Evidence of KA21.pdf

8/17/2019 Evidence of KA21.pdf

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Evidence of KA21


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Antitumor beta glucan from the cultured fruit body of Agaric

http://www.ncbi.nlm.nih.gov/pubmed/11456124

http://www.ncbi.nlm.nih.gov/pubmed/11456124http://www.ncbi.nlm.nih.gov/pubmed/11456124


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Antitumor activity


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Ipomoea batatas and Agarics blazei ameliorate diabetic disordtherapeutic antioxidant potential in streptozotocin-induced drats.




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Diabetes

Blood sugar

normal

control

Ipomoea bata

Kingagaricus

Week


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Immunomodulating Activity of Agaricus brasiliensis KA21 in MHuman Volunteers.




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Biochemical

parameters

Before (mean ± SD) After (mean ± SD) Statistics ( P -valu

Total protein (g dl – 1) 7.50 ± 0.16 7.41 ± 0.25 0.31

BUN (mg dl – 1) 15.81± 5.93 13.45± 2.25 0.12

Creatinine (mg dl – 1) 0.92 ± 0.21 0.90 ± 0.20 0.19

GOT (µ l – 1) 18.8 ± 4.75 19.8 ± 4.40 0.10

GPT (µ l – 1) 15.7 ± 6.90 16.3 ± 4.90 0.52

-GTP (µ l – 1) 35.4 ± 29.6GTP 35.9 ± 30.1 0.89

(N = 11).

Table 3. Safety of A. brasi l iensis KA21 in human volunteers

Kingagaricus100 9g a day was administrated for 6 months to 11 subjects

Safety data


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Copyright restrictions may apply.

Liu, Y. et al. eCAM 2007 0:nem016v1-15; doi:10.1093/ecam/nem016

Effect of A. brasiliensis on body weight

The normal dose was administrated to 12 subjects for 3 months


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Effect of A. brasiliensis on BMI



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Effect of A. brasiliensis on percentage body fat



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Effect of A. brasiliensis on percentage visceral fat



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Effect of A. brasiliensis on blood glucose level



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Effect of A. brasiliensis on blood cholesterol level from the viewpoint of Mibyou


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Effect of A. brasiliensis on neutral fat level from the viewpoint of Mibyou


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Comparison of NK cell activity before and after administration of A. brasiliensis

The normal dose or placebo was administrated to 8 subjects for 7 days (


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Comparison of NK cell activity before and after administration of placebo

The normal dose or placebo was administrated to 8 subjects for 7 days (


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Agaricus brasiliensis KA21 improves circulatory functions inspontaneously hypertensive rats.




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Improve Circulatory Function （SHR)


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Diet


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Neutral Fat (Triglyceride)


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Protect Heart FunctionCentraｌ Nerve system

He

Muscle


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Differences in antioxidant activities of outdoor- and indoor-cuAgaricus brasiliensis, and protective effects against carbontetrachloride-induced acute hepatic injury in mice.




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Antioxidant activity

Kingagaricus Green house


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Liver Protection

Normal

Kingagaricus 3%

Green house agaricus 3%

10


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Liver Protection

Normal

Kingagaricus 10%

24hours


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Open-Label Study of the Influence of Food Containing the RoyMushroom, Agaricus brasiliensis KA21 (Higher BasidiomyceteQuality of Life of Healthy Human Volunteers.




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QOL

2.0

2.2

2.4

2.6

2.8

3.0

3.2

3.4

3.6

3.8

4.0

Pre-intake 6th week 12th week

Fatigue

L H

2.0

2.2

2.4

2.6

2.8

3.0

3.2

3.4

3.6

3.8

4.0


Hair Loss

L H

2.0

2.2

2.4

2.6

2.8

3.0

3.2

3.4

3.6

3.84.0

Pre-intake 6th w

Grey H

L

900mg or 1500mg


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QOL

0.0

0.2

0.4

0.6

0.8

1.0

1.2

1.4

1.6

1.8

2.0


difficulty staying awake during the day

L H

0.0

0.2

0.4

0.6

0.8

1.0

1.2

1.4

1.6

1.8

2.0

Pre-intake 6th week

ease of getting out of bed

L H


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Not published data

IGF 1


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IGF-1

IGF-1 level High

Low

Peak

Aging


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IGF-1

• Anti-Aging effects

Hair regrowth

Improve immunity

Better skin condition, less spots, wrinkles

Improve cognitive function

Improve metabolic syndrome

Generative function


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IGF-1

This is not K

Anti-Aging


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0

50

100

150

200

Control(n=5)

Agalicus blazei(water extract) (10 mg/kg/day,

po)(n=5)

*, p


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IGF-1

2 months

Dog took Kingagaricus100 for 2 months


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Reduce side effect from anti cancer dru

Number of Leucocyte

Control

cyclophosphamide; CPA

cyclophosphamide; CPA+agaricus hot

cyclophosphamide; CPA+agaricus cold

Evidence of KA21.pdf

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