FARMAKOEPIDEMIOLOGI

FARMAKOEPIDEMIOLOGI

Drugs withdrawn from the market28Harus melakukan keputusan terapiKetidakyakinan terhadap value dari masing-masing opsi

Variasi terapi

29all medicines are prescribed, dispensed or sold inappropriatelyOveruseUnderuseWHO report (May 2010)half of all patients fail to take medicines correctlyMisuse3022. Rational Use of DrugBlock 1.6, June 23, 2009 Week 4 International Programmedr. Jarir At Thobari, Ph.DIRRATIONAL USE OF DRUGSPolypharmacyIncorrect drug(s) for specific indication(s):Steroid for sore throatDose, route, frequency of treatment course: antibiotics for 3 days treatmentRisk > benefit : corticosteroid for pharyngitis Expensive prescribing : cephalosporin for ARI 313119. Rational Use of DrugBlock 1.6, June 24, 2008 Week 4 International ProgrammeProf. dr. Iwan Dwiprahasto, M.Med.Sc., Ph.D22. Rational Use of DrugBlock 1.6, June 23, 2009 Week 4 International Programmedr. Jarir At Thobari, Ph.D1. No treatment is required2. Wrong indications4. Incorrect frequency & route of treatment3. Risk of adverse event > efficacy5. Expensive6. Limited evidence of efficacy & safety7. Affect patient perceptions on treatmentINAPROPRIATE USE OF DRUGS

323219. Rational Use of DrugBlock 1.6, June 24, 2008 Week 4 International ProgrammeProf. dr. Iwan Dwiprahasto, M.Med.Sc., Ph.D22. Rational Use of DrugBlock 1.6, June 23, 2009 Week 4 International Programmedr. Jarir At Thobari, Ph.DRational use of medicine

AppropriateFollow upDiagnosisIndicationDrug(s)InformationDose, route, treatment coursePatients333319. Rational Use of DrugBlock 1.6, June 24, 2008 Week 4 International ProgrammeProf. dr. Iwan Dwiprahasto, M.Med.Sc., Ph.D22. Rational Use of DrugBlock 1.6, June 23, 2009 Week 4 International Programmedr. Jarir At Thobari, Ph.DTreatment ChoicesPrior Knowledge HabitsScientific InformationRelationshipsWith PeersInfluenceof DrugIndustry

Workload & StaffingInfra-structureAuthority & SupervisionSocietalInformationIntrinsicWorkplaceWorkgroupSocial &CulturalFactorsEconomic &Legal FactorsMany Factors Influence Use of Medicines

35