GBIME0088MR-Wound Closure Devices Market to 2019 Sample 1 ... · Source: GBI Research’s...

Wound Closure Devices Market to 2019 New Product Launches and Favorable Clinical Outcomes for Tissue Sealants and Hemostats Drive Physician Adoption

GBI Research Report Guidance

GBIME0088MR / Published JUL 2013

© GBI Research. This is a licensed product and is not to be photocopied

GBI Research Report Guidance

Chapter three provides an overview of the devices covered under wound closure.

Chapter four provides information on market size for the 2005–2012 historic period and the 2012–2019 forecast period, as well as trends, dynamics, drivers and restraints, and the competitive landscape.

Chapter five discusses hemostats, ligating clips, mechanical stapling devices, tissue sealants, and wound closure strips. It also gives information on the market size for the 2005–2012 historic period and the 2012–2019 forecast period for each category, as well as market dynamics and competition.

Chapter six gives information on the market size for the 2005–2012 historic period and the 2012–2019 forecast period for the US, Canada, the UK, France, Germany, Italy, Spain, Japan, China, India, Australia, and Brazil. A cross-country analysis of these countries is also discussed.

Chapter seven gives a brief overview of reimbursement for wound closure devices.

Chapter eight explains the distribution system for wound closure devices.

Chapter nine profiles leading wound closure device companies and covers products and SWOT analysis.

Chapter 10 focuses on pipeline products in various categories. Key products are listed and discussed in detail and product approval and expected launch dates are provided where available.

Chapter 11 discusses the consolidation landscape in the wound closure devices industry, looking at deals which took place between 2008 and 2012.


© GBI Research. This is a licensed product and is not to be photocopied

Executive Summary

Executive Summary

Wound Closure Devices Market is Forecast to Reach $XX Billion by 2019

Wound Closure Devices Market, Global, Revenue Forecast ($bn), 2012–2019

2012 2019

Rev

enue

($bn

)

CAGR (2012-2019): XX%

Source: GBI Research’s proprietary database [accessed March 5, 2013]; interviews with marketing managers and other industry experts

The global market for wound closure devices, which are used following injuries or surgical procedures, was valued at $XX billion in 2012 and is forecast to exceed $XX billion by 2019 at a Compound Annual Growth Rate (CAGR) of XX%. This growth will be driven by the increasing number of surgical procedures, which has led to high demand for efficient wound closure devices. The number of cosmetic, orthopedic, and cardiovascular procedures has increased over the past decade.

The US has the Largest Wound Closure Devices Market

The US had the largest market for wound closure devices in 2012, valued at $XX billion or XX% of the global market. It is forecast to reach $XX billion by 2019 at a CAGR of XX%, driven primarily by the rise in the number of aesthetic surgeries and subsequent demand for advanced wound closure devices that minimize the chance of scarring and post-surgical infection. The increasing number of procedures performed on the country’s aging population is also expected to increase demand. In 2009, almost XX million procedures were performed on the elderly population (people aged 65 years and over) in the US (CDC, 2009).

The global wound closure devices market was valued at $XX billion in 2012 and is forecast to exceed XX billion by 2019 at a Compound Annual Growth Rate (CAGR) of XX%


Page 7 © GBI Research. This is a licensed product and is not to be photocopied

Table of Contents

1 Table of Contents

1 Table of Contents................................................................................................................................. 7 1.1 List of Tables............................................................................................................................10 1.2 List of Figures...........................................................................................................................12

2 Introduction........................................................................................................................................13 3 Global Wound Closure Devices Market: Device Overview.....................................................................14

3.1 Mechanical Stapling Devices ....................................................................................................14 3.2 Hemostats ...............................................................................................................................15

3.2.1 Collagen based Hemostats ...............................................................................................15 3.2.2 Oxidized Regenerated Cellulose based Hemostats .............................................................15 3.2.3 Thrombin based Hemostats..............................................................................................15

3.3 Tissue Sealants ........................................................................................................................15 3.3.1 External Sealants .............................................................................................................15 3.3.2 Internal Sealants ..............................................................................................................15

3.4 Ligating Clips............................................................................................................................15 3.5 Wound Closure Strips...............................................................................................................15

4 Global Wound Closure Devices Market: Market Characterization.........................................................16 4.1 Global Wound Closure Devices Market, Revenue ($bn), 2005–2012..........................................16 4.2 Global Wound Closure Devices Market, Revenue ($bn), 2012–2019..........................................17 4.3 Global Wound Closure Devices Market, Key Company Shares (%), 2011 ....................................18 4.4 Global Wound Closure Devices Market: Key Trends ..................................................................19

4.4.1 Wound Closure Devices Market is Witnessing a Shift from Traditional to Advanced Wound Closure Devices ................................................................................................................19

4.4.2 Consolidation in the Wound Closure Devices Market through Strategic Acquisitions...........20 4.5 Global Wound Closure Devices: Market Dynamics ....................................................................20

4.5.1 Market Drivers.................................................................................................................20 4.5.2 Market Restraints ............................................................................................................29

5 Global Wound Closure Devices Market: Segment Analysis and Forecasts..............................................30 5.1 Mechanical Stapling Devices Market, Global, Revenue ($bn), 2005–2012..................................30 5.2 Mechanical Stapling Devices Market, Global, Revenue ($bn), 2012–2019..................................31 5.3 Hemostats Market, Global, Revenue ($m), 2005–2012..............................................................32 5.4 Hemostats Market, Global, Revenue ($m), 2012–2019..............................................................33 5.5 Tissue Sealants Market, Global, Revenue ($m), 2005–2012.......................................................34 5.6 Tissue Sealants Market, Global, Revenue ($m), 2012–2019.......................................................35 5.7 Ligating Clips Market, Global, Revenue ($m), 2005–2012..........................................................36 5.8 Ligating Clips Market, Global, Revenue ($m), 2012–2019..........................................................37 5.9 Wound Closure Strips Market, Global, Revenue ($m), 2005–2012.............................................38 5.10 Wound Closure Strips Market, Global, Revenue ($m), 2012–2019.............................................39

6 Global Wound Closure Devices Market: Country Analysis and Forecasts...............................................40 6.1 Wound Closure Devices Market: Cross-country Analysis ...........................................................40 6.2 Historic and Forecast Revenue, By Country...............................................................................41

6.2.1 Wound Closure Devices Market, US, Revenue ($m), 2005–2012.........................................41 6.2.2 Wound Closure Devices Market, US, Revenue ($m), 2012–2019.........................................43 6.2.3 Wound Closure Devices Market, Japan, Revenue ($m), 2005–2012....................................44 6.2.4 Wound Closure Devices Market, Japan, Revenue ($m), 2012–2019....................................45 6.2.5 Wound Closure Devices Market, Germany, Revenue ($m), 2005–2012...............................46 6.2.6 Wound Closure Devices Market, Germany, Revenue ($m), 2012–2019...............................47 6.2.7 Wound Closure Devices Market, France, Revenue ($m), 2005–2012...................................48 6.2.8 Wound Closure Devices Market, France, Revenue ($m), 2012–2019...................................49 6.2.9 Wound Closure Devices Market, Italy, Revenue ($m), 2005–2012 ......................................50 6.2.10 Wound Closure Devices Market, Italy, Revenue ($m), 2012–2019 ......................................51



Table of Contents

6.2.11 Wound Closure Devices Market, UK, Revenue ($m), 2005–2012.........................................52 6.2.12 Wound Closure Devices Market, UK, Revenue ($m), 2012–2019.........................................53 6.2.13 Wound Closure Devices Market, Australia, Revenue ($m), 2005–2012 ...............................54 6.2.14 Wound Closure Devices Market, Australia, Revenue ($m), 2012–2019 ...............................55 6.2.15 Wound Closure Devices Market, Spain, Revenue ($m), 2005–2012.....................................56 6.2.16 Wound Closure Devices Market, Spain, Revenue ($m), 2012–2019.....................................57 6.2.17 Wound Closure Devices Market, China, Revenue ($m), 2005–2012 ....................................58 6.2.18 Wound Closure Devices Market, China, Revenue ($m), 2012–2019 ....................................59 6.2.19 Wound Closure Devices Market, Canada, Revenue ($m), 2005–2012 .................................60 6.2.20 Wound Closure Devices Market, Canada, Revenue ($m), 2012–2019 .................................61 6.2.21 Wound Closure Devices Market, Brazil, Revenue ($m), 2005–2012 ....................................62 6.2.22 Wound Closure Devices Market, Brazil, Revenue ($m), 2012–2019 ....................................63 6.2.23 Wound Closure Devices Market, India, Revenue ($m), 2005–2012 .....................................64 6.2.24 Wound Closure Devices Market, India, Revenue ($m), 2012–2019 .....................................65

7 Global Wound Closure Devices Market: Reimbursement System..........................................................66 7.1 US ...........................................................................................................................................67 7.2 Japan.......................................................................................................................................68 7.3 Germany .................................................................................................................................68 7.4 France .....................................................................................................................................68 7.5 Italy.........................................................................................................................................69 7.6 UK ...........................................................................................................................................69 7.7 Spain .......................................................................................................................................69 7.8 Australia..................................................................................................................................70 7.9 China.......................................................................................................................................70 7.10 Canada ....................................................................................................................................70

8 Global Wound Closure Devices Market: Distribution System ................................................................71 9 Global Wound Closure Devices Market: Competitive Assessment.........................................................72

9.1 Covidien Plc. ............................................................................................................................73 9.1.1 Business Overview............................................................................................................73 9.1.2 Marketed Products...........................................................................................................73

9.2 Ethicon, Inc..............................................................................................................................74 9.2.1 Business Overview............................................................................................................74 9.2.2 Marketed Products...........................................................................................................74

9.3 Baxter International Inc............................................................................................................75 9.3.1 Business Overview............................................................................................................75 9.3.2 Marketed Products...........................................................................................................75

9.4 Takeda Pharmaceuticals International GmbH ...........................................................................76 9.4.1 Business Overview............................................................................................................76 9.4.2 Marketed Products...........................................................................................................76

9.5 3M Health Care Ltd. .................................................................................................................76 9.5.1 Business Overview............................................................................................................76 9.5.2 Marketed Products...........................................................................................................76

9.6 B. Braun Melsungen AG ...........................................................................................................77 9.6.1 Business Overview............................................................................................................77 9.6.2 Marketed Products...........................................................................................................77

9.7 Lohmann & Rauscher GmbH & Co. KG......................................................................................78 9.7.1 Business Overview............................................................................................................78 9.7.2 Marketed Products...........................................................................................................78

10 Global Wound Closure Devices Market: Product Pipeline Analysis........................................................79 10.1 Wound Closure Devices – Product Pipeline Summary................................................................79 10.2 Hemostats: Product Pipeline Analysis .......................................................................................79

10.2.1 Hemostats: List of Key Pipeline Products ...........................................................................79



Table of Contents

10.2.2 Hemostats: Profiles of Key Pipeline Products .....................................................................80 10.3 Tissue Sealants: Product Pipeline Analysis ................................................................................83

10.3.1 Tissue Sealants: List of Key Pipeline Products.....................................................................83 10.3.2 Tissue Sealants: Profiles of Key Pipeline Products ..............................................................84

11 Global Wound Closure Devices Market: Consolidation Landscape ........................................................91 11.1 Key Deals: 2008–2012..............................................................................................................93

11.1.1 Johnson & Johnson’s Acquisition of Omrix BioPharmaceuticals ..........................................93 11.1.2 Johnson & Johnson’s Acquisition of Quill Intellectual Property from Angiotech ...................94 11.1.3 Johnson & Johnson’s acquisition of Guangzhou Bioseal Biotech Co., Ltd. ............................94 11.1.4 Stryker’s Acquisition of Orthovita......................................................................................95 11.1.5 CryoLife Enters into an Agreement with Starch Medical.....................................................95 11.1.6 Asahi Kasei’s Acquisition of CryoSeal FS System from ThermoGenesis ................................96 11.1.7 Baxter International’s Acquisition of Synovis Life Technologies, Inc. ...................................97

12 Appendix ............................................................................................................................................98 12.1 Definitions...............................................................................................................................98

12.1.1 Mechanical Stapling Devices.............................................................................................98 12.1.2 Hemostats .......................................................................................................................98 12.1.3 Tissue Sealants.................................................................................................................98 12.1.4 Ligating Clips ...................................................................................................................98 12.1.5 Wound Closure Strips .......................................................................................................98

12.2 Acronyms ................................................................................................................................99 12.3 Sources....................................................................................................................................99 12.4 Research Methodology ..........................................................................................................101

12.4.1 Secondary Research .......................................................................................................101 12.4.2 Primary Research ...........................................................................................................101 12.4.3 Models ..........................................................................................................................102 12.4.4 Forecasts .......................................................................................................................102 12.4.5 Expert Panels .................................................................................................................102

12.5 Contact Us.............................................................................................................................103 12.6 Disclaimer..............................................................................................................................103



Table of Contents

1.1 List of Tables

Table 1: Wound Closure Devices Market, Global, Revenue ($bn), 2005–2012 ........................................16 Table 2: Wound Closure Devices Market, Global, Revenue Forecast ($bn), 2012–2019 ..........................17 Table 3: Wound Closure Devices Market, Global, Key Company Revenue ($m), 2011.............................18 Table 4: Wound Closure Devices Market, US, Top Surgical Cosmetic Procedures (‘000), 1997–2012.......21 Table 5: Wound Closure Devices Market, UK, Top Surgical Cosmetic Procedures, 2008–2012 ................22 Table 6: Wound Closure Devices Market, US, Orthopedic Procedures (‘000), 1997–2009.......................23 Table 7: Wound Closure Devices Market, US, Inpatient Cardiovascular Operations and Procedures

(million), 1997–2007...............................................................................................................24 Table 8: Wound Closure Devices Market, Key Product Launches, 2011-2013 .........................................25 Table 9: Wound Closure Devices Market, Global, Marketed Combination Hemostats ............................26 Table 10: Wound Closure Devices Market, Global, Studies of PRP in Sports-related Injuries, 2006–2011..27 Table 11: Wound Closure Devices Market, US, Procedures by Age (‘000), 2009 .......................................28 Table 12: Wound Closure Devices Market, US, Procedures in Population Aged 65 Years and Over (‘000),

2007–2009 .............................................................................................................................29 Table 13: Mechanical Stapling Devices Market, Global, Revenue ($bn), 2005–2012 .................................30 Table 14: Mechanical Stapling Devices Market, Global, Revenue Forecast ($bn), 2012–2019 ...................31 Table 15: Hemostats Market, Global, Revenue ($m), 2005–2012.............................................................32 Table 16: Hemostats Market, Global, Revenue Forecast ($m), 2012–2019...............................................33 Table 17: Tissue Sealants Implants Market, Global, Revenue ($m), 2005–2012........................................34 Table 18: Tissue Sealants Market, Global, Revenue Forecast ($m), 2012–2019 ........................................35 Table 19: Ligating Clips Market, Global, Revenue ($m), 2005–2012 .........................................................36 Table 20: Ligating Clips Market, Global, Revenue Forecast ($m), 2012–2019 ...........................................37 Table 21: Wound Closure Strips Market, Global, Revenue ($m), 2005–2012............................................38 Table 22: Wound Closure Strips Market, Global, Revenue Forecast ($m), 2012–2019 ..............................39 Table 23: Wound Closure Devices Market, Global, Cross-country Analysis, CAGR (%), 2005–2019............40 Table 24: Wound Closure Devices Market, US, Revenue ($m), 2005–2012...............................................42 Table 25: Wound Closure Devices Market, US, Revenue Forecast ($m), 2012–2019.................................43 Table 26: Wound Closure Devices Market, Japan, Revenue ($m), 2005–2012 ..........................................44 Table 27: Wound Closure Devices Market, Japan, Revenue Forecast ($m), 2012–2019 ............................45 Table 28: Wound Closure Devices Market, Germany, Revenue ($m), 2005–2012.....................................46 Table 29: Wound Closure Devices Market, Germany, Revenue Forecast ($m), 2012–2019.......................47 Table 30: Wound Closure Devices Market, France, Revenue ($m), 2005–2012.........................................48 Table 31: Wound Closure Devices Market, France, Revenue Forecast ($m), 2012–2019...........................49 Table 32: Wound Closure Devices Market, Italy, Revenue ($m), 2005–2012 ............................................50 Table 33: Wound Closure Devices Market, Italy, Revenue Forecast ($m), 2012–2019 ..............................51 Table 34: Wound Closure Devices Market, UK, Revenue ($m), 2005–2012...............................................52 Table 35: Wound Closure Devices Market, UK, Revenue Forecast ($m), 2012–2019.................................53 Table 36: Wound Closure Devices Market, Australia, Revenue ($m), 2005–2012 .....................................54 Table 37: Wound Closure Devices Market, Australia, Revenue Forecast ($m), 2012–2019........................55 Table 38: Wound Closure Devices Market, Spain, Revenue ($m), 2005–2012...........................................56 Table 39: Wound Closure Devices Market, Spain, Revenue Forecast ($m), 2012–2019.............................57 Table 40: Wound Closure Devices Market, China, Revenue ($m), 2005–2012 ..........................................58 Table 41: Wound Closure Devices Market, China, Revenue Forecast ($m), 2012–2019 ............................59 Table 42: Wound Closure Devices Market, Canada, Revenue ($m), 2005–2012........................................60 Table 43: Wound Closure Devices Market, Canada, Revenue Forecast ($m), 2012–2019..........................61 Table 44: Wound Closure Devices Market, Brazil, Revenue ($m), 2005–2012...........................................62 Table 45: Wound Closure Devices Market, Brazil, Revenue Forecast ($m), 2012–2019.............................63 Table 46: Wound Closure Devices Market, India, Revenue ($m), 2005–2012 ...........................................64 Table 47: Wound Closure Devices Market, India, Revenue Forecast ($m), 2012–2019 .............................65 Table 48: Wound Closure Devices Market, Inpatient ($) and Outpatient (%) Reimbursement for Most

Frequent DS Procedures, 2012 ................................................................................................66 Table 49: Wound Closure Devices Market, Inpatient ($) and Outpatient (%) Reimbursement for

Endoscopic Procedures, 2012..................................................................................................66 Table 50: Wound Closure Devices Market, Inpatient ($) and Outpatient (%) Reimbursement for Most

Frequent DS Complex Procedures, 2012 ..................................................................................67 Table 51: Covidien, Key Marketed Products, 2013...................................................................................73 Table 52: Ethicon, Key Marketed Products, 2013 ....................................................................................74



Table of Contents

Table 53: Baxter, Key Marketed Products, 2013......................................................................................75 Table 54: Takeda, Key Marketed Products, 2013.....................................................................................76 Table 55: 3M Health Care, Key Marketed Products, 2013........................................................................76 Table 56: B. Braun, Key Marketed Products, 2013...................................................................................77 Table 57: L&R, Key Marketed Products, 2013..........................................................................................78 Table 58: Wound Closure Devices Market, Global, Hemostats, Key Pipeline Products, 2013.....................79 Table 59: Next Generation Hemostasis Device, Product Status, 2013 ......................................................80 Table 60: Next Generation Hemostasis III, Product Status, 2013..............................................................81 Table 61: CovaStat BioActive Absorbable Hemostatic Sponge, Product Status, 2013................................81 Table 62: Tachosil Fibrin Patch – Neurology, Product Status, 2013 ..........................................................82 Table 63: Tachosil Fibrin Patch - Vascular, Product Status, 2013..............................................................82 Table 64: Wound Closure Devices Market, Global, Tissue Sealants, Key Pipeline Products, 2013 ..............83 Table 65: Adherus Dural Sealant, Product Status, 2013 ...........................................................................84 Table 66: Adherus Vascular Sealant, Product Status, 2013 ......................................................................85 Table 67: Advanced Tissue Sealant, Product Status, 2013........................................................................85 Table 68: GammaSeal, Product Status, 2013...........................................................................................85 Table 69: Interkor, Product Status, 2013.................................................................................................86 Table 70: Laser Tissue Welding Device, Product Status, 2013 ..................................................................86 Table 71: LifeSeal GI, Product Status, 2013 .............................................................................................86 Table 72: Prevent GI Sealant, Product Status, 2013.................................................................................87 Table 73: Vivostat Autologous Fibrin Sealant, Product Status, 2013.........................................................87 Table 74: Vivostat Platelet Rich Fibrin, Product Status, 2013 ...................................................................87 Table 75: Adherus Spinal Sealant, Product Status, 2013 ..........................................................................88 Table 76: Dural Membrane Sealant, Product Status, 2013.......................................................................88 Table 77: Progel Adhesion Barrier Sealant, Product Status, 2013.............................................................89 Table 78: Progel Dural Sealant, Product Status, 2013 ..............................................................................89 Table 79: Sylys Surgical Sealant, Product Status, 2013.............................................................................89 Table 80: Tissue Adhesive For Surgical Mesh - Gynecologic Procedures, Product Status, 2013..................90 Table 81: Wound Closure Devices Market, Global, Number of Deals and Deal Value ($m), 2008–2012.....91 Table 82: Wound Closure Devices Market, Global, Consolidation Landscape, 2008–2012 ........................92



Table of Contents

1.2 List of Figures

Figure 1: Wound Closure Devices Market, Global, Segmentation............................................................14 Figure 2: Wound Closure Devices Market, Global, Revenue ($bn), 2005–2012 ........................................16 Figure 3: Wound Closure Devices Market, Global, Revenue Forecast ($bn), 2012–2019 ..........................17 Figure 4: Wound Closure Devices Market, Global, Key Company Shares (%), 2011 ..................................18 Figure 5: Global Wound Closure Devices Market, Global, Opportunity and Risk Analysis, 2012–2019 ......19 Figure 6: Wound Closure Devices Market, US, Top Surgical Cosmetic Procedures (‘000), 1997–2012.......21 Figure 7: Wound Closure Devices Market, UK, Top Surgical Cosmetic Procedures, 2008–2012 ................22 Figure 8: Wound Closure Devices Market, US, Orthopedic Procedures (‘000), 1997–2009.......................23 Figure 9: Wound Closure Devices Market, US, Inpatient Cardiovascular Operations and Procedures

(million), 1997–2007...............................................................................................................24 Figure 10: Wound Closure Devices Market, US, Sports-related Injuries (million), 2008–2011.....................27 Figure 11: Wound Closure Devices Market, US, Procedures by Age (‘000), 2009 .......................................28 Figure 12: Mechanical Stapling Devices Market, Global, Revenue ($bn), 2005–2012 .................................30 Figure 13: Mechanical Stapling Devices Market, Global, Revenue Forecast ($bn), 2012–2019 ...................31 Figure 14: Hemostats Market, Global, Revenue ($m), 2005–2012.............................................................32 Figure 15: Hemostats Market, Global, Revenue Forecast ($m), 2012–2019...............................................33 Figure 16: Tissue Sealants Market, Global, Revenue ($m), 2005–2012......................................................34 Figure 17: Tissue Sealants Market, Global, Revenue Forecast ($m), 2012–2019 ........................................35 Figure 18: Ligating Clips Market, Global, Revenue ($m), 2005–2012 .........................................................36 Figure 19: Ligating Clips Market, Global, Revenue Forecast ($m), 2012–2019 ...........................................37 Figure 20: Wound Closure Strips Market, Global, Revenue ($m), 2005–2012............................................38 Figure 21: Wound Closure Strips Market, Global, Revenue Forecast ($m), 2012–2019 ..............................39 Figure 22: Wound Closure Devices Market, Global, Cross-country Analysis, CAGR (%), 2005–2019............40 Figure 23: Wound Closure Devices Market, US, Revenue ($m), 2005–2012...............................................41 Figure 24: Wound Closure Devices Market, US, Revenue Forecast ($m), 2012–2019.................................43 Figure 25: Wound Closure Devices Market, Japan, Revenue ($m), 2005–2012 ..........................................44 Figure 26: Wound Closure Devices Market, Japan, Revenue Forecast ($m), 2012–2019 ............................45 Figure 27: Wound Closure Devices Market, Germany, Revenue ($m), 2005–2012.....................................46 Figure 28: Wound Closure Devices Market, Germany, Revenue Forecast ($m), 2012–2019.......................47 Figure 29: Wound Closure Devices Market, France, Revenue ($m), 2005–2012.........................................48 Figure 30: Wound Closure Devices Market, France, Revenue Forecast ($m), 2012–2019...........................49 Figure 31: Wound Closure Devices Market, Italy, Revenue ($m), 2005–2012 ............................................50 Figure 32: Wound Closure Devices Market, Italy, Revenue Forecast ($m), 2012–2019 ..............................51 Figure 33: Wound Closure Devices Market, UK, Revenue ($m), 2005–2012...............................................52 Figure 34: Wound Closure Devices Market, UK, Revenue Forecast ($m), 2012–2019.................................53 Figure 35: Wound Closure Devices Market, Australia, Revenue ($m), 2005–2012 .....................................54 Figure 36: Wound Closure Devices Market, Australia, Revenue Forecast ($m), 2012–2019........................55 Figure 37: Wound Closure Devices Market, Spain, Revenue ($m), 2005–2012...........................................56 Figure 38: Wound Closure Devices Market, Spain, Revenue Forecast ($m), 2012–2019.............................57 Figure 39: Wound Closure Devices Market, China, Revenue ($m), 2005–2012 ..........................................58 Figure 40: Wound Closure Devices Market, China, Revenue Forecast ($m), 2012–2019 ............................59 Figure 41: Wound Closure Devices Market, Canada, Revenue ($m), 2005–2012........................................60 Figure 42: Wound Closure Devices Market, Canada, Revenue Forecast ($m), 2012–2019..........................61 Figure 43: Wound Closure Devices Market, Brazil, Revenue ($m), 2005–2012...........................................62 Figure 44: Wound Closure Devices Market, Brazil, Revenue Forecast ($m), 2012–2019.............................63 Figure 45: Wound Closure Devices Market, India, Revenue ($m), 2005–2012 ...........................................64 Figure 46: Wound Closure Devices Market, India, Revenue Forecast ($m), 2012–2019 .............................65 Figure 47: Wound Closure Devices Market, Global, Competitive Assessment, 2013 ..................................72 Figure 48: Wound Closure Devices Market, Global, Key Pipeline Products (%), 2013 .................................79 Figure 49: Wound Closure Devices Market, Global, Hemostats, Pipeline Products by Unmet Need, 2013 ..80 Figure 50: Wound Closure Devices Market, Global, Tissue Sealants, Pipeline Products by Unmet Need, 2013

...............................................................................................................................................84 Figure 51: Wound Closure Devices Market, Global, Number of Deals and Deal Value ($m), 2008–2012.....91



Introduction

2 Introduction

Traditional wound closure techniques involve the use of sutures, commonly known as stitches, while modern wound closure techniques comprise staples, adhesives, hemostats and sealants. Their primary function is to close a wound, both internally and externally, and stop bleeding through hemostasis. An important secondary function is avoiding or minimizing scarring, the importance of which depends on the location of the wound, but is particularly crucial for facial wounds and incisions.



Global Wound Closure Devices Market: Market Characterization

4.3 Global Wound Closure Devices Market, Key Company Shares (%), 2011

The figure below shows company shares for the global wound closure devices market in 2011.

Figure 4: Wound Closure Devices Market, Global, Key Company Shares (%), 2011

Covidien

Ethicon

Baxter International

Takeda Pharmaceuticals

International3M Health Care

B. Braun Melsungen

Lohmann & Rauscher

Others


The table below shows key company shares for the global wound closure devices market in 2011.

Table 3: Wound Closure Devices Market, Global, Key Company Revenue ($m), 2011

Company name Revenue ($m)

Covidien

Ethicon

Baxter International

Takeda Pharmaceuticals International

3M Health Care

B. Braun Melsungen

Lohmann & Rauscher

Others




Global Wound Closure Devices Market: Segment Analysis and Forecasts

5.3 Hemostats Market, Global, Revenue ($m), 2005–2012

The figure below shows the global revenue for the hemostats market segment from 2005 to 2012.

Figure 14: Hemostats Market, Global, Revenue ($m), 2005–2012

2005 2006 2007 2008 2009 2010 2011 2012

Rev

enue

($m

)

Thrombin based hemostats Oxidized regenerated cellulose based hemostats Collagen based hemostats


The table below shows the global revenue for the hemostats market from 2005 to 2012.

Table 15: Hemostats Market, Global, Revenue ($m), 2005–2012

2005 2006 2007 2008 2009 2010 2011 2012 CAGR

(%)

Thrombin based hemostats

Oxidized regenerated cellulose based hemostats

Collagen based hemostats

Total


The global hemostats market was valued at $XXm in 2005 and grew to $XXm in 2012 at a CAGR of XX%. Growing awareness of the clinical benefits associated with hemostats was the major driver of the hemostats market.



Appendix

12 Appendix

12.1 Definitions

12.1.1 Mechanical Stapling Devices

Mechanical stapling devices are hand-held wound closure devices used to fix staples after surgery, such as stapling equipment and staples. These devices can either be disposable or reusable. One unit refers to one stapling device.

12.1.2 Hemostats

Hemostats are used to improve hemostasis and promote wound healing after a surgical procedure. They contain fibrinogen, thrombin and other plasma proteins which help to promote clotting and the formation and cross-linking of fibrin. Only hemostats in the form of matrix and gauze are included. One unit refers to a pack of 10 hemostats.

12.1.2.1 Collagen Based Hemostats

Collagen based hemostats are composed of resorbable microfibrillar collagen. They attract platelets, thereby promoting the formation of a blood clot when they come into contact with blood. Only hemostats in the form of matrix and gauze are included. One unit refers to a pack of 10 collaged based hemostats.

12.1.2.2 Oxidized Regenerated Cellulose Based Hemostats

Oxidized regenerated cellulose based hemostats are polyanions with polyanhydroglucuronic acid as a functional unit, which helps platelets to initiate the adhesion and aggregation process, leading to coagulation. Only hemostats in the form of matrix and gauze are included. One unit refers to a pack of 10 oxidized regenerated cellulose based hemostats.

12.1.2.3 Thrombin Based Hemostats

Thrombin based hemostats transform fibrinogen into fibrin, activate factor XIII, and promote the stabilization of clots formed by fibrin and other proteins. Only hemostats in the form of matrix and gauze are included. One unit refers to a pack of 10 thrombin based hemostats.

12.1.3 Tissue Sealants

Tissue sealants are a type of surgical tissue adhesive that is used to control bleeding during surgery. This category includes internal sealants and external sealants.

12.1.3.1 External Sealants

External sealants are synthetic sealants which bind covalently to tissue surface proteins. External sealants consist of cyanoacrylate glue and polyethylene glycol hydrogels. One unit of external sealants refers to one 5ml vial.

12.1.3.2 Internal Sealants

Internal sealants are the tissue adhesives which assist in the process of coagulation by delivering fibrinogen to the affected area. Internal sealants consist of fibrin sealants and protein sealants. One unit of internal sealants refers to one 5ml vial.

12.1.4 Ligating Clips

Ligating clips are made of titanium and are conventionally used for clamping tissues as needed during various procedures. One unit refers to one cartridge containing six ligating clips.

12.1.5 Wound Closure Strips

Wound closure strips are adhesive strip-like bandages that help to seal skin wounds, thus eliminating the need for surface stitches or staples. One unit refers to a pack of 50 wound closure strips.



Appendix

12.2 Acronyms

bTcM: bovine Thrombin with collagen Matrix

CAGR: Compound Annual Growth Rate

CPT: Current Procedural Terminology

CSF: Cerebrospinal Fluid

DPC: Diagnosis Procedure Combination

DRG: Diagnosis-Related Group

DS: Day Surgery

GPO: Group Purchasing Organization

HCPCS: Healthcare Common Procedure Coding System

J&J: Johnson & Johnson

MAH: Marketing Authorization Holder

MPH: Microporous Polysaccharide Hemosphere

NHS: National Health Service

NHI: National Health Insurance

NPWT: Negative-Pressure Wound Therapy

PCT: Primary Care Trust

PRP: Platelet-Rich Plasma

12.3 Sources

3M Health Care (2013). Skin Closures. Available form: http://solutions.3m.com/wps/portal/3M/en_US/3MSWC/Skin-Wound-Care/ProductDirectory/. [Accessed March 14, 2013].

B. Braun (2013). Wound Closure. Available from: http://www.bbraun.com/cps/rde/xchg/bbraun-com/hs.xsl/products.html?id=00020742770000000420. [Accessed March 14, 2013].

BAAPS (2013), via The Guardian. “UK plastic surgery statistics 2012: brows up, breasts down”, The Guardian, January 28, 2013. The British Association of Aesthetic Plastic Surgeons. Available from: http://www.guardian.co.uk/news/datablog/2013/jan/28/uk-plastic-surgery-statistics-brow-lifts. [Accessed March 16, 2013].

Bajardi G, et al. (2009). Efficacy of TachoSil patches in controlling Dacron suture-hole bleeding after abdominal aortic aneurysm open repair. Journal of Cardiothoracic Surgery; 4(60). Available from: http://www.cardiothoracicsurgery.org/content/4/1/60.

Baxter (2007). TachoSil [Absorbable Fibrin Sealant Patch]. Available from: http://www.ecomm.baxter.com/ecatalog/browseCatalog.do?lid=10001&hid=10001&cid=10016&key=b2978a88d06e96f413a0a2e2bc3cf5&pid=592063. [Accessed March 14, 2013].

Baxter BioSurgery (2013). Hemostatic Agents. Available from: http://www.baxterbiosurgery.com/us/spaces/hemostasis.html. [Accessed March 14, 2013].

Baxter International Inc. (2012). 2012 Annual Report. Available from: http://www.baxter.com/downloads/investors/reports_and_financials/annual_report/2012/baxter_annual_report_2012.pdf.

Carson JS, et al. (2011). National trends in minimally invasive and open operative experience of graduating general surgery residents: implications for surgical skills curricula development? The American Journal of Surgery; 6(202): 720–726.



Appendix

CDC (2009). Number of all-listed procedures from discharges from short-stay hospitals by procedure category and age: United States, 2009. Centers for Disease Control and Prevention. Available from: http://www.cdc.gov/nchs/data/nhds/4procedures/2009pro4_numberprocedureage.pdf.

CDC (2012). National Health Statistics Report. Centers for Disease Control and Prevention. Available from: http://www.cdc.gov/nchs/data/nhsr/nhsr057.pdf.

Comadoll JL, et al. (2012). Comparison of Hemostatic Matrix and Standard Hemostasis in Patients Undergoing Primary TKA. Orthopedics; 35(6): 785–793.

ConvaTec (2011). ConvaTec 2011 ANNUAL REPORT. Available from: http://www.convatec.com/media/4234325/2011-annual-report.pdf.

Covidien (2012). Wound Closure Devices. Available from: http://www.syneture.com/syneture/pagebuilder.aspx?topicID=184139&breadcrumbs=0:66860. [Accessed March 14, 2013].

de Leon JM, et al. (2009). Cost-effectiveness of negative pressure wound therapy for postsurgical patients in long-term acute care. Advances in Skin & Wound Care; 22(3):122-7.

Ethicon (2013). Wound Closure Devices. Available from: http://www.ethicon.com/healthcare-professionals/products/wound-closure. [Accessed March 14, 2013].

Hansen E, et al. (2013). Negative Pressure Wound Therapy Is Associated With Resolution of Incisional Drainage in Most Wounds After Hip Arthroplasty. Clinical Orthopaedics and Related Research; March 2013.

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Appendix

Sánchez M, et al. (2006). Comparison of surgically repaired Achilles tendon tears using platelet-rich fibrin matrices. The American Journal of Sports Medicine; 35(2): 245–251.

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Woodworth BA, et al. (2009). A gelatin-thrombin matrix for hemostasis after endoscopic sinus surgery. American Journal of Otolaryngology; 30(1): 49–53.

12.4 Research Methodology

GBI Research’s dedicated research and analysis teams consist of experienced professionals in marketing and market research with consulting backgrounds in the medical devices industry and advanced statistical expertise.

GBI Research adheres to the codes of practice of the Market Research Society (www.mrs.org.uk) and the Strategic and Competitive Intelligence Professionals (www.scip.org).

All GBI Research databases are continuously updated and revised. The following research methodology is followed for all databases and reports.

12.4.1 Secondary Research

The research process begins with exhaustive secondary research on internal and external sources being carried out to source qualitative and quantitative information relating to each market.

The secondary research sources that are typically referred to include, but are not limited to:

Company websites, annual reports, financial reports, broker reports, investor presentations and SEC filings

Industry trade journals, scientific journals and other technical literature

Internal and external proprietary databases

Relevant patent and regulatory databases

National government documents, statistical databases and market reports

Procedure registries

News articles, press releases and web-casts specific to the companies operating in the market

12.4.2 Primary Research

GBI Research conducts hundreds of primary interviews a year with industry participants and commentators in order to validate its data and analysis. A typical research interview fulfills the following functions:

It provides first-hand information on the market size, market trends, growth trends, competitive landscape and future outlook.

It helps in validating and strengthening the secondary research findings.

It further develops the analysis team’s expertise and market understanding.



Appendix

Primary research involves email correspondence, telephone interviews and face-to-face interviews for each market, category, segment and sub-segment across geographies.

The participants who typically take part in such a process include, but are not limited to:

Industry participants: CEOs, VPs, marketing/product managers, market intelligence managers and national sales managers.

Hospital stores, laboratories, pharmacies, distributors and paramedics.

Outside experts: investment bankers, valuation experts, research analysts specializing in specific medical equipment markets.

Key opinion leaders: physicians and surgeons specializing in different therapeutic areas corresponding to different kinds of medical equipment.

12.4.3 Models

Where no hard data is available GBI Research uses modeling and estimates in order to produce comprehensive data sets. The following rigorous methodology is adopted:

Available hard data is cross referenced with the following data types to produce estimates:

Demographic data: population, split by segment

Macro-economic indicators: Gross Domestic Product, Inflation rate

Healthcare indicators: health expenditure, physician’s base, healthcare infrastructure and facilities

Selected epidemiological and procedure statistics

Data is then cross-checked by the expert panel.

All data and assumptions relating to modeling are stored and are available to clients on request.

12.4.4 Forecasts

GBI Research uses proprietary forecast models. The following four factors are utilized in the forecast models:

Historic growth rates

Macro indicators such as population trends and healthcare spending

Forecast epidemiological data

Qualitative trend information and assumptions

Data is then cross-checked by the expert panel.

12.4.5 Expert Panels

GBI Research uses a panel of experts to cross verify its databases and forecasts.

GBI Research’s expert panel comprises marketing managers, product specialists, international sales managers from medical device companies; academics from research universities, KOLs from hospitals, consultants from venture capital funds and distributors/suppliers of medical equipment and supplies.

Historic data and forecasts are relayed to GBI Research’s expert panel for feedback and adjusted in accordance with this feedback.



Appendix

12.6 Disclaimer

All Rights Reserved.

No part of this publication may be reproduced, stored in a retrieval system or transmitted in any form by any means, electronic, mechanical, photocopying, recording or otherwise, without the prior permission of the publisher, GBI Research.

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