“Forget Antibodies. Use Aptamers!”. Opportunity for Employer Savings Smoking employee costs the...

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“Forget Antibodies. Use Aptamers!”

Transcript of “Forget Antibodies. Use Aptamers!”. Opportunity for Employer Savings Smoking employee costs the...

Page 1: “Forget Antibodies. Use Aptamers!”. Opportunity for Employer Savings Smoking employee costs the Employer an additional ~$3,000/year 40 Million employees.

“Forget Antibodies. Use Aptamers!”

Page 2: “Forget Antibodies. Use Aptamers!”. Opportunity for Employer Savings Smoking employee costs the Employer an additional ~$3,000/year 40 Million employees.

Opportunity for Employer Savings

Smoking employee costs the Employer an additional ~$3,000/year

40 Million employees work for large self-insured Companies

Page 3: “Forget Antibodies. Use Aptamers!”. Opportunity for Employer Savings Smoking employee costs the Employer an additional ~$3,000/year 40 Million employees.

Opportunity for Life Insurance

Quick Facts for Smoking Individuals:

Life Insurance Premium Increase= 50-65%

Life Insurance Policies = 10 Million annually (USA)

Page 4: “Forget Antibodies. Use Aptamers!”. Opportunity for Employer Savings Smoking employee costs the Employer an additional ~$3,000/year 40 Million employees.

The Problem of Testing for Tobacco Use

Tobacco Use

Nicotine Products

$2Results in minutes

Page 5: “Forget Antibodies. Use Aptamers!”. Opportunity for Employer Savings Smoking employee costs the Employer an additional ~$3,000/year 40 Million employees.

Only anabasine detection available in the market: LC-MS

COST of Assay= ~$100Time = 1 day before Results

Trained Technician & Equipment needed

Anabasine is a definitive marker for Tobacco Use.

Nicotine products are negative for Anabasine.

Page 6: “Forget Antibodies. Use Aptamers!”. Opportunity for Employer Savings Smoking employee costs the Employer an additional ~$3,000/year 40 Million employees.

Apta-basine™Test Strip (Y/N)

The Solution:

Quantify

Short-term Vision

Long-term Vision

Page 7: “Forget Antibodies. Use Aptamers!”. Opportunity for Employer Savings Smoking employee costs the Employer an additional ~$3,000/year 40 Million employees.

Caffeine Theophylline

Apta-beacon™ (GQ-EXPAR)Demonstration Kit (Theophylline/Caffeine)

Selectivity:Distinguish just a few Atoms!

Current PlatformTest Strip

(Lateral Flow Platform)

ReconfigureColorimetric

Page 8: “Forget Antibodies. Use Aptamers!”. Opportunity for Employer Savings Smoking employee costs the Employer an additional ~$3,000/year 40 Million employees.
Page 9: “Forget Antibodies. Use Aptamers!”. Opportunity for Employer Savings Smoking employee costs the Employer an additional ~$3,000/year 40 Million employees.

Apta-basine™ Licensing Strategy

Apta-basine™Test Strip (Y/N)

$2/test X 50 million individuals =$100M Market

Page 10: “Forget Antibodies. Use Aptamers!”. Opportunity for Employer Savings Smoking employee costs the Employer an additional ~$3,000/year 40 Million employees.

“Forget Antibodies. Use Aptamers!”


Utilization of G-Quadruplex-Forming Aptamers for the ...

Utilization of G-Quadruplex-Forming Aptamers for the ...

IN VITRO SELECTION OF RNA APTAMERS THAT SPECIFICALLY …eprints.usm.my/40838/1/Dr.__Siti_Mariam_Mawarni_Ramli_TSTZ.pdf · IN VITRO SELECTION OF RNA APTAMERS THAT SPECIFICALLY BIND

IN VITRO SELECTION OF RNA APTAMERS THAT SPECIFICALLY …eprints.usm.my/40838/1/Dr.__Siti_Mariam_Mawarni_Ramli_TSTZ.pdf · IN VITRO SELECTION OF RNA APTAMERS THAT SPECIFICALLY BIND

Functional DNA Aptamers as Biotherapeutic … DNA aptamers as biotherapeutic molecules ... with high affinity and specificity. ... Modification of aptamer VR11 for in vivo ...

Functional DNA Aptamers as Biotherapeutic … DNA aptamers as biotherapeutic molecules ... with high affinity and specificity. ... Modification of aptamer VR11 for in vivo ...

THERAPEUTIC ANTISENSE AGENTS AND APTAMERS

THERAPEUTIC ANTISENSE AGENTS AND APTAMERS

APPLICATIONS OF APTAMERS IN DRUG DELIVERY SYSTEM

APPLICATIONS OF APTAMERS IN DRUG DELIVERY SYSTEM

A simple colorimetric system for detecting target antigens ... · aptamer binding affinities are similar to those of traditional antibodies, aptamers can exhibit unparalleled target

A simple colorimetric system for detecting target antigens ... · aptamer binding affinities are similar to those of traditional antibodies, aptamers can exhibit unparalleled target

Aptamers as enhancers of oncolytic virus therapy

Aptamers as enhancers of oncolytic virus therapy

Aptamers in oncology: a diagnostic perspective

Aptamers in oncology: a diagnostic perspective

Chapter Aptamers for Targeted Delivery: Current Challenges ...

Chapter Aptamers for Targeted Delivery: Current Challenges ...

Cancer Research Surface-Immobilized Aptamers for …cancerres.aacrjournals.org/content/canres/70/22/9371.full.pdfTumor and Stem Cell Biology Surface-Immobilized Aptamers for Cancer

Cancer Research Surface-Immobilized Aptamers for …cancerres.aacrjournals.org/content/canres/70/22/9371.full.pdfTumor and Stem Cell Biology Surface-Immobilized Aptamers for Cancer

SELECTION OF CELL-INTERNALIZING CIRCULAR DNA APTAMERS

SELECTION OF CELL-INTERNALIZING CIRCULAR DNA APTAMERS

Sonia Da Rochas / Novaptech, biotechnological development of aptamers

Sonia Da Rochas / Novaptech, biotechnological development of aptamers

Antibodies and antigens Antibodies = immunoglobulins Antibodies bind antigens.

Antibodies and antigens Antibodies = immunoglobulins Antibodies bind antigens.

RNA-metabolite interactions (riboswitches). RNA aptamers RNA aptamers are structures that bind specifically to target ligands Many aptamers have been.

RNA-metabolite interactions (riboswitches). RNA aptamers RNA aptamers are structures that bind specifically to target ligands Many aptamers have been.

“Forget Antibodies. Use Aptamers!”. Presentation Contents: 1. Introduction and Background 2. Aptamer Introduction 3. Diagnostic Applications 4. Drug Discovery.

“Forget Antibodies. Use Aptamers!”. Presentation Contents: 1. Introduction and Background 2. Aptamer Introduction 3. Diagnostic Applications 4. Drug Discovery.

Recombinant Antibodies and Aptamers are Viable … Aptamer Poster 2011...The precise specificity and strong affinity of binding that ... modification. Post-SELEX aptamers ... aptamer

Recombinant Antibodies and Aptamers are Viable … Aptamer Poster 2011...The precise specificity and strong affinity of binding that ... modification. Post-SELEX aptamers ... aptamer

Review Generating Cell Targeting Aptamers for ... › v06p1440.pdf · Key words: Aptamers, Cell-SELEX, nanotheranostic, aptamer drug conjugates, DNA network. Introduction The molecular

Review Generating Cell Targeting Aptamers for ... › v06p1440.pdf · Key words: Aptamers, Cell-SELEX, nanotheranostic, aptamer drug conjugates, DNA network. Introduction The molecular

Nucleic acid aptamers

Nucleic acid aptamers

Aptamers: Diagnostic and Therapeutic Applications

Aptamers: Diagnostic and Therapeutic Applications

Fluorescence Enhancing Aptamers in Biosensing Applications...Fluorescence Enhancing Aptamers in Biosensing Applications Volition La, Thorsten Dieckmann University of Waterloo, 200

Fluorescence Enhancing Aptamers in Biosensing Applications...Fluorescence Enhancing Aptamers in Biosensing Applications Volition La, Thorsten Dieckmann University of Waterloo, 200