FART •E H . WEISS, M. 0 .57 South Street

Natick, MA 01760(508) 653-2625

PRESENT TITLES

Senior Pulmonary Research Scientist, Jan . 1940AND ADDRESSES :

Department of Anesthesia Research LaboratoriesBrigham and Women' s Hospital75 Francis StreetBoston, MA 02115(617) 732-0879

Visiting Professor of Anesthesia, June 1990Harvard Medical School25 Shattuck St .Boston, MA 02115

PERSONAL INFORMATION Date of Birth : November 23, 1932Citizenship :

AmericanSocial Security No . : 026 24-2372Marital Status : Married, December 2, 1953 to

Ruth Lithwick, RegisteredPhysical Therapist andOccupational Therapist

Children :

1 daughter Ilana - 19671 son Joshua - 1969

Military.

Selective Service No . :19 23 32 966Captain, V .S. Air ForceReserves, 19th MedicalDivision, Serial No . FV3Q63241Otis Air Force Base, Cape Cod,Massachusetts, HonorableDischarge, October 1970

EDUCATION ANDTRAINING :

Northeastern UniversityBoston, MADegree : Biology-Chemistry (With Honors) B .S .

9/51-fi/55

Massachusetts Institute of TechnologyCambridge, MADecree : Biochemistry

MS .9/55-fi/57

Albert Einstein College of MedicineNew York, NYDeq. . :

M.D.9/57-5/G1

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EDUCATION ANDTRAINING :

President-elect, Massachusetts ThoracicSociety

5J74-5176

Director, niWi.sioa of Respiratory DiseasesSaint Vincent Hospital, Inc .Worcester, MA 01644

7/71-11189

Associate Professor e~ MedicineUniversity of Massachusetts Medical 5chav1Worcester, MA 8145

9J71-x/'37

i

Tuberculosis ConsultantMassachusetts Department of Public HealthDirector, Regional. Inpatient Tuberculosis ServiceWorcester, MA

4/72-

Visiting Professor of MedicineUniversity of Gaudalajsra Medial School

Worcester, MA

4/'7$

Presi3ent, Massachusetts. Thoracic Society b175-8/ 78

Gaudalajara, Jalisco, Mexico 1973,

Associate Professor of MedicineTufts University School of MedicineHasten, MA

1977, 1981

9/69-7/70

Associate Physician, Tufts Medical ServiceBoston city HospitalBoston, NA 7/67-5/73

physician-in-Charge, Pulmonary Function,Physiology Section, Central Arterial SloadLaboratory and Respiratory Intensive CareUnitTufts Lung Station, Boston City HospitalBoston, MA 765-6l71

Consultant in PhysiologyNorfolk County SanatoriumSouth Braintree, MA 7/66-7J69

Consultant, FDA Advisory Panel :Pulmonary Devices ClassificationScientific Evaluation 11!75-9177

Associate Professor of Life SciencesWorcester Polytechnic Institute

RESEARCHEXPERIENCE :

GraduateSchool- -First isolation andcharacterizat1&n of as enzyme from hog renal cortexresponsible far oxidation of alpha-hydroxy acids to

keto acids .Massachusetts Institute of TechnologyCambridge, MA 195-195?

Medical School- -Three years in project concernedwith the effect of thyroid hormone upon thematuration of rat cerebral cortex as measured bybehavioral patterns, enzyme alteration and oxygenconsumption.Albert Einstein College of MedicineNew York, NY }.958-1961

MEDICAL SOCIETIES :

Ma Rsachusetts Medial Sac.ietyMassachusetts Thoracic SocietyAmerican Federation for Clinical ResearchAmerican Thoracic SocietyAmerican Association far the Advancement of ScienceAmerican Medical AssociationAffiliate, Royal Society of Medicine, London

Earle B. Weiss, M .D .Page 4,

EDUCATION AN1}TRAINING : Professor of Medicine

University of Massachusetts Medical SchoolWorcester, MA

American Thoracic SocietyRepresentative Councillor

2J77-

5179

Lecturer in MedicineTufts University Scboal of MedicineBoston, MA 8/81-

Associate Medical DirectorSaint Vincent Hospital, Inc .Worcester, MA 4184-7/85

Acting Medical directorSaint Vincent Hospital, Ina .Worcester, MA 785-6J87

Editor, Pulmonary SectionPractical Cardiology 4/85-b187

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Earle B, Weiss, M .D .Page 6 .

PUALICATIONS :

Weiss, E .BB and Dulfana, J .J . : The QuantitativeAcid Base Dynamics in Chronic Pulmonary Disease :Defense of pH During Acute Respiratory AcidosisSuperimposed Upon Chronic Hypercapnia . Annals ofInternal Medicine 59l 2 :263, August, 1968 .

Chadosh, S ., Weiss, E .B . and Segal, MS : ChronicBronchitis (Book Chapter) . Current nia oasis,1968 & 1970 .

Weiss, E .B ., Chodosh, 5 . and Segal, M1S . : ChronicDfuse Emphysema (Book Chapter ) . CurrentDiagnosis, 1968 .

Weiss, E .B ., and Falinq, L .J . : ClinicalSignificance of PaCO2 During Status Asthma : TheCros;'Dver Point . Annals of Allergy 26J_1 :545,QOctober, 1986 .

Weiss E .B ., Faling, L .J ., Brooks, S .M., Mintz, S .,Chodosh, S . and legal, MS . : Bronchial Asthma :Current Concepts in Pathophysiology and Managementof the Patient with Advanced end Status. Asthma(Book Chapter) . Modern Treatment 612 :Z7a . Forth,1969 .

Weiss, E .B ., Faliag, 1.3,., Brooks, S., Mints, S .,Chodosh, S . and Segal, M . S . : Acute RespiratoryFailure in Chronic Obstructive Pulmonary Disuse--Pathaphysialogy and Treatment . Disease of theMonth f Monagraph), October and Nauember, 1969 .

Falinq, L .J ., Weiss, E .B ., Chodosh, S . and Segal,M . S . : The Preoperative Management of Patients withBranchial Asthma . Hahnnerman Symposium, p . 108,1969 .

Weiss, E .B ., Cohen, M .L . arid Monaco, M.D . :Successful Management of Pneumocystis Carinii andNocardia Asteroids is a Regal Transplant Patient ..American Journal of Medicine 50 :269, 1971 .

Segal, M .S . and Weiss, E .B . : Rectal AminophyllineBlood Levels with Concentrated Solutions . Annalsof Allergy 2g :13 5 , 19?1 .

Earle B . Weiss, M .D .Fuge 7 .

PiTBLICATIaNS :

saeiss, ~ .H . anal De sforge s, J . : OxyhemoglobinAffinity in Chronic Gr andulamatosis (Sarcoidasis)and Fibrosis. American Review of RespiratoryDisease 104 :694 . 1971 .

CCohere, M.LL and Weiss r E.B . : Pneumocystis CariniiPneumonia : Percutaneous Lung Biopsy and Review ofLiterature . Chest fiQ :195-199, ].971 .

Weiss, E.H ., Mintz S . and Brooks, S . : HraehvdilatarEffects After Individual Combined and ProlongedDosing in Patients with Hronehlal.Asthma. Journalof Laboratory and Clinical Investigation, February,1972 .

Weiss, E.B ., et al : Z`he Radiographic features ofEarly Chronic Bronchitis . American College ofChest Physicians International Symposium, 1971,(Abstract) .

Weiss, E .B ., Mint, S . and. Brooks, S . : The Effectof So-Cabled Inert Propellants on the AirwayResistance of Asthmatic Patient . American Reviewof Respiratory Disease 1O5 :643, 1972 .

Weiss, E .B, and Charlson, C .J . : Record of Breathsounds . American Review of Respiratory Disease105 :835, 1972 .

Weiss E .H. and Desfvrges, +1, : Oxyhemaq.lobinAffinity in Bronchial Asthma: Chronic Stable StateAcute and Status Aathzaaticus. Chest fi2 :7Q3, 1972 .

Weiss, E .B . : Sacteriacidal Action of ozone :Application to Respiratory Streilizatioa. AmericasCollege of Chest Physicians International symposium(Abstract), 1971 .

Weiss, E .B . : In pursuit of Pneumocystis Carinii .Cheat (Editorial) b4 :547, 1373 .

Weiss, E.B ., Syndex L .M. and Fartier N : The Effectof Propranolol and Calcium on Human Erythrocytes .15th International Society of Hematalogg,Jerusalem, Israel, (Abstract), September, 1974 .

Earle e . Weiss, M.n .Page 8 .

PV3LI CATIONS :

Weiss, E.B ., Andersen, W .H. and o'Brian , K.P . :Effect of Lidocaine on Trachealis smooth muscle,In-Vitro (Abstract) . Clinical Research 23 :353A,1975 .

Weiss, E .H ., Anderson, WH. and o'Brian, IC.P . : TheEffect of a Local Anesthetic, Lidocaine, on GuineaPig Trachealis Muscle In-Vitro . American Review o+Respiratory Disease l.lZ :303, 1975 .

Weiss, E .B . and Cugell, D .W . : Introductioa toBreath Sounds (Audio Cassette) . American Collegeof Chest Physicians, 1975 .

Weiss, E .S . (Guest Editor) : Branchial. Asthma . GIAClinical Symposia, 1975, Summit, New Jersey .

Weiss, E .H . and Saga],, M.5 . : Bronchial Asthma :Mechantsms and Thera eutics . Sastoa, L tt7.e, 8rawr_and C~mpany, July, 1976 , Textbook I,4aQ pages .

Weiss, E .3 . and Patwardhan, A .V . : The Response toLidocaine in Branchial Asthma . . Chest ?2 :4Z9, 1977 .

Haigrdves, W .A . and Weiss, E.S. : Effect o~Histamine on the Lenglnt-tensioa Properties ofGuinea Pig Trachealis Muscle . RespiratoryPhysiology 199 :111, 1977 .

weissI E .B . : The Inhibitory Action of Lidocaine inAnaphylaxis American Review of Respiratory Disease}.7 :859, 1978 .

General Chairman, Statute Asthmaticus Symposium,sponsored by The Massachusetts Thoracic Society,Boston, June 3, 1977 .

Weiss, E .B . (Ed.) : Status Asthmaticus . Haltincre,University Park Press r 197$, from Bcstoi Symposium,1977 .

Weiss, LB . : CIBA Collection, Bronchial Asthma imthe Respiratory System by Dr . F . Natter C 1978publication).

Weiss, E . H . et al : Effect of Propranolol on Norssa1Human Erythrocytes . Journal of Laboratory andClinical Medicines 89 :4, 1977 .

Earle H . Weiss, M.D .Page 9 .

PUBLICATIONS :

Weiss, E.B . and Viswanath, S .G . : CalciumHypersensitivity in Airway Smooth Muscle : IsometricTension Responses Following Anaphlaxis .Respiration 3$ :26fi-272, 1979 .

Weiss, E.B . : Effect of Anaphylactic MediatorsAeetycholine and B'adrenergic Blockage Upon CalciumHypersensitivity in Airway Smooth Muc1e(Abstract) American Review of Respiratory Disease121 :%4, 101, April, 1980 .

Janower, M .L, and Weiss, E.B . : Mycoplasma, Viraland Rickettsial Pneumonias . Seminars isRoentgenology 15, * }., 25-34, January , 198D .

Faling, L .J . and Weiss, LB . : Comparison of AcuteSmoke Inhalation In Hon-Firemen and in Firemen.(Abstract) American Review of Respiratory nisease19 :4, 111, April, 1979 .

Weiss, E .S . : The Mechanism of Lidocaine Contractionand Relaxation in Resting Tracheal Smooth. Muscle .(Abstract) American Review of Respiratory Disease121:#4, 102, April, 1980 .

Pathwardhar:, LV ., Kendall, R .L . and Weiss, E .B . :Prophylactic Post-operative Tracheal Intubation inChronic Obstructive Airways Disease . (Abstract)American Review of Respiratory Disease 1Z1 :~4 1 1?4,April, 1980 .

Weiss E .H . and Markawicz, J . : Inhibition o~Anaphylaxis is Airways Smooth Muscle by the CalciumChannel Drugs verapamil and Nifedipine . (Abstract)American review of Reapiratary disease 323 :4,April, 1981 .

Raheja, A .K. and Weiss E .H . : The Si gAificance ofFever in Acute Exacerbations of Chronic ObstructiveAirways Disease . ~Abstract) American Review ofRespiratory Disease 123 :~4, April, 19R1 .

Weiss, E . B . , Mg='kowicZ, J . and Harbera, L . : Effectof Calcium Antagonists is Experimer~tal Asthma..Allergy 37 :513, 198 .

Weiss, E .B . and Sarberv, L . : Calcium Homestasis inAsthma. Chest 83 :834, 19fl3 .

Earle B . Weiss, M .D .Page 10 .

PUBLICATIONS :

Weiss, E . B . and Mullick, P .C . : Leukotriene Effectin Airways Smooth Muscle : Calcium Dependency andVerapamil. Inhibition . Prostaglandins, Leukotrienesand Medicine 12 .53-b6, i983 .

Weiss, E .B . : Clubbing . In H Kowaloff (Eds .), AnIntroduction to Clinical Medicine . I991 •

Weiss, E.B., Segal, M.S . and Stein, M . (Eds .) :Branchial Asthma : Mechanisms and Therapeutics, 2ndEdition . Boston : 1 . Status Asthmaticus 2 . Caleumand its Role in the Asthma Process .

Weiss, E.B . : Leukotriene-Associated Toxic OxygenMetabolies Induced Airways Hyperreactivity. Chest83 :709-716, 1386 .

Weiss, E .B . : Toxic Oxygen Product Alter CalciumHernevstatis is an Asthma Model . Journal of Allergyand Clinical Immunology 75 :692-697, 1985 .We iss, E .H . and Sellinc r J . R . : Superoxide AnionGeneration During Airway Anaphylaxis . Fnt . Arch .Allergy and Applied Immunology 80 :r2, Z11-213,1986 .

Weiss, E.BB and Bellina, F .R . : Intesactioa ofLeukotriene D, and Superaxidre Amos InduceAirways Hyperreactivity. (Abstract) AmericanReview of Respiratory tiaease 131 :A2, 1985 .

Weiss , E .B . : Airways Hyperreactivity Induced byInteraction of LTA, and Superoxide Anion .(Abstract) XIY Interasthma Congress 196, ngers,France .

Weiss, E .B ., et . aL : Isolation andCbaracterization Qf Guinea-pig Tracheal SmoothCells that Retain Differentiated Function is Long-Term Subculture . Cell Tissue Ref . 253. : 325-331(1988) .