Gastroenterohepatic Npa 070905
-
Upload
abdianto-ilman -
Category
Documents
-
view
219 -
download
0
Transcript of Gastroenterohepatic Npa 070905
-
7/24/2019 Gastroenterohepatic Npa 070905
1/56
Asuhan Nutrisipada Saluran Cerna dan Hati
Nurpudji A Taslim
Bagian Gizi
Fakultas Kedokteran Unhas
@!!"
-
7/24/2019 Gastroenterohepatic Npa 070905
2/56
Saluran Cerna dan Hati
#so$agus
%am&ungHati
#mpedu
'an(reas
Usus BesarUsus Ke(il
-
7/24/2019 Gastroenterohepatic Npa 070905
3/56
)ietar* Histor*+clues to GI disease
s*mptom 'ossi&le disorder ,ngestion o$ solid $ood (auses
distress &ut li-uid do not
)i$$i(ult* in s.allo.ing
#pigastri( pain .hen eating'ain +" hours a$ter eating/
relie0ed a$ter eating
A&dominal pain se0eral hours
a$ter a $att* meal
Cramps/ distention/ $latulan(e 12+
3 a$ter drinking milk
Heat&urn a$ter eating a large o$
$att* meal
#sophageal stri(ture or tumor
#sophageal spasm/ a(halasia
Gastri( ul(er)uodenal ul(er
'an(reati( or &iliar* tra(t disease
%a(tose intoleran(e pro&a&l*
o.ing to la(tase de$i(ien(*
Hiatal hernia/ a(halasia/
esophageal motilit* pro&lem
-
7/24/2019 Gastroenterohepatic Npa 070905
4/56
Nutritional care for Esophagitis
A0oid $ood 4 (aused o$ heart&urn#at small/ $re-uent meals to pre0ent stoma(h distentionand resultant gastri( a(id se(retion
A0oid high $at meals and de(rease $at in the diet
A0oid (ho(olate/ al(ohol and (a$$eine+(ontaining&e0erages 5(o$$ee/ tea and (ola drinks6
A0oid peppermint and spearmint oils
A0oid l*ing do.n/ &ending o0er/ or straining immediatel*a$ter eating
A0oid eating .ithin +7 hours o$ going to &ed
A0oid tight+$itting (lothing/ espe(iall* a$ter a meal
8edu(e .eight i$ o0er.eight
A0oid or -uit (igarette smoking
-
7/24/2019 Gastroenterohepatic Npa 070905
5/56
Gastritis
Common (ause o$ Gastritis
Heli(o&a(ter p*loriaspirin
Chili
Al(oholCigarettes
-
7/24/2019 Gastroenterohepatic Npa 070905
6/56
Nutritional care for GastritisHal yang perlu diperhatikan
19 Manajemen diet Keaktifan sekret lambung, usus kecil, pancreas, liver,dan empedu
Gerakan usus Bakteri flora usus rasa nyaman dan mudah dicerna
perbaikan dan maintenance mucosa usus! "engaruh makanan terhadap asam lambung
"rot # buffering efek $at % &H'# menurunkan pengosongan lambung E(tr daging, tannin )teh*, caffein )kopi* % alkohol
menyebabkan iritasi mucosa gaster
+! "engaruh makanan terhadap gerakan
lambung
! Efek makanan terhadap lesi
-! "engaruh makanan terhadap rasa tidak nyaman
-
7/24/2019 Gastroenterohepatic Npa 070905
7/56
'#NATA%AKSANAAN.ujuan:
makanan adekuat; tidak merangsang; menurunkan
produksi asam lam&ung; menetralisir kele&ihan
asam lam&ung9
/yarat:
mudah di(erna/ porsi ke(il/ $rekuensi tinggi; protein
(ukup untuk mengganti jaringan rusak; tidakmerangsang 5mekanis/ termis < kimia6; memenuhi
ke&utuhan gizi Normal
-
7/24/2019 Gastroenterohepatic Npa 070905
8/56
Faktor *ang =>eningkatkan? Asam
%am&ung dan 'roduksi #nz*m19 /timulasi kimia0i )E(trak 1aging,
"enyedap, Bumbu2bumbu, alkohol %
makanan kecut*!
! Makanan enak dan menarik selera
+! Keadaan bahagia! /uasana pada saat makan
-
7/24/2019 Gastroenterohepatic Npa 070905
9/56
>eningkatkan Tone dan Gerakan Usus =
19 Makanan hangat
! Makanan &air dan lunak
+! Makanan Berserat! .inggi &H' dan rendah $at
-! "enyedap dan makanan manis
3! .akut, marah, dan stres
-
7/24/2019 Gastroenterohepatic Npa 070905
10/56
Faktor =>enurunkan? Asam %am&ung dan
'roduksi #nz*m19 Makanan berlemak tinggi )gorengan,
kacang2kacangan*
! "orsi besar+! .idak dikunyah baik
! .idak menarik )bentuk dan
rasa*
-! .idak disukai
3! .akut, marah, dan sakit
-
7/24/2019 Gastroenterohepatic Npa 070905
11/56
=>enurunkan? tone dan Gerakan Usus
19 Makanan dingin
! "adat dan kering
+! 4endah serat
! .inggi $at-! 1efisiensi 5itamin B &omp!
)6tamanya B7*
3! 8elah
9! .akut, marah, dan sakit
:! /edentary habit
-
7/24/2019 Gastroenterohepatic Npa 070905
12/56
Fa(tors that a$$e(t to Gastri( A(idit*
#$$e(t o$ $ood in the stoma(h
)istension o$ the $undusparietal (ellsprodu(e a(id
,n(reased alkalinit* o$ antrumrelease gastrinstimulates
gastri( a(id se(retion )istention o$ antrumrelease o$ gastrin
Su&stan(es in $ood and digesti0e produ(tsin(reased
a(idit*; (o$$ee/ al(ohol/ pol*peptides and amino a(ids
'rotein 4 has an initial &u$$ering e$$e(t
Fat/ a(id/ and h*per osmolarit* in the small intestinestimulate release o$ one or more gastrointestinal hormones
that inhi&it gastri( a(id se(retion
-
7/24/2019 Gastroenterohepatic Npa 070905
13/56
'athogeneti( $a(tors in the de0elopment
o$ pepti( ul(er disease
Gasric ulcer 1uodenal ulcer
A&+N p*lori( $un(tion
Uodenopastri( re$lu
)e$e(ti0e gastri( mu(osal de$en(es)e(reased mu(osal prostaglandin
produ(tionde(reased mu(osal
&i(ar&onat produ(tion
)e(reased mu(ous gel la*er
Heli(o&a(ter p*lori in$e(tion
,n(reased a(id se(retor*
(apa(it*
,n(reased &asal a(idse(retion
,n(reased parietal (ell mass
and sensiti0it*
A&+N gastri( empt*ng
A&+n duodenal mu(osalde$en(es
)e(reased &i(ar&onate
se(retion
-
7/24/2019 Gastroenterohepatic Npa 070905
14/56
'rin(iples o$ nutritional (are
$or 'epti( Ul(er )isease
#at three regular meals dail*
#at small meals to a0oid stoma(h distention
A0oid drinking (o$$ee and al(ohol
Cut do.n or -uit smoking (igarettesA0oid using large amounts o$ aspirin/ other NSA,) or
other drugs kno.n to damage the stoma(h lining
A0oid $oods or drinks that (aused dis(om$ort
#at meals in as relaed an atmosphere as possi&leTake anta(ids 1+7 hours a$ter meals and &e$ore
&edtime
-
7/24/2019 Gastroenterohepatic Npa 070905
15/56
)umping s*ndrom
,s a (omple ph*siologi( response to presen(e o$undigested $ood in the jejunum
Follo.ing gastri( surger*4 7 o$ the stoma(hremo0ed
S*mptom; a&dominal $ullness/ nausea (ramp*a&dominal pain/ $ollo.ing &* diarrhea/ 1" minutesa$ter ingestion9
%*ing do.n immediatel* a$ter eating redu(es theses*mptoms &e(ause $ood remains longer in the
stoma(h pou(hAlimentar* h*pogl*(emiao((urs 1+ hours a$tereating+(aused &* the rapid digestion and a&sorptiono$ $ood espe(iall* o$ sugar
-
7/24/2019 Gastroenterohepatic Npa 070905
16/56
Nutritional (are in intestinal disease
A&sorption+++ jejunum
Terminal ileum4 $ats/ &ile salts/ 0itaminB1
%arge intestine or (olon4 purpose
a&sor&ing .ater and e(reting the $e(almass
-
7/24/2019 Gastroenterohepatic Npa 070905
17/56
Constipation
/ystemic /E of medication
Metabolic and endocrine ab2n)hypothyroidism,
uremia and hyperglycemia*
8ack of e(ercise
;gnoring the urge to defacate
5ascular disease of the large bo0el
/ystemic neuromuscular disease "oor diet lo0 in fiber
pregnancy
-
7/24/2019 Gastroenterohepatic Npa 070905
18/56
Continues++
Gastrointestinal)iseases o$ upper G,T
Sprue/ duodenal ul(er/ gastri( ul(er/ C*sti( $i&rosis
)iseases o$ the large &o.el that result inFailure o$ propulsion along the (olon/ $ailure o$
passage through anore(tal stru(tures
,nitial &o.el s*ndrom
Anal $issures or hemorhoids
%aati0e a&use
-
7/24/2019 Gastroenterohepatic Npa 070905
19/56
,NF%A>>AT8D BE#% ),S#AS#
C8HNS ),S#AS#
U%C#8AT,# C%,T,S
-
7/24/2019 Gastroenterohepatic Npa 070905
20/56
C8HNS ),S#AS# U%C#8AT,# ),S#AS#
S*mptomati(all* similar
Gradual insidious de0t o$ episodediarrhea/ a&dominal pain/ .eight loss/&lood/ pus or mu(ous in the stool
Fo(al/ o$ten granulomatousin$lammation in mu(osal and su&+mu(osal la*ers in an* area o$
digesti0e tra(tGenerall* a$$e(ts the terminal ileum
and right (olon/ sometimes the entire&o.el/ rarel* the entire digesti0e tra(t
)iarrhea is less (ommon
Segmental in0ol0ement is (ommon
Stri(ture $ormationpalpa&le massin the lo.er right -uadrant
'atients tent to &e nonsmoker
S*mptomati(all* similar
Gradual insidious de0elopment o$episode diarrhea/ a&dominal pain/ .eightloss/ &lood/ pus or mu(ous in the stool
Al.a*s a$$e(ts the re(tum/ o$ten thesigmoid and des(ending (olon in(ontinuit* and sometimes entire (olon
)iarrhea is (ommon
Segmental in0ol0ement is rare
'atients tent to &e nonsmoker
-
7/24/2019 Gastroenterohepatic Npa 070905
21/56
CIRROHIS HEPATIS
Final stage of liver injury & degeneration
& occurs 15% of heavy drinkers
Normal liver tissue destroyed replaced by
inactive fibrous connective tissue (scar
tissue)
-
7/24/2019 Gastroenterohepatic Npa 070905
22/56
HEPATIC FAILURE
Menurunkan liver function +>> )phenylalanine tyrosine % free
tryptophan*Menurunkan B&>> )8ececene, valine, isoleucine*
menyebabkan false neurotransmitters sehingga
terjadi HE
Meningkatkan aminobatyric acid inhibitoryneurotransmitter HE
N B&>> # >>> + # 7
-
7/24/2019 Gastroenterohepatic Npa 070905
23/56
>mino acids of importance in 8iver 1isease
Aromati( AA 5 AAA6 T*rosine/ phen*l alanine/ $ree tr*pthopan
Bran(hed (hain amino a(ids 5BCAA6 aline/ leu(ine/ isoleu(ine
Ammoniogeni( amino a(ids Glutamin/ histidine/ l*sine/ asparagine/ l*(ine/ serine/
threonin/
indispensable AA
-
7/24/2019 Gastroenterohepatic Npa 070905
24/56
=itamin>ineral )e$i(its in
Hepati( Failure?itamin !"#N
A
D
E
K
BG
B12
Niacin
Folate
B1
Zn
Mg
Fe
Deratiti!" nig#t $lin%ne!!
O!teoalacia
E%ea" Perieral ne'ro&at#(
Blee%ing
M'co'! e$r le!ion!" %eratiti!
Megalo$la!tic an" glo!!iti!" CNS %(!)'nction
Megalo$la!tic an" glo!!iti!" irrita$ilit(
Deratiti!" %eentia" %iarr#ea
Ne'ro&at#(" a!cite!" e%ea" CNS %(!)'nction
I'no%e)" i&aire% ta!te" *o'n% #ealing" &rot !(nt#e!a
Ne(ron(!c'lar irrita$ilit(" #(&o+aleia" #(&ocalcei
Stoatiti!" icroc(tic aneia" alai!e
-
7/24/2019 Gastroenterohepatic Npa 070905
25/56
Tujuan )iet 'en*akit Hati
&ukup makan mempercepat perbaikan hati/yarat#
7! .inggi Energi, &H' meningkat, $at sedang, "rotberangsur
! &ukup mineral dan vitamin
+! 4endah Na&l! Mudah dicerna, tidak merangsang
-! Hindari makan yang mengandung gas tinggi!
Bahan makanan tidak boleh diberikan #
a! Makanan mengandung fat tinggi )babi, dagingkambing*
b! Makanan mengandung gas )ubi, kacang merah,kol, sa0i, lobak, ketimun, durian, nangka*
-
7/24/2019 Gastroenterohepatic Npa 070905
26/56
NUT8,T,N CA8# %,#8 ),SS
$ep%&errh &oma rep
Rationale
Kcal
CHO
Prot
Fat
,it-in
Fl'i%
. re&air li/er !el. !&are &rot
. $alance e%ea 0 a!ater
3 4 -%
.4 g-%l 5678
1.2 g-+gBB
li$er-'!e MCT ril
B co&9
Fat !ol'lle /it
,it C 0 Zn
Re!tract i: e%ea - recite!;
-
7/24/2019 Gastroenterohepatic Npa 070905
27/56
GA%% B%A))#8 ),SS
Fs : men*impan empedu meta& < degest $at
#nz : (hole(*stkinine
Ienis 'en*:7! Biliary dyskinesia )spasme sp! 'ddi*
! &holelithiasis )batu empedu*
+! &holecystitis )imflamasi GB*
! &holedocholithiasis )batu pada sp! 'ddi*-! cholecystectomi!
-
7/24/2019 Gastroenterohepatic Npa 070905
28/56
Nutrition (are in Gall&ladder disease
.ujuan# Memberi istirahat kantung empedu, mengurangi rasa sakit
$ood ade?uate
/yarat#
.inggi fat )mudah dicerna* mengurangi kontraksi
E, prot, &H' cukup
.inggi )larut lemak*
.inggi cairan
.idak merangsang dalam porsi kecil
-
7/24/2019 Gastroenterohepatic Npa 070905
29/56
>cute @ related to obstruction#makanan per oral sementara dihentikan
hindari makanan *ang mengandung lemak
diet rendah lemak
!+7!J dari kalori 5$at tidal le&ih dari "! gd6
&hronic22cholecystiasis8endah lemak 5"J dari total kalori6
Turunkan BB &ila o0er.eight
'rotein sesuai dengan ke&utuhsn
CH disesuaikan dgn ke&utuhsn utkmempertahankan BB normal
Batasi makanan *ang mengandung gas
Supl9 itamin *ang larut dalam $at5A)#K6
-
7/24/2019 Gastroenterohepatic Npa 070905
30/56
'an(reatitis
,n$lammation (hara(terized &*;
edema/(ellular eudate/and $at ne(rosis
,t (an &e mild and sel$ limiting or se0ere .ith
ne(rosis o$ pan(raeti( tissue
Can &e a(ute or (hroni(+++pan(reati(
destru(tion4de(reased endo(rine and
eo(rine pan(reati( $un(tion/ steatorrhea ordia&etes results
-
7/24/2019 Gastroenterohepatic Npa 070905
31/56
Nutrition (are in 'an(reatitis disease
A(ute and se0ere atta(ks4 oral $eeding is .ithheld
and h*dration is maintained intra0enous
A$ter 3+32 hours 4 (lear li-uid diet as toleran(e
Formula diet (onsisting o$ amino a(id/ glu(ose/ and
small amount o$ $at .ill not stimulate pan(reati(
se(retions9
'rolonged se0ere pan(reatitisT'N
Fat emulsion (an &e used as long as 4a(ute
pan(reatittis is not the &asis $or h*pertrigl*(eridemia
-
7/24/2019 Gastroenterohepatic Npa 070905
32/56
The Role of Probiotic In
Immunity System
-
7/24/2019 Gastroenterohepatic Npa 070905
33/56
God Bless us with Lactobacillus
and Bedobacteria. They benetmankind in many ways, thouh
medical science knows !ery littleabout these bacteria.
Professor "itsuokaBadobacteria # $ealth
"orinaa %o.
-
7/24/2019 Gastroenterohepatic Npa 070905
34/56
&'(I)ITI*)
Probiotics are food that contain li!ebacteria which are benet to health
Prebiotics are substances such aslactulose, lactitol, +ylitol, inulin, andcertain nondiestible oliosaccharidesthat selecti!ely stimulate the rowth of
bidobacteria in the colon.Symbiotic is a combination of -robioticsand -rebiotic.
-
7/24/2019 Gastroenterohepatic Npa 070905
35/56
-
7/24/2019 Gastroenterohepatic Npa 070905
36/56
-
7/24/2019 Gastroenterohepatic Npa 070905
37/56
INFLUENCES OF THE HUMAN INTESTINALMICROBIOTA ON THE HOST
Benefcial eects Harmul eects
Ini!iti"n " #at"$ens C"nsti#ati"n
Stimulati"n i immune s%stem &iarr"ea
S%ntesis " 'itamins Inecti"n
Ai( in (i$esti"n Li'er (ama$e
Pr"(uce meta!"lic uel "r
enter"c%tes
Cancer
Maintain sta!ilit% " ec"s%stem Flatulence
Meta!"lise (ru$s
Patricia L. Conway, Selection Criteria for probiotic microorganisms,
Asia Pacic J Clin Nutr (1!" #$ 1#%1
-
7/24/2019 Gastroenterohepatic Npa 070905
38/56
-
7/24/2019 Gastroenterohepatic Npa 070905
39/56
-
7/24/2019 Gastroenterohepatic Npa 070905
40/56
-
7/24/2019 Gastroenterohepatic Npa 070905
41/56
MECHANISMS OF PROBIOTICFUNCTIONALIT) AN& ITS BENEFICIAL
EFFECTS
Mecanisms "Functi"nalit%
Benefcial Eects
Antimicr"!ial acti'it%
C"ntr"l " r"ta'irus an(cl"stri(ium (i*cile
C"ntr"l " ulcer relate( t"H+#
Anti!i"tic tera#%
Treatment " (iarr"eaass"ciate(
,it tra'el
C"l"ni-ati"n resistance Balancin$ " c"l"nicmicr"!i"ta
&. 'ubillaga et al., Nutrition esearc) *1 (*++1" #!%#
-
7/24/2019 Gastroenterohepatic Npa 070905
42/56
MECHANISMS OF PROBIOTICFUNCTIONALIT) AN& ITS BENEFICIAL
EFFECTS
Mecanisms "Functi"nalit%
Benefcial Eects
Immune eects
A(.u'ant eect
C%t"/ine e0#ressi"nStimulati"n "#a$"c%t"sis !% #eri#eral!l""( leuc"c%tes
Secret"r% I$A
1accine a(.u'ant eect
Enance immune res#"nse
Enance immune res#"nse
In2uence "n en-%me acti'it% Re(ucti"n " ecal en-%mesim#licate( in cancerinitiati"n
En-%me (eli'er% Re(ucti"n " serumc"lester"l
Ameli"rati"n " lact"se mala!s"r!ti"n s%m#t"ms
&. 'ubillaga et al., Nutrition esearc) *1 (*++1" #!%#
-
7/24/2019 Gastroenterohepatic Npa 070905
43/56
PUTATI1E MECHANISMS OF THE ACTIONOF FUNCTIONAL FOO&S
Functi"nal""(s 3e$+Pr"!i"tic4
Increase tee0#ressi"n
Su#er"0i(e(ismutase56lutati"nPer"0i(ase an(Catalase
Pr"(ucti"n "7uencers
6lutati"nre(uctase5 1it+ A5E5 C5 etc
Ca#tati"n " Ir"nan( Lact"errine
In2uence "n cell si$nali-ati"n
Free ra(icals5 nitric "0i(e5 /inases5 an( c%clic nucle"ti(s
E0#ressi"n " transcri#ti"nal act"rsNeut"#il Fact"r 8/9B5 Anti #r"tease5 etc
In2uence "n $enic trans(ucti"n
3C%t"/ines5 En-%mes5 Cellular mar/ers4
Pase I
Pase III
Pase II
Pase I1
&. 'ubillaga et al. - Nutrition esearc) *1 (*++1" #!%#
-
7/24/2019 Gastroenterohepatic Npa 070905
44/56
PRO&UCTION OF ANTI9MICROBIALSUBSTANCES B) PROBIOTIC
BACTERIOCIN PRO&UCEROR6ANISM
PROPERTIES
)isin Lactococcus latis
Subs-. Lactis T%%//010
Lantibiotic, broads-ectrum,
chromosome2-lasmidmediated, bactericidal,-roduced late in therowth cycle
Pediocin Pediococcus
Pentosaceus
(BB3/ and L4567
Broad s-ectrum,-lasmid mediated
Pediocin c$ Pediococcus
Acidilactici $
Broad s-ectrum,-lasmid mediated
Table Properties of some well characterized bacteriocins
C. &is)ra an J. Lambert, Asia Pacic J Clin Nutr (1!" #$*+%*/
-
7/24/2019 Gastroenterohepatic Npa 070905
45/56
PRO&UCTION OF ANTI9MICROBIALSUBSTANCES B) PROBIOTIC
BACTERIOCIN PRO&UCEROR6ANISM
PROPERTIES
Leucocin Leuconostoc
Gelidum 8L /94
Broad s-ectrum,
-lasmid mediated,bacteriostatic,-roduced early in therowth cycle
$el!eticin : Lb. helveticus 09/ )arrow s-ectrum,chromosomally
mediated, bacteridal
%ernobacteriocin Carnobacterium
Pisciola L ;/4
)arrow s-ectrum,chromosomallymediated, bacteridal
C. &is)ra an J. Lambert, Asia Pacic J Clin Nutr (1!" #$*+%*/
Table Properties of some well characterized bacteriocins
-
7/24/2019 Gastroenterohepatic Npa 070905
46/56
I""8)' S
-
7/24/2019 Gastroenterohepatic Npa 070905
47/56
I""8)' S
-
7/24/2019 Gastroenterohepatic Npa 070905
48/56
T$' '(('%T *( PR*BI*TI%S *)
$eliobacter -ylori
T" a'e a stimulat"r% eect "n te m"t"ran( em#t%in$ uncti"n " te $astric
stum# ,ereas mil/ an( mil/ ,e%5c"tta$e5 ceese5 an( !utter ,as s",n t"a'e ini!it"r% eects
Te (iatetic mana$ement " te #atientsun(er$"in$ $astric "#erati"ns "r ,it H+#%l"ri c"l"ni-ati"n s"ul( !e carrie( "ut"n a strictl% in(i'i(uali-e( !asis
-
7/24/2019 Gastroenterohepatic Npa 070905
49/56
SHORT9CHAIN FATT) ACI&S PRO&UCE& B)INTESTINAL BACTERIA
SCFA SPECIFIC EFFECT BENEFIT
T"tal L",erin$ " #H &iminise( !i"a'aila!ilit%
" al/aline c%t"t"0ic
c"m#"un(s
Ini!iti"n " 6r",t "
#H sensiti'e "r$anism
Acetate P"ssi!le increase in Ca
an( M$ a!s"r#ti"n
Rela0ati"n "resistance
'essels
&iminise( aecal l"ss "
Ca an( M$
6reater c"l"nic an(
e#atic #"rtal 'en"us
!l""( 2",
Pr"#i"nate Enance c"l"ricmuscular
c"ntracti"n
Rela0ati"n "resistance
'essels
Easier la0ati"n5 relie "
c"nsti#ati"n
6reater c"l"ric an(e#atic
#"rtal 'en"us !l""( 2",
6a7i L. 8opping Asia Pacic J Clin Nutr (1!" #$ 1#%1
Table General and Specic health benets of SCFA in the colon
-
7/24/2019 Gastroenterohepatic Npa 070905
50/56
SHORT9CHAIN FATT) ACI&S PRO&UCE& B)INTESTINAL BACTERIA
6a7i L. 8opping Asia Pacic J Clin Nutr (1!" #$ 1#%1
SCFA SPECIFIC EFFECT BENEFIT
Pr"#i"nate Stimulati"n " c"l"nic
muscular c"ntracti"n
C"l"nic e#itlial
#r"lierati"n
6reater i"n an( 2ui(
a!s"r#ti"n5 #re'enti"n "
(iarr"ea
P"ssi!le $reater
a!s"r#ti'e ca#acit%But%rate Rela0ati"n "
resistance
'essels
Meta!"lism n%
c"l"n"c%tes
6reater c"l"nic an(
e#atic 'en"us !l""( 2",
Maintenance " muc"sal
inte$rit%5 re#air "
(i'ersi"n an( ulcerati'e
c"litis5 c"l"n"c%te
#r"lierati"n
Maintenance " n"rmal
c"l"n"c%te #en"t%#e
Stiulati"n " c"l"nic
electr"l%te trans#"rt
&iminise( ris/ "mali$nanc%
6reater i"n an( 2ui(
a!s"r#ti"n5 #re'enti"n "
(iarr"ea
-
7/24/2019 Gastroenterohepatic Npa 070905
51/56
HABITUAL INTA8E OF LACTIC ACI&BACTERIA AN& RIS8 RE&UCTION OF
BLA&&ER CANCER
T" assess te #re'enti'e eect " te inta/e" L+ casei5 ,i(el% ta/en as ermente( mil/#r"(ucts in :a#an5 a$ainst !la((er cancer5c"n(ucte( a case c"ntr"l stu(%
Te O((s rati"n " sm"/in$ ,as ;5?c"nf(ence inter'al@ ;+;9+
-
7/24/2019 Gastroenterohepatic Npa 070905
52/56
SAFET) OF PROBIOTIC BACTERIA
Pr"!i"ticstrain
Re#"rte( eects
Saet% stu(ies
In 'itr" Animalstu(ies
Humanstu(ies
Lactobacilus
aciop)ilus
NCFB ;DG
Treatment "c"nsti#ati"n5 alle'iati"n" ra(i"tera#% relate((iarr"ea5 l",erin$ "aecal en-%mes
Lactobacilus
Casei sir"ta
Balancin$ intestinal
micr"2"ra5 #re'enti"n" intestinal(istur!ances treatment" su#erfcial !la((ercancer
6ono)ue 6C an S. Salminen, Asia Pacic J. Clin Nutr (1!" #$ *#%*