Functional definition of seizure provides new insight into post-traumatic epileptogenesis

by Raimondo D'Ambrosio, Shahin Hakimian, Tessandra Stewart, Derek R. Verley, Jason S. Fender, Clifford L. Eastman, Aaron H. Sheerin, Puneet Gupta, Ramon

Diaz-Arrastia, Jeffrey Ojemann, and John W. Miller

BrainVolume 132(10):2805-2821

October 8, 2009

© The Author(s) 2009. Published by Oxford University Press on behalf of Brain.

Quality control of chronic implantation of epidural electrodes.

Raimondo D'Ambrosio et al. Brain 2009;132:2805-2821

© The Author(s) 2009. Published by Oxford University Press on behalf of Brain.

Electroclinical syndrome of PTE induced by rpFPI in the rat.

Raimondo D'Ambrosio et al. Brain 2009;132:2805-2821

© The Author(s) 2009. Published by Oxford University Press on behalf of Brain.

Behavioural changes are temporally specifically associated with rpFPI-induced CRSPSs lasting at least 2 s.

Raimondo D'Ambrosio et al. Brain 2009;132:2805-2821

© The Author(s) 2009. Published by Oxford University Press on behalf of Brain.

Loss of theta rhythm following rpFPI-induced CRSPSs lasting longer than 2 s.

Raimondo D'Ambrosio et al. Brain 2009;132:2805-2821

© The Author(s) 2009. Published by Oxford University Press on behalf of Brain.

Electroclinical evidence that short (<2 s) recurrent spontaneous focal epileptiform ECoG discharges induced by rpFPI are ictal.

Raimondo D'Ambrosio et al. Brain 2009;132:2805-2821

© The Author(s) 2009. Published by Oxford University Press on behalf of Brain.

Spectral evidence that short (<2 s) recurrent spontaneous focal epileptiform ECoG discharges are ictal in the rat.

Raimondo D'Ambrosio et al. Brain 2009;132:2805-2821

© The Author(s) 2009. Published by Oxford University Press on behalf of Brain.

Simultaneous scalp-EEG and epidural ECoG recordings in the rat reveal focal seizures undetected by scalp EEG. (A) Schematics of the montage employed: five epidural electrodes (1

through 5) and two scalp electrodes placed parieto-temporally (pt) and occipitally (o).

Raimondo D'Ambrosio et al. Brain 2009;132:2805-2821

© The Author(s) 2009. Published by Oxford University Press on behalf of Brain.

Short recurrent spontaneous focal seizures in the human.

Raimondo D'Ambrosio et al. Brain 2009;132:2805-2821

© The Author(s) 2009. Published by Oxford University Press on behalf of Brain.

Seizure frequency and time course of epileptogenesis after rpFPI depend on the definition of epilepsy and on the diagnostic technique employed.

Raimondo D'Ambrosio et al. Brain 2009;132:2805-2821

© The Author(s) 2009. Published by Oxford University Press on behalf of Brain.