Figure 22-99 Molecular Biology of the Cell (© Garland Science 2008)

Figure 22-80 Molecular Biology of the Cell (© Garland Science 2008)

Figure 22-102b Molecular Biology of the Cell (© Garland Science 2008)

Figure 22-102a Molecular Biology of the Cell (© Garland Science 2008)

Growthcone

•  Growthconepropulsion:protrusion,engorgementandconsolida6on

•  Growthconemo6lityandprotrusionoftheleadingedgemembranedependonthedynamicproper6esofac6n

Growthcone

•  Growthconepropulsion:protrusion,engorgementandconsolida6on

•  Growthconemo6lityandprotrusionoftheleadingedgemembranedependonthedynamicproper6esofac6n

Figure 16-34b Molecular Biology of the Cell (© Garland Science 2008)

Figure 16-34c Molecular Biology of the Cell (© Garland Science 2008)

Figure 16-49a Molecular Biology of the Cell (© Garland Science 2008)

Figure 16-51 Molecular Biology of the Cell (© Garland Science 2008)

Figure 16-87 Molecular Biology of the Cell (© Garland Science 2008)

Figure 16-90 Molecular Biology of the Cell (© Garland Science 2008)

Figure 16-91 Molecular Biology of the Cell (© Garland Science 2008)

Figure 16-92a–c Molecular Biology of the Cell (© Garland Science 2008)

Figure 16-92d Molecular Biology of the Cell (© Garland Science 2008)

Figure 16-93 Molecular Biology of the Cell (© Garland Science 2008)

Aplysiacalifornica

APCAM(NCAM)

Figure 19-20 Molecular Biology of the Cell (© Garland Science 2008)

Figure 22-102a Molecular Biology of the Cell (© Garland Science 2008)

Figure 22-102b Molecular Biology of the Cell (© Garland Science 2008)

Axonalguidance

•  Unc6,codesforthehomologofnetrin•  Unc40,codesforitstransmembranereceptor–homologDCC

•  Localizedac6va6onofDCCbynetrinleadstoopeningofaspecializedclassofionchannels(Ca++)intheplasmamembrane–TRCP

•  Noncommissuralneuronsintheneuraltube,lackingDCC,arenotaKractedtothefloorplate

•  Unc5(Unc5H),adifferentnetrinreceptorac6velyrepelledbythefloorplateandsendtheiraxonsinsteadtowardtheroofplate.

MTsinvolvedinthelocaliza6onofSrcfamilyofproteins

Environmentalcuesthedirectgrowthcone

•  ‐Adhesivemoleculesliketransmembranecelladhesionmolecules(CAMs)

•  Complexextracellularmatrix(ECM)likelamininandfibronec6n.

•  An6‐adhesivesurface‐boundmoleculessuchasslits,ephrinsandchondroi6nsulphateproteoglycans

•  Diffusiblechemotropiccuessuchasnetrinsandsemaphorins

•  MorphogenssuchasWnt,sonichedgehog(SHH)andbonemorphogene6cprotein(BMP)

•  Growthorneurotrophicfactorssuchasbrain‐derivedneurotrophicfactor(BDNF),andneurotransmiKers

Figure 16-90 Molecular Biology of the Cell (© Garland Science 2008)

Figure 16-98b Molecular Biology of the Cell (© Garland Science 2008)

Figure 22-103 Molecular Biology of the Cell (© Garland Science 2008)

Figure 16-98a Molecular Biology of the Cell (© Garland Science 2008)

Figure 16-98b Molecular Biology of the Cell (© Garland Science 2008)