DISCOVERY OF NEW CLASS OF DAMAGE-PRONE DNA REGIONS COULD LEAD TO

BETTER CANCER TREATMENTS AND A NEW MECHANISM THAT CONTRIBUTES TO

EVOLUTION OF CANCER

Ángela Maria Aragon Canencio

Medicine Student -III Semester.

Universidad Pontificia Bolivariana

Molecular Biology- february 18 2013

The findings could leadto the development ofmore effectivetreatments for B celllymphoma, knowbetter the causes ofcancer, allow thecreation of newstreatments for thesedesease.

MARTINEZ S, Lina Maria. BiologíaMolecular. 5 ed Medellin: UPBFac. Medicina

Discovery of New Class ofDamage-Prone DNA RegionsCould Lead to Better CancerTreatments, Science daily.( jan 24 2013)

A New Mechanism ThatContributes to the Evolution ofCancer, science daily.(jan 31 2013)

MEDICAL UTILITY BIBLIOGRAPHY MOLECULAR BIOLOGY

DISCOVERY OF NEW CLASS OF DAMAGE-PRONE DNA REGIONS COULD LEAD TO

BETTER CANCER TREATMENTS AND A NEW

MECHANISM THAT CONTRIBUTES TO

EVOLUTION OF CANCER

Ángela Maria Aragon

Canencio

Medicine Student -III

Semester.

Universidad Pontificia

Bolivariana

Molecular Biology-

february 18 2013

when DNA is replicated in celldivision can take damage inplaces that are known asfragile sites for double-strandbreak

B cells divide rapidly and soare at greater risk, in thisstudy described theirinstability

Cancer arises from theaccumulation of mutationsand structural changes inchromosomes , this tendto lose or duplicate entireregions

INTRODUCTION A NEW MECHANISM

THAT CONTRIBUTES TO EVOLUTION OF CANCER

DISCOVERY OF NEW CLASS OF DAMAGE-PRONE DNA REGIONS COULD LEAD TO

BETTER CANCER TREATMENTS

The fragile sites are regions of chromosome likely to break or separate by certain cell activities like replication and division. Consist of repeated sequences

of CGG.

Cancer is a DNA damage disease associated with replication. Also accumulation of mutations and structural changes in chromosomes. Is for that reason tthat the study of fragile sites provides to the understanding of cancer and the possibility of better treatment

INTRODUCTION

The fragile sites are regions ofchromosome likely to break orseparate by certain cell activitieslike replication and division.Consist of repeated

sequences of CGG.

Cancer is a DNA damage diseaseassociated with replication. Alsoaccumulation of mutations andstructural changes inchromosomes. Is for that reasonthat the study of fragile sitesprovides to the understanding ofcancer and the possibility ofbetter treatment

Cancer becomes in a public healthproblem due to of its high incidencein recent years. The increase wasinfluenced by environmental factors,genetic and lifestyle. Therefore theneed was created by the scientificcommunity to find an effectivetreatment, thus decreasing possibleside effects of treatments allowingbetter quality of life for thesepatients

when DNA is replicated in celldivision can take damage inplaces that are known asfragile sites for double-strandbreak

B cells divide rapidly and soare at greater risk, in thisstudy described theirinstability

DISCOVERY OF NEW CLASS OF DAMAGE-PRONE DNA REGIONS COULD LEAD TO

BETTER CANCER TREATMENTS

DISCOVERY OF NEW CLASS OF DAMAGE-PRONE DNA REGIONS COULD LEAD TO BETTER CANCER

TREATMENTS

B cells are leukocytes which dependsmediated immunity with antibodiesspecific activity of antigen binding.

DISCOVERY OF NEW CLASS OF DAMAGE-PRONE DNA REGIONS COULD LEAD TO BETTER CANCER TREATMENTS

a somatic cell of thebody undergoes adivision called mitosisand it results in twohaploid daughtercells, this process hasfour steps are:prophase, metaphase, anaphase and telophaseand result is thedevelopment of theorganism

cells called B cell lymphocytes are among the most rapidly dividing cells, they are at

great risk for replication-induced DNA damage.

DISCOVERY OF NEW CLASS OF DAMAGE-PRONE DNA REGIONS COULD LEAD TO BETTER CANCER

TREATMENTS

FRAGILES SITESThe fragile sites are specificloci that show fracturesduring karuoyping performunder specific, the fragilessites have provided insightinto understanding of theeffects of replicative stress onDNA damage and genomicinstability in cancer cells.

DISCOVERY OF NEW CLASS OF DAMAGE-PRONE DNA REGIONS COULD LEAD TO BETTER CANCER

TREATMENTS

In this study theteam uncovered an AID-independent source of DNAbreaks associated withreplication called earlyreplicating fragile sites (ERFSs).these sites overlappedsignificantly with DNAalterations associated with Bcell lymphoma, suggesting thatERFSs are a major feature ofthe mutational landscape ofthis type of cancer and possiblyother cancers.

I think that this is soimportan becauseundertand howreplication hanppenin the B cells we willdo more specifictreatment

OBSERVATION

Cancer is a disease caused by a group

of cells that grow and multiplyuncontrollably autonomously,invading other tissues locally andremotely.

Cancer arises from theaccumulation ofmutations andstructural changes inchromosomes , thistend to lose or duplicateentire regions

A NEW MECHANISM THAT CONTRIBUTES TO

EVOLUTION OF CANCER

A NEW MECHANISM THAT CONTRIBUTES TO EVOLUTION OF CANCER

A NEW MECHANISM THAT CONTRIBUTES TO EVOLUTION OF CANCER

Cancer occurs after the appearanceof mutations and chromosomechanges, lost or duplicatedchromosomes entire regions

the cancer cells are not divide asnormal cells of the body, these cellscan produce up to 5 daughters, thedifferent process of this divisioncauses the daughters have more orfewer chromosomes than a normalone leading to aneuploidy

It was thought thatthe problemsoriginated in partsdifficult toduplicate but thisstudy found thatareas that replicatequickly also areprone

A NEW MECHANISM THAT CONTRIBUTES TO EVOLUTION OF CANCER

"In these cases, thecollision between thetwo machineries, theduplication machineand the transcriptionmachine, can beresponsible forgeneratingchromosomalalterations that aredeadly for cells," says

ndez‐Capetillo

A NEW MECHANISM THAT CONTRIBUTES TO EVOLUTION OF CANCER

OBSERVATION

The importance of this research isthe knowlodge of the mechanisms

that explain the cromosomalalteration furthemore the study

help us to understand the changesin the genome throughout

evolution.

The findings could lead tothe development of moreeffective treatments for Bcell lymphoma, know betterthe causes of cancer, allowthe creation of newstreatments for thesedesease.

MEDICAL UTILITY

MEDICAL UTILITY

with this new knowledge aboutcancer, you can make new andbetter treatments to treat andprevent so many deaths fromthis disease.

MEDICAL UTILITY

how advanced the disease

according to this

how is the chromosome division

what is the right treatment

in what time should be applied

MEDICAL UTILITY

is very important for sciencecontinue investigating causesof this disease, as this notonly affects the personsuffering but also his entirefamily circle and bring thisallows for a better way, justbecause you can explain itbetter the patient ishappening inside.

MEDICAL UTILITY knowing that fragilesites are easilydamaged in thedivision and thatcancer is a diseasethat occurs whenthere isaccumulation ofmutations may startthinking thatdecreasing fragilesites can reachdecreser disease

BIBLIOGRAPHY

•MARTINEZ S, Lina Maria. Biología Molecular. 5 edMedellin: UPB Fac. Medicina

•Discovery of New Class of Damage-Prone DNARegions Could Lead to Better Cancer Treatments,Science daily.( jan 24 2013)

•A New Mechanism That Contributes to theEvolution of Cancer, science daily.(jan 31 2013)