Extraction and reflection: early evolution of the Hymenoptera Anatomy Ontology
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Transcript of Extraction and reflection: early evolution of the Hymenoptera Anatomy Ontology
Formal representation of concepts within a domain and the relationships between those concepts.
ontology ≠ ontogeny
Ontology
domain = hymenopteraconcept = class (an real anatomical thing) label = words used to represent anatomical things ****a class can contain many labels***
male genitalia phallus parameres copulatoria genital capsule genital armaturephallic apparatus genital apparatusarmatura genitalis genital appendagecopulatory apparatusexternal genital organmale copulatory organ
www.hymao.org
a class can have many labels
www.hymao.org
this real thing is a class
male genitalia phallus parameres copulatoria genital capsule genital armaturephallic apparatus genital apparatusarmatura genitalis genital appendagecopulatory apparatusexternal genital organmale copulatory organ
a class can have many labels
male genitalia phallus parameres copulatoria genital capsule genital armaturephallic apparatus genital apparatusarmatura genitalis genital appendagecopulatory apparatusexternal genital organmale copulatory organ
www.hymao.org
a class can have many labelsthis real thing is a class
these are all labels
[Term]id: HAO:0000312name: external male genitaliadef: "The compound organ that is involved in coupling with the female genitalia and with the intromission of spermatozoa and seminal fluid." [HAO:im]synonym: "armatura genitalis" []synonym: "copulatoria" []synonym: "copulatory apparatus" []synonym: "genital apparatus" []synonym: "genital appendage" []synonym: "genital armature" []synonym: "genital capsule" []synonym: "genital organ" []synonym: "male copulatory organ" []synonym: "parameres" []synonym: "phallic apparatus" []synonym: "phallus" []relationship: part_of HAO:0000505 ! male genitaliais_a: HAO:0000024 ! compound organ
[Term]id: HAO:0000313name: external parameradef: "The anatomical cluster that is composed of the gonostipites and volsellae." [HAO:im]relationship: part_of HAO:0000312 ! external male genitaliais_a: HAO:0000041 ! anatomical cluster
OpenBiomedicalOntologies(OBO)
Nasonia spp. >50 mutants
implications: vehicle to integrate research
process
http://purl.oclc.org/NET/mx-database
MX
process mx software(development)
community feedback(Hymenoptera, ontology & computer science)
exposure
2,682 labels
1,382 classes 865 references 3058 times referenced 1201 from just a few papers
Term extraction from BHL353 JHR
number of new labels added to database: 347 number of papers: 23--------------------------------------------------------------137 PATO labels "PATO is an ontology of phenotypic qualities, intended for use in a number of applications, primarily defining composite phenotypes and phenotype annotation"(i.e. NOT ending up in the HAO) before: 464now: 601only 55 of these presently in PATO -----------------------------------------------------------210 new labels for the HAO(Do not know how many will result in new classes)
----------------------------In the 23 papers…..• 1145 distinct labels• 8802 occurrences of those terms• 4469 < 50 times• 4333 > 50 times
results
results
highest number > 50
vein (465)
wing (282)
cell (219) wing vein (114)
results
carina (187)
tergum (183)tergites (128)
propodeum (83)
sternum (65)
highest number > 50
results
smooth (94)
small (87)
short (85)
highest number > 50
resultsglossa (72)
highest number > 50
results
cell (219) area (116) base (84)
apex (76)body (71)
highest number > 50
Future
add the rest of the 353 articles
define new classes
define PATO terms
reevaluate workflow (create better proofing tools)work with Biodiversity Heritage Library (link to label descriptions?)
capture complex information in MX and assemble information using ontology (HAO, PATO, etc..)
funding: Advances in Biological Informatics (NSF DBI-0850223) NESCent (NSF EF-0423641) Morphbank (NSF DBI-0446224) HymAToL (NSF EF-0337220) PEET: Monographic research on parasitic Hymenoptera (NSF DEB-0328922)
intellect and enthusiasm: Fredrik Ronquist (NRM) Jim Balhoff, Hilmar Lapp, Todd Vision, Wasila Dahdul (NESCent) Rod Page, Biodiveristy Heritage Library, Rick Prelinger Paula Mabee (USD) Anne Maglia (MUS & T) International Society of Hymenopterists All the contributors
Acknowledgments