fNIRS poster
1
Cortical responses to social auditory and visual stimuli: A functional near-infrared spectroscopy (fNIRS) study. Lucas Peek 1,3 , Thibaud Audevard 2 , Étienne Bisaillon-Sicotte 1,4,5 , Shirin Tabrizi, Manon Maheux 1,2,4 , Pierre Jolicoeur 1,2,4 & Jorge L. Armony 1,2,3,5 1. International Laboratory for Brain, Music, and Sound Research (BRAMS); 2. Department of Psychology, Universite de Montreal; 3. Dept. of Psychiatry, McGill University; 4. Centre de recherche de l’Institut universitaire de gériatrie de Montréal (CRIUGM); 5. Douglas Mental Health University Institute. INTRODUCTION CONCLUSIONS RESULTS Previous fMRI studies have shown that temporal lobe responses to auditory stimuli vary between different types of sounds, such as human language and music, with a stronger response produced in response to language. Likewise, occipital lobe responses to visual stimuli vary between type of visual stimuli, such as human faces and bodies, with a stronger response produced in response to bodies. Similar to fMRI, functional near infrared spectroscopy (fNIRS) measures hemodynamic responses induced by neural activity, but with some advantages over fMRI: • It doesn’t involve electromagnetic fields • It doesn’t require subjects to lie in a restricted environment • The sampling rate of the system can be high (~20-100Hz as compared to ~0.4Hz for fMRI), allowing more sensitive time- resolved measures of the hemodynamic response OBJECTIVES 1. Investigating whether fNIRS is able to replicate previous fMRI findings and whether it can be used to measure reliably and differentiate responses to complex social visual and auditory information. 37 healthy young adults were presented with alternating blocks of auditory (language and music) and visual (bodies and faces) stimuli. Oxy- and deoxygenated cerebral blood concentrations were recorded using a Brainsight-NIRS 32-channel system covering the left temporal and occipital lobes which was set to a sampling rate of 20 Hz. 6 stimuli with an average duration of 1.7 seconds were presented in each block. This amounted to an average block duration of 10 seconds. The experiment consisted of 4 runs of 7 minutes, with each run consisting of 6 blocks of each category and 12 blocks of silence. Light intensity data obtained by the machine was converted to variations in HbO/HbR concentrations using the Beer-Lambert law. Data from 31 participants were further analyzed. Blocks containing movement artifacts were removed. Physiological (adaptive) filtering was applied to the light intensity data and the NIRS signal was band-pass filtered to isolate the hemodynamic response (0.01Hz- 0.1Hz). Resulting data was averaged over a window of -5 to 30 seconds around each stimulus. Several of the channels overlying auditory regions within the temporal lobe captured significant auditory-evoked responses. In the auditory condition, a higher number of channels activated in response to speech compared to music and a stronger response was observed to speech than to music, although the difference did not reach statistical significance. These results are consistent with those previously obtained in fMRI with the same stimuli and confirm the feasibility of using NIRS to investigate temporal and occipital lobe responses to complex social auditory and visual stimuli, respectivley. METHODS [HbO] [HbR] Channel Activations and Changes in [HbO] and [HbR] in Response to Visual and Auditory stimuli Languages Instruments 2 2 2 5 2 6 Languages Instrumen ts Audito ry Visua l Faces Bodies 2 2 22 25 26 0.00E+00 2.00E+09 4.00E+09 6.00E+09 8.00E+09 1.00E+10 Mean Peak [HbO] Language Channels Average [HbO] (mol/L) 22 25 26 -7.00E+09 -6.00E+09 -5.00E+09 -4.00E+09 -3.00E+09 -2.00E+09 -1.00E+09 0.00E+00 Mean Peak [HbR] Language Channels Average [HbR] (mol/L) 8 [HbO] [HbR] 6 7 1 2 Faces Bodies 6 7 12 0.00E+00 2.00E+09 4.00E+09 6.00E+09 8.00E+09 1.00E+10 1.20E+10 Mean Peak [HbO] Faces Bodies Channels Average [HbR] (mol/L) 6 7 12 -6.00E+09 -5.00E+09 -4.00E+09 -3.00E+09 -2.00E+09 -1.00E+09 0.00E+00 Mean Peak [HbR] Faces Bodies Channels Average [HbR] (mol/L)
-
Upload
lucas-peek -
Category
Documents
-
view
78 -
download
2
Transcript of fNIRS poster
Cortical responses to social auditory and visual stimuli: A functional near-infrared spectroscopy
(fNIRS) study.Lucas Peek1,3, Thibaud Audevard2, Étienne Bisaillon-Sicotte1,4,5,
Shirin Tabrizi, Manon Maheux1,2,4, Pierre Jolicoeur1,2,4 & Jorge L. Armony1,2,3,5
1. International Laboratory for Brain, Music, and Sound Research (BRAMS); 2. Department of Psychology, Universite de Montreal; 3. Dept. of Psychiatry, McGill University;
4. Centre de recherche de l’Institut universitaire de gériatrie de Montréal (CRIUGM); 5. Douglas Mental Health University Institute.
INTRODUCTION
CONCLUSIONS
RESULTS
Previous fMRI studies have shown that temporal lobe responses to auditory stimuli vary between different types of sounds, such as human language and music, with a stronger response produced in response to language. Likewise, occipital lobe responses to visual stimuli vary between type of visual stimuli, such as human faces and bodies, with a stronger response produced in response to bodies.
Similar to fMRI, functional near infrared spectroscopy (fNIRS) measures hemodynamic responses induced by neural activity, but with some advantages over fMRI:
• It doesn’t involve electromagnetic fields
• It doesn’t require subjects to lie in a restricted environment
• The sampling rate of the system can be high (~20-100Hz as compared to ~0.4Hz for fMRI), allowing more sensitive time-resolved measures of the hemodynamic response
OBJECTIVES1. Investigating whether fNIRS is able to replicate previous fMRI findings
and whether it can be used to measure reliably and differentiate responses to complex social visual and auditory information.
37 healthy young adults were presented with alternating blocks of auditory (language and music) and visual (bodies and faces) stimuli.
Oxy- and deoxygenated cerebral blood concentrations were recorded using a Brainsight-NIRS 32-channel system covering the left temporal and occipital lobes which was set to a sampling rate of 20 Hz.
6 stimuli with an average duration of 1.7 seconds were presented in each block.
This amounted to an average block duration of 10 seconds. The experiment consisted of 4 runs of 7 minutes, with each run consisting of 6 blocks of each category and 12 blocks of silence.
Light intensity data obtained by the machine was converted to variations in HbO/HbR concentrations using the Beer-Lambert law.
Data from 31 participants were further analyzed. Blocks containing movement artifacts were removed. Physiological (adaptive) filtering was applied to the light intensity data and the NIRS signal was band-pass filtered to isolate the hemodynamic response (0.01Hz-0.1Hz).
Resulting data was averaged over a window of -5 to 30 seconds around each stimulus.
Several of the channels overlying auditory regions within the temporal lobe captured significant auditory-evoked responses.
In the auditory condition, a higher number of channels activated in response to speech compared to music and a stronger response was observed to speech than to music, although the difference did not reach statistical significance.
These results are consistent with those previously obtained in fMRI with the same stimuli and confirm the feasibility of using NIRS to investigate temporal and occipital lobe responses to complex social auditory and visual stimuli, respectivley.
METHODS
[HbO]
[HbR]
Channel Activations and Changes in [HbO] and [HbR] in Response to Visual
and Auditory stimuli
LanguagesInstruments
22 25 26
Languages Instruments
AuditoryVisual
Faces Bodies
22
22 25 260.00E+001.00E+092.00E+093.00E+094.00E+095.00E+096.00E+097.00E+098.00E+099.00E+09
Mean Peak [HbO]
LanguageInstruments
Channels
Aver
age
[HbO
] (m
ol/L
) 22 25 26
-7.00E+09
-6.00E+09
-5.00E+09
-4.00E+09
-3.00E+09
-2.00E+09
-1.00E+09
0.00E+00
Mean Peak [HbR]
LanguageInstruments
Channels
Aver
age
[HbR
] (m
ol/L
)
8
[HbO]
[HbR]
6 7 12FacesBodies
6 7 120.00E+00
2.00E+09
4.00E+09
6.00E+09
8.00E+09
1.00E+10
1.20E+10
Mean Peak [HbO]
Faces
Bodies
Channels
Ave
rage
[HbR
] (m
ol/L
) 6 7 12
-6.00E+09
-5.00E+09
-4.00E+09
-3.00E+09
-2.00E+09
-1.00E+09
0.00E+00
Mean Peak [HbR]
FacesBodies
Channels
Ave
rage
[HbR
] (m
ol/L
)
