Funded by the An Interdisciplinary Doctoral Training Program · Raman Micro-spectroscopic...
Transcript of Funded by the An Interdisciplinary Doctoral Training Program · Raman Micro-spectroscopic...
Heather
Brodkin
Computationall
y
Guided Protein-
Specific
Labeling
with NPs
Adam
Hendricks
Synthesis of
Spin Labeled
Nanosensors
for the
Estrogen
Receptor
Tatyana
Chernenko
Raman Micro-
spectroscopic
Techniques for
Drug-delivery
Applications
Agnes Rafalko
Gold NPs for
imaging cell
surface
oligosaccharide
s for early
diagnosis of
cancer
Paula Lampton
Using NPs to
Analyze Key
Immune
System
Molecules in
Embryonic
Stem Cells
Anthony
D’Onofrio
Nanoparticle
Antimicrobial
Development
Sucharita Saha
Visualization
and
Enhancement
of Spinal Cord
Regeneration
using
Nanoparticles
Robert Camp:
MIE
Quantifying
Collagen’s
Mechanosensiti
vity to
Enzymatic
Cleavage
by MMPs
Savidra
Lucatero:
ChemE
Transport
Behavior of
Drugs and NPs
Intestinal
Mucus
Yogesh Patel:
ECE
Basal Cell
Carcinoma
Brian
Plouffe:Chem E
Microfluidic
Cell Separation
Using
Functionalized
Magnetic NPs
Lilian van
Vlerken
Development of
a Polymeric NP
Formulation to
Overcome
Multidrug
Resistance of
Cancer via a
Multifunctional
Therapy
Mattia Migliore
Intranasal
Delivery of
GDNF
for the
Treatment of
Parkinson’s
Disease
Luis Brito
Endothelial
Nitric Oxide
Synthase
(eNOS) Gene
Therapy with
Gelatin-Based
Nanovectors
Lara Jabr
Mitochondriotr
opic Gold NP
Vectors
Thomas
Barchet
Role of
Polyunsaturate
d Fatty Acid-
Containing
nano-
emulsions in
Drug Delivery
and
Neuroprotectio
n in Alzheimer’s
Disease.
Associates:The IGERT Associate Program is
intended for Undergraduates and Masters students interested in
the area of nanomedicine. The program has supported over 32
students from 8 different departments that include Physics,
Chemistry, Biotechnology, Pharmaceutical Sciences, Mechanical
and Industrial Engg, Electrical and Computer Engg, Chemical
Engg and Biology. The research experience has influenced
several of these students to pursue graduate education.
IGERT
NANOMEDICINE
VISION
Inter-disciplinary researchNanoplatforms for targeted delivery; Optical
sensors and therapies; Magnetic nanoplatforms; Nanoplatforms for
Antimicrobial, Implant and Neural applications; Ethical and Policy issues in Nanomedicine
Internships and
outreachCommunity engagementIntellectual
propertyCultural diversity
International outlook
Communication Skills
Professional Conduct
Reports Publications
Presentations Research
Integrity Ethics
Multi-disciplinary coursesIntroduction to Nanomedical Technology ;
Nanosystems Design for Biomedical Applications; Scientific Skills, Ethics, and
Commercialization; Nanomedicine Seminar
FacilitiesThe Nanomedicine Core Facility has been established to provide
nanoparticles and nanomaterials for various interdisciplinary
research projects. Facility includes: Hitachi 2nm Hi Res FESEM,
SQUID, AFM, STM, TEM, NSOM
OutreachIGERT Outreach provides education and leadership skills to both
students and teachers from participating schools in the Greater
Boston area. Outreach activities including RET, the Young
Scholars Program, Field Trip hosting, and Science Fair Mentoring
have proven to be a very positive experience to all involved.
Partners and Collaborators
An Interdisciplinary Doctoral Training Program
Research
Program VisionThe Integrative Graduate Education, Research & Training
(IGERT) program in Nanomedicine Science and Technology was
established at Northeastern University in 2005 (Phase 1) with
funding from the National Science Foundation.
The IGERT Nanomedicine program aims to train the next
generation of scientists and technologists who are skilled in
research at the interface of nanotechnology, biology and
medicine, who are aware of the path to translate fundamental
knowledge to marketplace products, who are informed of the
ethical and social issues relating to the discipline, and who have
a strong sense of community involvement as well as a global
perspective.
The program received funding for a second phase Phase 2
(2010-2015), with additional partners – Tuskegee University and
University of Puerto Rico, Mayaguez, as well as faculty from
Harvard Medical School, to establish a national multi-site
training program. International partners have also expressed an
eagerness to replicate the model in their institutions.
The Faculty
www.igert.neu.edu
Funded by the
National Science
Foundation
IGERT Faculty Collaborators/Advisors
Biology: K. Lewis, D. O'Malley, C. Warner, E.Cram
Chemistry: M. Diem, G. Jones, R. Hanson, M.Ondrechen
Physics: D. Heiman, L. Menon, M. Williams
Pharmaceutical Sciences: A. Makryannis, V. Torchilin,
B.Waszczak,
Chemical Engg: R. Carrier, S. Murthi , L.P.Murphy
Mech and Ind Engg: J.Ruberti
Elec and Comp Engg: C. Di Marzio, N. Sun
(TU) Materials Science and Engg: Vijaya Rangari
Integrative Biosciences: Clayton Yates, Timothy Turner
(UPRM) Applied Chemistry: Oscar Perales-Perez, Marco
DeJesus, Felix Roman Chemical Engg: Carlos Rinaldi,
Madeline Torres
Materials Science: Surinder Singh, Marcelo Suarez
VISITING FACULTY MENTORS
T. Hassan – MGH M. Makrigiorgos- DFCI N. Soukos –
Forsyth O. Farokhzad – BWH S. Sengupta – BWH M.
Harisinghani – MGH N.Goldberg – BIDMC A. Patri - NCL
Director and PI: Srinivas Sridhar
Co-PIs: Mansoor Amiji , Laura H. Lewis, Carlos Rinaldi, Tamara Floyd-Smith
Dattatri Nagesha (Research Coordinator), Rita Kaderian (Program Coordinator)
Nanoplatforms
• Polymers, lipids, organelles, self-assembling ampiphiles,
• Magnetic nanoparticles
• Quantum dots
• Nanoporous coatings on implants
Characterization toolkit
• Nanoscale Microscopies: SEM, TEM, AFM, STM, NSOM,
• Fluorescence confocal and optical microscopy
• Zeta Potential, SQUID, Coulter
Cellular and Phyiological Mechanisms
• Apoptosis
• Delivery to nucleus, mitochondria or ribosome
• Endocytosis, Cellular uptake
• Gene Silencing
• Organ biodistribution and pharmacokinetics
Medical Challenge
• Photodynamic Therapies
• Image guided drug delivery
• Localized energy delivery
• Nano-enhanced implants
• Nanomedicine Ethics and Policy
The tightly-integrated interdisciplinary team of medical researchers, pharmaceutical scientists, physicists, chemists, and
chemical engineers, has an extensive range of expertise to facilitate research on nanomedicine:
• Nanotechnology platforms such as polymeric nanoparticles, lipid nanoparticles, metal nanoparticles, and self-
assembling nanosystems,
• Synthetic chemistry to design and optimize new strategies for nanoparticle preparation and functionalization,
• Cancer diag-nostic and imaging techniques using nano-particles as reporter platforms and contrast enhancing agents,
• Therapeutic targeted and intra-cellular drug and gene delivery using nanocarriers,
• Nanoparticles for electromagnetic hyper/hypothermia and imaging
• Theoretical modeling of nanoparticle processes in biological and medical environments, and of drug and gene delivery,
•Clinical diagnosis and therapy of prostate, breast, and liver cancer.
Doctoral Trainees
Engineering
The IGERT Nanomedicine PhD program recruits students from
various disciplines (Biology, Chemistry, Physics, Engg, and
Pharmaceutical Sciences) to work collaboratively on
Nanomedicine related projects. The IGERT Ph.D Trainee will
graduate with a Ph.D. degree in their core subject with
specialization in Nanomedicine Science and Technology. In
Phase – I, 26 Ph.D. students representing 3 colleges and 9
Departments have been trained. IGERT fellows have contributed
to excellent research that has resulted in over 50 journal
publications , 1 patent approved, 2 patents filed, 15 book
chapters, 3 books and over 125 conference presentations and
posters. A few representative projects are listed below.
Biology
Chemistry
Pharmaceutic
al Sciences