Create Transformative MedicinesTM

FormulationSolutionsCustomized Projects for Your Nanomedicine Development Needs

Accelerate Your Discoveries

You need a formulation partner who tackles your drug delivery challenge as their own.

One who sharesyour determination and commitment fromproof-of-concept R&D through scale-up for clinical success.

Our team of scientists can undertake projects ranging from proof-of-concept, to tech-transfer of the manufacturing process for GMP production.

Start Your Journey

Examples of our Formulation Solutions work packages include:

PNI scientists deliver your custom solution faster and with greater efficiency using our innovative and scalable microfluidics technology.

Our experts have over 100 years of combined experience in developing nanoparticle formulations. Operating from our state-of-the-art, custom-designed facility, projects span the entire nanoparticle formulation development continuum from discovery to clinical formulations.

PARTICLE TYPE ACTIVE INGREDIENT

Nucleic acid Lipid Nanoparticles (LNP)

Liposomes

Polymer NPs

Emulsions

Organic/ Inorganic NPs

• Identify nanoparticle formulations suitable for proof-of-concept and pre-clinical testing

• Support development on the NanoAssemblr Benchtop and Blaze instruments for existing users

• Provide hands-on expertise designing liposomes, lipid nanoparticles, and polymeric nanoparticles

• Facilitate delivery of nucleic acids, peptides, proteins, small molecules and other therapeutics

• Optimize and oversee tech-transfer of the manufacturing process to the NanoAssemblr Scale-Up system and over see technology transfer to cGMP manufacturing site

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We Create Transformative Medicines

Advanced Technology for Advanced Nanomedicines

Spark™ Benchtop Blaze™ Scale-UpLeadCandidates

Optimized Formulations

ClinicalCandidate

ClinicalData

25 - 250 µL

Discovery and Development Preclinical Development Clinical Development

Screen Develop Advance Break GroundRapidly prepare low-volumenanoparticle formulationswith a push of a button

1 - 15 mL

Rationally optimize a widerange of nanomedicineformulations

10 - 1000 mL

Efficiently scale bench formulations for expanded preclinical studies

24L in 4.5 h

cGMP-ready nanomedicine manufacturing

We are committed to a flexible, individualized approach to accelerate your drug delivery and development results.

Utilizing our established NanoAssemblr platform, we develop optimized formulations and process parameters for manufacturing lipid- or polymer-based nanomedicines that meet your target specifications.

NanoAssemblr technology uses microfluidics to reproducibly control process conditions for rapid optimization and seamless scale up of nanomedicine formulations.

The NanoAssemblr® Platform is the only inherently scalable solution designed for all stages of nanomedicine development

Advanced Technology for Advanced Nanomedicines

Specialized, Customer-Focused Approach

We will work side-by-side with your team to identify the optimal drug formulation candidates.

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RNA encapsulation efficiency >95%

siRNA LNPs against FVII or non-targeting (NT) control were administered to CD1 mice by tail vein injection at doses indicated.

Knockdown efficacy maintained between LNPs pro-duced at different stages of development on the Nano-Assemblr platform

RNA lipid nanoparticle formulations optimized and scaled through different stages of development, maintaining size and PDI

In vivo knockdown efficacy maintained through different stages of development

Benchtop BenchtopBlaze BlazeScale-Up Scale-Up

Trusted Globally

About Precision NanoSystemsPrecision NanoSystems Inc. (PNI) creates innovative solutions for the discovery,

development and manufacture of novel nanoparticles for use as medicines

and in medical research. PNI’s proprietary NanoAssemblr Platform enables the

rapid, reproducible, and scalable manufacturing of next-generation nanoparticle

formulations for the targeted delivery of therapeutic and diagnostic agents

to cells and tissues in the body. PNI provides instruments, reagents and services

to life sciences researchers and pharmaceutical companies, and builds

strategic collaborations to revolutionize healthcare through nanotechnology.

Or to learn more about our full line of solutions, visit www.precisionnanosystems.com

Headquarters:50 - 655 West Kent Ave. N.,Vancouver, BC, V6P 6T7Canada

Global Sales:395 Oyster Point Boulevard, Suite 145South San Francisco, CA 94080USA

www.precisionnanosystems.com

The most innovative biopharmaceutical companies and academic research institutes use the NanoAssemblr Platform to accelerate their nanomedicine programs. NanoAssemblr instruments are used in over 20 countries worldwide and supported by a global team of field application scientists.

We have the expertise, flexibility and resources to provide a full range of custom formulation solutions.

Precision NanoSystems scientists apply innovative approaches to advance your drug development needs in an uncomplicated, straightforward process.

Contact our Formulation Solutions Experts:precisionnanosystems.com/services/formulation-solutionsinfo@precision-nano.com1-888-618-0031

For Research Use or Further Manufacturing. Not for direct administration into humans. Copyright © Precision NanoSystems Inc. 2018 All rights reserved. NanoAssemblr® is registered in the U.S. Patent and Trademark Office. Create Transformative Medicines™ is a trademark of Precision NanoSystems Inc.

Document ID: formlnsolns-BR-1118