technologyexclusive by Genacol®

Genacol®- Clinical Trials (continued)

Although more clinical research is required inorder to determine the effectiveness of the variousfood supplements, numerous studies havealready revealed the beneficial effects of certainnutrients on joint health. Collagen hydrolysateproves to be up to now, one of the most promisingfood supplements. Collagen is the most abundantprotein in the system. It structures tendons,cartilaginous tissues, bones and connective tissues.The composition of collagen hydrolysate ofanimal origin is similar to the collagen found inhuman cartilage.

Why does collagen hy-drolysate contribute tothe treatment of osteo-arthritis?

Research leads to believethat collagen hydrolysatecan stimulate the synthesisof collagen, which playsan important role inmaintaining healthy joints.During the convention, Steffen Oesser Ph. D,who is part of the General and Thoracic SurgeryDepartment at the University of Kiel in Germany,presented a resume of study results on collagenhydrolysate. In order to determine if collagenhydrolysate can effectively reach the jointtissues and modify them, researchers ofthe University of Kiel studied the absorptionrate and the accumulation level of collagenhydrolysate by controlling its absorption in thehuman organism. According to the results ofthat study, the rapid absorption of the collagenhydrolysate in the gastrointestinal tract doubledthe quantity of nutrients accumulated in the

cartilaginous tissue of the treated patients incomparison with the patients from the controlgroup. These results lead to believe that thecollagen hydrolysate reaches the tissues andcan cumulate in the long term.

The next step of the trial consisted in determiningif collagen hydrolysate could have a positiveinfluence on the joint tissue after its accumulation.That positive influence had to translate intwo effects: inhibition of the deterioration of

the supporting joint tissueand/or stimulation of newcartilaginous cells, aiming tocompensate for the naturallydamaged tissues. Thanks toa benchmark cellular culture,researchers were able todemonstrate that the pre-sence of collagen hydrolysatestimulated collagen produc-tion. However, natural colla-gen would not exert thatstimulating effect.

Furthermore, researchers stimulated the supportingjoint tissue in order to assure their reproductionin the presence of collagen hydrolysate, dimini-shing the degenerative impairing of the jointtissue. “These results are of certain importance.They allow us to understand that collagenhydrolysate reaches not only the aimed jointtissue but its presence can also positively trans-form the joint”, added the Dr Oesser.

Reference: PR Newswire on behalf of GELITAHealth Initiativewww.gelita-health-initiative.com/en

Collagen hydrolysatehas proved to beup to now, one of

the most promisingfood supplements.

In the mid 90’s, a research and developmentcompany located north of Montreal,Quebec, discovered collagen’s propertiesas a dietary supplement. These researchersdeveloped various formulas in collaborationwith laboratories with very high technologicalstandards of manufacturing. These formulaswere quickly appreciated by the naturalhealth community.

Over several years, this product wasdistributed successfully in various ways.Under Mr. Guy Michaud’s presidency, inOctober 2000, a new laboratory, DirectLabInc. was created and Genacol® madeits market debut. DirectLab Inc. is nowa biotechnological laboratory that usesa unique process called AminoLock®

Sequence Technology. This concept isnow one of the best available.

History of Genacol®

M. Guy MichaudPresident of DirectLab Inc.

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A year and a half ago, during a wrestling match, I seriouslyinjured my left shoulder: tears in the ligaments and tendonsof the shoulder. I really thought that it was the end ofmy career. Doctors prescribed anti-inflammatory drugsbut they didn’t work. The pain persisted. One day, one ofmy students suggested I try Genacol® but I was sceptical.Since I was continuing to train and as my injury was stillhurting a lot, I finally decided to take Genacol®.

At the end of the first month, I already had very goodresults. Before beginning Genacol®, my shoulder worked only at 25%.After two months of Genacol®, my shoulder has improved to 80%!!! Ilearned that Genacol® helps to rebuild tissues, I know now that it’s truebecause I am living proof!! I had excellent results with Genacol® and Iconfirm that it is a wonderful product! I want to suggest to all athleteswho have joint, tendon or muscular pain to use Genacol®. I use my body towrestle and Genacol® helps my body to wrestle!!!!

Congratulations and thanks to Genacol®!

Jacques Rougeau, Professional wrestler

DirectLab has collected numerous testimonies sent regularly by satisfiedGenacol® users

Testimonials

I’m pleased to tell you that my wife Marjorie definitely feels that theGenacol® program is good for her. She was recently advised to undergoknee replacement surgery, having almost no cartilage left. We have noMedicare plan and, as you know, the cost of knee replacements is prettyhigh. We saw your ad in a national magazine and decided to contact you.Marjorie has been taking Genacol® for over a month. She used tocomplain constantly about feeling tired and lacking energy. Now, shefeels that Genacol® is doing the trick: she walks better and uses hercrutch less and less. Let’s see what happens later on, but it’s already amajor improvement. She will continue taking Genacol® and will haveanother X-ray done in six months. For now, surgery is no longer an alter-native, but Genacol® is. Thanks again and I will keep you posted on theevolution of her condition on a regular basis.

Kind regards,Grant Cooper, Port Elizabeth, South Africa

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I originally purchased Genacol® because I have very thin hair and wanted itto thicken, which is what happened. It’s great. But something else alsohappened: now, when I get up in the morning and walk down the stairs, myknees are a lot more flexible and don’t creak any more. It’s a lovely surprise!

Rene Arnold

Being on the Pro-Celebrity Golf Circuit and always a fitness enthusiast, I feltI had done irreversible damage to my knees. When I was first approachedabout Pure-Col*, I was sceptical, but willing to give anything a try. I tried theproduct for 6 months. When I stopped taking it, the pain returned. Now, Iwould not do without Pure-Col*! This is a revolutionary product, and, as abonus I look and feel younger.

John Miles, musician and artist, UK

*Genacol® is distributed under the name ”Pure-Col” in the UK

After a great career in the National Hockey League,I was suffering from multiple injuries. Two years ago,I heard about Genacol®. I was really sceptical aboutthe effectiveness of all these natural products. Inspite of this fact, I started to take it. I felt thedifference right away. Since I had a knee injury whichrequired surgery, Genacol® helped me to go on with allmy activities without too much pain. Recently, Ifinally had my surgery and I have to say that Genacol® allowed me to recoverin the most encouraging way! So, I am now a spokesman for Genacol® and I talkabout it to a lot of people. It’s still a pleasure to hear about those people whocome back and thank me for advising them about this great product! Also, myspouse is no longer suffering from a painful arm tendonitis.

I am truly encouraging everybody who’s suffering from arthritis or joint painto use this great Canadian product, Genacol®.

Thanks Genacol®!!!

Yvan Cournoyer, #12 Montreal Canadian Ambassador

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I am a retired 62 year old. For the past two years I’ve suffered fromtendonitis in my left knee, which restricted my physical activities. Cycling,walking and training became, for someone very active, completely impossible.I tried chiropractors, many cortisone injections, and even the services of anorthotherapeutic practitioner. Despite all these treatments, my paincontinued and even became worse. I was considering knee surgery whena friend suggested I try Genacol®. I had nothing to lose. I started at 5capsules a night for the first week, and then reduced to 4 capsules for thefollowing weeks. To my great satisfaction, I was able to see an improvementin 12 days. I am now on my second bottle. I take 3 capsules at night beforebedtime and I let Genacol® do its work. My knee no longer hurts, I’vestarted gardening and cycling again, which in itself is a great improvement,and I’ve lost 5 pounds. I feel so much better!

Thank you Genacol®. Thank you also to my friend for recommending thiswonderful, completely natural product.

Hélène Benoît, Gatineau

Dear Sir/Madam,

My wife is 75 years old, and I am 79 years old. Both of us were sufferingfrom arthritis pain. Only one week after taking your miracle "CollagenExclusive Matrix" supplement, at the dosage recommended on your bottle,our quality of life has improved tremendously.

I highly recommend your product to anyone whom can use it for its intendedpurpose. Your product caught my eye, on your display unit, conspicuouslyplaced at the front counter of our local Pharmacy. At first I thought it waskind of expensive, but then after trying your product, I concluded that it wasmoney well spent. It most certainly performed as advertised.

May I take this opportunity to congratulate your Company for introducingsuch an excellent product?

Regards,V. Pucci

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I have been afflicted by fibromyalgia for more than eleven years. Thisdiagnosis was confirmed by an experienced rheumatologist. For a long time,the pain restricted my quality of life. Without any strength in my legs, Ihad to resign myself to using a wheelchair. I started to take Genacol®, 6capsules each day, and 3 weeks after, results are there! My sleep is better,my pain which I lived with 24 hours a day, diminished a lot! I am now ableto take a little walk and I feel really happy!

Thank you Genacol®!!Benoit Cyr, Québec

Being a high-level athlete for many years,I often have to deal with injuries. Forseveral months, I had to endure awfulsciatic pain. Given my allergy to anti-inflammatory drugs, I didn’t know whatto do anymore. One day, someone told meabout Genacol®, a product that couldsurely help me. A few months before theWorld Championship, I had nothing to

lose, so I decided to try this natural product. To my big surprise, the pain lessenedand I rediscovered the flexibility that I had lost. I kept on taking Genacol® and thepain completely disappeared. I came back from the World Championship injury-freeand with two medals! With Genacol®, I am a sure winner!

Marie-Hélène Leboeuf, 24-year old, World Champion W.K.A. 2003-2005 Karate

I had been suffering from acute tendonitis (tennis elbow) for over a year. Anti-inflammatory drugs had bad side effects for me. Cortisone injections were painfuland not very helpful in the long run. I was taking ibuprofen every single day to helpease the intense pain. I started taking Genacol® on January 26, 2007. For 2 weeksI took 6 capsules a day, following the recommendation of a friend who had takenthis supplement. I then reduced the dosage to 3 capsules a day. Here we are,February 22, 2007, and I am no longer in need of any type of pain reliever, indeed,I haven’t been taking anything for the pain for about 2 weeks. I am convinced thatGenacol® is the reason why. I have added no other supplement to my diet exceptGenacol®. I plan on continuing to take this wonderful collagen supplement, and willlet you know how I am doing with long term use of Genacol®.

Thanks Genacol®, for giving me back the use of my arm!Christine Lockett, Blainville, Québec

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I had problems with the mobility of one arm and one leg as well as problemswith my back, my cartilage and my tendons. Following a problem in my spinalcolumn, I had surgery that was, thank God, successful. After the surgery Iwas prescribed anti-inflammatory drugs, which I had no interest in taking. Myson had me try Genacol® and seeing the beneficial results that he had withthis product, I decided to follow the treatment for 6 months. After thisperiod, I have had an improvement of 90% in the mobility of my leg and myshoulder problems have also disappeared. Conscientious of the well being ofpeople, I counselled a few doctors on my experience. They have followed thetreatment and are now prescribing it to their patients.

Thank you Genacol®Mr. Raymond Touret, businessman

Fort-de-France, Martinique

I have been diabetic for more than 25 years, and must give myself many insulininjections a day. When you are diabetic, it is strongly recommended to exercise.However, I could not exercise because I had very painful knees. Taking Genacol®has changed my life! Working as a construction contractor, walking on site tosupervise the work had become very difficult. But with Genacol® the aches andpains in my knees have disappeared and I no longer have difficulty walking orclimbing stairs. The fact that I can now exercise, on the advice of my doctor, Ihave been able to reduce my insulin injections by 40 %. When you are diabetic,doctors tell you to keep away from natural products so you don’t dare try some-thing natural. Now I am convinced that, thanks to Genacol®, I have a new life!

Yvon Deschesnes, Mirabel, Qc.Contractor thanks to new and healthy life!

For several years I have been suffering from arthritis pain, sore back,muscle cramping, pain in my fingers, knees, bones, joints, etc. I am 56years old, work as an office technician and an activity coordinator forsenior citizens. I have many social activities. I did research on Internetto try to find something that would help ease my many aches and pains.I do not believe in taking products like Vioxx or other medication of thatnature. I found Genacol®, I tried it, and I can tell you that after only 4days I started to feel the benefits in my joints. I tell my friends thatGenacol® is truly miraculous. I certify that Genacol® is a real miracle! Itold my doctor about and also told him that my aches and pains havediminished by 80 % after only 3 weeks of using Genacol®. I continue totake Genacol® because I can now exercise and continue to do my workwithout any pain.

Yours Truly, Jacqueline Vézina, Rivière-au-Renard, QC

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February 8, 2006

I wanted to let you know that this is a fantastic product. I purchasedthis product for my mother who is 71 years old. She really suffers fromfibromyalgia and arthritis and severe leg cramps every night. She hasbeen on your product now for about 3 weeks and she thinks it is a miraclein a bottle. She has not experienced one single leg cramp and her movementis fantastic! She feels wonderful and I am so happy for her because Ihave seen her suffer for years. I personally have been on this productfor about the same amount of time and I have noticed skin changes andgreat bowel movements.

Thank you for a wonderful product!I have told lots of people about this great thing!

Tammy

Quelle merveille!

I have been taking Genacol® for 50 days now - my knee is so much better(I injured it 2 years ago). The pain is almost gone and my range of motionis so much improved. You can count on me for a testimonial – eh oui,même en français. Vraiment, je suis épatée.

Merci,

Sabine Davies

Hello,

I just wanted to let people know that I have started using Genacol® andin only one week I have noticed the difference in my skin and pain in mybones. I have Lupus and also have skin cancer and since I have been takingthis product I noticed my bone pain is not as bad as usual and my skin isstarting to smooth in only one week. I cannot imagine what I will feel likein a few months! I am getting this product for my mother and my sistersas this is amazing I will not stop using this, just give it a try!! You will notbe unhappy I can tell you.

Shelley CraigToronto, ON

What is the difference between collagen andglucosamine?

Collagen makes up 67% of cartilage as opposed toonly 1% of glucosamine. Glucosamine is an aminosugar whereas collagen is a molecule containingamino acids. Glucosamine is only found in largequantities in the liquid of the synovial membrane.Collagen is also found in the synovial membranebut in larger quantities since it is the most abundantstructural protein in the body. Glucosamine actsmore like a lubricant in the joints while collagencontributes to the global regeneration of the joint atall levels: tendons, ligaments, cartilage, muscles,membranes and the synovial liquid.

What’s the difference between Genacol® andother products such as those containing Type IIcollagen?

Genacol® is a matrix created by a procedure calledAminoLock® Sequence Technology developedby DirectLab Inc. This matrix is produced from acomplex containing many types of collagen, thusmaking it a far more complete product than theones using only Type II collagen. See reference onpage 9.

Why is it suggested taking Genacol® at bedtime?

It is suggested taking Genacol® at bedtime, becauseduring the Alpha phase which takes place during thefirst 90 minutes of sleep, the body searches for thenutrients necessary to repair itself. The essentialnutrients contained in Genacol® (amino acids) willbe used by the body at this precise time in anoptimal manner. Therefore, it’s better to take it atbedtime. Even though it’s better to take Genacol® atnight, certain circumstances may make it impossibleto take it at that time. It would then be preferable totake it in the morning, 30 minutes before breakfast.See reference on page 5.

What is the ideal dosage?

If you drink about 1.5 liters of water per day(please note that this quantity is the one recom-mended for good health and not only for takingGenacol®), you can begin with 3 capsules per dayat bedtime. If you are not used to drinking thisminimum quantity of water, start with 1 capsule perday during the first week, increase the quantity ofwater you drink and then you may go on to therecommended dosage. After a few weeks oftreatment and in order to optimize the results, youcan double the dose to 6 capsules per day, i.e.,3 at bedtime and 3 before breakfast. Caution: forpeople taking medication, it would be preferable toleave a 2 hour period between Genacol® and anymedication.

How long must I take Genacol®?

We suggest taking 3 capsules per day for the first3 to 6 weeks and then progressively move to thedosage that best suits you. In cases of degene-rative diseases, in order to maintain the beneficialeffects and avoid recurring problems of pain anddiscomfort, it is suggested taking Genacol® on apermanent basis. Please note: According to aninternal survey, the majority of people had resultsafter only one bottle.

What other situations could Genacol® be used for?

Besides arthritis, osteoarthritis and fibromyalgia,Genacol® can be used in cases of tendonitis, bursitis,hernia, carpal tunnel syndrome and all otherauto-immune diseases as well as for aestheticpurposes such as toning the skin and muscles.Generally speaking, Genacol® can be used incases of joint and muscular pain, as well as to helphydrate and tone the skin.

Frequently Asked Questions about Genacol®

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Who should take Genacol®?

Given that the body produces less collagen withaging, every adult can benefit from Genacol®.

Can I take Genacol® if I am diabetic?

Contrary to glucosamine, Genacol® should notaffect the glucose level in your blood. Proteins donot affect blood sugar levels. Since Genacol® is aprotein; you can safely use this product withoutany fear with the approval of your health careprofessional. Therefore people with diabetes canbenefit fully from Genacol®.

Can I take Genacol® if I have a fragile stomach?

Yes, there are no side effects from taking Genacol®

for people having a fragile stomach. In order tofacilitate digestion, you can remove the collagenpowder from the capsule and take it with somewater.

Is Genacol® absorbed by the body?

Yes, absolutely. The protein is micronised orreduced to a fine powder which permits a moreeffective absorption.

Are there certain health conditions for which itis not recommended to take Genacol®?

Collagen products are generally recognized assafe. However, if you are pregnant or breastfeeding,there is not enough current information in regardsto the safe use of collagen. According to HealthCanada, the manufacturers of natural products arenot permitted to express an opinion on the subject.We therefore recommend that you get a medicalopinion.

Can I take Genacol® with medicine orsupplements?

As far as we know, there is no medical interactionwith the use of Genacol®. Genacol® is a safe aminoacid complex and it is considered as a nutritionalsupplement. Yet, we recommend you get a medicalopinion. As already mentioned, you should wait 2hours before taking Genacol®, in order to minimizethe risk of interaction with each substance.

How many amino acids does Genacol® contain?

Genacol® contains all common amino acids in itsmatrix, except for Tryptophan. Tryptophan is notone of the amino acids found naturally in collagen.Every capsule contains 400 mg. of our pure collagenmatrix without fillers, which makes Genacol® one ofthe purest collagen supplements on the market.

What does “AminoLock® SequenceTechnology” mean?

We use a unique manufacturing process calledAminoLock® Sequence Technology, which inturn generates an enzymatic process that recon-figures the profile of amino acids. This exclusiveapproach developed by our Research & DevelopmentDivision meets the highest nutraceutical standards,creating a unique product promoting the five maintypes of collagen and using a specific sequence ofamino acids. See reference on page 9.

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What is the source of the amino acids foundin Genacol®?

Genacol® is composed of hydrolyzed collagenproteins which mean that they have been purifiedwith a unique enzymatic process. DirectLab Inc.,through its AminoLock® Sequence Technology,only uses certain fragments of bovine protein fromGermany (subcutaneous source, therefore there isno contact with the animal’s blood or organs) thathave undergone strict and thorough analysis toguarantee that the product is totally safe. No typesof mad cow disease (bovine spongiform ence-phalopathy) or any other illnesses have ever beendetected from this source. The product is certifiedby the Government of Canada and by HealthCanada among other agencies to meet the highestnutraceutical standards.

Can I give Genacol® to my pet?

The good news is that you can give Genacol® toyour pet. Calculate one capsule per 40 poundsdaily. It is more effective to open the capsule andgive the powder in it to your pet between meals(empty stomach). Place the powder on a dry andclean surface. Pets normally love it! There is nopossibility to give an overdose of collagen to yourpet as the body naturally eliminates any excess.

Please note:

These statements have not beenevaluated by Health Canada.However, Genacol® conformsto the requirements of HealthCanada This booklet has beenproduced as a source of informa-tion about collagen. The bookletis not to be used as a diagnostictool, nor to treat, heal, or preventillness. Genacol® should beconsidered as a basic nutritionalsupplement. However, it isrecommended to seek advicefrom your health care professional.

BIBLIOGRAPHY:Miller-Keane, Medical Dictionary, 2002.A. Berton, V. Rigot and al., “Involvement of Type IIFibronectin in the efficient inhibition of gelatinasesA and B by long-chain unsaturated fatty acids”,Journal of Biological Chemistry, June 2001.Alex Suth, DC, during a personal interview, April2003.Shelton, Gene, “Collagen and arthritis”, HealthRemedies Notebook, 2002.National Cardiovascular Disease Statistics, Officeof the Surgeon General, Washington D.C 2003.“Effects of oral administration of collagen onrheumatoid arthritis”, a Harvard School of Medicinestudy published in the Journal of Science, Boston,Massachusetts, 2003.Cochran, Charles, “Lubricate your joints”,Canadian Journal of Health and Nutrition, March2001.Christopher M. and al., “The hierarchical role inbinding Timp-2 of the unique cationic clusters ofhemopexin modules Iii and Iv”, Department ofBiochemistry and Molecular Biology, Faculty ofMedicine, University of British Columbia,Vancouver, and the Division of Hematology-Oncology, Children’s Hospital, L.A., and Universityof Southern California, L.A. 1998.Tuan T.L. and al., “ In vitro fibroplasia: matrix con-traction, cell growth, and collagen production offibroblasts cultured in fibrin gels”, Experimental CellResearch, 223: 127-134.O. Steinbrocker et al., Journal of AmericanMedicine 155, 1949, and as referenced anddetailed by Dr. Sal Martingano in his collagen audioseries, Florida, 2001.Li S. and al., “Innate diversity of adult humanarterial smooth muscle cells: cloning of distinctsubtypes from the internal thoracic artery”,Circulation Research, 89:517-525.Michael W.Smith, “Understanding Arthritis”,Treatment and Detection, June 2002.Anu Muona: Type XV collagen. “Completestructures of the human Col15A1and mouseCol15a1genes, location of type XV collagen proteinin mature and developing mice, and generation ofmice expressing truncated type XV collagen”, ActaUniversitatis Ouluensis D 662, 2001.Dr. Sal Martingano, one of the nation’s acknow-ledged collagen experts and researchers, speakingin a taped national radio broadcast appearance,“Reasons for aging”, 2002

DiGiovanna, Augustine G., “Human Aging:Biological Perspectives”, New York: McGraw-Hill,1994.Kari Kivirikko and al., “Molecular biology of colla-gens and enzymes of collagen biosynthesis”,Collagen Research Unit, Biocentre Oulu andDepartment of Medical Biochemistry and MolecularBiology, University of Oulu, Finland, 2001.Collagen studies, Brown University, Department ofOrthopedics, 1997.Bjorn Steffensen Dagger and al., “The involvementof Type II fibronectin modules of human gelatinaseA in cell surface localization and activation”,abstract from the Faculty of Dentistry and theDepartment of Biochemistry and Molecular Biology,University of British Columbia.Ho Stephen, “A catalyst study of collagen interac-tion”, Journal of Applied Research, Las Vegas, NA,2003Jeff Wilson and al. “Ca++ induced switch from helixto sheet triggers collagen binding”, AmericanCrystallographic Association, annual meeting, July21, 2001.Leroux J.Y., a well-known Canadian immunologistspecializing in collagen research, speaking duringa nationally broadcast television special, “The lossof youth”, 2003.Hunter G.K and al., “Modulation of crystal formationby bone phosphoproteins: Role of glutamic Acid-rich sequences in the nucleation of hydroxyapatiteby bone sialoprotein”, Biochemistry Journal.302:175-179.N.A. Nandriopoulos and al., Arthritis Rheum. 19,613 (1976); D.E. Trentham et al., NEJM, 299, 327(1978); A.Tarkowski et al., Arthritis Rheumatism,32, 1087 (1989)Olson GB., Savage S, Olson J., “The effects ofcollagen hydrolysate on symptoms of chronicfibromyalgia and tempomandibular joint pain,Cranio, 18(2): 135-41, 2000Sprott H., Muller A., Heine H., “Collagen cross-linksin fibromyalgia syndrome”, Z. Rheumatol. 57 Suppl2: 52-5, 1998Gronemann ST., Ribel-Madsen S., Bartels EM.,Danneskiold-Samsoe B., Bliddal H., “Collagen andmuscle pathology in fibromyalgia patients”,Rheumatology. 43: 27-31, 2004

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