IBS®

us. ass. $iii-ii!i99>dii. i^s-sis-fis. 9i8S]

5 S T'lSl^T I4(,ut S •t^^„

)± E • Ji

1 is^pgaoisctt. Fpii:i-e)Fp^9 0 4-e<D9 0B§o

2 Mi§-yj^li}k<Dtiii)X'i)i>o

(1) i o-c^^o

Fpis®sf?K®tt'5j>e.:^x«r io«!>% )k(Dmzt£h-oxi^mmmzmxt^

Xbo 2-:^IU±M^t^ii. aut::4-5»g>a:t-t^.r j:o

(W Fp^ 400 1

1 h •;'i'A 2 yn/x-y 3

iELv>t:A{± r4j

Fp^4oo oooooooo<&o o^ dfln ^ 23456789 10rp1 400 OOO^OOOOOO

(3) iK-T r?iL::i'Aj J; 7 to

^mx>mim-::>t:<o. r3®CJ^ L 1 i: ^ f) V> f> J±E1" S r t o

COjE^®fj Bf5:5^<6 r v> 4 5r 6^ < o

4 SSawfilSlC'^v^-CtiSPgL^v^i to

mm • - ±m

LT:DELV^<D^i^^tu;6\ 1 O3i-<o

1 2 :ty^^ 3

4 =^y h 5

Pp^2 TU:=^^y (Arrhenius) T^n y h COllI'jfriil/^; '̂̂ InJt = 26.2—10250' (l/f) 'X:$:)^:^M^J^

(kJmol-i) iC:ft>b3£V^fi{i^tL;6\ 1 Oii-<o tifcL.

= 8.3 J K"! mol"! tir^,

1 1.2X103 2 1.0X104 3 8.5X104 4 - 8.5X104 5 85.1

Pp^3 ilk(DmM^mm(D^h. IojI

1 lie 2 32p 3 90S 4 1251 5 1311

Pp^4 y>m~7km--i-hv^j>>-vi^m-Ti^mr.i-hyph

1 Oii^o

1 pH 2~4 2 pH 4~5 3 pH 6~8

4 pH9~10 5 pH8~ll

— 1 —

1 X I&II0J

2 PET (positron emission tomography)

4 MRI (magnetic resonance imaging)

5

Po^6 ioii-<c

1 NO 2 NO2 3 N2O4 4 N2O 5 N2O5

Pp^ 7 07r

NH2

H2N''

1 Oil

NH2 NH2 o o\V/

N NH2

1 ^ ^

4 yyv

2 1,4-i^t Kd fc"!) v^>

5

— 2 —

3

HBr

HO OH

H3C ) ( CH3H3C CH3

H2SO4

Br

O, CH3y-(-CH3

H3C CH3

NO2 NO2Cl NaOH .OH

H2SO4 SO3H

Pp^ 9 y.r(Dm^m(Dmii: a t b omo 0 h. 1 OjI

B

COOH

H-

H-

H-

HO-

-OH

-OH

COOH

COOH

-OH

-H

COOH

COOH

H-

H-

•OH

-OH

COOH

HO-

HO-

COOH

-H

-H

COOH

H pH

H OH

H pHX^C02HHO2C

H OH

— 3 —

COOH

OH

H'^^OHCOOH

COOH

OH

HO-^-^HCOOH

COOH

Hy^^OHH'̂ ^OH

COOH

COOHHO^HCOOH

BgiO KToAi 1 oa'<.

1 2 3 4 5

A oO

UHsC^CHa

H. .H,C=C,

H H

0

uHaC^OCHa

0 0

X XHaC^C^CHa

H2

B o0 0

X XHaC^C^CHa

H2

H-CEC-H

0

uHaC"^CHa

0 0

X XHaCC^C^OCHa

H2

P=111 y y/-<lirSS|L^troi41 o»^.

1 %mv 2

Fn112 g#ttg»©±®/iS^«:(cM«^i-5t©(42f4i.2i^ 1 oa-<.

2 Gi^'y/^yR 3 Gs^'y^-':?

5 cr'^^^-yi-

1 Gq^' yy<

4 Na'^y^-r^/V

5 ffFI

Bgi3 ^'y/^yRroffllR^ltfiitKia-rsfSJfirop^), iEtv^(D(4t*4i^s 1 oa-^o

1 ^'y/^yRroyy^ittt.-feyy< hy:t:^yxi4rp^/-«7^ya*T-fir5.

2 N^-g-a»«Ci<4APtt. -®^:l^^/^^'Sy^SS^^:er5<,

3 0 -mi^f-o-yy^smcmz6.

4 y yo#< liTkKlkSti-cv'^i,

5 t h yro y -yyaattTkiift^Sit-c dna t

— 4 —

Fp^i4 ioii-<o

3 MWt. Mm^^Xh^o

5 ^?^CV^AX;@tfeT^ti5itT^ §o

1 TKl/-:J-y:/ 2 =i/U^y—/V 3 lj;Wyh=^y

4 5 "T^nyy^y

— 5 —

&mfm

Fu^16 1 oS'<.

1 ^T'v'y 2 € 3 7^'^'—g

4 t-UT'i/v 5 rs y^yg^-y-i?

Fb^17 Jkffi«Sjafe©A(cjif1

1 77^h*v^is 2 3 7^t-hy'<y9^K

4 ;(;-gy V/^7,7tN-<y^K 5 t'^'5 7K2

B5 18 PenicHliumMl ^ 1 "^S

1 ^y^uy-zl- 2 777h^'yyBi 3 7:/Ud'^'Sx

4 5

Bai9 i|tS«9^l»(cfcfc5trofit*iT-/6>o 1 oS

1 2 3 (^«) <r>m

4 5 ^xsroiei^

Fb^2o i-3ii'<,

1 5feAtth^yy9X-7jm 2 yxxyr 3 H0I®

4 5 T-yyT

6 —

PiS 21 fL/is A/® t'M\ 1

1 K«*ti®ris 2 m&Wiomm s t

4 iSAig* 5

1 2 7iy-/wtt;!K^Sro;y/i'^ct=^ K

5 y®3i/Jfdr-> K

Bg23 1-Dm^.

1 K-ras 2 HB 3 APC 4 src 5 As

BS 24 j lb, tt^iM.ffi'(t;4^-7->'->-^/i'A5g:t>iBiV''®i4ifti'^s 1 o3

1 -K-ftra?g 2 a

4 5 yny

Bg25 ;ii#ffl7k«lcff5±ffiSiE®«^(cB|-r5««Sii®5'^, Si^KSflSiL^toitifivA'

1 oa^o

1 pH 2 DO 3 *:»®ll

4 5 ss (mm^w)

7 —

mm}

Pb^ 26 G ^5^ t ^^mmt t'tif)\ i -om^,

1 rvui-vy^i^mi^ 2 rvy'rvy^2^mi^

3 hy<^yi>2^^i^ 4 12^^#:

5

1

4 yyV1^^(D^^

5 7 5/

WMmk

T-fe:^/v=i y >-

y yyy-Y^)y

y)VT Y^^ui-vy

yzii::^yy y y

M^B

r hp t^y

Tyy p-zw

yyfy % y

-fy^yy

Pb^28 1 oii-<.

1 'bY^WcWt'P 2 3

4 mm 5 mm

Pb^29 TY^ui-vy^ a ^^-ron t'M\ i -om^c

1 yuz^y y u^/U 2 ^zl/-7:^P—zW 3 Tp^/p^zI^

4 f-zl'T'i^^^—zv 5 hT'pp—zl/

— 8 —

PpIso 1051

1 =i:fy^y 2 -fuijyCy 3 V

4 5 'rhy:^4y

Pb^ 31 (COMT) J: «9 ]'y<(Di'^m^m^ir^(Ditt^ti

1 Oil^o

1 2 •^V^))y 3

4 5

Pb^32 TF^i-vyaio^-<,

1 y<yay^,y 2 3 'f'Ty'V F

4 yt:ii-ify<M 5

1 yt2±^F 2 f^^yyy 3 }jy/y"}J/i-

4 5 :^/U^V^F

— 9 —

1 OjI^o

1 yD;^'<vT^K 2 i^yt:"'75:K 3

4 5 fcVViy;&-f^K

Pp135 -fen h^y 5-HT3§:^#:^iiflc:J:!9. 1 oil

1 TT'l^t'yyh 2 3 iyyytKy-:^—h

4 Ky^y Ky 5 y^irhoy

Pp^36 loji

1 2 3 i^hny—/v

4 yx/ny 5 yn i^yy

Pp137 1 oil

1 2 Tny^yy—3 yn^;^i/K

4 y'nn—A 5 yyyy;^—if

PpI 38 iltR^vy n ;^-=3r Vffy---^XC0X)-2 1 Oii-<o

1 ±u=2:^i/zf 2 3 -yynyj^y-y

4 ndryyny^cy 5

— 10 —

Pp^39 1051

1 y/i^i/h-y^ 2 3

4 ^ hyn-^y"—/!✓ 5 ry^>

Pol 40 ^(Dm^m(D 9 ib.

1 03i^„

1 i^tKn^xVy 2 yy:^\i°y 3

4 y^y hr:i ^ h/i^yy y 5 -yy^/uyry

— 11 —

Bg41 glbteftlcM-rSffia® 5 t.,

2 pH;asSV'iii*Ji®®L-^-rv\

5

fSAZ P-^t^'V/^^'a(co^^T^ 1 ol

5

Pb143 3ELV>ro(4i:'JX/!i>o 1 oa

2 ^J-^-l:(4 4000aS4?fc5o

5

F=^44 CYP3A4S:^<K*-f5ft#til4i:*tL7S^ 1

1 2 rf'a-fyjn—iv 3

4 'yzl^i/-y 5

— 12 —

BB45 y CLr SrS-rSt 1 Oj8'<o fcfc*L> GFR »*«»-?>

issff, cLse y T 7 . r ttw®iix¥^ t-rs.

1 CU- = ft) (GFR+CLse) (1-R)

2 CLr = ft) (GFR+CLse) -R

3 CLr = ft) (GFR-ft)+CLse) (1-R)

4 CLr = (GFR-ft) + CLse) (1-R)

5 CLr = GFR-ft)+CLse-R

Fo^ 46 h ^ h+'x/V/iSgjcfi-rsS-g-,

1 -o'M^c

1 a-¥*iifii1'««^FBW«TB«AUCi4it^J1-5o

3 yr7>'^tt-$T-fc5.

4 a-^*(Cj:e,-f^>:|))^«f4-®-eS)5o

5

H47 $47^y;^-^:/xi'a(cii6-oT('^at;6se#5S-a'> 1 Km

i454)7;y7.^V7Vmax(4fl:*{t»f)iSi-fS,

1 S«ii«(cJt6ajLT(+l«)tS^s±;455.

2 SKSISASKm S:*(tat)i«i''45o

3 y T9Vmax/Km

4 Km J: y a®®SdS(gV)tff;lit)SS(4-^iC)fe5.

5 Km:6S*#V)(5i*e^i:*Ki:®«?Ptt:)Si«SV\

— 13 —

F>848 i t>»Pa-^Sro¥i®®eB#FflMRT:i^?>^ftSK)MRT

1 o»'<,

1 2 1 / PliKita^S: 3

4 1 / 5

1 BET ^ 2 Washburn ^ 3 KozenyCarman ^

4 Young S 5 Langmuir

BgSO 2fe©#BStt»lro4'T?, 1 oS

1 bso 2 W-y^V 3 Span20

4 5^t^ 5 -<yy-Vv=i = !yAlg{t;#i

Rgsi ».<r>mnmijm<o<px\

1 y7/yy o—:^:^7yyy^>A 2 3 fyoyn—y

4 5 y'9^;y-fe/H3—

Fb^52 qEi®icj;y*3ajt5^^acm-r5PEffl^9Jttirti:o^o ioig-<„

1 bn-y^jSfiJ 2 ST® 3 4 5 ifM-M

— 14 —

i -om^o

1 2 3 rzn^ K^/i^

4 i/ai y h^/i" 5 if—

Pp^54 \^m\amMcB<Dm^^-r^nmmmmmm\tt'ti^\ ioji-<,

1 :^/<y7./u 2 3 ^y'f=^;^yh

4 :^y<y^y^ 5 7^/<7s^y^

PdI 55 i\^^\^io\^Xi<a.^^yy^yX%\t\^XWiMi\^fc o/w ^:x.-^;vya DDS

i -om^o

1 •ry(^u:fy^±/u 2 y^Ky—A 3 y l:°5/K-^-f y n>;y:iir

4 iryiry^i—h 5

— 15 —

imm •

1 miJ}) ^j-.ik&. 2 i&i-i-IJ <>•t^iSsL& 3

4 5 ifi?tw=y±#

Fp^57 BSffFii?!>i'/v^-^—*—|rov>T, 1

1 HBsfetMroKlt^dSMv^

3 HBe^JSrofflttftli^ HBett#:®^tt-fbro«(cac:.5o

4 HBc—HBe^HBs ©lif

5 HBsiiift:©IH4(i< BaffFI)Se"fJ;OTftfiLft:©®#^E?te-f5,

B958 UttBliTH (CKD) (:i|a-t-5iea©5*>^ 1 ©a-<<,

1 (GFR) vm^ti6Wmm(DlS:Ti^3:^M&.±i^^i-6il^mr-t>6,

3 lflil£©'ff9@Stt 140/90 mmHg 5|?)St"f"5o

5 (NSAIDs) ttWmm^&r'D!) 7.^

©a'<o

1 X D ^2 Tyt'T"?;/—yW 3 y K-^ t°n vy

4 5 •:/oy-Vby>'

— 16 —

^<Dtt}ffii)\ 1 -oM^c

1 ffFJii)®*®<6T

2 (GFR) roffiT

3

4 jh!K4'r/i':^$>iSaroffiT

5 SrtpH©±#

5 yh3y-y-/Kl, »fil::J;5«fettjeSilE(-*a-Cfc5,

62 1 0»-<0

4 5

Fb163 mmru/uif-(Dm!¥x'9im-r6^miit'ti7i\

1 T h f—i4ftjSi<s 2 3

4 a e^&iKtt»jfn.tt®ifiL 5 ^.i.

— 17 —

Rg64 HllSrSISE*<01SHt1

1 2 T/W 3 Tn-r^—g

4 5a-®7C®^ 5 ^

BRSS AIDS i-MI-SiaiiCi 5 ]Et^^©(4^4^^!l^ 1 0)g'<„

1 AIDSli, HIV (t ®S^(CJ;9 CD8IH4Tilfflja«s^'>-r.5i^,ft-Cfe5.

2 HIV(4> WhDr>^'/V;^(r^>aStl-5DNA!>'l'/W;^T-fe5o

3 HTV i:. •r-<X<DXi'^ 1 AIDS Sr^jEt"5o

4 HIVi®§^a#T-(4, •T'f

5

B3 66 i:^r©af£:ciiB-g-a:<0 5%. iELV^®(4if4i,As 1 oi

1 h 7 ;=<. S' •/ MM

2 HER2iaSlM^^s«M:S4^fc?US^

3 T^ji'Tys.zf yyyT/i'y-(rPk&^mtMitV>y<itBikm

4 vy^'y-ry CD2om^O'Bm\t4¥^yy^'yV y^m

5 y/y-ry EGFR A/

Fb^67 L-croH2feS»l4f4xd^o 1

1 Excerpta Medica

2 Index Medicus

3 Annals of Internal Medicine

4 Goodman & Gilman's The Pharmacological Basis of Therapeutics

5 Journal ofAmerican Medical Association

— 18 —

—61—

S#09xa/*0ZBMl'H/TnOOilc—9

S—f

0:a®3S)>0.^E

0—iaawiB®z

0Sh"""98/\Z\B1?rX

VifcI

W5viic,^^<45dvos^dvosoiBy

ez^mx

Btf4KiSvi!|!0)¥»in}^8f

B:^^9'4-i¥X')ai§i(•ifB8mmn^mzwsax

Vise.I89

• $iis • ^9]

B9 71 E«D°DroiKjgi|©fF=r5#J: LT, 1 o9'<,

1

2 (gpsp)

3 EBifis.o'E^s^fproiSittaavfi.Hwaros^i-M-rs*^ (gmp)

4 ESgp'i. EBSa!^p°p, {t;ffliPpS.U'Bit«Srop°p®faro**(:iM1-'5€^ (GQP)

5 is«p°p> Bna^p^p, (gvp)

Bg72 1 oa-<.

1 til:»S«fe4# 2 ±m<Dit'm^ a

4 ^»(rM-r5'FiEfi-^;asfcofc# 5 ffl^«±©JfiJ(c®-a:6>tLfc#

Ba73 EaXkl5®ttif:hz2)^ 1 o3

2 fiKlJifc/cor.

3 i««roEit(cM1-5W»Srfffc-&5E;0%*1-5

4 400Aa±®a«-SrAKS-fr5/cfe®liKS:*-i-.5

5 *tteSS^(DtSK^*-rs

F>a74 1 •:)»-<„

1 -^yu/jU7^:y 2 :^9vy 3 y-tf;v^fK

4 -fel^ify:/ 5 ^y^yW7=p-x—f-

— 20 —

m75 mmmt Lxnm

1 ^:=:>>y^/

4 y y -Xi^y

2 -y- y K

5 y D D

3

Bg76 l-oil-^.

1

4 180 0(J1±®AK

2 4#sij©«#a# 3

5 \s.m&<r)mm^w>i^m

fsn ¥fife23¥g©lRIS«groSt!!S®5^>, &®rol®i*SrIt<^S^UTV^5ffltti:'tt;i)^ 1 o

5

P=178 ©•f 1 og

(%) = [ /

1

4 lS«B8irfc-it5AK®:frfrf

5

— 21 —

] XlOO

F>g79 1

1 %Mm.wm<r)^ 2 ?6»aftisw 3

Pb^SO 3iy5E(;:i6li!i^5'M®5®|igra7'D-fe;^cop|ig)^

ASjELV^®l4ifiXi{i\ 1 oa'<,

2 !gy-»»y§it->fflipo-»5B:tm5£^g«

3 »po^®y§it^5®im3i;^!gy^S«

5 Jgy^«lpo-<-5KtffiSr^®9§|#-.SS

— 22 —

19 81 (cASiiW'tK'ejttiriXiO^ 1 oji-<

IHSiJ. E«p°p<Dtt^-?r®<tll^»:«4^od>$i'5ri:(cj:-3T, | | W|6)±

SVJiitSr^^b^ t>o-CHRro«*''£^iSSr5«S:-r5fc®i-t-6.j

1 HS«tK»g^ 2 3 JSfUff^

4 5

B9 82 1-3®-

1 Befft 2 3

4 s

Ba 83 ^AKtsifiT-y^ B 1 0 c73BRffl|511:i: UTJE 1 oa-

1 1@ 2 2111 3 SHI 4 4111 5 513

B984 #$$aea^ii!*DSro*^Si:7k5/^'l'y 1-^a

4 tfcr^A'Aym 5 jn®ttM5»^I

K 85 (mOsm) (cS:t.ffiV^<lt(4i*ix;is 1 oa-^.

7' 180 t-rso

1 28 2 36 3 180 4 280 5 360

— 23 —

Pp186 1 o5l

1 -20 "CUT 2 2-6 °C 3 10 "Ci^T

4 20-24 5 30 'Ci^T

Pp187 1 Oj|

3 -^4 4 5

88 Tir hT^ y 1 051-<c

1 i^y/V;^7'c2—/W 2 y "yiby

3 iV-Ti?^zVi/;^x-r 4 h^y7/l-^>'yi^~y-hy

5

Pp^89 :dm^i'^(Dnt'M\ ioii-<,

1 2 ^ 3 jfil/Mg 4 filk^ 5 ^jfiL^

1 Ty-x>fx^i^— 2 xx^—7'>';:^ • >^3:/y

5 n

— 24 —