Feasibility, safety, adherence, and efficacy of high ... · RESULTS – Exercise Adherence...
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Feasibility, safety, adherence, and efficacy of high intensity
interval training in a hospital-‐ini8ated rehabilita8on
program for pa8ents with coronary heart disease
Jenna Taylor
Exercise Physiologist & Dietitian – The Wesley Hospital
PhD Candidate – The University of Queensland
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Cardiorespiratory Fitness and Survival
VO2 = > 22ml/kg/min
VO2 = 15-‐22ml/kg/min
VO2 = < 15ml/kg/min For every 1ml/kg/min
increase in fitness, survival
improved by 9%
Kavanagh, T., et al., Prediction of long-term prognosis in 12 169 men referred for cardiac rehabilitation. Circulation, 2002. 106(6): p. 666.
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High intensity Interval Training (HIIT) increased cardiorespiratory fitness
compared to moderate intensity con8nuous training (MICT)
é 6ml/kg/min é 2.7ml/kg/min
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HIIT increases VO2peak by 19.4% compared to moderate intensity 10.9%
Weston, Wisloff and Coombes, BriOsh Journal of Sports Medicine, Published Online First: [ 23 Oct, 2013]
Equivalent to ~ 10-20% reduction in risk of death over 8 years
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RATIONALE RELEVANCE TO REAL WORLD
Maximal exercise tesOng not rouOnely conducted à No Peak HR data
Cardiac medicaOons can affect HR
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AIM
To compare High Intensity Interval Training (HIIT) with
Moderate Intensity Con8nuous Training (MICT) in paOents with
Coronary Artery Disease (CAD) compleOng a hospital-‐based
cardiac rehabilitaOon program, using subjec8ve measures of
exercise intensity:
Primary outcome = cardiorespiratory fitness (VO2peak) a_er 4 weeks
Secondary outcomes = feasibility, safety, and exercise adherence
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Stage 3 9 months Maintenance Program
> 3 x home-based sessions No routine support
Stage Timeframe Weekly Exercise Training Level of support
Stage 1 1 month Hospital Cardiac Rehab Program
= 2 x supervised sessions
+ 1 home-based session
Supervised exercise
classes
Stage 2 2 months Home-based Program
> 3 x home-based sessions
Routine support
METHODS
• The FITR Heart Study
• Single centre randomised controlled trial (The Wesley Hospital)
• HIIT (intervenOon) vs MICT (usual care)
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METHODS
Recruitment
• Recruited paOents with angiographically proven coronary artery disease
• Commencing hospital-‐based cardiac rehabilitaOon
• Includes MI, Stent, CABG, Medical
• Main exclusion criteria = ContraindicaOons to Maximal Exercise TesOng
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Absolute Exclusion Criteria
• < 4 weeks following ACS or CABG
• <3 weeks following PCI
• ObstrucOve le_ main artery disease
• Unstable angina
• Uncontrolled cardiac arrhythmia
• Acute endocardiOs, myocardiOs or pericardiOs
• Moderate to severe aorOc stenosis
• Decompensated heart failure
• Acute pulmonary embolism, or deep vein
thrombosis
• AorOc dissecOon
• Higher degree heart block
• Hypertrophic obstrucOve cardiomyopathy
• Recent stroke or transient ischemic afack
• Uncontrolled diabetes
• Acute or chronic renal failure
• Pulmonary fibrosis or intersOOal disease
• Severe neuropathy
Screening Process
• Angiographically proven CAD
• < 80 years old
• Screened by study medical advisor
for eligibility
• TreaOng cardiologist informed of
their paOent’s parOcipaOon, with
opportunity to exclude
involvement
• Baseline maximal exercise test
supervised by medical doctor.
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Baseline
TesOng
METHODS Cardiorespiratory Fitness (VO2peak)
EFFICACY
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Exercise
Training
METHODS MICT HIIT
Frequency 3 sessions per week
(2 supervised + 1 home-‐based)
Warm-‐up 3min RPE < 11 3min RPE < 11
1 min RPE 11-‐13
Exercise
Intensity
34min moderate
intensity at RPE
11-‐13
4 x 4 min high intensity
intervals at RPE 15-‐18
interspersed with 3min
recovery at RPE 11-‐13
Warm-‐down 3min RPE < 11 3min RPE < 11
DuraOon 40 minutes 32 minutes
RPE = Ra8ng of Perceived Exer8on
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Cool down
4:00 3:00 3:00 3:00 3:00
4:00 4:00 4:00 4:00
Warm up 3 minute active recovery at RPE 11-13
(Fairly light to Somewhat hard)
4 x 4 minutes at RPE 15-18 (Hard to Very Hard) Various exercise machines
HIIT Protocol
32 mins/session
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Follow-‐Up
TesOng
METHODS FEASIBILITY ParOcipants and Staff
• QuesOonnaires for quanOtaOve + qualitaOve data
EXERCISE ADHERENCE
Measured as:
1. CompleOon of exercise sessions
2. Ability to achieve prescribed intensity & duraOon
Measured from
• Supervised exercise records
• Self-‐report weekly exercise training records
SAFETY
• Type, incidence and severity of adverse events.
• Grade 1: Mild; Grade 2: Moderate; Grade 3: Severe;
Grade 4: Life-‐threatening; and Grade 5: Death
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METHODS
Follow-‐Up
TesOng
TIME POINTS
• 5 Weeks
• 13 Weeks
• 6 Months
• 12 Months
STATISTICAL ANALYSIS
One-‐way ANCOVA
Independent Samples Kruskal-‐Wallis Test
Independent Sample T-‐Test
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RESULTS – Inclusion/Exclusion
Pa8ents with CAD
Approached
N = 290
Referred to Cardiac Rehab
N = 406
Par8cipants Recruited
N = 96
Par8cipants Randomised
N = 93
PaOents Declined
N = 178
ParOcipants Excluded for
posiOve stress test
N = 3
PaOents Excluded
N = 16 Reasons included:
• No significant CAD • Severe pulmonary disease (n=1)
• Orthopaedic limitaOon (n=1)
• Planned operaOon (n=1)
• New PPM inserOon (n = 2)
• CKD < stage 3 (n=2) • Unstable arrhythmia (n=2)
• Embolism risk (n=2)
• Cardiologist declined (n=3)
PaOents with no CAD
(i.e. valve or PPM only)
N = 116
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RESULTS – Baseline Par8cipant Characteris8cs HIIT (n= 47) MICT (n= 46) p value
Age (years) 65 + 7 65 + 8 >0.05
VO2peak (ml/kg/min) 27.7 + 6.0 27.4 + 7.3 >0.05
BMI (kg/m2) 28.0 + 4.0 29.0 + 4.0 >0.05
Males 39 39 >0.05
Females 7 8 >0.05
Cardiac event / interven8on (n)
CABG 15 10 >0.05
PCI/Stent 23 24 >0.05
Medical 8 13 >0.05
Acute coronary syndrome 9 14 >0.05
Other risk factors (n)
Diabetes 2 7 >0.05
Smoking 1 2 >0.05
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RESULTS – Baseline
Medica8ons HIIT (%) MICT (%) p value
B-‐Adrenergic blockers 40 41 >0.05
StaOns 98 93 >0.05
ACE inhibitor 19 37 >0.05
Angiotensin II receptor blockers 34 35 >0.05
Calcium channel blockers 4 15 >0.05
AnOplatelet agents
• Aspirin 96 91 >0.05
• Other 53 59 >0.05
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RESULTS – 5 weeks
26
27
28
29
30
31
32
33
34
35
Baseline Week 5
VO2 m
l/kg/m
in
Cardiorespiratory Fitness (VO2Peak)
HIIT (n=43)
MICT (n=43)
Group
p = >0.05
2.9
1.1
HIIT = +2.9 + 3.5 ml/kg/min; MICT = 1.1 + 0.0 ml/kg/min
Group
p = 0.012
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RESULTS – Feasibility (Par8cipants)
0
1
2
3
4
5
6
7
8
9
10
Confidence in
Exercise Protocol
Ease of
Instruc8ons
Ability to
Manage Intensity
Enjoyment of
Exercise
HIIT (n=43)
MICT (n=43)
Score on 7-‐Point Likert Scale
Feelings about Exercise Protocol
Sta8s8cal Test = Non-‐Parametric
Independent Samples Kruskal-‐Wallis Test
Group
p = 0.032
Group
p = 0.933
Group
p = 0.412
Group
p = 0.335
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RESULTS – Feasibility (Staff)
0
1
2
3
4
5
6
7
8
Confidence in delivery
of protocol
Pa8ent acceptance
of protocol
Pa8ent's ability to
manage intensity
Work associated with
monitoring
HIIT (n=43)
MICT (n=43)
Score on 5-‐Point Likert Scale
Comparison of Exercise Protocol
Sta8s8cal Test = Non-‐Parametric
Independent Samples Kruskal-‐Wallis Test
Group
p = 0.147
Group
p = 0.382
Group
p = 0.336 Group
p = 0.562
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RESULTS – Feasibility (Staff)
Feasibility of HIIT Number of Staff
Is HIIT feasible (n=6):
• Definitely feasible
• Some-‐what feasible
• Not feasible
4
2
0
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RESULTS – Safety Serious Adverse Events – life-‐threatening OR requiring hospitalisaOon
• None related to exercise intervenOon
Reported symptoms Severity HIIT (n) MICT (n)
FaOgue Grade 2
Moderate
2 3
Soreness (muscle/joint/feet) Grade 2
Moderate
5 3
Shortness of breath Grade 2
Moderate
1 1
Angina pain (chest/throat) Grade 2
Moderate
1 2
Feeling light-‐headed Grade 2
Moderate
3 2
Total 12 11
Mild or moderate symptoms with exercise
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RESULTS – Exercise Adherence
Sta8s8cal Test = Independent Sample T Test
Adherence to intensity & dura8on HIIT (n=43) MICT (n=43) p value
Adherence to exercise protocol 84 + 19 90 + 19 0.094
Average Training RPE 16 + 1 12 + 1 0.000
Peak Training RPE 17 + 2 13 + 1 0.000
Average Training %HRpeak 90 + 7 74 + 8 0.000
Peak Training %HRpeak 95 + 7 77 + 8 0.000
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RESULTS – Exercise Adherence
Sta8s8cal Test = Independent Sample T Test
Comple8on of exercise sessions HIIT (n=43) MICT (n=43) p value
CompleOon of sessions (%) 91 + 14 90 + 19 0.918
Average sessions per week 3 + 1 4 + 2 0.010
Total exercise minutes per week 125 + 59 222 + 146 0.000
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SIGNIFICANCE / INNOVATION
Our RPE-‐based HIIT protocol:
• Overcomes the limitaOons of HR-‐based HIIT protocols
• Allows for conOnual progression of workload
• Can be applied to various exercise modes (TM, bike, rower, cross-‐trainer)
• Can be implemented in cardiac rehab classes alongside MICT
• Allows for a broader range of exercise goals to be achieved
• Fosters independence with regards to managing exercise intensity
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CONCLUSIONS
HIIT improved cardiorespiratory fitness by almost 3-‐fold compared to MICT
HIIT was equally feasible and safe compared to MICT
Exercise adherence was high in both groups
HIIT is more Ome efficient for improving fitness
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FUTURE DIRECTIONS • The FITR Heart Study -‐ 12 Month Follow-‐Up
• Incorporate HIIT into Australian Cardiac Rehab Guidelines
• Offer guidance to clinicians around HIIT implementaOon
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ACKNOWLEDGMENTS
TEAM – University of Queensland • Dr David Holland, MBBS, PhD
• Dr Shelley KeaOng, PhD
• Dr Michael Leverif, PhD
• Professor Jeff Coombes, PhD
FUNDING
• Wesley Medical Research
• NHMRC Postgraduate Scholarship
Wesley Hospital Cardiac Rehabilita8on