Feed worldd3hip0cp28w2tg.cloudfront.net/uploads/2016-12/nutrition...•Cosucra’s Fibruline®:...
Transcript of Feed worldd3hip0cp28w2tg.cloudfront.net/uploads/2016-12/nutrition...•Cosucra’s Fibruline®:...
![Page 1: Feed worldd3hip0cp28w2tg.cloudfront.net/uploads/2016-12/nutrition...•Cosucra’s Fibruline®: prebiotic; stimulation of gut bacteria -> metabolites e.g. acetate, propionate & butyrate](https://reader035.fdocuments.us/reader035/viewer/2022081620/611c7507c066d4654a164cb4/html5/thumbnails/1.jpg)
Copyright Cosucra 1
Feed
your
world
dr Loek Pijls
for Cosucra
![Page 2: Feed worldd3hip0cp28w2tg.cloudfront.net/uploads/2016-12/nutrition...•Cosucra’s Fibruline®: prebiotic; stimulation of gut bacteria -> metabolites e.g. acetate, propionate & butyrate](https://reader035.fdocuments.us/reader035/viewer/2022081620/611c7507c066d4654a164cb4/html5/thumbnails/2.jpg)
Copyright Cosucra 2
![Page 3: Feed worldd3hip0cp28w2tg.cloudfront.net/uploads/2016-12/nutrition...•Cosucra’s Fibruline®: prebiotic; stimulation of gut bacteria -> metabolites e.g. acetate, propionate & butyrate](https://reader035.fdocuments.us/reader035/viewer/2022081620/611c7507c066d4654a164cb4/html5/thumbnails/3.jpg)
Copyright Cosucra
Nice to meet
3
https://www.youtube.com/watch?v=Wrxxv_8rL1I&list=PL-UqyRlowYJwfQCN5fMIy-VEanGbzeJYC
![Page 4: Feed worldd3hip0cp28w2tg.cloudfront.net/uploads/2016-12/nutrition...•Cosucra’s Fibruline®: prebiotic; stimulation of gut bacteria -> metabolites e.g. acetate, propionate & butyrate](https://reader035.fdocuments.us/reader035/viewer/2022081620/611c7507c066d4654a164cb4/html5/thumbnails/4.jpg)
Copyright Cosucra 4
“Ask not (only) what your
microbes can do for you,
but (also) what you can do
for your microbes”
![Page 5: Feed worldd3hip0cp28w2tg.cloudfront.net/uploads/2016-12/nutrition...•Cosucra’s Fibruline®: prebiotic; stimulation of gut bacteria -> metabolites e.g. acetate, propionate & butyrate](https://reader035.fdocuments.us/reader035/viewer/2022081620/611c7507c066d4654a164cb4/html5/thumbnails/5.jpg)
Copyright Cosucra 5
Feed
your
world
![Page 6: Feed worldd3hip0cp28w2tg.cloudfront.net/uploads/2016-12/nutrition...•Cosucra’s Fibruline®: prebiotic; stimulation of gut bacteria -> metabolites e.g. acetate, propionate & butyrate](https://reader035.fdocuments.us/reader035/viewer/2022081620/611c7507c066d4654a164cb4/html5/thumbnails/6.jpg)
• We eat
• Left-overs small-intestine -> enter large-intestine
• Dinner for microbes in large intestine
• Their metabolites:
• change colonic “weather”
• impact colonic cells - barrier
• are absorbed into & impact whole body
23/11/2016 6
WHAT ARE WE LOOKING AT?
![Page 7: Feed worldd3hip0cp28w2tg.cloudfront.net/uploads/2016-12/nutrition...•Cosucra’s Fibruline®: prebiotic; stimulation of gut bacteria -> metabolites e.g. acetate, propionate & butyrate](https://reader035.fdocuments.us/reader035/viewer/2022081620/611c7507c066d4654a164cb4/html5/thumbnails/7.jpg)
Copyright Cosucra 7
![Page 8: Feed worldd3hip0cp28w2tg.cloudfront.net/uploads/2016-12/nutrition...•Cosucra’s Fibruline®: prebiotic; stimulation of gut bacteria -> metabolites e.g. acetate, propionate & butyrate](https://reader035.fdocuments.us/reader035/viewer/2022081620/611c7507c066d4654a164cb4/html5/thumbnails/8.jpg)
Copyright Cosucra 8
What are wheat AXOS?
AXOS = Arabino-Xylo-Oligo-Saccharides
From wheat bran - naturally sourced
Chain of xylose, substituted by arabinose &
containing ferulic acid units: anti-ox, anti-
inflammatory
![Page 9: Feed worldd3hip0cp28w2tg.cloudfront.net/uploads/2016-12/nutrition...•Cosucra’s Fibruline®: prebiotic; stimulation of gut bacteria -> metabolites e.g. acetate, propionate & butyrate](https://reader035.fdocuments.us/reader035/viewer/2022081620/611c7507c066d4654a164cb4/html5/thumbnails/9.jpg)
Copyright Cosucra 9 17 17
![Page 10: Feed worldd3hip0cp28w2tg.cloudfront.net/uploads/2016-12/nutrition...•Cosucra’s Fibruline®: prebiotic; stimulation of gut bacteria -> metabolites e.g. acetate, propionate & butyrate](https://reader035.fdocuments.us/reader035/viewer/2022081620/611c7507c066d4654a164cb4/html5/thumbnails/10.jpg)
Origin of Fibruline chicory inulin & oligofructose
Fibruline® (inulin) & Fibrulose® (oligofructose): soluble fibres, gently extracted from the root of chicory (Cichorium intybus L.).
16%
7%
3%
Water
Inulin/oligofructose
Pulp
Other soluble matter
74%
Our chicories are locally grown in Belgium and North of France
We supply our farmers with our chicory seeds (Chicoline), and ensure good agricultural
practices
![Page 11: Feed worldd3hip0cp28w2tg.cloudfront.net/uploads/2016-12/nutrition...•Cosucra’s Fibruline®: prebiotic; stimulation of gut bacteria -> metabolites e.g. acetate, propionate & butyrate](https://reader035.fdocuments.us/reader035/viewer/2022081620/611c7507c066d4654a164cb4/html5/thumbnails/11.jpg)
Copyright Cosucra 11 11
What is chicory inulin? What is chicory inulin? What is chicory inulin?
• Linear chain of fructose units
• Feed for chicory leaves, blossom, fruit &
seeds - like breast milk for a baby
• Most well-established prebiotic
![Page 12: Feed worldd3hip0cp28w2tg.cloudfront.net/uploads/2016-12/nutrition...•Cosucra’s Fibruline®: prebiotic; stimulation of gut bacteria -> metabolites e.g. acetate, propionate & butyrate](https://reader035.fdocuments.us/reader035/viewer/2022081620/611c7507c066d4654a164cb4/html5/thumbnails/12.jpg)
Copyright Cosucra
From Belgium
12
![Page 13: Feed worldd3hip0cp28w2tg.cloudfront.net/uploads/2016-12/nutrition...•Cosucra’s Fibruline®: prebiotic; stimulation of gut bacteria -> metabolites e.g. acetate, propionate & butyrate](https://reader035.fdocuments.us/reader035/viewer/2022081620/611c7507c066d4654a164cb4/html5/thumbnails/13.jpg)
Inulin & oligofructose in Europe
Spelt & poppy seed yogurt Danone, Austria 2016 Contains oligofructose
Source: Mintel -GNPD Wholegrain breakfast cereals Kellogg’s, Ireland 2016 Contains inulin as source of fibre
![Page 14: Feed worldd3hip0cp28w2tg.cloudfront.net/uploads/2016-12/nutrition...•Cosucra’s Fibruline®: prebiotic; stimulation of gut bacteria -> metabolites e.g. acetate, propionate & butyrate](https://reader035.fdocuments.us/reader035/viewer/2022081620/611c7507c066d4654a164cb4/html5/thumbnails/14.jpg)
Copyright Cosucra 15 13
Chicory inulin & AXOS
![Page 15: Feed worldd3hip0cp28w2tg.cloudfront.net/uploads/2016-12/nutrition...•Cosucra’s Fibruline®: prebiotic; stimulation of gut bacteria -> metabolites e.g. acetate, propionate & butyrate](https://reader035.fdocuments.us/reader035/viewer/2022081620/611c7507c066d4654a164cb4/html5/thumbnails/15.jpg)
ProDigest VIB Bio-incubator Gent | Technologiepark 4
B-9052 GENT (Belgium)
tel. +32(0) 9/241.11.90 | fax. +32(0) 9/241.11.91
Part 1 • Bacterial faecal samples of three male Gent students • Incubation in “simulated large intestine” • Evaluate the effect of (5 g/L): Inulin: Fibruline Instant AXOS: arabinoxylan-oligosaccharide-enriched
compound, from wheat arabinoxylan Control: colon medium
Sampling at 0, 24 & 48 h Endpoints: pH Gas production Short-chain fatty acid
Part 2 Effects of metabolite mix on colonic cells • Permeability • Viability • Immune markers
SHIME: IN-VITRO SIMULATOR HUMAN INTESTINAL MICROBIAL ECOSYSTEM
![Page 16: Feed worldd3hip0cp28w2tg.cloudfront.net/uploads/2016-12/nutrition...•Cosucra’s Fibruline®: prebiotic; stimulation of gut bacteria -> metabolites e.g. acetate, propionate & butyrate](https://reader035.fdocuments.us/reader035/viewer/2022081620/611c7507c066d4654a164cb4/html5/thumbnails/16.jpg)
23/11/2016 18
PH
![Page 17: Feed worldd3hip0cp28w2tg.cloudfront.net/uploads/2016-12/nutrition...•Cosucra’s Fibruline®: prebiotic; stimulation of gut bacteria -> metabolites e.g. acetate, propionate & butyrate](https://reader035.fdocuments.us/reader035/viewer/2022081620/611c7507c066d4654a164cb4/html5/thumbnails/17.jpg)
23/11/2016 20
GAS
![Page 18: Feed worldd3hip0cp28w2tg.cloudfront.net/uploads/2016-12/nutrition...•Cosucra’s Fibruline®: prebiotic; stimulation of gut bacteria -> metabolites e.g. acetate, propionate & butyrate](https://reader035.fdocuments.us/reader035/viewer/2022081620/611c7507c066d4654a164cb4/html5/thumbnails/18.jpg)
23/11/2016 22
ACETATE
![Page 19: Feed worldd3hip0cp28w2tg.cloudfront.net/uploads/2016-12/nutrition...•Cosucra’s Fibruline®: prebiotic; stimulation of gut bacteria -> metabolites e.g. acetate, propionate & butyrate](https://reader035.fdocuments.us/reader035/viewer/2022081620/611c7507c066d4654a164cb4/html5/thumbnails/19.jpg)
30/06/2016 24
PROPIONATE
![Page 20: Feed worldd3hip0cp28w2tg.cloudfront.net/uploads/2016-12/nutrition...•Cosucra’s Fibruline®: prebiotic; stimulation of gut bacteria -> metabolites e.g. acetate, propionate & butyrate](https://reader035.fdocuments.us/reader035/viewer/2022081620/611c7507c066d4654a164cb4/html5/thumbnails/20.jpg)
23/11/2016 26
BUTYRATE
![Page 21: Feed worldd3hip0cp28w2tg.cloudfront.net/uploads/2016-12/nutrition...•Cosucra’s Fibruline®: prebiotic; stimulation of gut bacteria -> metabolites e.g. acetate, propionate & butyrate](https://reader035.fdocuments.us/reader035/viewer/2022081620/611c7507c066d4654a164cb4/html5/thumbnails/21.jpg)
23/11/2016 27
Barrier integrity (TEER)
Inflammation (cytokines & chemokines)
Macrophages - THP1-B
Colonocytes - Caco-2
Lipopolysaccharide from E. coli
Intestinal lumen
Blood stream
MODEL INFLAMMATORY BOWEL DISEASE
↓ incubation mix with metabolites
![Page 22: Feed worldd3hip0cp28w2tg.cloudfront.net/uploads/2016-12/nutrition...•Cosucra’s Fibruline®: prebiotic; stimulation of gut bacteria -> metabolites e.g. acetate, propionate & butyrate](https://reader035.fdocuments.us/reader035/viewer/2022081620/611c7507c066d4654a164cb4/html5/thumbnails/22.jpg)
23/11/2016 29
EFFECTS ON COLONOCYTES
![Page 23: Feed worldd3hip0cp28w2tg.cloudfront.net/uploads/2016-12/nutrition...•Cosucra’s Fibruline®: prebiotic; stimulation of gut bacteria -> metabolites e.g. acetate, propionate & butyrate](https://reader035.fdocuments.us/reader035/viewer/2022081620/611c7507c066d4654a164cb4/html5/thumbnails/23.jpg)
23/11/2016 31
IMMUNE MARKERS
![Page 24: Feed worldd3hip0cp28w2tg.cloudfront.net/uploads/2016-12/nutrition...•Cosucra’s Fibruline®: prebiotic; stimulation of gut bacteria -> metabolites e.g. acetate, propionate & butyrate](https://reader035.fdocuments.us/reader035/viewer/2022081620/611c7507c066d4654a164cb4/html5/thumbnails/24.jpg)
23/11/2016 33
PRINCIPAL COMPONENT ANALYSIS: 5 -> 2
Inulin
Ctrl
Na-Butyrate
BNC
Axos
![Page 25: Feed worldd3hip0cp28w2tg.cloudfront.net/uploads/2016-12/nutrition...•Cosucra’s Fibruline®: prebiotic; stimulation of gut bacteria -> metabolites e.g. acetate, propionate & butyrate](https://reader035.fdocuments.us/reader035/viewer/2022081620/611c7507c066d4654a164cb4/html5/thumbnails/25.jpg)
23/11/2016 35
•Cosucra’s Fibruline®: prebiotic; stimulation of
gut bacteria -> metabolites e.g. acetate,
propionate & butyrate
•Impacted markers of immunity/inflammation &
improve intestinal gut barrier function.
•May moderate leaky gut resulting from e.g.
food intolerances, allergies, Crohn disease
![Page 26: Feed worldd3hip0cp28w2tg.cloudfront.net/uploads/2016-12/nutrition...•Cosucra’s Fibruline®: prebiotic; stimulation of gut bacteria -> metabolites e.g. acetate, propionate & butyrate](https://reader035.fdocuments.us/reader035/viewer/2022081620/611c7507c066d4654a164cb4/html5/thumbnails/26.jpg)
Copyright Cosucra 46
![Page 27: Feed worldd3hip0cp28w2tg.cloudfront.net/uploads/2016-12/nutrition...•Cosucra’s Fibruline®: prebiotic; stimulation of gut bacteria -> metabolites e.g. acetate, propionate & butyrate](https://reader035.fdocuments.us/reader035/viewer/2022081620/611c7507c066d4654a164cb4/html5/thumbnails/27.jpg)
Copyright Cosucra 47 17 17