Excellence in phenotyping: Assessment of oxidative stress and microinflammation Jan Menne/Hermann...
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Transcript of Excellence in phenotyping: Assessment of oxidative stress and microinflammation Jan Menne/Hermann...
![Page 1: Excellence in phenotyping: Assessment of oxidative stress and microinflammation Jan Menne/Hermann Haller Department of Nephrology Medical School Hannover.](https://reader035.fdocuments.us/reader035/viewer/2022070305/551536a4550346a87d8b5b18/html5/thumbnails/1.jpg)
Excellence in phenotyping: Excellence in phenotyping: Assessment of oxidative stress and Assessment of oxidative stress and
microinflammationmicroinflammation
Jan Menne/Hermann Haller Department of NephrologyMedical School Hannover [email protected]
![Page 2: Excellence in phenotyping: Assessment of oxidative stress and microinflammation Jan Menne/Hermann Haller Department of Nephrology Medical School Hannover.](https://reader035.fdocuments.us/reader035/viewer/2022070305/551536a4550346a87d8b5b18/html5/thumbnails/2.jpg)
The problem: The problem: how translate risk factors into vascular disase ?how translate risk factors into vascular disase ?
Risk factors Vascular damage Vascular damage „subclinical“„subclinical“
Clinical diseaseClinical disease
years and decadesyears and decades
glucoseglucoselipidslipids
smokingsmokinghypertensionhypertension
![Page 3: Excellence in phenotyping: Assessment of oxidative stress and microinflammation Jan Menne/Hermann Haller Department of Nephrology Medical School Hannover.](https://reader035.fdocuments.us/reader035/viewer/2022070305/551536a4550346a87d8b5b18/html5/thumbnails/3.jpg)
The problem: The problem: how to recognize these „patients“ ?how to recognize these „patients“ ?
Risk factors Vascular damage Vascular damage „subclinical“„subclinical“
Clinical diseaseClinical disease
years and decadesyears and decades
glucoseglucoselipidslipids
smokingsmokinghypertensionhypertension
![Page 4: Excellence in phenotyping: Assessment of oxidative stress and microinflammation Jan Menne/Hermann Haller Department of Nephrology Medical School Hannover.](https://reader035.fdocuments.us/reader035/viewer/2022070305/551536a4550346a87d8b5b18/html5/thumbnails/4.jpg)
phenotyping - what are we looking for ?phenotyping - what are we looking for ?
hypertensionhypertension
OxidativeOxidativestressstress
Micro-Micro-inflammationinflammation
![Page 5: Excellence in phenotyping: Assessment of oxidative stress and microinflammation Jan Menne/Hermann Haller Department of Nephrology Medical School Hannover.](https://reader035.fdocuments.us/reader035/viewer/2022070305/551536a4550346a87d8b5b18/html5/thumbnails/5.jpg)
EM Gefäß
![Page 6: Excellence in phenotyping: Assessment of oxidative stress and microinflammation Jan Menne/Hermann Haller Department of Nephrology Medical School Hannover.](https://reader035.fdocuments.us/reader035/viewer/2022070305/551536a4550346a87d8b5b18/html5/thumbnails/6.jpg)
PermeabilityPermeabilityNONO
NOS NOS
NONO
Non-adhesiveNon-adhesive
Healthy endotheliumHealthy endothelium
![Page 7: Excellence in phenotyping: Assessment of oxidative stress and microinflammation Jan Menne/Hermann Haller Department of Nephrology Medical School Hannover.](https://reader035.fdocuments.us/reader035/viewer/2022070305/551536a4550346a87d8b5b18/html5/thumbnails/7.jpg)
NONO
NOS NOS
NONO
Non-adhesiveNon-adhesive
Healthy endotheliumHealthy endothelium Hypertension Glucose Cholesterol riskHypertension Glucose Cholesterol risk
factorsfactors
ROSROS
Oxidases Oxidases
NOSNOS
inhibitorsinhibitors
ChemokinesChemokines
PermeabilityPermeabilityPermeabilityPermeability
![Page 8: Excellence in phenotyping: Assessment of oxidative stress and microinflammation Jan Menne/Hermann Haller Department of Nephrology Medical School Hannover.](https://reader035.fdocuments.us/reader035/viewer/2022070305/551536a4550346a87d8b5b18/html5/thumbnails/8.jpg)
PermeabilityPermeabilityNONO
NOS NOS
NONO
Non-adhesiveNon-adhesive
Healthy endotheliumHealthy endothelium
PermeabilityPermeability
Oxidases Oxidases
ROSROS
NOSNOS
inhibitorsinhibitors
ChemokinesChemokines
Hypertension Glucose Cholesterol riskHypertension Glucose Cholesterol risk
factorsfactors
![Page 9: Excellence in phenotyping: Assessment of oxidative stress and microinflammation Jan Menne/Hermann Haller Department of Nephrology Medical School Hannover.](https://reader035.fdocuments.us/reader035/viewer/2022070305/551536a4550346a87d8b5b18/html5/thumbnails/9.jpg)
EM Leukozytenadhäsion
![Page 10: Excellence in phenotyping: Assessment of oxidative stress and microinflammation Jan Menne/Hermann Haller Department of Nephrology Medical School Hannover.](https://reader035.fdocuments.us/reader035/viewer/2022070305/551536a4550346a87d8b5b18/html5/thumbnails/10.jpg)
PermeabilityPermeabilityNONO
NOS NOS
NONO
Non-adhesiveNon-adhesive
Healthy endotheliumHealthy endothelium
PermeabilityPermeability
Oxidases Oxidases
ROSROS
NOSNOS
inhibitorsinhibitors
ChemokinesChemokines
MCP-1, CCR-7 etcMCP-1, CCR-7 etc
selectinsselectins
Hypertension Glucose Cholesterol riskHypertension Glucose Cholesterol risk
factorsfactors