From Mendel to DNA
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Transcript of From Mendel to DNA
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From Mendel to DNALearning Objectives
1. What did Mendel’s experiments teach us about inheritance?
2. What are DNA fingerprints?3. How are specific proteins made in the body?
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Gregor Mendel
• Carried out breeding experiments with peas.
• Used pure strains of: round, wrinkled, green and yellow peas.
• Cross bred the peas and counted the different offspring.
• Found that characteristics were inherited in clear predictable patterns.
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Mendel suggested that there were separate units of inherited material. He realised
some characteristics were dominant over others and that they never mixed together.
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Inheritance - the story of life
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Genes
A gene is a section of DNA coding for a particular feature.
e.g. eye colour, attached/unattached ear lobes, ability to roll tongue.
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DNA is a chemical that stores your genetic material.
So what is DNA....
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DNA
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Structure of DNA
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Sequence of bases forms the genetic code
G C
AT
CG
Each base is like one letter in a four-letter alphabet.
These letters make up 3 letter groups called codon triplets.
Each triplet is one piece of information.
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Questions1. How did Mendel’s experiments with peas
convince him that there were distinct ‘units of inheritance’ which were not blended together in offspring?
2. Why didn’t people accept his ideas?3. The development of the microscope
played an important part in helping to convince people that Mendel was right. How?
4. Explain with reference to the structure of DNA the saying ‘One gene, one protein’.
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DNA fingerprinting
‘DNA fingerprinting’ – a technique that uses the unique patterns in your
DNA to identify you.
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DNA fingerprinting• Certain areas of your DNA produces very
variable patterns under the microscope. • These patterns are more similar between
people who are related than between total strangers.
• The patterns are known as DNA fingerprints.
• They can be produced from very tiny samples of DNA from body fluids such as blood, saliva, semen.
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DNA fingerprinting – what are some of the
uses?
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Questions 1. Two men claim to be the father of
the same child. Explain how DNA fingerprinting
could be used to find out which one is the real father.
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Inheritance in Action
Learning Objectives1. How is sex determined in humans?2. Can you predict what features a
child might inherit?
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We inherit characteristics from our parents....
Nucleus
chromosome
gene
DNA
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Humans have 46 chromosomes – 23 from the mother and 23 from the father.
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The complexity of an organism does not seem to be correlated with the
number of chromosomes it has.
Fruit fly – 8
Kangaroo – 12
Human – 46
Chicken – 78
Fern - 1200
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In 22 cases each chromosome in the pair is a similar shape and has genes carrying information
about the same things. But one pair of chromosomes may be different – these are the sex
chromosomes.
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Chromosomes from a female
Chromosomes from a male
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• Sex chromosomes– Two X chromosomes
mean you are female– One X chromosome
and a Y chromosome mean you are male.
• Twins are born. Twin A is XY and twin B is XX. What sex are the two babies?
Pair 23 – the non-matching pair of chromosomes
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Chromosomes• The chromosomes we
inherit carry our genetic information in the form of genes. A gene can be pictured as a position on a chromosome.
• Many of these genes have different forms.
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• Alleles – are different versions of the same gene.– For example the gene for dimples may have
the dimple or no-dimple allele.• An allele can be dominant or
recessive.• Individuals can be homozygous or
heterozygous.– Individuals who are homozygous for a
certain gene carry two copies of the same allele.
– Individuals who are heterozygous for a certain gene carry two different alleles.
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• A recessive characteristic will only be shown if an individual is homozygous for the recessive allele.
• A dominant characteristic will be shown even if an individual is heterozygous for the dominant allele.
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Genetic diagrams are used to show possible outcomes of a particular cross. Dominant allele is shown by a capital letter, and a recessive allele by a lower case letter.
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Cystic fibrosis
Huntington’s disease
Downs syndrome
Haemophilia
Malaria Measles
Meningitis
Tetanus
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Inherited or not?