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FAD Simon J. Kenyon Ross University. Learning Objectives Understand the global context of FADs and...
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Transcript of FAD Simon J. Kenyon Ross University. Learning Objectives Understand the global context of FADs and...
FAD
Simon J. Kenyon
Ross University
Learning Objectives
• Understand the global context of FADs and their importance
• Recognize the clinical signs of important FADs• Know what to do if you encounter an unusual
disease that is possibly and FAD
FAD Myths
• FADs are a problem for large animal veterinarians
• FADs look like the pictures• USDA/APHIS/VS doesn’t like false alarms• It can’t happen to me
Jan - Jan 2010 - 2011
IAHSolid colour = PanAsian strain present
Hashed colour = Type O present, PanAsian strain suspected
Spread of the PanAsia lineage of the Middle East-South Asian (ME-SA) topotype of FMDV-O
200019991998199719961995199419931990
First appearance
N.J. Knowles, 15 October 2001
2001
Some recent cases
• Screwworm, Sept 2007, Mississippi • Avian Influenza HPAI, 2004 - H5N2 Texas, H7N3
British Columbia• Exotic Newcastle Disease 2003 – California,
Texas • BSE, 2003 - 2007 – imported and US bred cattle• Monkey Pox, multi-state, June 2003• Bluetongue – Montana, Wyoming 2007
Monkey Pox
• Imported Gambian Giant Rat• Prairie Dogs• Humans
Screwworm
Image from “The Gray Book”, University of Georgia
Screwworm
Screwworm - Third instar larvae, Cochliomyia hominivorax
Recent Outbreaks
Exotic Newcastle Disease – California 2002-2003
Moynihan Report on Collaborative Networks, 2005
“On average 40 new employees joined the task force daily”
www.EDEN.lsu.edu
Opportunities for Veterinarians
• Initial Accreditation Training Course• USDA/APHIS/VS and State Animal Health Depts.• Animal Surveillance Emergency Response Teams
(ASERT)• Purdue’s Graduate Certificate Program in Veterinary
Homeland Security
FMD - Cattle
Vesicles or blisters on tongue, dental pad, or teats
FMD
Hogs and other species – vesicles on coronary band
Hog - Vesicle on snout
Clinical Comparisons: Snouts
• Swine Vesicular Disease
• Vesicular Stomatitis
• Foot and Mouth Disease
• Vesicular Exanthema
FMD
Swine Vesicular Disease
Sheep – disease may be very mild
Public Information
FMD Issues
• Early Diagnosis• Time from diagnosis to slaughter• Models• Vaccination• Carcass disposal• Societal change
North Carolina Live Animal Shipments
SwineGoats
Sheep and LambsPoultry
Beef CattleDairy Cattle
CanadaMexico
South America
CanadaMexico
Live animals are shipped to a total of 27 states, Puerto Rico, Mexico, Canada and South America!
Puerto Rico
Diff. Diagnosis of Vesicular Dis.
Cattle Sheep Swine Horse
FMD S S S R
Vesicular stomatitis S S S S
Vesicular Exanthema of Swine R R S R
Swine Vesicular Disease R R S R
Sources of Primary Outbreaks
SourceSource Percent of OutbreaksPercent of Outbreaks
1870-1968 1969-1993
Meat, meat products, garbage 71 23
Airborne (wind) or migrating birds 24 9
Livestock importations 2 36
Contaminated objects, persons 3 4
Vaccines 1 25
Wildlife <1 3
FMD, Worldwide
Source: USDA
Airborne Spread?
“O Lausanne 1965”
National Animal Health Laboratories Network (NAHLN) 2003
Proposed Biosafety Level 4 sites
• Flora, Mississippi• Athens, Georgia
• San Antonio, Texas• Butner, North Carolina
Manhattan, Kansas
African Horse Sickness
African Horse Sickness
African Horse Sickness
African Horse Sickness
African Horse Sickness
Low Pathogenicity (LPAI) High Pathogenicity (HPAI)
Avian influenza
• Natural Host: Waterfowl (ducks, geese etc.)• Domestic species affected
– Chickens, ducks, geese, turkeys, guinea fowl, quail and pheasant
– Some pet birds
• 16 H (hemagglutinin antigens) and 9 N (neuraminidase antigens)
• All subtypes can be found in birds, but only subtypes H5 and H7 have caused severe outbreaks of disease in birds
Type A Influenza
Avian Influenza
Symptoms of HPAI• A lot of birds affected
– Dead birds– Very sick birds– Coughing and sneezing– Swollen combs and wattles– Discolored and swollen joints– Diarrhea
Avian Influenza
Avian Influenza
Cyanotic Comb
Avian Influenza H5N1
H5N1 - WHO mortality stats January 13 2011
Avian Influenza and the U.S.
Could enter as:
A bird disease
A human disease
VVND
Edema and hemorrhage of the head esp. eyelids
VVND
Hemorrhages in proventriculus
VVND
Necrosis of cecal tonsil and Peyer’s patches
African Swine Fever
Reddening of ears and skin (non-specific)
African Swine Fever
Enlarged dark red or black spleen. Note kidney
African Swine Fever
Hemorrhagic gastro-hepatic lymph nodes
African Swine Fever
Enlarged, hemorrhagic peri-renal lymph nodes
Hog Cholera
Conjunctivitis and exudate at medial canthus
Hog Cholera
Tonsillar necrosis
Hog Cholera
Splenic infarcts
Hog Cholera
Petechial hemorrhages in renal cortex
Rinderpest
BVD
EHD in a cow
Bluetongue
EHD
Rinderpest
Necrosis of Peyer’s patches
Rinderpest
Zebra stripe hemorrhages of colonic mucosa
Peste des Petits Ruminants
Zebra stripe hemorrhages of colonic mucosa - goat
Stomatitis-Enteritis Case Definition
Ocular Discharge
Nasal Discharge
And
Fever
Oral Erosions/Lesions
Salivation
Corneal Opacity
Diarrhea
Death
Outbreaks of contagious disease exhibiting discharge (ocular and nasal) and any two of the above-mentioned symptoms should be reported as stomatitis-enteritis outbreaks. Note that it is the outbreak that must meet the case definition, not individual animals.
The stomatitis-enteritis case definition is used to ensure that all case that could be Rinderpest are investigated
How to Do the Gel Diffusion Test for Rinderpest
Rinderpest 1980’s
Rinderpest 2003
Contagious Bovine Pleuropneumonia
Contagious Bovine Pleuropneumonia
Contagious Bovine Pleuropneumonia
Malignant Catarrhal Fever
Malignant Catarrhal Fever
Cutaneous lymphosarcoma
Lumpy Skin Disease
Lumpy skin disease
massive lymphadenopathy and edema of the forelimb is common
Lumpy Skin Disease
From: The Gray Book
Sheep pox lesions on underside of tail of a sheep
Recovered case of lumpy skin disease. The scars are called “sitfasts”