fMRI you can use

What we offer

• Synthesis of Neuroimaging and Behavior in Real Time– The greatest level of detail about brain function

technologically available

• Fully detailed reports provided by NNI are based on the 5 year collection of qualified, comparative data

• Assessment of a broad coverage of cognitive functions with minimal testing

• Minimal scan time: Each protocol only 4 minutes

• Compatible with both 1.5T and 3T scanners

• Cost effective, convenient, easy to use

NNI Research and Development

Valid and Reliable Data

Concept

Concept

NNI Research and Development

The myriad ways in which fMRI studies can vary from center to center has complicated the standardization of methods across sites. Little standardization currently exists.

Despite the potential for developing representative norms for clinical application, no such datasets exist.

--Brown, 2007

fMRI you can use

NNI provides working solutions to the major challenges of making fMRI clinically viable

6 Protocols

Cover a full range of cognitive functions(See Attachment A)

NNI Protocols

Assesses abstract problem solving ability

f-MRT

Matrix

Reasoning

NNI Protocols

Assesses cognitive set shifting, cognitive processing speed, attention, sequencing, mental flexibility, and visual search

f-TMT

Trail

Making

Assesses object recognition and language production

f-PNT

Picture

Naming

Assesses long-term memory processingf-FMT

Face

Memory

Assesses short-term memory processing

f-VMT

Verbal

Memory

Assesses a broad range of executive and linguistic functions

f-VFT

Verbal

Fluency

NNI

fMRI

Analysis

Neurology

Radiology

Neuropsychology

Enhanced

Assessment

Benefits of NNI fMRI Analysis

Case Study 1 : f-VFT (Hypoactivation)

Letter Fluency TaskNormal Subject

Letter Fluency TaskPatient with MTBI Normal Subject MTBI Patient

Case Study 2 : f-FMT (Discernable Activation)

Case Study 3 : f-MRT (Alternate Patterns of Disrupted Activation)

Patient 1 Patient 2

Sex F F

Age 26 22

Years of education 16 14

Time since injury (months) 24 10

Coma Scale 14 Not reported

Loss Of Consciousness (minutes) <30 <5

Post Traumatic Amnesia (hours)AnterogradeRetrograde

1224

8None

RBANS Total scale score (percentile) 89 (23) 94 (34)

Matrix Reasoning subtest WAIS-IIIRaw Score (Age

Percentile)

10/24 (7) 9/24 (6)

RCPM raw score (*z-score) 32/36 (-2.32) 33/36 (-1.52)

f-MRT performance (z-score)Accuracy Mean Reaction Time (ms)

92% (-1.92)4807 (-1.07)

96% (-0.61)5842 (-1.93)

Patient 1• Superior/Middle Frontal Gyri• Medial SMA• Frontal Pole• Inferior Frontal Gyrus

Patient 2• Superior Parietal Lobe• Basal Ganglia

Case Study 3 : f-MRT (Alternate Patterns of Disrupted Activation)

See Page 9 in Information Packet

Case Studies

See Information Packet p.5

Other examples include Hyperactivation and Compensatory Activation

70555: fMRI by physician/radiologist

- in conjunction with -

96020: functional brain mapping by neuropsychologist

Billing

What you get from NNI

• Fully detailed statistical reports including functional images (Attachment B & C)

Comprehensive Statistical Reports

Image Reports: 3D and Axial Slices

What you get from NNI

• Fully detailed statistical reports including functional images (Attachment B & C)

• Return on Investment• Competitive Advantage• Minimize Scanner Idle Time• Customer Service• Extra Value – custom protocols including

pre-surgical functional mapping• We can help you implement fMRI in

other areas

• Enhanced Patient Care• Accommodate neuropsychology

patient demand• Synthesis of Neuroimaging and

Behavior• Clarification of Diagnosis and

Prescription of Treatment• Patients get answers unavailable

elsewhere• Evaluate treatment effectiveness (i.e.

Rehabilitation therapies)• Monitor/track treatment outcomes

Most importantly…

fMRI you can use