From stem cells to platelets regulation, environment and...
Transcript of From stem cells to platelets regulation, environment and...
From stem cells to plateletsregulation, environment and pathology
Alessandra Balduini, MDDepartment of Biochemistry
University of Pavia
Progetto Regione 7 Marzo 2008
Megakaryocyte Differentiation
Kaushansky K, Blood 1995, 86: 419
Mattia G et al, Blood 2002, 99: 888
Ploidy
Proplatelet extension
Patel S et al, JCI 2005,115: 3348
Proplatelets
Italiano J et al, J Thromb Haemost 2003, 1: 1174
Proplatelet branching
Patel S et al, JCI 2005,115: 3348
Proplatelet cytoskeleton
Hartwig J et al, J Thromb Haemost 2003, 1: 1580
Platelet release
Hartwig J et al, J Thromb Haemost 2003, 1: 1580
Bone marrow niches
Experimental model ofthrombopoiesis
Avecilla St et al, Nature Medicine 2004,10: 64
α2β1
PPF regulation model
Chen Z, Balduini A et al, Blood 2007
Acknowledgments
Harvard Medical SchoolZhao Chen
Ramesh Shivdasani
University of PaviaCristian Gruppi
Enrica TiraMauro Torti
Cesare Balduini
Fondazione San MatteoAlessandro Pecci
Valeria BozziCarlo Balduini
Tufts UniversityChris CanizzaroMichael LovettDavid Kaplan
Isabella PallottaAlessandro MalaraStefania Badalucco