GBililMdii German Biological Medicine€¦ · German Biological Medicine in the Treatment ofin the...

http://publichealth.msu.edu/pph/index.php/academic- http://www cmrf org/appeal/show/8http://publichealth.msu.edu/pph/index.php/academicprograms/graduate-certificate/chronic-disease

The Use ofG Bi l i l M di i

http://www.cmrf.org/appeal/show/8

German Biological Medicinein the Treatment ofin the Treatment of

Chronic Infectious DiseasesAnn F. Corson, MD

January 26, 2013

O’Conner et al., Emerging Infectious Determinants of Chronic DiseasesDeterminants of Chronic Diseases

Emerg Infect Dis 2006; 12(7): 1051-1057 “ i f ti i l t th fi t i t• “…infection may simply represent the first misstep along a continuum from health to long-term illness and disability.”

• “…infectious agents likely determine more cancers, immune-mediated syndromes, neurodevelopmental disorders, and other chronic conditions than currently yappreciated.”

• “If a mere 5% of chronic disease is attributable to infectious agents, in the US alone 4.5 million of theinfectious agents, in the US alone 4.5 million of the 90 million people living with chronic disease might benefit from strategies designed to prevent or appropriately treat selected infections.”

January 26, 2013 Ann F. Corson, MD 2

appropriately treat selected infections.

“Recent immunologic, epidemiologic, microbiologic and neuropsychiatricmicrobiologic and neuropsychiatric studies point to infectious etiologies of several important neuropsychiatric disorders…several infectious diseases including human influenza virus, HIV, syphilis and Lyme disease , , yp yare associated with neuropsychiatric symptoms following transmission of infectious agents to the centralinfectious agents to the central nervous system. …evidence also points to potential for peri-, pre-, and

l i f i fS. Hossein Fatemi, Ed.,Neuropsychiatric Disorders and InfectionTaylor and Francis, 2005

postnatal infections as causes for several neuro-developmental disorders.”

ISBN 1 84184 520 5


German Biological Medicineg• A unique field of medicine that integrates:

– modern western medical science– traditional European herbal medicine

l i l h th– classical homeopathy– pleomorphism

terrain based medicine– terrain based medicine– bio-energetic medicine

• Molded by the philosophies of the ancient• Molded by the philosophies of the ancient Chinese medical tradition Shang Han Lun


German Biological Medicineg• GBM appreciates biological diversity

– individual approach to each patient• GBM provides a framework for:

– removal of toxicities of all kinds from the body– clearing of immunological confusion– clearing of chronic infections/biofilms– repletion of nutritional deficiencies– restoration of neuro-immune and neuro-

endocrine balance and plasticity


German Biological Medicineg• Paracelsus – Swiss

h i i d l h i tphysician and alchemist1493-1541

f th f i d• father of spagyrism and toxicology• advocated use isopathics• advocated use isopathics

“Chemistry is not to make gold y gbut to make medicines”


German Biological Medicineg• Samuel Hahnemann, MD

1755 18431755-1843• founder of homeopathy

– Everyone is subject to a universal “vital energy”

hi h d t bwhich needs to be balanced to promote the body’s self-healing y gresponses. Imbalance or disruption of this energy creates disease.creates disease.

http://dranoop.com/


German Biological Medicineg• Günther Enderlein, PhD

1872 19681872-1968

• theory of Pleomorphism– founded Sanum, later

Sanum-Kehlbeck

– used fungal and bacterial products in isopathic homeopathicisopathic homeopathic remedies

http://dranoop.com

January 26, 2013

http://dranoop.com

Ann F. Corson, MD 8

German Biological Medicineg• Hans-Heinrich Reckeweg, MD

1905 19851905-1985

• theory of homotoxicologyy gy– model of body’s physiologic

response to toxins– utilized concepts from Shang p g

Han Lun• multiple homeopathic

remedies in one formularemedies in one formula• homochord

– multiple potencies of one remedy mixed together

www.homeoint.org/photo/r/reckeweghh.htmmixed together


German Biological Medicineg• Gary and Rain Klepper,

DC CTNDC, CTN“..unwind the log-jam of chronic

illness appropriately dealingillness, appropriately dealing with the web of

interconnected issues of deficiency, inflammation,

fatigue, toxicity, infection and devitalization ”devitalization.

“Integrated Case Manangement” BioResource Seminar May, 2008


Homotoxicology - Shang Han LunHomotoxicology Shang Han Lun

1 ExcretionTai Yang

2 InflammationYang Ming

3 DepositionShao Yangg g g g

BIOLOGICAL DIVIDE

4 ImpregnationT i Yi

5 DegenerationSh Yi

6 NeoplasmJ YiTai Yin Shao Yin Jeu Yin


Homotoxicology - Shang Han LunHomotoxicology Shang Han Lun1 Excretion 2 Inflammation 3 Deposition

Tai YangBody eliminates toxins via portals: skin, tears, mucous membranes

Yang Ming Shao Yang

mucous membranes, sputum, vomit, urine, bile, diarrhea, sweat Surface intact, normal immune response

BIOLOGICAL DIVIDE4 ImpregnationTai Yin

5 DegenerationShao Yin

6 NeoplasmJeu Yin




Yang MingBody reacts with inflammation to remove toxins: innate and cell

Shao Yang

mucous membranes, sputum, vomit, urine, bile, diarrhea, sweat Surface intact, normal

toxins: innate and cell mediated immunityCold toxins transform into dryness and heat

immune responsey



6 NeoplasmJeu Yin




Yang MingBody reacts with inflammation to remove toxins: innate and cell

Shao YangBody stores and deactivates toxins:ACVD sclerosismucous membranes,

sputum, vomit, urine, bile, diarrhea, sweatSurface intact, normal

toxins: innate and cell mediated immunityCold toxins transform into dryness and heat

ACVD, sclerosis, polyps, cystsCold transforms into heat as disease deepens, half excess

immune responsey deepens, half excess

and half deficiency



6 NeoplasmJeu Yin



1 Excretion 2 Inflammation 3 Deposition1 ExcretionTai Yang


3 DepositionShao Yang


Latent or active toxic foci


6 NeoplasmJeu Yin

develop in “locus minoris resistentiae”Depletion of vital heat with deepening coldwith deepening cold damage, warming needed









Destruction of intra-

6 NeoplasmJeu Yin

develop in “locus minoris resistentiae”Depletion of vital heat with deepening cold

Destruction of intracellular enzyme function and mitochondrial energy production

with deepening cold damage, warming needed

Deepening of cold damage, heart and kidney deficiency









Destruction of intra-

6 NeoplasmJeu Yin

Dysregulation of develop in “locus minoris resistentiae”Depletion of vital heat with deepening cold

Destruction of intracellular enzyme function and mitochondrial energy production

y ggenetic function: tumors and cancerWorsening of devitalization coldwith deepening cold

damage, warming needed

Deepening of cold damage, heart and kidney deficiency

devitalization, cold damage with trapped heat toxins


Extracellular matrix

j k d


jpkc.scu.edu.cn

Extracellular matrix

sciencedirect.com


sciencedirect.com

Primary respiratory mechanism

• Cranial Osteopathyi l dwww.cranialacademy.com

• William Sutherland, DOPMR which originates in the– PMR, which originates in the

floor of the fourth ventricle is thepulsatile driving force behind thepulsatile driving force behind thefluid wave that bathes the ECMand stimulates all cell bio-chemical respiration and meta-bolism


Primary respiratory mechanism

• Nelson, DO et al., Cranial rhythmic impulse related to the Traube Hering Mayer oscillation: comparingthe Traube-Hering-Mayer oscillation: comparing laser-Doppler flowmetry and palpation. Journal of the American Osteopathic Association vol.101:3, March 2001, p.163-172.

• Lee, DO., The primary respiratory mechanism beyond the craniospinal axis American Academy ofbeyond the craniospinal axis. American Academy of Osteopathy Journal Spring 2001, p. 24-34.

• Nelson, DO., The Primary Respiratory Mechanism. American Academy of Osteopathy Journal Winter 2002, p. 25-31.



Pischinger, The Extracellular Matrix and Ground Regulation North Atlantic Books, 2007, p. 9

Patient complexity• Polymicrobial infections – all classes organisms• Gut dysbiosis• Gut dysbiosis• Liver/gallbladder dysfunction• Hormonal and metabolic dysfunction• Hormonal and metabolic dysfunction• Systemic inflammation unregulated• Vasculitis and hypercoagulabilityVasculitis and hypercoagulability• Toxic encumbered extracellular matrix• Mitochondrial dysfunctionMitochondrial dysfunction• Immune system/bone marrow dysfunction• Central and peripheral nervous system damage


p p y g

Patient complexity• Polymicrobial infections – all classes organisms

vector borne ticks mosquitos lice fleas biting– vector borne – ticks, mosquitos, lice, fleas, biting flies

– food/soil borne – parasites, bacteria and virusesp– pets and livestock – cats, dogs, horses, rabbits,

goats, pigs, sheepbi it i b t i d it– ubiquitous, common viruses, bacteria, and parasites

that become chronic infections– dental infections – root canals, crowns, cavitationsdental infections root canals, crowns, cavitations– biofilm formation on mucosal surfaces from mouth to

anus, in tissue, on skin and free floating in blood


Borrelia biofilmsEisendle et al., Focus Floating Microscopy “Gold Standard” for Cutaneous Borreliosis? American Journal of Clinical Pathology 2007; 127(2): 213-222

Eisendle et al., Morphea, a manifestation of infection with B li i B iti h J l fBorrelia species. British Journal of Dermatology 2007; 157:1189-1198

Eisendle et al The expandingEisendle et al., The expanding spectrum of cutaneous Borreliosis. Giornale Italiano di Dermatologia e Venereologia 2009; 144:157 171Venereologia 2009; 144:157-171


Am J Clin Pathol 2007;127(2):213-222, 219

Borrelia biofilms“Our results also

demonstrated that Borreliademonstrated that Borrelia burgdorferi is capable of

developing aggregates on diff bi i d bi idifferent abiotic and biotic

substrates, and is also capable of forming floatingcapable of forming floating

aggregates.”

Sapi, MacDonald et al., Characterization of Biofilm Formation

by Borrelia burgdorferi in VitroPL S ONE 7(10) 48277


PLoS ONE 7(10): e48277.

Fry Labs biofilmsy


Protomyxzoa biofilms


Patient complexity• Gut dysbiosis

fungal dominance parasites pathogenic bacteria– fungal dominance, parasites, pathogenic bacteria– up-regulated TH-2 +/- TH-1 abnormalities

shifting food allergies– shifting food allergies– leaky gut with altered basement membrane

permeabilitypermeability– direct infection of any portion of bowel wall– vasculitis of gut blood supplyvasculitis of gut blood supply– infection of nervous tissue controlling gut function

from autonomic ganglia to brain altering motility


Patient complexity• Liver/gallbladder dysfunction

parenchymal liver infection autoimmunity– parenchymal liver infection, autoimmunity– genetic mutations or acquired abnormalities

causing complex imbalances in Phase I and II g pdetoxification pathways

– hormonal dysregulation and imbalancesdi d d li id t b li ith l t d– disordered lipid metabolism with elevated cholesterol and LDL

– biliary stasis, insufficient or infected bilebiliary stasis, insufficient or infected bile– atonic gallbladder– gallstone formation


Patient complexity• Hormonal and metabolic dysfunction

gut dysbiosis upsets hormone regulation by liver– gut dysbiosis upsets hormone regulation by liver– insulin and leptin resistance– lipid metabolism abnormalitieslipid metabolism abnormalities– HPA axis

• adrenal stress and exhaustion• thyroid insufficiency• sex hormone deficiencies• renin angiotensinin and ADH abnormalities• renin-angiotensinin and ADH abnormalities

– Kryptopyrroluria – genetic or acquired• supra-physiological loss of Zn, Mn, Mg, B6, others


p p y g , , g, ,

Patient complexity• Systemic inflammation unregulated

chronic activation of innate immune system– chronic activation of innate immune system inflammatory response

– cytokine imbalancey– oxidative stress

• Vasculitis– endothelial infection/toxin deposition– vessel proliferation– autoimmunity– autoimmunity

• Hypercoagulability– genetic or acquired from toxins/infections


Patient complexity• Toxic encumbered extracellular matrix

immune system debris such as ag:ab complexes– immune system debris such as ag:ab complexes– heavy metals– other pollutants - protean!other pollutants protean!– non-biological frequencies

• Mitochondrial dysfunctiony– infections– drugs– nutritionally induced


Patient complexity• Immune system dysfunction

anergy and confusion of GALT and MALT– anergy and confusion of GALT and MALT– allergic up-regulation

• food, environment (MCS), ( )– autoimmunity

• endothelium, thyroid, connective tissue, CNS• leaky gut

– IgG subclass deficiencies• Bone marrow dysfunction• Bone marrow dysfunction

– thrombocytopenia, general neutropenia or lymphopenia– anemia


anemia

Patient complexity• Peripheral nervous system

direct invasion by infectious agents– direct invasion by infectious agents– altered gut motility– vascular instabilityvascular instability

• POTS• Central nervous system

– parenchymal infection and tissue damage– oxidative stress increases inflammation

l d lf d i l l• elevated sulfate and ammonia levels– insulin and leptin resistance


Patient complexity• Heavy metal toxicity

ubiquitous– ubiquitous• Traumatic history

– physicalp y– psychological

• Diet, habits, substance abuse– nutritional deficiencies– GMO food, factory farmed meats, HFCS….

alcohol and tobacco– alcohol and tobacco– illicit drugs


Patient complexity• Structural – physical trauma

i l t th– cranial osteopathy• Electromagnetic frequencies

Wi Fi cell phones electronics are everywhere– Wi-Fi, cell phones, electronics are everywhere• Emotional trauma

can lock toxins up in the ECM– can lock toxins up in the ECM• Spiritual

ask about patients’ belief systems– ask about patients belief systems• Other

– forces external to patient


forces external to patient

Biotoxin illness• MOLD! MOLD! MOLD! is EVERYWHERE!

ask once twice three ten times– ask once, twice, three….ten times……..• water intrusion, leaky pipes, musty smells

– genetic predisposition in 25% populationg p p p p• chromosome 6 major histocompatibility complex• DRB1 – DQB1 – DRB3, DRB4 or DRB5

– faulty “hard drive” in innate immune system detection of certain biological toxins

i t i t d ’t “ t” th• innate immune system doesn’t “present” these biotoxins to the cellular immune system for antibody production and subsequent elimination


y

Biotoxin illness• Biotoxins are fat and water soluble inonophores

indoor toxic mold Lyme apicomplexa protozoans– indoor toxic mold, Lyme, apicomplexa protozoans, Pfiesteria sp., dinoflagellates, algae

– epigenetic modifiers that up-regulate expression ofepigenetic modifiers that up regulate expression of inflammatory cytokines (especially in fat cells)

• increase insulin and leptin resistance, increase bad lipids, alter levels of PAI-1, VEGF

– bind to and damage leptin receptors in hypothalamus leading to breakdown of pro opiomelanocortin systemleading to breakdown of pro-opiomelanocortin system

• deficiencies of MSH, VIP and often ADH• damages both anterior and posterior pituitary


damages both anterior and posterior pituitary

Biotoxin illness• Resources:

– Ritchie Shoemaker MD www survivingmold com– Ritchie Shoemaker MD www.survivingmold.com– Public Health Alert August 2011

http://www.publichealthalert.org/Articles/miscellaneous/Shoemaker-%20Mold.pdf

– Gordon Medical Assoc. DVD 10/22-23/2011 http://www aaimed com/resources and events htmlhttp://www.aaimed.com/resources_and_events.html#Anchor-Biotoxin

– useful information www.mold-control-on-a-budget.com

• Remediation – beware – retest!


Hypercoagulabilityyp g y

• Hypercoagulabilityyp g y– Genetic abnormality of clotting found in 1 out of 5

people that makes them more “sticky”– Incredibly common in patients with up-regulated

systemic inflammation, which worsens conditionR– Resources:

• David Berg’s lectures April 11th available on DVD from Researched Nutritionalsfrom Researched Nutritionals

• Gary Klepper’s lectures available on the teleclass section of www.bioresourceinc.com



• Hypercoagulability – Signs and Symptomsyp g y g y p– head and neck becomes ruddy when supine– feet may get deep purple with dependency– cold distal extremities with prolonged capillary refill,

mottled skin, painful numbness, “pins and needles”pale swollen tongue with scalloping edges and full– pale swollen tongue with scalloping edges and full sublingual veins

– limbs “fall asleep easily”p y– complain that feet/lower legs begin to hurt during

early afternoon and worsen till bedtime



• Hypercoagulability – Signs and Symptomsyp g y g y p– insomnia, with or without restless legs at night– doughy abdomen with peri-umbilical soreness– stiffness and pain in am upon awakening or after

prolonged immobilitynausea upon awakening with poor am appetite– nausea upon awakening with poor am appetite

– brain fog, irritability, anxiety/panic, labile affect – generalized pain, which can be debilitatinggeneralized pain, which can be debilitating– presence of metals/mold toxins worsen symptoms

exponentially


Protomyxzoa Biofilms


Protomyxzoa rheumatica• Novel pathogen

i l t– apicomplexa protozoan • unknown vectors – mosquitos in Arizona

prodigious biofilm former– prodigious biofilm former • incorporates coccobaccilli, fungi, ? metals

– serologies may show Babesia duncani antibodies– serologies may show Babesia duncani antibodies– when attacked causes serious Herxheimer reaction

• dramatic increase in inflammationdramatic increase in inflammation• dramatic increase in hypercoagulability

– found in cord blood three patients so far


p

Protomyxzoa rheumatica


GBM Treatment Principlesp

• Restore vitality throughoutRestore vitality throughout– rebuild vital energy and heat

• Restore health to the extracellular matrixRestore health to the extracellular matrix – clear biofilms, toxins, infections, tissue injury and

scars– restore communication throughout entire matrix

• Restore health to the endothelial system– clear hypercoagulability, biofilms, toxins, infection– heal endothelial lining



• Restore metabolic function ofRestore metabolic function of– gut associated lymphoid tissue (GALT)

• remove immune up-regulating antigensremove immune up regulating antigens• restore healthy mucosa, heal leaky gut• break up pathogenic biofilms, remove infectious and p p g ,

dysbiotic organisms• repopulate with healthy pre- and probiotics• restore digestive vitality, normalize fluid flows,

optimize absorption nutrients and peristaltic motility



• Restore metabolic function ofRestore metabolic function of– liver and gallbladder

• clear detoxification blockades (genetic and acquired)clear detoxification blockades (genetic and acquired)• balance phase I and II detoxification pathways• normalize hormone regulation and metabolism• normalize lipid metabolism• improve bile production, flow and gallbladder function• clear toxins and infections



• Restore metabolic function ofRestore metabolic function of– mucocutaneous associated lymph tissue (MALT)

• sinus biofilms, up-regulated response to inhaledsinus biofilms, up regulated response to inhaled allergens

• oro-pharyngeal and cervical lymphatics• respiratory airway reactivity

– genitourinary tract– bone marrow

• restore normal immune cell line production



• Restore metabolic function ofRestore metabolic function of– central nervous system

• lower oxidative stress• lower ammonia and sulfate levels• repair myelin sheaths and cell membranes

• Restore regulatory function to– neuro-immune, neuro-endocrine and neuro-

vascular systems

• Cycle: harmonize/resolve - release/provoke


GBM Treatment Tools• Homeopathic and herbal medicines

– drainage, regulation and provocative medicines• regulate organ function, restore regulatory set points

f t b li h l i t d t iof metabolism, hormonal, immune system and matrix • Immune-metabolic, immunobiologic medicines

d t i bi l d i d h thi– adaptogens - microbial derived homeopathics• immunologic and metabolic regulation

• Meridian and energy medicineMeridian and energy medicine– acupuncture, acupressure, electrodermal screening,

various biofeedback machines


GBM Treatment Tools• Nutritional repletion and optimization

– supplementation• Dietary modifications

– Paleolithic dietary principles• Lifestyle changes

– exercise– toxin and chemical elimination– EMF reduction and avoidance


PEKANASpagyric homeopathic medicines• Spagyrism is the art of capturing the entire• Spagyrism is the art of capturing the entire

energetic essence inherent in herb/herbal mixture– unite the fermented herbal tincture with the vital

minerals extracted through incineration and purification to create a medicinal tincture

PEKANA remedies• PEKANA remedies– restore the body’s intrinsic self healing ability– resolve acute illness more rapidly without sequelae– resolve acute illness more rapidly without sequelae– energize and rejuvenate the organs and tissues


Syntrion and SanPharma immunobiologic medicines

• Isopathic - homeopathic preparations ofIsopathic homeopathic preparations of metabolic products from common fungi and bacteria- microbes necessary for maturation and regulation of

our immune system- immune regulating and modulating effects in theimmune regulating and modulating effects in the

constantly shifting and adapting terrain- Syntrion cellular reprogramming medicines

- shift the microbiome using fungal/bacterial products- extensively studied at the Medical University of Vienna

by Dr. Christopher Gerner using proteomics


y p g p

Approach to chronic patient• Simultaneously and sequentially deal with:

toxins metal environmental biological– toxins – metal, environmental, biological– infections – multiple classes of organisms – allergies – food and/or environmentalallergies food and/or environmental– structural – post traumatic, occupational– endocrine – adrenal, thyroid, gonadal , y , g– metabolic – genetic and acquired faults– hematologic – hypercoagulability, Fe deficiency– nutritional – deficiencies, excesses– other – EMFs, emotions, spiritual, past life


Approach to chronic patient• Simultaneously and sequentially treat to

restore vitality– restore vitality– reduce systemic inflammation

remove toxins eliminate hypercoagulation– remove toxins, eliminate hypercoagulation– address dominant pathogens– buffer download/Herxheimer reactionsbuffer download/Herxheimer reactions

• drainage• enzymes• restorative fats• nutrients, especially trace minerals• often need to chelate bile for metals toxins


• often need to chelate bile for metals, toxins

Patient responsibilitiesPatient responsibilities

• Tick (all blood sucking insect) avoidanceTick (all blood sucking insect) avoidance• Toxin avoidance in home, work, school and

automobile– MOLD, MOLD, MOLD!!!– Chemicals are everywherey

• Household cleaners, personal care products of all kinds including toothpastes, soaps, shampoos, hair d il li h l ti ti i ttdyes, nail polish, lotions, cosmetics, cigarette smoking, alcohol, non organic and processed foods, water, air


Patient responsibilitiesPatient responsibilities• Clean air

– purifiers• Clean water

– water testing– proper pH – 8.0 bestp p p– drinking bottles – HDPE, stainless steel or glass

• NO single-use PET or polycarbonate bottles• Stop smoking, little to no alcohol



• Dietary compliance is of utmost importanceDietary compliance is of utmost importance – Paleolithic oligoantigenic principles– fully organicfully organic– grass fed meats, free range poultry, wild fish– no processed food, no GMO, no HFCSp , ,– limit sugar to fresh fruit, no dried fruit– limit grains of all kindsg– often need to avoid gluten, dairy– GAPS diet



• Amalgam removal by biological dentist –Amalgam removal by biological dentist www.iabdm.org



• Compliance with treatment protocols• Compliance with treatment protocols• Cranial-osteopathic care• AcupunctureAcupuncture • EMF reduction• Psychological counselingPsychological counseling


CaveatsCaveats

• When patients are not getting better check for• When patients are not getting better, check for– compliance with treatment plan– mold mold mold mold mold MOLDmold, mold, mold, mold, mold, MOLD……..– hypercoagulability– heavy metal toxicityy y– structural– unrecognized infections or toxins– emotional issues, intrinsic or extrinsic


CaveatsCaveats

• Biotoxin illness with deficiencies in major• Biotoxin illness with deficiencies in major central regulatory hormones that crash the entire neuroimmune and neuroendocrine system is the final common pathway that results from indoor toxic mold exposure and chronic infections, in our patients it is usually both plus moreour patients it is usually both, plus more….


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