First Aid Haematology

8/16/2019 First Aid Haematology

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FIRST AID HAEMATOLOGY

1. Professional APCs??

2. Clock face chromatin distribution seen in? 3. CD stand for ?4. Universal recipient ?? 5. Majority of circulating lymphocytes are??6. Vit K def---- dec synthesis of???7. Dec ESR? Causes 8. Clopidogrel and tiopidine blocks?9. Basophils stippling seen in?

10. Oval cells are seen in? 11. In asplenia what bodies are found? 12. Iron def anemia manifests to which syndrome? 13. HBH genes --- deletion of how many genes? 14. Beta thalassemia is due to which type of mutation ? 15. Lead inhibits??16. Treatment of lead poisoning in kids?? 17. Inc homocysteine but normal methylmalonic acid andhypersegmented neutros ??18. Finding in intravascular hemolysis? 19. Pancytopenia ? Feature?20. Cause of aplastic anemia ?21. Hemolytic anemia following oxidative stress ?22. PNH impaired synthesis of which gene?23. Sickle cell anemia point mutation of which amino acid? 24. Osteomyelitis in sickle cell anemia?? Agent?25, erythroblastosis fetalis is due to which immunoglobulin?

26. Common cause of macroangiopathic anemia is ??27. CLL is associated with which autoimmune hemolyticanemia? 28. Treatment of sickle cell anemia? 29. Tea colored urine is seen in which condition? 30. Glanzman thrombosthenia Defect in?



31. Hemophilia defect in which coagulation pathway? 32. TTP --- deficiency of? 33. Causes of DIC? 34. Most common cause of inherited hypercoagubility? 35. Inc risk of thrombotic skin necrosis with hemorrhagefollowing administration of warfarin ? What is the deficiency? 36. In DIC what blood component should we give? 35. Cryoprecipitate contain??? 36. Hodgkin lymphoma has which characteristic cells ? 37. Inc WBC count with left shift and inc leukocyte alkalinephosphatase? What is this reaction?

38. Which Hodgkin lymphoma has excellent prognosis? 39. Starry sky appearance scene on which lymphoma?40. Most malignant gammopathy??? 41. t(11;14) associated with which lymphoma ?41. Waldenströms macroglobulinemia is associated with withwhich IG?42. CLL differs from SLL in having ??43. Philadelphia chromosome is seen in? 44. Vitamin is given as treatment of which malignancy? 45. Name the chromosome translocation which is responsiveto vitamin A ?46. Birbeck granules seen in ? 47. Teardrop cell seen in? 48. In polycythemia Vera which type of mutation seen ?49. Inappropriate absolute polycythemia is associated withwhich disease?50. Patient on heparin what we have to follow? 52. Warfarin toxicity is corrected by? 53. Methotrexate toxicity is reversible by which drug? 54. Drug used for childhood tumors ?55. Hemorrhagic cystitis is caused by? 56. Drug used in breast cancer and is an endometrialantagonist ??



57. Name the drug used in treatment of cml?58. Name the drug used is glioblastoma multiforme ?59. Side effects of cisplatin and Carboplatin??60. Paclitaxel hyper stabilize polymerized microtubles inwhich phase ? 61. Thrombolytic toxicity is treated with ?62. A patient on warfarin what will be his follow up? 63. Histocytosis expresses which CD?64. Burkitt lymphoma is due to activation of which activation?? And mention it's translocation? 65. Most common gammopathy? 66. Burkitt lymphoma is endemic form in Africa have which

lesion? 67. Most common adult NHL?68. Reed stern Berg cells are which CD+??? 69. Constitutional signs and symptoms? Hodgkin/ nonHodgkin lymphoma 70. Defect in platelet plug formation ---- increase whatparameter? 71. Treatment of hereditary Spehrocytosis ?72. Name the tapeworm causing b12 deficiency ?73. Chipmunk facies are seen in ??74. Cooleys anemia??? 75. Heinz bodies seen in? 76. Helmet cells seen in? 77. Delta granules of platelets secrete?78. Factor VIII is produced by?79. Multiple myeloma is a neoplasm of whic cell ? 80. Mast cell stabilizer ?81. APC cells perform their function via? 82. Universal donor? 83. B blood group person what have on Rbc surface andwhat in plasma?84. Master of iron regulatory hormone ? 85. Most common cause of anemia in malignancy?



86. Alcohol is toxic to which organelle ? 87. Form of glutamate for synthesis for folic acid is absorbedin jejunum ??88. Thymidylate synthase irreversible inhibited by ??? 89. Most common cause of vit B 12 def? 90. Most common cause of macrocytosis?? 91. Car scratch disease ? Agent92. Smudge cells are seen in ? 93. Blood antibodies are natural antibodies synthesize in ----after birth? 94. Burr cells seen in?? 95. Sickle cell disease is protective against which disease?

96. Job syndrome is associated with inc of which IG? 97. Dec LAP score is seen in which blood malignancy ? 98. Numerous auer rod cells are seen in ? 99. Painless lymphadenopathy occur almost in all leukemiaexcept? 100. Hereditary spherocytosis is which type of Mendeliandisorder? 101. Most sensitive blood cells to radiation exposure are? 102. Gum infiltration is seen in which leukemia? 103. Protozoa causing eosinophilia ??? 104. Free vit B12 binds to R binder which is synthesized in? 105. Only leukemia with thromocytosis? 106. Most common cause of pyridoxine def? 107. Marker for folate or vit b12 def? 108. Aplastic crisis is due to which agent? 109. Heterophile antibodies are which Ig antibodies ? 110. Cns and testicle involvement ? Which malignancy ? 111. Common causes of death in multiple myeloma? 112. Most common cause of qualitative platelet defect? 113. Most sensitive screen for DIC? 114. Most common pathogen transmitted by transfusion ?? 115. If factor IX is not available , what is next best choice ?



116. DIC is stimulated by ? 117. Intrinsic and extrinsic pathways converge at ?? 118. Bence jones proteins are derivatives from ? 119. Splenic infarction commonly occurs in ? 120. AIHA is which type of hypersensitivity reaction? 121. Iron is stored in the form of ?122. Best indicator of iron stores is? 123. HB binds with ---- In blood?124. t(11;22) translocation??? 125. Cell surface marks of macrophage ?

KEYS1. Dendritic cell 2. Plasma cells3. Cluster of differentiation4. AB5. T cells 6. 2,7,9,10 protein c and s

7. Causes? Polycythemia , sickle cell anemia , CCF, 8. ADP Receptor 9. Thalassemia, iron def, lead poisoning , ACD10. Megaloblastic anemia 11. Howell jolly bodies 12. Plummer Vinson syndrome 13. 3 gene deletion 14. Point mutation15. Ferrochelatase + ALA dehydratase16. Succimer 17. Megaloblastic due to folate deficiency 18. Dec haptoglobin, inc LDH, hemoglobinuria19. Severe anemia, neutropenia and thrombocytopenia 20. Failure or destruction of myeloid stem 21. G6PD def



22. mutant PIGA gene 23. L Glutamic aid with valine 24. Salmonella paratyphi25, IgG26. Prosthetic heart valves 27. Cold agglutinin (IGM)28. Hydroxy urea and BMT29. Porphyria cutanea tarda30. GP IIb/IIIa 31. Intrinsic pathway32. ADAMTS 1333. Sepsis, trauma, obstetric complication, malignancy

34. Factor V ladien disease 35. Protein c and s 36. FFP35. Factor VIII and factor XIII36. Reed-Sternberg cells 37. Leukemoid reaction 38. Lymphocyte predominant 39. Burkitts lymphoma 40. Multiple myeloma41. Mantle cell lymphoma 41. IGM 42. ? inc peripheral blood lymphocytesis 43. CML44. AML45. t(15:17)46. Histiocytosis X47. Myelofibrosia48. JAK2 mutation49. RCC , wilms tumor 50. APTT52. vit k and FFP53. leucovorin54. Dactynomycin



55. Cyclophosphamide 56. Raloxifene57. Imatinib mesylate58. Nitrosourase59. Nephrotoxicity and acoustic nerve damage 60. M PHASE 61. Aminocaproic acid 62. PT, APTT, INR 63. CD1 64. t(8;14) c myc activation 65. Monoclonal gammopathy of undermined significance 66. Jaw lesion

67. Diffuse large B cell lymphoma 68. CD15+ And CD 30+69. Hodgkin lymphoma70. Bleeding time71. Splenectomy 72. Diphylobothrium latum73. Beta thalassemia major 74. Thalassemia major 75. G6PD76. DIC,TTP HUS, traumatic hemolysis77. Serotonin, ADP, Ca (SAC)78. endothelial cell 79. Plasma cell 80. Coromonyl sodium81. MHC II82. O83. Antigen on Rbc surface and A antibody in serum 84. Hepcidin 85. ? ACD 86. Mitochondria 87. Monoglutamate88. 5 florouracil89. Pernicious anemia



90. Alcohol access91. -- Bartonela henslae92. CLL 93. Payer patches 94. CRF ( dec EPO)95. Plasmodium falciparum 96. IgE97. CML98. Acute premyeolitic leukoemia ----M399. Hairy cell leukemia .100. Autosomal dominant 101. Lymphocyte

102. Acute monocytic leukemia 103. Dientamoeba fragilis 104. Salivary glands 105. CML106. INH 107. Hypersegmented neutrophils 108. Parvo virus 109. IGM 110. ALL111. Sepsis and renal failure112. Aspirin113. D dimer 114. CMV 115. FFP116. Thromboplastin117. Activator X118. Gamma globulins119. CML120. Type 2121. ferritin 122. Serum ferritin 123. Haptoglobin



124. Ewing sarcoma 125. CD14

REGARDS DR NOOR UL BASAR

First Aid Haematology

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