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SCHB Joseph Sabol Monday, March 26, 2012

Oral Session

Exponential Technologies: Disruptive Influences and Rapid Advancements in Chemistry - PM Session

Location: San Diego Convention Center Monday March 26, 2012

Room: Room 26B

Cosponsored by: CEPA, COMSCI

Organizers: Lisa Butters

Presiders: Lisa Butters

Duration: 1:30 pm - 4:20 pm

Pres Time Pub # Presentation Title

1:30 pm

Introductory Remarks

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1:35 pm 6

Digital biology: Life under Moore's Law

Raymond McCauley, Genomera, Inc., Mountain View, CA 94041, United States

The ability to read DNA is in the midst of an unprecedented exponential change. The Human Genome

Project took about $300 million and 11 years to complete, we now do for under $5000 in a week, and

there's no end in sight. What are the practical applications of this technology? What are the technical

and economic trends driving this revolution? How can small, agile companies ride along? And where are

we going next?

2:05 pm 7

Broadband magnetic signatures of solvated chemistries

Bennett M. Butters, Nativis, Inc., United States

A low temperature SQUID (super conducting quantum interference device) based approach to

broadband molecular interrogation is discussed with an emphasis on the technical basis for detection,

signal analysis, and the usefulness of acquired data. Also, presented are the analytical results of selected

materials and the implications to biochemistry.

2:35 pm 8

Nanostructured materials for large and small molecule selectivity

Robert Meagley, ONE Nanotechnologies, LLC, Berkeley, CA 94710, United States

We describe work ongoing at ONE Nanotechnologies, LLC to create and refine chemoselective films for

application as recognition elements in several sensor platforms. Organic materials and nanocomposites

have been developed that allow gas phase and liquid phase detection of explosives and chemical agents.

Very high surface area interfaces are achieved through processes suitable for high volume manufacture.

Novel strategies enabling high molecular weight precursors to be used in a plasma enhanced deposition

mode will be shown. Highly structured surfaces shown to have significant capability to recognize

individual proteins from mixtures will be presented and implications for advanced biomarker sensing

will be discussed. The thrust of this work illustrates the value of an interdisciplinary approach to

advanced material design and integration in devices.

3:05 pm

Intermission

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3:15 pm 9

Sequencing DNA by looking at it: Seeing chemistry with atoms rather than ensembles of atoms (or,

"Why I left a full professorship to join a startup")

Andrew Bleloch, Halcyon Molecular, Redwood City, CA 94063, United States

The development of highly multiplexed sequencing reactions via clonal oligonucleotide clusters has

provided the means to reduce the cost of sequencing by roughly five orders of magnitude over the last

six years. This "next generation" sequencing has enabled sequencing as a basic tool to inquire the state

of DNA variation, the transcriptional levels of the multitude of RNAs, the location of transcriptional

cofactors, and many other molecular characteristics that can be expressed as an oligonucleotide. This

presentation will summarize the technology and showcase several vignettes of current biological and

medical interest.

3:45 pm 10

Next generation sequencing: Redefining growth beyond Moore's Law

Scott D. Kahn, Illumina, Inc., San Diego, CA 92121, United States

The development of highly multiplexed sequencing reactions via clonal oligonucleotide clusters has

provided the means to reduce the cost of sequencing by roughly five orders of magnitude over the last

six years. This "next generation" sequencing has enabled sequencing as a basic tool to inquire the state

of DNA variation, the transcriptional levels of the multitude of RNAs, the location of transcriptional

cofactors, and many other molecular characteristics that can be expressed as an oligonucleotide. This

presentation will summarize the technology and showcase several vignettes of current biological and

medical interest.

4:15 pm

Concluding Remarks