Gastric polypoid lesions - mucosalimmunology.ch · • Response to a chronic inflammatory...
Transcript of Gastric polypoid lesions - mucosalimmunology.ch · • Response to a chronic inflammatory...
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Gastric Polyps
Bible class 29.08.2018
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Bible Class 29.08.18/ I.Linas 2
Universitätsklinik für Viszerale Chirurgie und Medizin
“Starting my training in gastroenterology, some decades ago, my first chief always told me that colonoscopy may seem technically more challenging but gastroscopy has findings definitely harder to
interpret.”
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Bible Class 29.08.18/ I.Linas 3
Universitätsklinik für Viszerale Chirurgie und Medizin
Case 1
• 42 yo male with heartburn and regurgitation since early 2018
• Personal and family history unremarkable
• GP - > trial of ranitidine > incomplete response > gastroscopy
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Bible Class 29.08.18/ I.Linas 4
Universitätsklinik für Viszerale Chirurgie und Medizin
Case 1
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Bible Class 29.08.18/ I.Linas 5
Universitätsklinik für Viszerale Chirurgie und Medizin
Case 1
What is it? What to do?
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Bible Class 29.08.18/ I.Linas 6
Universitätsklinik für Viszerale Chirurgie und Medizin
Fundic Gland Polyps
Characteristics
• usually multiple transparent sessile
polyps
• 1-5 mm in diameter
• located in the body and fundus
• more frequent in women than in men
Endoscopic management:
• >10 mm in size should be removed*
• Consider sampling healthy mucosa*
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Bible Class 29.08.18/ I.Linas 7
Universitätsklinik für Viszerale Chirurgie und Medizin
Case 1• You decide to resect it and start PPI for esophagitis
• Forget to attach report, confusion in pathology
• Which one is our polyp?
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Bible Class 29.08.18/ I.Linas 8
Universitätsklinik für Viszerale Chirurgie und Medizin
Fundic Gland Polyps
Histology
• Cystically dilated glands
• lined by gastric body type mucosa
• Dysplasia occurs in <1%
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Bible Class 29.08.18/ I.Linas 9
Universitätsklinik für Viszerale Chirurgie und Medizin
Case 1
• Which would likely be the course of the polyp on PPI?
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Bible Class 29.08.18/ I.Linas 10
Universitätsklinik für Viszerale Chirurgie und Medizin
Fundic Gland Polyps
• Grow in size on PPI
• Controversial if they appear more frequently on PPI
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Bible Class 29.08.18/ I.Linas 11
Universitätsklinik für Viszerale Chirurgie und Medizin
Case 1
• If random biopsies had been taken, what would you expect the H. pylori
status of the patient to be?
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Bible Class 29.08.18/ I.Linas 12
Universitätsklinik für Viszerale Chirurgie und Medizin
Fundic Gland Polyps
• Prevalence of H.pylori infection is very low
• H pylori may even have an inhibitory effect on the development of FGPs
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Bible Class 29.08.18/ I.Linas 13
Universitätsklinik für Viszerale Chirurgie und Medizin
Case 1
• Surveillance recommendations?
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Bible Class 29.08.18/ I.Linas 14
Universitätsklinik für Viszerale Chirurgie und Medizin
Fundic Gland Polyps
• Surveillance is not routinely recommended in sporadic FGPs without
dysplasia
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Bible Class 29.08.18/ I.Linas 15
Universitätsklinik für Viszerale Chirurgie und Medizin
Case 2
• 19yo male with dyspepsia, unremarkable personal and family history
• GP: PPI trial: no response, H. pylori UBT: negative -> Gastroscopy
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Bible Class 29.08.18/ I.Linas 16
Universitätsklinik für Viszerale Chirurgie und Medizin
Case 2• 19yo male with dyspepsia, unremarkable personal and family history
• GP: PPI trial: no response, H.pylori UBT: negative -> Gastroscopy
What to do next?
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Bible Class 29.08.18/ I.Linas 17
Universitätsklinik für Viszerale Chirurgie und Medizin
Fundic Gland Polyps in the setting of FAP
• Usually multiple, may present “carpet-like”
• No clear cut-off number
• 25-41% harbor dysplasia
Recommendation to refer patients for colonic investigation
• Multiple FGPs in patients < 40 yo
• FGPs with Dysplasia
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Bible Class 29.08.18/ I.Linas 18
Universitätsklinik für Viszerale Chirurgie und Medizin
Case 2• 19yo male with dyspepsia, unremarkable personal and family history
• GP: PPI trial: no response, H.pylori UBT: negative -> Gastroscopy
Surveillance recommendations?
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Bible Class 29.08.18/ I.Linas 19
Universitätsklinik für Viszerale Chirurgie und Medizin
Fundic Gland Polyps in the setting of FAP
• Upper endoscopy every two years
• Except if the spiegelman score dictates a shorter interval!
Spigelman AD , Williams CB , Talbot IC et al. Lancet 1989 ; 2 : 783 – 5 .
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Bible Class 29.08.18/ I.Linas 20
Universitätsklinik für Viszerale Chirurgie und Medizin
Case 3
• 36yo female from Syria referred for gastroscopy with persisting epigastric pain
• Personal and family history unknown (no translator present), Basic labs ok
What do you think this lesion is?
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Bible Class 29.08.18/ I.Linas 21
Universitätsklinik für Viszerale Chirurgie und Medizin
Case 3
• Histology: H. pylori gastritis with extensive intestinal metaplasia
• Hyperplastic polyp
Patient: “what’s caused my polyp? Am I
in risk of cancer?”
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Bible Class 29.08.18/ I.Linas 22
Universitätsklinik für Viszerale Chirurgie und Medizin
Hyperplastic polyps of the stomach
• Very common, 30-93% of all gastric epithelial Polyps
• Response to a chronic inflammatory environment, particularly H. pylori gastritis
Risk of malignancy
• Neoplastic progression is rare (1.5-2.1%)
• Risk increased when pedunculated and >10 mm
• increased risk of synchronous cancer elsewhere in the gastric mucosa
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Bible Class 29.08.18/ I.Linas 23
Universitätsklinik für Viszerale Chirurgie und Medizin
Endoscopy:
• tubular mucosal pattern, of several shapes, thick but regular vessels
• Dense but regular microvascular pattern in NBI
• Erosions and bleeding
• Sessile or pedunculated
• Mostly < 20 mm
• Often single polyps in the antrum
Hyperplastic polyps of the stomach
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Bible Class 29.08.18/ I.Linas 24
Universitätsklinik für Viszerale Chirurgie und Medizin
Histology:
• hyperplastic foveolae
• Serrated crypts
• an inflamed stroma
• Evidence of chronic gastritis in the
surrounding mucosa
Hyperplastic polyps of the stomach
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Bible Class 29.08.18/ I.Linas 25
Universitätsklinik für Viszerale Chirurgie und Medizin
Case 3
• 36yo female from Syria referred for gastroscopy with persisting epigastric pain
• Personal and family history unknown (no translator present), Basic labs ok
• Endoscopy+ Histology: hyperplastic Polyp, H. pylori gastritis with extensive
atrophy and intestinal metaplasia
Management and surveillance recommendation?
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Bible Class 29.08.18/ I.Linas 26
Universitätsklinik für Viszerale Chirurgie und Medizin
Resection:
• All > 5mm*
• Symptomatic (bleeding)
*5-10mm without dysplasia associated with H.pylori consider eradication without
resection
Surveillance
• Endoscopy at 1 year post polypectomy
If extensive metaplasia/atrophy in the gastric mucosa:
• No Dysplasia: 3yearly
• LGD in random biopsies: yearly
• HGD in random biopsies, immediate, 6monthly/Surgery
Hyperplastic polyps of the stomach
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Bible Class 29.08.18/ I.Linas 27
Universitätsklinik für Viszerale Chirurgie und Medizin
Case 4
• 59yo female with H.pylori associated extensive atrophy and intestinal
metaplasia since 2001, lost to follow up since 2005
• You suspect adenoma and decide to biopsy it.
Endoscopic characteristics adenomas?
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Bible Class 29.08.18/ I.Linas 28
Universitätsklinik für Viszerale Chirurgie und Medizin
Endoscopic characteristics
of gastric adenomas
• Solitary, often flat or sessile
• Frequently in the antrum
• Tubular or villous mucosal pattern
• some regular but thin vessels (similar
to intestinal metaplasia)
• Irregular area of absent or distorted
glands with some irregular vessels
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Bible Class 29.08.18/ I.Linas 29
Universitätsklinik für Viszerale Chirurgie und Medizin
Case 4
• 59yo female with H.pylori associated extensive atrophy and intestinal
metaplasia since 2001, lost to follow up since 2005
• You suspect adenoma and decide to biopsy it.
How many biopsies? Where?
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Bible Class 29.08.18/ I.Linas 30
Universitätsklinik für Viszerale Chirurgie und Medizin
• Initial step for most lesions
• Even if macroscopic findings hint at FGP or dysplasia
Number of biopsies of polyp
• Former recommendation for ≥6 may induce non lifting sign
• Thorough inspection with NBI and 2 targeted biopsies may be reasonable
Sampling of surrounding mucosa
• Obligatory for hyperplastic polyps, adenomas and NET
• Probably helpful for all other polyps
Biopsies for gastric polyps
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Bible Class 29.08.18/ I.Linas 31
Universitätsklinik für Viszerale Chirurgie und Medizin
Case 4
• 59yo female with H.pylori associated extensive atrophy and intestinal
metaplasia since 2001, lost to follow up since 2005
• Histology confirms tubulovilous adenoma with LGD. Lesion size 2 cm.
No dysplasia in the surrounding mucosa. Resection method?
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Bible Class 29.08.18/ I.Linas 32
Universitätsklinik für Viszerale Chirurgie und Medizin
Morphology
• Paris 0-Ip or
• 0-Isp
• Size 10-15mm
• Size >15mm
• NET III <10mm?
Endoscopic resection of gastric polyps
Histology
• FGPs
• Hyperplastic
• NET (I and II)
• LGD
• LGD/HGD
• NET(I and II)
Method
Snare
polypectomy
EMR
ESD
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Bible Class 29.08.18/ I.Linas 33
Universitätsklinik für Viszerale Chirurgie und Medizin
Morphology
• Paris 0-Ip or
• 0-Isp
• Size 10-15mm
• Size >15mm
• NET III <10mm?
Endoscopic resection of gastric polyps
Histology
• FGPs
• Hyperplastic
• NET (I and II)
• LGD
• LGD/HGD
• NET (I and II)
Method
Snare
polypectomy
EMR
ESD
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Bible Class 29.08.18/ I.Linas 34
Universitätsklinik für Viszerale Chirurgie und Medizin
Case 4
• ESD is performed
• Histology: tubulovilous
adenoma with LGD and
dysplasia-free resection
margins
Surveillance?
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Bible Class 29.08.18/ I.Linas 35
Universitätsklinik für Viszerale Chirurgie und Medizin
Surveillance of gastric adenomas
Complete resection, size ≤ 20mm
• Endoscopy after 3-6 months and then annually
Piece-meal resection or positive lateral margins* or complete resection ≥
20mm
• Endoscopy after 3 and 9 months and then annually
Gastric mapping in every endoscopy
*depending on histology surgery may be indicated
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Bible Class 29.08.18/ I.Linas 36
Universitätsklinik für Viszerale Chirurgie und Medizin
Case 5
• 55yo female with macrocytic anemia
• GP: CBC, vitamin-B12 deficiency and positive anti-parietal cell antibodies
• Refers for gastroscopy to search for autoimmune gastritis.
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Bible Class 29.08.18/ I.Linas 37
Universitätsklinik für Viszerale Chirurgie und Medizin
Case 5
• 12-15mm lesion in the gastric body
• You biopsy the lesion and take random
biopsies
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Bible Class 29.08.18/ I.Linas 38
Universitätsklinik für Viszerale Chirurgie und Medizin
Case 5
• Histology reveals round monomorphic cells growing
in nests and trabecula
• IHC reveals positivity for chromogranin A
• Histologic findings from the random biopsies are
compatible with extensive autoimmune atrophic
gastritis
What are the types of gastric NET?
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Bible Class 29.08.18/ I.Linas 39
Universitätsklinik für Viszerale Chirurgie und Medizin
Gastric NET types
Type
I
II
III
Gastrin
-
Gastrin Source
Gastric G cells
- AIG, atrophy,
achlorhydria
Gastrinoma
-
Percentage
80%
5%
15%
Characteristics
women (50-70y), multiple,
small (<10 mm), central
depression or ulceration
Same as type I
solitary, large (20-50 mm)
anywhere in the stomach
Worst prognosis
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Bible Class 29.08.18/ I.Linas 40
Universitätsklinik für Viszerale Chirurgie und Medizin
Case 5
• You resect the lesion with EMR, histology confirms
complete resection
Surveillance recommendations?
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Bible Class 29.08.18/ I.Linas 41
Universitätsklinik für Viszerale Chirurgie und Medizin
Case 5
• You resect the lesion with EMR, histology confirms
complete resection
Surveillance recommendations?
• Yearly endoscopy
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Bible Class 29.08.18/ I.Linas 42
Universitätsklinik für Viszerale Chirurgie und Medizin
Rare gastric polyps in histology
Hamartomas:
• Think of a syndrome (Peutz-jegers, Cowden)
Juvenile:
• Solitary in adolescences, no malignant potential
• Multiple: juvenile polyposis – risk of gastric cancer
Inflammatory fibroid polyps (IFP)
• Gastric submucosal granulomas with eosinophilic infiltration
• no malignant potential
• prevalence of 0.1%, middle-aged women
• usually small (<15 mm), sessile, solitary lesions, distal antrum
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Bible Class 29.08.18/ I.Linas 43
Universitätsklinik für Viszerale Chirurgie und Medizin
Remember…
• 80% of gastric polyps are non neoplastic
• Despite typical appearance, should be sampled at the initial endoscopy
• Biopsies of normal appearing mucosa
• Multiple FGPs, consider FAP
• Sporadic FGP and IFP, no further surveillance
• Hyperplastic > 5mm : resect, follow-up at 1 year
• Adenomas regardless of size: resect, follow up.
• Hamartomas: search for syndrome.
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Bible Class 29.08.18/ I.Linas 44
Universitätsklinik für Viszerale Chirurgie und Medizin
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Bible Class 29.08.18/ I.Linas 45
Universitätsklinik für Viszerale Chirurgie und Medizin
Case 6
49yo male with NASH cirrhosis
• Presents in ER with
hematemesis
• Endoscopy:
What is the lesion?
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Bible Class 29.08.18/ I.Linas 46
Universitätsklinik für Viszerale Chirurgie und Medizin
“Starting my training in gastroenterology, some decades ago, my first chief always told me that colonoscopy may seem technically more challenging but gastroscopy has findings definitely harder to
interpret.” Ove Carstens