FOR MEDICAL PROVIDERS | www.PolarityTE.com | www.PolarityTE.com/products/SkinTE Where Self Regenerates Self™

SkinTE is a human cellular and tissue-based product derived from a patient’s own skin to regenerate full-thickness, functionally-polarized skin with all of its layers (epidermis, dermis and hypodermis) and appendages, including hair follicles and glands.

For the autologous homologous treatment of skin tissue1

• Wounds (acute & chronic)• Surgical reconstruction events• Burns (acute, subacute & burn

reconstruction)

• Scar revision• Traumatic injuries• Replacement of skin grafts

or failed flap coverage

For the repair, reconstruction & replacement of full-thickness skin

1. Conditions treated with SkinTE

SkinTE™ – A Simple Product Designed for A ll Types of Providers

Comparing Native Skin to Wound Treated with SkinTE2

The PolarityTE platform technology simplifies regeneration. We are maintaining the correct

cellular niche and employing innate cellular polarity to harness the regenerative capacity of

a patient’s own tissues to create products that deliver full-thickness tissues that function like

native tissue. We are transforming regenerative medicine into what has been envisioned

since its inception. Created by providers for providers and the patients they serve.

POLARITYTE PLATFORM

TECHNOLOGY

Welcome to the SHIFT™

SkinTE is intended to be used by physicians or other appropriate healthcare providers for homologous uses of skin tissues/integument. SkinTE is for autologous use only. Aseptic technique during harvest and deployment of SkinTE is mandatory. POLARITYTE , the POLARITYTE logo, WELCOME TO THE SHIFT, WHERE SELF REGENERATES SELF and SKINTE are all trademarks or registered trademarks of PolarityTE, Inc.

The PolarityTE Real-Time Assistant (RTA) application is a HIPAA-compliant product support tool to facilitate communication between PolarityTE and providers.

SkinTE is available for patients who have functional loss or void of skin/integument systems. SkinTE can be used as an adjunct and/or in place of skin grafting, temporizing skin coverage and/or skin substitute products.

Contact PolarityTE for more information about clinical use of SkinTE. ClinicalOperations@PolarityTE.com or 1-833-631-9954

For more information about reimbursement for SkinTE contact: Reimbursement@PolarityTE.com or 1-800-284-0262

To order SkinTE contact: SkinTE@PolarityTE.com

Access to the product sparking a paradigm shif t 24-Hour Product Support with PolarityTE RTA

Native skin Wound treated with SkinTE

Before treatment Midstage healing aftertreatment with SkinTE

Clinical Use of SkinTE in Refractory Wound3

A AB B

C C

A = Rete Ridge B = Hair Follicle C = Sebaceous Glands/Blood Vessels

1. Provider uses materials from the all-inclusive Harvest Box to take a small, full-thickness skin sample from the patient and return it to PolarityTE in the provided parcel

2. PolarityTE manufactures SkinTE

3. SkinTE is contained within a syringe and is returned to provider in all-inclusive Deployment Box as soon as same day, and typically within 48-72 hours based on providers’ requests

4. Provider applies SkinTE to patient’s wound/defect, covers with dressings and cares for wound/defect similar to standard of care for skin grafts

2. Pre-clinical H&E Histology 3. Actual SkinTE Patient, photo used with permission Where Self Regenerates Self™