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Furanyl FentanylThe Drug Enforcement Administration's Special Testing and Research Laboratory
generated this monograph using structurally confirmed reference material.
Latest Revision: 6/15/2016 Page 1 of 5SWGDRUG.org/monographs.htm
1. GENERAL INFORMATION
IUPAC Name: N-phenyl-N-[1-(2-phenylethyl)piperidin-4-yl]furan-2-carboxamide
CAS#: 101345-66-8
Synonyms: 2-Furanyl fentanyl
Source: DEA Reference Material Collection
Appearance: White powder
UVmax(nm): Not determined
2. CHEMICAL AND PHYSICAL DATA
2.1 CHEMICAL DATA
Form Chemical Formula Molecular Weight Melting Point (oC)
Base C24H26N2O2 374 Not Determined
HCl C24H26N2O2 HCl 411 232.7
N
N
O
O
Furanyl FentanylThe Drug Enforcement Administration's Special Testing and Research Laboratory
generated this monograph using structurally confirmed reference material.
Latest Revision: 6/15/2016 Page 2 of 5SWGDRUG.org/monographs.htm
3. QUALITATIVE DATA
3.1 NUCLEAR MAGNETIC RESONANCE
Sample Preparation: Dilute analyte to ~12 mg/mL in DMSO-d6 containing TMS for 0 ppm reference anddimethylfumarate as quantitative internal standard.
Instrument: 400 MHz NMR spectrometerParameters: Spectral width: at least containing -3 ppm through 13 ppm
Pulse angle: 90o
Delay between pulses: 45 seconds
1HNMR: Furanyl fentanyl HCl; Lot# ALB-288-12; 400MHz
dimethylfumarate
H2ODMSO
TMSimpurity
10.5 10.3
1
7.50 7.25
3431
6.350
1
5.45
1
4.90 4.80
1
3.60
2
2.1 2.0 1.9 1.8
22
10 9 8 7 6 5 4 3 2 1 0
2224211134311
3.2 3.1 3.0
24
NH+
Furanyl FentanylThe Drug Enforcement Administration's Special Testing and Research Laboratory
generated this monograph using structurally confirmed reference material.
50
Latest Revision: 6/15/2016 Page 3 of 5SWGDRUG.org/monographs.htm
3.2 GAS CHROMATOGRAPHY/MASS SPECTROMETRY
Sample Preparation: Dilute analyte ~3 mg/mL in CHCl3
Instrument: Agilent gas chromatograph operated in split mode with MS detectorColumn: DB-1 MS (or equivalent); 30m x 0.25 mm x 0.25 µmCarrier Gas: Helium at 1.5 mL/minTemperatures: Injector: 280oC MSD transfer line: 280oC
MS Source: 230oC MS Quad: 150oCOven program:
1) 100oC initial temperature for 1.0 min2) Ramp to 280oC at 12 oC/min3) Hold final temperature for 9.0 min
Injection Parameters: Split Ratio = 23:1, 1 µL injectedMS Parameters: Mass scan range: 30-550 amu Threshold: 150
Tune file: stune.u Acquisition mode: scanRetention Time: 20.634 min
EI Mass Spectrum: Furanyl fentanyl HCl; Lot# ALB-288-12
m/z35030025020015010050
[x 1
06 ]In
tens
ity
0.5
42424242424242424242424242424242424242424242
51515151515151515151515151515151515151515151
77777777777777777777777777777777777777777777
95959595959595959595959595959595959595959595
130130130130130130130130130130130130130130130130130130130130130130158158158158158158158158158158158158158158158158158158158158158158
170170170170170170170170170170170170170170170170170170170170170170186186186186186186186186186186186186186186186186186186186186186186
198198198198198198198198198198198198198198198198198198198198198198212212212212212212212212212212212212212212212212212212212212212212
240240240240240240240240240240240240240240240240240240240240240240
253253253253253253253253253253253253253253253253253253253253253253
283283283283283283283283283283283283283283283283283283283283283283
327327327327327327327327327327327327327327327327327327327327327327 341341341341341341341341341341341341341341341341341341341341341341 372372372372372372372372372372372372372372372372372372372372372372
m/z350300250200150100
[x 1
05 ]In
tens
ity
0.5
1.0
1.5
42424242424242424242424242424242424242424242
51515151515151515151515151515151515151515151
77777777777777777777777777777777777777777777
95959595959595959595959595959595959595959595
130130130130130130130130130130130130130130130130130130130130130130
158158158158158158158158158158158158158158158158158158158158158158
170170170170170170170170170170170170170170170170170170170170170170
186186186186186186186186186186186186186186186186186186186186186186
198198198198198198198198198198198198198198198198198198198198198198
212212212212212212212212212212212212212212212212212212212212212212
240240240240240240240240240240240240240240240240240240240240240240
253253253253253253253253253253253253253253253253253253253253253253
283283283283283283283283283283283283283283283283283283283283283283
327327327327327327327327327327327327327327327327327327327327327327 341341341341341341341341341341341341341341341341341341341341341341 372372372372372372372372372372372372372372372372372372372372372372
Furanyl FentanylThe Drug Enforcement Administration's Special Testing and Research Laboratory
generated this monograph using structurally confirmed reference material.
Page 4 of 5Latest Revision: 6/15/2016 SWGDRUG.org/monographs.htm
3.3 INFRARED SPECTROSCOPY (FTIR)
Instrument: FTIR with diamond ATR attachment (1 bounce)Scan Parameters: Number of scans: 32
Number of background scans: 32Resolution: 4 cm-1
Sample gain: 4Aperture: 80
FTIR ATR (Diamond 1 Bounce): Furanyl fentanyl HCl; Lot# ALB-288-12
Wavenumber (cm-1)3500 3000 2500 2000 1500 1000
%Tr
ansm
ittan
ce
32
40
48
56
64
72
442442442442442442442442442442442442442442442442442442442442442442
600600600600600600600600600600600600600600600600600600600600600600
713713713713713713713713713713713713713713713713713713713713713713
772772772772772772772772772772772772772772772772772772772772772772
885885885885885885885885885885885885885885885885885885885885885885
947947947947947947947947947947947947947947947947947947947947947947
1031103110311031103110311031103110311031103110311031103110311031103110311031103110311031
1134113411341134113411341134113411341134113411341134113411341134113411341134113411341134
1238123812381238123812381238123812381238123812381238123812381238123812381238123812381238
133813381338133813381338133813381338133813381338133813381338133813381338133813381338133814071407140714071407140714071407140714071407140714071407140714071407140714071407140714071471
147114711471147114711471147114711471147114711471147114711471147114711471147114711471
1629162916291629162916291629162916291629162916291629162916291629162916291629162916291629
2376237623762376237623762376237623762376237623762376237623762376237623762376237623762376
2443244324432443244324432443244324432443244324432443244324432443244324432443244324432443
2501250125012501250125012501250125012501250125012501250125012501250125012501250125012501
2625262526252625262526252625262526252625262526252625262526252625262526252625262526252625
2930293029302930293029302930293029302930293029302930293029302930293029302930293029302930
3086308630863086308630863086308630863086308630863086308630863086308630863086308630863086
3417341734173417341734173417341734173417341734173417341734173417341734173417341734173417
Wavenumber (cm-1)1760 1680 1600 1520 1440 1360 1280 1200 1120 1040 960 880 800 720 640
%Tr
ansm
ittan
ce
32
40
48
56
64
72
418418418418418418418418418418418418418418418418418418418418418418
442442442442442442442442442442442442442442442442442442442442442442
482482482482482482482482482482482482482482482482482482482482482482
516516516516516516516516516516516516516516516516516516516516516516
552552552552552552552552552552552552552552552552552552552552552552
600600600600600600600600600600600600600600600600600600600600600600
607607607607607607607607607607607607607607607607607607607607607607
623623623623623623623623623623623623623623623623623623623623623623
661661661661661661661661661661661661661661661661661661661661661661
713713713713713713713713713713713713713713713713713713713713713713
738738738738738738738738738738738738738738738738738738738738738738
751751751751751751751751751751751751751751751751751751751751751751
772772772772772772772772772772772772772772772772772772772772772772
787787787787787787787787787787787787787787787787787787787787787787
847847847847847847847847847847847847847847847847847847847847847847
885885885885885885885885885885885885885885885885885885885885885885
920920920920920920920920920920920920920920920920920920920920920920
947947947947947947947947947947947947947947947947947947947947947947
9729729729729729729729729729729729729729729729729729729729729729721001
100110011001100110011001100110011001100110011001100110011001100110011001100110011001
1031103110311031103110311031103110311031103110311031103110311031103110311031103110311031
1046104610461046104610461046104610461046104610461046104610461046104610461046104610461046
1089108910891089108910891089108910891089108910891089108910891089108910891089108910891089
1134113411341134113411341134113411341134113411341134113411341134113411341134113411341134
1158115811581158115811581158115811581158115811581158115811581158115811581158115811581158
1189118911891189118911891189118911891189118911891189118911891189118911891189118911891189
1238123812381238123812381238123812381238123812381238123812381238123812381238123812381238
1281128112811281128112811281128112811281128112811281128112811281128112811281128112811281
13021302130213021302130213021302130213021302130213021302130213021302130213021302130213021324
1324132413241324132413241324132413241324132413241324132413241324132413241324132413241338
133813381338133813381338133813381338133813381338133813381338133813381338133813381338
1357135713571357135713571357135713571357135713571357135713571357135713571357135713571357
1388138813881388138813881388138813881388138813881388138813881388138813881388138813881388
14071407140714071407140714071407140714071407140714071407140714071407140714071407140714071463
146314631463146314631463146314631463146314631463146314631463146314631463146314631463
1471147114711471147114711471147114711471147114711471147114711471147114711471147114711471
1493149314931493149314931493149314931493149314931493149314931493149314931493149314931493
15591559155915591559155915591559155915591559155915591559155915591559155915591559155915591594
159415941594159415941594159415941594159415941594159415941594159415941594159415941594
1629162916291629162916291629162916291629162916291629162916291629162916291629162916291629
Furanyl FentanylThe Drug Enforcement Administration's Special Testing and Research Laboratory
generated this monograph using structurally confirmed reference material.
Latest Revision: 6/15/2016 Page 5 of 5SWGDRUG.org/monographs.htm
https://en.wikipedia.org/wiki/Furanylfentanyl
4. ADDITIONAL RESOURCES
Wikipedia