FOSBE 2009FOSBE 200933rdrd Conference on Conference on

Foundations of Systems Foundations of Systems Biology in EngineeringBiology in Engineering

Denver, ColoradoDenver, ColoradoInverness Hotel & Inverness Hotel & Conference CenterConference CenterAugust 9-12, 2009August 9-12, 2009

www.fosbe.orgwww.fosbe.org

OrganizationOrganization Conference chairConference chair

Mike Henson, Department of Chemical Engineering, Mike Henson, Department of Chemical Engineering, UMassUMass

Conference co-chairsConference co-chairs David de Graaf, Vice-President of Biotherapeutics David de Graaf, Vice-President of Biotherapeutics

and Integrative Biology, Boehringer-Ingelheimand Integrative Biology, Boehringer-Ingelheim Hiroaki Kitano, Director of Sony Computer Science Hiroaki Kitano, Director of Sony Computer Science

Laboratories, JapanLaboratories, Japan Linda Petzold, Department of Computer Science, Linda Petzold, Department of Computer Science,

UCSBUCSB Hans Westerhoff, Professor of Systems Biology, The Hans Westerhoff, Professor of Systems Biology, The

University of Manchester, United KingdomUniversity of Manchester, United Kingdom FacilitatorsFacilitators

Kathryn Jurgensen & Robin CravenKathryn Jurgensen & Robin Craven International Program CommitteeInternational Program Committee

Technical Program & Technical Program & SponsorsSponsors

SundaSundayy

MondayMonday TuesdayTuesday WednesdayWednesday

MorninMorningg

TraininTraining g WorkshWorkshopop

Drug Drug DevelopmeDevelopmentnt

Network Network ModelingModeling

Circadian Circadian SystemsSystems

AfternoAfternoonon

TraininTraining g WorkshWorkshopop

Free timeFree time Federal Funding Federal Funding Roundtable Roundtable

Free timeFree time

EveninEveningg

ReceptiReceptionon

Alternative Alternative FuelsFuels

EducationEducation Synthetic Synthetic BiologyBiology

NightNight KeynotKeynotee

Poster Poster Session ISession I

Poster Session IIPoster Session II Award Award Ceremony & Ceremony & BanquetBanquet

Invited SpeakersInvited Speakers Erin O’SheaErin O’Shea, Harvard , Harvard

(Keynote)(Keynote) Adam ArkinAdam Arkin, UC-Berkeley, UC-Berkeley David BalabanDavid Balaban, Amgen, Amgen Bill BentleyBill Bentley, U. Maryland, U. Maryland Frank DoyleFrank Doyle, UC-Santa , UC-Santa

BarbaraBarbara Dan GillespieDan Gillespie, Gillespie , Gillespie

ConsultingConsulting Albert GoldbeterAlbert Goldbeter, U. , U.

Brussels, BelgiumBrussels, Belgium Bruce GomesBruce Gomes, Pfizer, Pfizer Vassily HatzimanikatisVassily Hatzimanikatis, ,

EPFL, SwitzerlandEPFL, Switzerland Erik HerzogErik Herzog, Washington , Washington

U.U.

Ravi IyengarRavi Iyengar, Mount , Mount Sinai Medical SchoolSinai Medical School

Iya KhalilIya Khalil, Gene Network , Gene Network SciencesSciences

Art LanderArt Lander, UC-Irvine, UC-Irvine Doug LauffenburgerDoug Lauffenburger, ,

MITMIT Jim LiaoJim Liao, UC-Los Angeles, UC-Los Angeles Jens NielsenJens Nielsen, Chalmers , Chalmers

U. Technology, SwedenU. Technology, Sweden Bodo SternBodo Stern, Harvard, Harvard Masaru TomitaMasaru Tomita, Keio U., , Keio U.,

JapanJapan Hiroki UedaHiroki Ueda, Kyushu U., , Kyushu U.,

JapanJapan Eberhard VoitEberhard Voit, Georgia , Georgia

TechTech Huimin ZhaoHuimin Zhao, U. Illinois, U. Illinois

Student Training Student Training WorkshopWorkshop

Sunday, August 9, 9:00 am - 5:00 pmSunday, August 9, 9:00 am - 5:00 pm Mathematical Modeling Methodology at Amgen Mathematical Modeling Methodology at Amgen

(David Balaban, Amgen)(David Balaban, Amgen) Network Robustness (Frank Doyle, UCSB )Network Robustness (Frank Doyle, UCSB ) An Example of How Systems Biology is An Example of How Systems Biology is

Contributing to Drug Discovery in the Contributing to Drug Discovery in the Pharmaceutical Setting (Bruce Gomes, Pfizer)Pharmaceutical Setting (Bruce Gomes, Pfizer)

Bioenergetics and Biochemical Network Bioenergetics and Biochemical Network Thermodynamics (Vassily Hatzimanikatis, EPFL)Thermodynamics (Vassily Hatzimanikatis, EPFL)

Circadian Entrainment and Rhythm Generation Circadian Entrainment and Rhythm Generation (Erik Herzog, Washington U and Hiroki Ueda, (Erik Herzog, Washington U and Hiroki Ueda, Kyushu U)Kyushu U)

Stochastic Chemical Kinetics (Dam Gillespie, Stochastic Chemical Kinetics (Dam Gillespie, Gillespie Consulting)Gillespie Consulting)

Parameter Estimation and Structure Identification Parameter Estimation and Structure Identification in Metabolic Networks (Eberhard Voit, Georgia in Metabolic Networks (Eberhard Voit, Georgia Tech)Tech)

FOSBE Founders AwardFOSBE Founders Award Established to recognize exceptional Established to recognize exceptional

contributions to the systems biology fieldcontributions to the systems biology field Award winner was selected by a committee Award winner was selected by a committee

comprised of the five conference co-chairs comprised of the five conference co-chairs of FOSBE 2009 and the two chairs of the of FOSBE 2009 and the two chairs of the previous FOSBE meetingsprevious FOSBE meetings

Prof. Doug Lauffenburger (MIT) was Prof. Doug Lauffenburger (MIT) was selected as the first award winnerselected as the first award winner

Prof. Lauffenburger will be honored at the Prof. Lauffenburger will be honored at the banquet the final night of FOSBE 2009banquet the final night of FOSBE 2009

Inverness HotelInverness Hotel

SponsorsSponsors NSF - $15KNSF - $15K ARO - $10KARO - $10K ICB - $9KICB - $9K Amgen - $5KAmgen - $5K AztraZeneca - $5KAztraZeneca - $5K Boehringer-Boehringer-

Ingelheim - $5KIngelheim - $5K Entelos - $5KEntelos - $5K Pfizer - $2KPfizer - $2K Total - $56KTotal - $56K

Budget SummaryBudget Summary

IncomeIncome 98 registrants98 registrants $56K in sponsorship$56K in sponsorship $20K in expected CACHE revenue$20K in expected CACHE revenue

Unexpected expensesUnexpected expenses $30K food & beverage requirement$30K food & beverage requirement $83K hotel room commitment $83K hotel room commitment Estimated $25K loss from hotelEstimated $25K loss from hotel

Conference expected to lose about Conference expected to lose about $5K$5K