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INCI :

Pseudozyma Epicola/Apricot Kernel Oil/Olive Fruit Oil/Sunflower Seed Oil/Sweet Almond Oil/(Angelica Gigas/Lithospermum Erythorhizon) Root Extract Ferment

Extract Filtrate

Origin of Shiunko

Lithospermum Erythrorhizon

City Features

Manufacturing process Application

Lithospermum Erythrorhizon, commonly called red-root gromwell and redroot lithospermum, is a plant species in the genus

Lithospermum.

Country of origin

Harvest season

China HunanAbundant Sun,

Long frostless period,

Enough water

Boost circulationSkin conditioningJuly

TraditionalManufacturing technique

Shiunko

Deoxyshikonin , β,β-dimethylacrylshikonin , isobutylshikonin , shikonin , 5,8-dihydroxy-2-(1-methoxy-4-methyl-3-pentenyl)-1,4-naphthalenedione, β-sitosterol and a mixture of two caffeic acid esters

*Shikonin and its derivatives(acetylshikonin, isobutyroylshikonin) are the key active chemicals in Shiunko.

Main compounds of Shiunko

What is Shikonin?

Shikonin is a naturally occurring active chemical found in the root of Lithospermum erythrorhizon and used as a Chinese herb. The compound is a naphthoquinone derivative and has been shown to have anti-inflammatory and anti-tumor properties, as well as alter chemokine expression and function. Angiogenesis studies have shown that Shikonin can inhibit proliferation and migration of endothelial cells, block integrin αvβ3 expression, and inhibit B16 melanoma- and tumor necrosis factor-alpha-inuced angiogenesis.

Reference : https://www.scbt.com/scbt/ko/product/shikonin-517-89-5

Dig the root up

Dry the root under the sun

Pour the plant oil on dried root and heat to get efficacy and color.

Pack the Siunko oil for market

Fermentation processing on Shiunko oil for better texture

“FERMENTOIL is ready!!”

Manufacturing process

Purification Centrifugation

Fermentation

LABIO’s Fermentation

Inoculation

Fermentoil Normal oil

Manufacturing process

The development of Fermentoil series aimed to the better feeling with the better efficacy, when comparing to the conventional oil.

Effect of Shiunko

Proliferation rate of fibroblast cells

(Synergistic effect)Whitening effect

Control α-MSH Kojic acid 0.01 0.05 0.1

Melaningenesis is inhibited 15% with 0.1% of fermentoil shiunko extractReference : A Study of the Effect of Shiunko, a Traditional Chinese Herbal Medicine, on Fibroblasts

and Its Implication on Wound Healing Processes. Adv Wound Care (New Rochelle). 2013 Oct; 2(8):

448–455.

History of Shiunko

Beauty item of ancestors

Donguibogam: Principles and Practice of Eastern Medicine

Boiled Shiunko roots and Angelica root works on hemostatic, pain relief, Skin regeneration, athlete’s foot, burn and Frostbite.

Hanbang Medical consultation

Shiunko roots can be used topical Burn or Chronic skin disease.

Ueiguajungjong : Consultation of general surgery

It has been named as ‘Jaungo’ by ‘Hanaoka seisu’, who is a Japanese surgeon recorded in the book from Chinese ‘Meong’ dynasty.

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