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Forms of Nimesulide

Nimesuilde is a pain killer NSAIDs drug is the best prescribed drug for treatment of acute pain, Primary

dysmennorhea and also to treat degenerative joint disease.

Nimesulide drug was launched in Italyfor the first time as Aulin and Mesulid in 1985 and is presently

available in more than 50 countries worldwide with different trademarks.

Its multifactorial mode of action gives it a unique and broad action on inflammatory processes.

It has superior gastrointestinal safety as compared to other NSAIDs. It is an analgesic and antipyretic in

action, other than its anti inflammatory action.

Unlike, other NSAIDs, the chemical structure of nimesulide does not contain a carboxylic group but a

sulfonanilide moiety as the acidic group.

Apart from tablet the drug- Nimesulide is also available in various forms such as in the form of Gell,

powder, and suppositories. Its also available in various brand names of Sulide, Nimalox, Nimesil,

Nimulid, Nicip, Nimcap, Nise, Sulidene and Zolan e.t.c.

The Nimulid Transgel a brand from Nimesulide Transdermal Gel is indicated for post-traumatic

inflammation, acute musculoskeletal disorders including sprains, strains, tendinitis, tenosynovitis, low

back pain, periarthritis (shoulder pain) and osteoarthritis (joint pains), stiffness.

As with all drugs, therapy appropriateness when using nimesulide is of outmost importance to safeguard

patients health and guarantee the products therapeutic value.

NImesulide is available in the dosage of 100 mgs for tablets, 100 mg for granules for oral suspension,

200mg for suppositories and 3% of gel. And the prescribed duration to use is for 15 days.

Continuous use of NImesulide may cause cetain side effects like Diarrhea, vomiting, skin rash e.t.c, It

also preffered to use for the age above 12. Women should use the drug with caution during lactation

and it is contraindicated during pregnancy.

It must be used under supervision by a doctor in accordance with the approved indications and in

compliance with the recommendations

The prescription of a drug is appropriate when the benefit it is able to provide to a specific patient

outweigh the risks associated with its use. A careful evaluation of individual risk factors is therefore of

crucial importance.

In practice, a prescription can be considered appropriate when it is in accordance with the approved

indications of a drug in terms of demonstrated efficacy, dosage, and treatment duration.

Nimesulide should only be prescribed as second line treatment. The decision to prescribe nimesulide

should be based on assessment of the individual patients overall risks.

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Nimesulide's therapeutic value in effectively and rapidly controlling inflammation and pain is supported

by significant clinical evidence.

Clinical studies have been carried out in a wide variety of acute inflammatory and painful conditions

with the aim of evaluating the analgesic activity of nimesulide in comparison to placebo and to some of

the most common NSAIDs.

In these studies, it is observed that the efficacy of nimesulide was consistently superior to placebo with

a particularly fast onset of the analgesic in action.

The rapid action shows the immediate relief within the 15 min from the drug intake for the acute pain.

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20. Nimesulide Medicine

Nimesulide drug was launched in Italy for the first time as Aulin and Mesulid in 1985 and is presently

available in more than 50 countries worldwide with different trademarks.

Nimesulide is a relatively COX-2 selective, non-steroidal anti-inflammatory drug (NSAID) with analgesic

and antipyretic properties.

Nimesulide is a prescription non-steroidal anti-inflammatory drug with a multifactorial mode of action

for the treatment of for post-traumatic inflammation, acute musculoskeletal disorders including sprains,

strains, tendinitis, tenosynovitis, low back pain, periarthritis (shoulder pain) and osteoarthritis (joint

pains), stiffness.

It has superior gastrointestinal safety as compared to other NSAIDs.

It is an analgesic and antipyretic in action. Its multifactorial mode of action gives it a unique and broad

action on inflammatory processes.

The maximum duration and dose of a treatment course with Nimesulide medicine is 15 days, 100 mg

twice a day, to minimize the risk of hepatotoxicity.

It undergoes extensive biotransformation.

NImesulide is available in the dosage of 100 mgs for tablets, 100 mg for granules for oral suspension,

200mg for suppositories and 3% of gel. And the prescribed duration to use is for 15 days.

Clinical studies have been carried out in a wide variety of acute inflammatory and painful conditions

with the aim of evaluating the analgesic activity of nimesulide in comparison to placebo and to some of

the most common NSAIDs.

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In these studies, the efficacy of nimesulide was consistently superior to placebo with a particularly fast

onset of the analgesic action.

This rapid onset of analgesic action shows meaningful reductions in pain and inflammation observed

within 15 minutes from drug intake.

Continuous use of NImesulide may cause cetain side effects like Diarrhea, vomiting, skin rash e.t.c, It

also preffered to use for the age above 12. Women should use the drug with caution during lactation

and it is contraindicated during pregnancy.

It must be used under supervision by a doctor in accordance with the approved indications and in

compliance with the recommendations

The prescription of a drug is appropriate when the benefit it is able to provide to a specific patient

outweigh the risks associated with its use. A careful evaluation of individual risk factors is therefore of

crucial importance.

In practice, a prescription can be considered appropriate when it is in accordance with the approved

indications of a drug in terms of demonstrated efficacy, dosage, and treatment duration.

Nimesulide should only be prescribed as second line treatment. The decision to prescribe nimesulide

should be based on assessment of the individual patients overall risks.

Nimesulide's therapeutic value in effectively and rapidly controlling inflammation and pain is supported

by significant clinical evidence.

Food, gender and advanced age have negligible effects on nimesulide pharmacokinetics.

SIDE EFFECTS:

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The use of nimesulide in children under the age of 12 is contraindicated.[citation needed]. Continuous

use of nimesulide (more than 15 days) can cause the following side effects:

Diarrhea

Vomiting

Skin rash

Pruritis

Dizziness

Bitterness in mouth

Women should use the drug with caution during lactation and it is contraindicated during pregnancy.